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    Compositions containing, methods involving, and uses of non-natural amino acids and polypeptides
    6.
    发明授权
    Compositions containing, methods involving, and uses of non-natural amino acids and polypeptides 有权
    含有，涉及非天然氨基酸和多肽的方法和使用的组合物

    公开(公告)号：US08153758B2

    公开(公告)日：2012-04-10

    申请号：US11925740

    申请日：2007-10-26

    申请人： Zhenwei Miao ,  Junjie Liu ,  Thea Norman

    发明人： Zhenwei Miao ,  Junjie Liu ,  Thea Norman

    IPC分类号： C07K2/00 ,  C07K4/00 ,  C07K14/50 ,  C07C251/00

    CPC分类号： C07K2/00 ,  C07C229/42 ,  C07K1/006

    摘要： Disclosed herein are non-natural amino acids and polypeptides that include at least one non-natural amino acid, and methods for making such non-natural amino acids and polypeptides. The non-natural amino acids, by themselves or as a part of a polypeptide, can include a wide range of possible functionalities, but typical have at least one aromatic amine group. Also disclosed herein are non-natural amino acid polypeptides that are further modified post-translationally, methods for effecting such modifications, and methods for purifying such polypeptides. Typically, the modified non-natural amino acid polypeptides include at least one alkylated amine group. Further disclosed are methods for using such non-natural amino acid polypeptides and modified non-natural amino acid polypeptides, including therapeutic, diagnostic, and other biotechnology uses.

    摘要翻译： 本文公开了包含至少一种非天然氨基酸的非天然氨基酸和多肽，以及制备这种非天然氨基酸和多肽的方法。 非天然氨基酸本身或作为多肽的一部分可以包括广泛范围的可能的官能团，但典型地具有至少一个芳族胺基团。 本文还公开了在翻译后进一步修饰的非天然氨基酸多肽，用于实现这种修饰的方法，以及纯化这些多肽的方法。 通常，修饰的非天然氨基酸多肽包括至少一个烷基化胺基团。 进一步披露的是使用这种非天然氨基酸多肽和修饰的非天然氨基酸多肽的方法，包括治疗，诊断和其他生物技术用途。