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公开(公告)号:US09526914B2
公开(公告)日:2016-12-27
申请号:US14716394
申请日:2015-05-19
申请人: IMMUNOLIGHT, LLC , DUKE UNIVERSITY
发明人: Tuan Vo-Dinh , Jonathan P. Scaffidi , Venkata Gopal Reddy Chada , Benoit Lauly , Yan Zhang , Molly K. Gregas , Ian Nicholas Stanton , Joshua T. Stecher , Michael J. Therien , Frederic A. Bourke, Jr. , Harold Walder , Zak Fathi , Jennifer A. Ayres , Zhenyuan Zhang , Joseph H. Simmons , Stephen John Norton
CPC分类号: A61N5/062 , A61B5/0059 , A61B5/0071 , A61B5/055 , A61B5/4848 , A61B6/481 , A61K41/0042 , A61K41/0052 , A61K41/0061 , A61K49/0039 , A61L2/0047 , A61L2/08 , A61L2202/21 , A61L2202/22 , A61M5/007 , A61N1/406 , A61N5/02 , A61N5/0601 , A61N5/0618 , A61N5/0622 , A61N5/0624 , A61N5/10 , A61N2005/063 , A61N2005/0656 , A61N2005/0659 , A61N2005/0662 , A61N2005/067 , A61N2005/1098
摘要: Products, compositions, systems, and methods for modifying a target structure. The methods may be performed in a non-invasive manner by placing a nanoparticle having a metallic shell on at least a fraction of a surface in a vicinity of a target structure in a subject and applying an initiation energy thus producing an effect on or change to the target structure directly or via a modulation agent. The nanoparticle is configured, upon exposure to a first wavelength λ1, to generate a second wavelength λ2 of radiation having a higher energy than the first wavelength λ1. The methods may further be performed by application of an initiation energy to activate a photoactivatable agent directly or via an energy modulation agent, optionally in the presence of one or more plasmonics active agents, thus producing an effect on or change to the target structure.
摘要翻译: 用于修改目标结构的产品,组成,系统和方法。 所述方法可以以非侵入性方式进行,通过将具有金属壳的纳米颗粒放置在受试者的靶结构附近的表面的至少一部分上,并施加引发能量,从而产生作用或改变 目标结构直接或通过调制剂。 纳米颗粒在暴露于第一波长λ1时被配置为产生具有比第一波长λ1更高的能量的辐射的第二波长λ2。 所述方法还可以通过施加起始能量来直接地或经由能量调节剂,任选地在一种或多种等离子体激元活性剂的存在下活化可光活化剂,从而对目标结构产生影响或改变。
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公开(公告)号:US11324965B2
公开(公告)日:2022-05-10
申请号:US16511536
申请日:2019-07-15
申请人: IMMUNOLIGHT, LLC. , DUKE UNIVERSITY
发明人: Tuan Vo-Dinh , Jonathan P. Scaffidi , Venkata Gopal Reddy Chada , Benoit Lauly , Yan Zhang , Molly K. Gregas , Ian Nicholas Stanton , Joshua T. Stecher , Michael J. Therien , Frederic A. Bourke, Jr. , Harold Walder , Zak Fathi , Jennifer A. Ayres , Zhenyuan Zhang , Joseph H. Simmons , Stephen John Norton
IPC分类号: A61N5/06 , A61K49/00 , A61N1/40 , A61N5/02 , A61B5/00 , A61B5/055 , A61B6/00 , A61K41/00 , A61M5/00 , A61L2/00 , A61L2/08 , A61N5/067 , A61N5/10
摘要: Products, compositions, systems, and methods for modifying a target structure which mediates or is associated with a biological activity, including treatment of conditions, disorders, or diseases mediated by or associated with a target structure, such as a virus, cell, subcellular structure or extracellular structure. The methods may be performed in situ in a non-invasive manner by placing a nanoparticle having a metallic shell on at least a fraction of a surface in a vicinity of a target structure in a subject and applying an initiation energy to a subject thus producing an effect on or change to the target structure directly or via a modulation agent. The nanoparticle is configured, upon exposure to a first wavelength λ1, to generate a second wavelength λ2 of radiation having a higher energy than the first wavelength λ1. The methods may further be performed by application of an initiation energy to a subject in situ to activate a pharmaceutical agent directly or via an energy modulation agent, optionally in the presence of one or more plasmonics active agents, thus producing an effect on or change to the target structure. Kits containing products or compositions formulated or configured and systems for use in practicing these methods.
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公开(公告)号:US11383098B2
公开(公告)日:2022-07-12
申请号:US16516463
申请日:2019-07-19
申请人: Immunolight, LLC , Duke University
发明人: Tuan Vo-Dinh , Jonathan P. Scaffidi , Venkata Gopal Reddy Chada , Benoit Lauly , Yan Zhang , Molly K. Gregas , Ian Nicholas Stanton , Joshua T. Stecher , Michael J. Therien , Frederic A. Bourke, Jr. , Harold Walder , Zak Fathi , Jennifer A. Ayres , Zhenyuan Zhang , Joseph H. Simmons , Stephen John Norton
IPC分类号: A61N5/06 , A61K49/00 , A61N1/40 , A61N5/02 , A61B5/00 , A61B5/055 , A61B6/00 , A61K41/00 , A61M5/00 , A61L2/00 , A61L2/08 , A61N5/067 , A61N5/10
摘要: Products, compositions, systems, and methods for modifying a target structure which mediates or is associated with a biological activity, including treatment of conditions, disorders, or diseases mediated by or associated with a target structure, such as a virus, cell, subcellular structure or extracellular structure. The methods may be performed in situ in a non-invasive manner by placing a nanoparticle having a metallic shell on at least a fraction of a surface in a vicinity of a target structure in a subject and applying an initiation energy to a subject thus producing an effect on or change to the target structure directly or via a modulation agent. The nanoparticle is configured, upon exposure to a first wavelength λ1, to generate a second wavelength λ2 of radiation having a higher energy than the first wavelength λ1. The methods may further be performed by application of an initiation energy to a subject in situ to activate a pharmaceutical agent directly or via an energy modulation agent, optionally in the presence of one or more plasmonics active agents, thus producing an effect on or change to the target structure. Kits containing products or compositions formulated or configured and systems for use in practicing these methods.
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公开(公告)号:US20190336785A1
公开(公告)日:2019-11-07
申请号:US16511536
申请日:2019-07-15
申请人: IMMUNOLIGHT, LLC , DUKE UNIVERSITY
发明人: Tuan VO-DINH , Jonathan P. Scaffidi , Venkata Gopal Reddy Chada , Benoit Lauly , Yan Zhang , Molly K. Gregas , Ian Nicholas Stanton , Joshua T. Stecher , Michael J. Therien , Frederic A. Bourke, JR. , Harold Walder , Zak Fathi , Jennifer A. Ayres , Zhenyuan Zhang , Joseph H. Simmons , Stephen John Norton
IPC分类号: A61N5/06 , A61B5/00 , A61L2/00 , A61K49/00 , A61M5/00 , A61K41/00 , A61N1/40 , A61N5/02 , A61B6/00 , A61B5/055
摘要: Products, compositions, systems, and methods for modifying a target structure which mediates or is associated with a biological activity, including treatment of conditions, disorders, or diseases mediated by or associated with a target structure, such as a virus, cell, subcellular structure or extracellular structure. The methods may be performed in situ in a non-invasive manner by placing a nanoparticle having a metallic shell on at least a fraction of a surface in a vicinity of a target structure in a subject and applying an initiation energy to a subject thus producing an effect on or change to the target structure directly or via a modulation agent. The nanoparticle is configured, upon exposure to a first wavelength λ1, to generate a second wavelength λ2 of radiation having a higher energy than the first wavelength λ1. The methods may further be performed by application of an initiation energy to a subject in situ to activate a pharmaceutical agent directly or via an energy modulation agent, optionally in the presence of one or more plasmonics active agents, thus producing an effect on or change to the target structure. Kits containing products or compositions formulated or configured and systems for use in practicing these methods.
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公开(公告)号:US10384071B2
公开(公告)日:2019-08-20
申请号:US15247367
申请日:2016-08-25
申请人: IMMUNOLIGHT, LLC. , DUKE UNIVERSITY
发明人: Tuan Vo-Dinh , Jonathan P. Scaffidi , Venkata Gopal Reddy Chada , Benoit Lauly , Yan Zhang , Molly K. Gregas , Ian Nicholas Stanton , Joshua T. Stecher , Michael J. Therien , Frederic A. Bourke, Jr. , Harold Walder , Zak Fathi , Jennifer A. Ayres , Zhenyuan Zhang , Joseph H. Simmons , Stephen John Norton
IPC分类号: A61N5/06 , A61K49/00 , A61N1/40 , A61N5/02 , A61B5/00 , A61B5/055 , A61B6/00 , A61K41/00 , A61M5/00 , A61N5/10 , A61L2/00 , A61L2/08 , A61N5/067
摘要: System for modifying a target structure which mediates or is associated with a biological activity, including treatment of conditions, disorders, or diseases mediated by or associated with a target structure, such as a virus, cell, subcellular structure or extracellular structure. The system can be used in methods which can be performed by application of an initiation energy to a subject in situ to activate a pharmaceutical agent directly or via an energy modulation agent, optionally in the presence of one or more plasmonics active agents, thus producing an effect on or change to the target structure.
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公开(公告)号:US09526913B2
公开(公告)日:2016-12-27
申请号:US14168795
申请日:2014-01-30
申请人: IMMUNOLIGHT, LLC , DUKE UNIVERSITY
发明人: Tuan Vo-Dinh , Jonathan P. Scaffidi , Venkata Gopal Reddy Chada , Benoit Lauly , Yan Zhang , Molly K. Gregas , Ian Nicholas Stanton , Joshua T. Stecher , Michael J. Therien , Frederic A. Bourke, Jr. , Harold Walder , Zak Fathi , Jennifer A. Ayres , Zhenyuan Zhang , Joseph H. Simmons , Stephen John Norton
CPC分类号: A61N5/062 , A61B5/0059 , A61B5/0071 , A61B5/055 , A61B5/4848 , A61B6/481 , A61K41/0042 , A61K41/0052 , A61K41/0061 , A61K49/0039 , A61L2/0047 , A61L2/08 , A61L2202/21 , A61L2202/22 , A61M5/007 , A61N1/406 , A61N5/02 , A61N5/0601 , A61N5/0618 , A61N5/0622 , A61N5/0624 , A61N5/10 , A61N2005/063 , A61N2005/0656 , A61N2005/0659 , A61N2005/0662 , A61N2005/067 , A61N2005/1098
摘要: A nanoparticle-based system for enhancement of emitted light inside a medium. The nanoparticle-based system includes a phosphorescent material which, upon activation, produces the emitted light, and a metallic structure attached to the phosphorescent material. The metallic structure has a surface plasmon resonance which resonates at a frequency which spectrally overlaps with one or more frequencies of the emitted light.
摘要翻译: 一种用于增强介质内发射光的基于纳米颗粒的系统。 基于纳米颗粒的系统包括磷光材料,其在激活时产生发射的光,以及附着到磷光材料的金属结构。 金属结构具有表面等离子体共振,其以与所发射的光的一个或多个频率光谱重叠的频率谐振。
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公开(公告)号:US20140243934A1
公开(公告)日:2014-08-28
申请号:US14168795
申请日:2014-01-30
申请人: IMMUNOLIGHT, LLC
发明人: Tuan VO-DINH , Jonathan P. Scaffidi , Venkata Gopal Reddy Chada , Benoit Lauly , Yan Zhang , Molly K. Gregas , Ian Nicholas Stanton , Joshua T. Stecher , Michael J. Therien , Frederic A. Bourke, JR. , Harold Walder , Zak Fathi , Jennifer A. Ayres , Zhenyuan Zhang , Joseph H. Simmons , Stephen John Norton
IPC分类号: A61N5/06
CPC分类号: A61N5/062 , A61B5/0059 , A61B5/0071 , A61B5/055 , A61B5/4848 , A61B6/481 , A61K41/0042 , A61K41/0052 , A61K41/0061 , A61K49/0039 , A61L2/0047 , A61L2/08 , A61L2202/21 , A61L2202/22 , A61M5/007 , A61N1/406 , A61N5/02 , A61N5/0601 , A61N5/0618 , A61N5/0622 , A61N5/0624 , A61N5/10 , A61N2005/063 , A61N2005/0656 , A61N2005/0659 , A61N2005/0662 , A61N2005/067 , A61N2005/1098
摘要: Products, compositions, systems, and methods for modifying a target structure. The methods may be performed in a non-invasive manner by placing a nanoparticle having a metallic shell on at least a fraction of a surface in a vicinity of a target structure in a subject and applying an initiation energy thus producing an effect on or change to the target structure directly or via a modulation agent. The nanoparticle is configured, upon exposure to a first wavelength λ1, to generate a second wavelength λ2 of radiation having a higher energy than the first wavelength λ1. The methods may further be performed by application of an initiation energy to activate a photoactivatable agent directly or via an energy modulation agent, optionally in the presence of one or more plasmonics active agents, thus producing an effect on or change to the target structure. Kits containing products or compositions formulated or configured and systems for use in practicing these methods.
摘要翻译: 用于修改目标结构的产品,组成,系统和方法。 所述方法可以以非侵入性方式进行,通过将具有金属壳的纳米颗粒放置在受试者的靶结构附近的表面的至少一部分上,并施加引发能量,从而产生作用或改变 目标结构直接或通过调制剂。 纳米颗粒在暴露于第一波长λ1时被配置为产生具有比第一波长λ1更高的能量的辐射的第二波长λ2。 所述方法还可以通过施加起始能量来直接地或经由能量调节剂,任选地在一种或多种等离子体激元活性剂的存在下活化可光活化剂,从而对目标结构产生影响或改变。 包含配制或配置的产品或组合的套件以及用于实施这些方法的系统。
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公开(公告)号:US12076579B2
公开(公告)日:2024-09-03
申请号:US17433768
申请日:2020-02-27
申请人: IMMUNOLIGHT, LLC
发明人: Frederic A. Bourke, Jr. , Harold Walder , Zakaryae Fathi , Wayne F. Beyer , Ronald A. Rudder , Joseph H. Simmons
IPC分类号: A61N5/06 , A61K35/12 , A61K41/00 , A61N5/067 , C09J133/08 , C09K11/02 , C09K11/59 , C09K11/76 , C09K11/77 , C12N15/01 , F21K2/00 , F21S11/00 , F21V9/40 , H01J45/00 , H01L23/00 , H01L31/0352 , H01L31/054 , H01L31/055 , H01L31/06
CPC分类号: A61N5/0625 , A61K35/12 , A61K41/00 , A61K41/0057 , A61N5/0601 , A61N5/062 , A61N5/067 , C09J133/08 , C09K11/025 , C09K11/595 , C09K11/76 , C09K11/7701 , C09K11/7792 , C12N15/01 , F21K2/00 , F21S11/007 , F21V9/40 , H01J45/00 , H01L24/29 , H01L24/83 , H01L31/035281 , H01L31/054 , H01L31/06 , A61N2005/0661 , A61N2005/0662 , A61N2005/0663 , H01L31/055 , H01L2224/2919 , H01L2224/29393 , H01L2224/8322 , H01L2224/83855
摘要: An emission enhancement structure having at least one energy augmentation structure; and an energy converter capable of receiving energy from an energy source, converting the energy and emitting therefrom a light of a different energy than the received energy. The energy converter is disposed in a vicinity of the at least one energy augmentation structure such that the emitted light is emitted with an intensity larger than if the converter were remote from the at least one energy augmentation structure. Also described are various uses for the energy emitters, energy augmentation structures and energy collectors in a wide array of fields, including various adhesives applications.
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公开(公告)号:US11964167B2
公开(公告)日:2024-04-23
申请号:US17433748
申请日:2020-01-30
申请人: IMMUNOLIGHT, LLC
发明人: Frederic A. Bourke, Jr. , Harold Walder , Zakaryae Fathi , Wayne F. Beyer , Ronald A. Rudder , Joseph H. Simmons
IPC分类号: A61N5/06 , A61K35/12 , A61K41/00 , A61N5/067 , C09J133/08 , C09K11/02 , C09K11/59 , C09K11/76 , C09K11/77 , C12N15/01 , F21K2/00 , F21S11/00 , F21V9/40 , H01J45/00 , H01L23/00 , H01L31/0352 , H01L31/054 , H01L31/06 , H01L31/055
CPC分类号: A61N5/0625 , A61K35/12 , A61K41/00 , A61K41/0057 , A61N5/0601 , A61N5/062 , A61N5/067 , C09J133/08 , C09K11/025 , C09K11/595 , C09K11/76 , C09K11/7701 , C09K11/7792 , C12N15/01 , F21K2/00 , F21S11/007 , F21V9/40 , H01J45/00 , H01L24/29 , H01L24/83 , H01L31/035281 , H01L31/054 , H01L31/06 , A61N2005/0661 , A61N2005/0662 , A61N2005/0663 , H01L31/055 , H01L2224/2919 , H01L2224/29393 , H01L2224/8322 , H01L2224/83855
摘要: An emission enhancement structure having at least one energy augmentation structure; and an energy converter capable of receiving energy from an energy source, converting the energy and emitting therefrom a light of a different energy than the received energy. The energy converter is disposed in a vicinity of the at least one energy augmentation structure such that the emitted light is emitted with an intensity larger than if the converter were remote from the at least one energy augmentation structure. Also described are various uses for the energy emitters, energy augmentation structures and energy collectors in a wide array of fields, such as color enhancement, and color enhancement structures containing the same.
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公开(公告)号:US12121746B2
公开(公告)日:2024-10-22
申请号:US17433890
申请日:2020-01-30
申请人: IMMUNOLIGHT, LLC
发明人: Frederic A. Bourke, Jr. , Harold Walder , Zakaryae Fathi , Wayne F. Beyer , Ronald A. Rudder , Joseph H. Simmons
IPC分类号: A61N5/06 , A61K35/12 , A61K41/00 , A61N5/067 , C09J133/08 , C09K11/02 , C09K11/59 , C09K11/76 , C09K11/77 , C12N15/01 , F21K2/00 , F21S11/00 , F21V9/40 , H01J45/00 , H01L23/00 , H01L31/0352 , H01L31/054 , H01L31/06 , H01L31/055
CPC分类号: A61N5/0625 , A61K35/12 , A61K41/00 , A61K41/0057 , A61N5/0601 , A61N5/062 , A61N5/067 , C09J133/08 , C09K11/025 , C09K11/595 , C09K11/76 , C09K11/7701 , C09K11/7792 , C12N15/01 , F21K2/00 , F21S11/007 , F21V9/40 , H01J45/00 , H01L24/29 , H01L24/83 , H01L31/035281 , H01L31/054 , H01L31/06 , A61N2005/0661 , A61N2005/0662 , A61N2005/0663 , H01L31/055 , H01L2224/2919 , H01L2224/29393 , H01L2224/8322 , H01L2224/83855
摘要: An emission enhancement structure having at least one energy augmentation structure; and an energy converter capable of receiving energy from an energy source, converting the energy and emitting therefrom a light of a different energy than the received energy. The energy converter is disposed in a vicinity of the at least one energy augmentation structure such that the emitted light is emitted with an intensity larger than if the converter were remote from the at least one energy augmentation structure. Also described are various uses for the energy emitters, energy augmentation structures and energy collectors in a wide array of fields, particularly medical uses for treatment of cell proliferation disorders.
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