公开(公告)号：US20180187127A1

公开(公告)日：2018-07-05

申请号：US15729406

申请日：2017-10-10

申请人： PROMEGA CORPORATION

发明人： Sergei Saveliev ,  Daniel Simpson ,  Keith V. Wood ,  Harry Tetsuo Uyeda ,  Carolyn Woodroofe Hitko ,  Dieter Klaubert

IPC分类号： C11D1/20 ,  C07C309/14 ,  C07C309/15 ,  C07C309/16 ,  C07C323/12 ,  C07C309/10 ,  C07D307/40 ,  C07D307/56 ,  C07D317/22 ,  C07D333/16 ,  C11D1/14 ,  C07C329/06

CPC分类号： C11D1/20 ,  C07C309/10 ,  C07C309/14 ,  C07C309/15 ,  C07C309/16 ,  C07C323/12 ,  C07C329/06 ,  C07D307/40 ,  C07D307/56 ,  C07D317/22 ,  C07D333/16 ,  C11D1/143

摘要： The invention provides surfactant compounds of formulas I-IX, which can be used in methods for aiding the solubilization, digestion, preparation, analysis, and/or characterization of biological material, for example, proteins or cell membranes. The compounds can also aid in the recovery of peptides generated during protein digestion, particularly for in-gel digestion protocol. Additionally, the compounds can improve enzymatic protein deglycosylation without interfering with downstream sample preparation steps and mass spectrometric analysis. The compounds can be specifically useful as digestion aids that can be decomposed by an acid, by heat, or a combination thereof. Decomposition of the surfactants allows for facile separation from isolated samples, and/or allows for analysis of the sample without interfering with the sensitivity of various analytical techniques.

公开(公告)号：US09896522B2

公开(公告)日：2018-02-20

申请号：US13819668

申请日：2011-08-26

申请人： Gyula Vigh ,  Roy T. Estrada, III

发明人： Gyula Vigh ,  Roy T. Estrada, III

IPC分类号： G01N33/58 ,  C07C311/39 ,  C08F20/26 ,  C07D317/22 ,  G01N33/543 ,  C09B57/00 ,  G01N33/68

CPC分类号： C08F20/26 ,  C07C311/39 ,  C07C2603/50 ,  C07D317/22 ,  C09B57/001 ,  G01N33/54306 ,  G01N33/54393 ,  G01N33/582 ,  G01N33/6809 ,  Y10T436/173845

摘要： A solid phase reagent and method for simultaneously capturing and fluorescently labeling an analyte with multiple reactive sites to provide a mono-labeled analyte are disclosed. The reagent can be used in the method and comprises a plurality of analyte-reactive groups tethered to a porous solid phase, wherein each analyte-reactive group is covalently attached to a fluorescent group either directly or indirectly, wherein the distance between adjacent analyte-reactive groups is greater than the gyration radius of a captured analyte; the fluorescent group is covalently attached to a cleavable anchor group either directly or through a first spacer; and the cleavable anchor group is covalently attached to the solid phase either directly or through a second spacer, wherein the solid phase is a porous solid or a porous gel.

公开(公告)号：US20180016227A1

公开(公告)日：2018-01-18

申请号：US15544939

申请日：2016-02-03

申请人： Trillium Therapeutics Inc.

发明人： Abdelmalik Slassi ,  Peter Dove

IPC分类号： C07C269/06 ,  C07D265/30 ,  C07D211/46 ,  C07D207/12 ,  C07C303/30 ,  C07D207/08 ,  C07D205/04 ,  C07C327/06 ,  C07D317/22 ,  C07D211/22

CPC分类号： C07C269/06 ,  C07C41/16 ,  C07C303/30 ,  C07C327/06 ,  C07D205/04 ,  C07D207/08 ,  C07D207/12 ,  C07D211/22 ,  C07D211/44 ,  C07D211/46 ,  C07D265/30 ,  C07D265/32 ,  C07D317/22 ,  C07C271/22 ,  C07C309/73 ,  C07C43/12

摘要： The present application relates to a novel process for the preparation of difluoromethyl ether-based derivatives from, for example, aliphatic and aromatic hydroxyl precursors, compositions comprising these compounds and their use, in particular as precursors for medicines for the treatment of diseases, disorders or conditions. In particular, the present application includes the process of preparing compounds of Formula (I), and compositions and uses thereof:

公开(公告)号：US20170107325A1

公开(公告)日：2017-04-20

申请号：US15300699

申请日：2015-03-30

申请人： NOF CORPORATION

发明人： Takuma TSUBUSAKI ,  Yuji YAMAMOTO

IPC分类号： C08G65/333 ,  C07D317/24 ,  C07D405/06 ,  C07D317/20

CPC分类号： C08G65/33396 ,  C07D317/20 ,  C07D317/22 ,  C07D317/24 ,  C07D317/28 ,  C07D405/06 ,  C08G65/329 ,  C08G65/3317 ,  C08G65/333 ,  C08G65/33324 ,  C08G65/33337 ,  C08G65/33341 ,  C08G65/3346 ,  C08G65/337

摘要： A hydrophilic polymer derivative having a cyclic benzylidene acetal linker represented by the following formula (1): wherein R1 and R6 are each independently a hydrogen atom or a hydrocarbon group; R2, R3, R4 and R5 are each independently an electron-withdrawing or electron-donating substituent or a hydrogen atom; X1 is a chemically reactive functional group; P is a hydrophilic polymer, s is 1 or 2, t is 0 or 1, and s+t is 1 or 2; w is an integer of 1 to 8; and Z1 and Z2 are each independently a selected divalent spacer.

公开(公告)号：US09290483B2

公开(公告)日：2016-03-22

申请号：US13643438

申请日：2011-04-29

申请人： Giuliana Schimperna ,  Riccardo Po' ,  Andrea Pellegrino ,  Maria Caldararo

发明人： Giuliana Schimperna ,  Riccardo Po' ,  Andrea Pellegrino ,  Maria Caldararo

IPC分类号： C08G65/26 ,  C08G65/04 ,  C07D317/22 ,  C07D409/12 ,  C07D405/12 ,  C08G61/12 ,  H01L51/00 ,  H01L51/42

CPC分类号： C07D405/12 ,  C07D317/22 ,  C07D409/12 ,  C08G61/123 ,  C08G61/124 ,  C08G61/126 ,  C08G75/06 ,  C08G2261/124 ,  C08G2261/1422 ,  C08G2261/1424 ,  C08G2261/3142 ,  C08G2261/3223 ,  C08G2261/3241 ,  C08G2261/3246 ,  C08G2261/411 ,  C08G2261/91 ,  H01L51/0036 ,  H01L51/0039 ,  H01L51/0043 ,  H01L51/0068 ,  H01L51/0072 ,  H01L51/42

摘要： Monomers having formula (I) and process for their synthesis which comprises the etherification reaction of a halogen-derivative (Z═Cl, Br, I) having formula (III) with the hydroxyl group of the glycerol derivative (IV), according to the following scheme:(Formula III, IV & I) (III) (IV) (I)

摘要翻译： 具有式（I）的单体及其合成方法，其包括具有式（III）的卤素衍生物（Z = Cl，Br，I）与甘油衍生物（IV）的羟基的醚化反应，根据 （式III，IV＆I）（III）（IV）（I）

公开(公告)号：US20150291567A1

公开(公告)日：2015-10-15

申请号：US14745957

申请日：2015-06-22

申请人： SEGETIS, INC.

发明人： Sergey Selifonov ,  Adam Edward Goetz ,  Feng Jing

IPC分类号： C07D407/14 ,  C07D407/04

CPC分类号： C07D407/14 ,  C07D317/12 ,  C07D317/22 ,  C07D317/30 ,  C07D407/04 ,  C07D407/12 ,  C07D493/04 ,  C07D493/10 ,  C07D493/14 ,  C07D493/16 ,  C07D493/18 ,  C07D493/22 ,  C08G63/668 ,  C08G69/26 ,  C08G69/28 ,  C08G69/44 ,  C08G69/48 ,  C08L77/06 ,  C08L77/12

摘要： The present disclosure relates to the preparation of ketal compounds from polyols and oxocarboxylates, and uses thereof.

摘要翻译： 本公开涉及由多元醇和氧代羧酸盐制备缩酮化合物及其应用。

公开(公告)号：US20150274667A1

公开(公告)日：2015-10-01

申请号：US14736062

申请日：2015-06-10

申请人： SCINOPHARM (CHANSHU) PHARMACEUTICALS, LTD.

发明人： Yi-Jing Chen ,  Stanislaw Pikul ,  Shen-Chun Kuo ,  Guo-dong Chu

IPC分类号： C07D213/74 ,  C07D319/06 ,  C07D317/22 ,  C07C43/307

CPC分类号： C07D213/74 ,  C07C43/2055 ,  C07C43/307 ,  C07C43/315 ,  C07D213/75 ,  C07D317/22 ,  C07D319/06

摘要： The present invention provides novel processes for the preparation of N-substituted benzamides having the formula VIc: In some embodiments, the invention provides a process for preparation of roflumilast and other pharmaceutically active species. Novel compounds, including intermediates for the synthesis of roflumilast, are also provided.

摘要翻译： 本发明提供用于制备具有式VIc的N-取代的苯甲酰胺的新方法：在一些实施方案中，本发明提供了制备罗氟司特和其它药学活性物质的方法。 还提供了新型化合物，包括合成罗氟司特的中间体。

公开(公告)号：US20150119586A1

公开(公告)日：2015-04-30

申请号：US14398246

申请日：2013-04-30

申请人： ISHIHARA SANGYO KAISHA, LTD.

发明人： Hisayoshi Jonishi ,  Tomohiro Okamoto ,  Norio Adachi ,  Akihiko Isogai ,  Tatsuya Jukurogi ,  Hideaki Konishi ,  Fumihiro Fukui

IPC分类号： C07D319/06 ,  C07C317/22 ,  C07D317/26

CPC分类号： C07D319/06 ,  C07C317/22 ,  C07D317/22 ,  C07D317/26

摘要： To provide an industrial method for producing a substituted benzoic acid compound useful as an intermediate of pharmaceutical and agricultural chemicals with high purity and high yield.A compound represented by the formula (II): (wherein Q is a 5- or 6-membered saturated heterocyclic group (the heterocyclic group may be substituted by alkyl) containing one or two of at least one type of hetero atom selected from the group consisting of an oxygen atom and a sulfur atom, or dialkoxymethyl, T is trifluoromethyl, nitro, cyano, —SOA1, —SO2A1, —PO(OA1)(OA2), —COA1, —CO2A1 or —CONA1A2, each of A1 and A2 which are independent of each other, is a hydrogen atom, alkyl or haloalkyl, X is halogen, alkyl, haloalkyl, alkoxy, haloalkoxy, alkylthio, haloalkylthio, alkylsulfinyl, haloalkylsulfinyl, alkylsulfonyl, haloalkylsulfonyl, dialkylaminosulfonyl, di(haloalkyl)aminosulfonyl, nitro or cyano, Y is a chlorine atom, a bromine atom or an iodine atom, and n is an integer of from 1 to 6), carbon monoxide and a compound represented by the formula R—OH (wherein R is alkyl) are reacted, followed by hydrolysis to obtain a compound represented by the formula (I): wherein Q, T, X and n are as defined above.

摘要翻译： 提供一种制备用作高纯度和高产率的药用和农药中间体的取代苯甲酸化合物的工业方法。 由式（II）表示的化合物：（其中Q是含有选自以下的至少一种杂原子中的一种或两种的5或6元饱和杂环基（杂环基可以被烷基取代） 由氧原子和硫原子组成，或二烷氧基甲基，T为三氟甲基，硝基，氰基，-SOA1，-SO2A1，-PO（OA1）（OA2），-COA1，-CO2A1或-CONA1A2，分别为A1和A2 它们彼此独立，是氢原子，烷基或卤代烷基，X是卤素，烷基，卤代烷基，烷氧基，卤代烷氧基，烷硫基，卤代烷硫基，烷基亚磺酰基，卤代烷基亚磺酰基，烷基磺酰基，卤代烷基磺酰基，二烷基氨基磺酰基，二（卤代烷基）氨基磺酰基，硝基或 氰基，Y是氯原子，溴原子或碘原子，n是1至6的整数），一氧化碳和由式R-OH（其中R是烷基）表示的化合物反应，随后 通过水解得到由式（I）表示的化合物：其中Q，T ，X和n如上所定义。

公开(公告)号：US20150076402A1

公开(公告)日：2015-03-19

申请号：US14447178

申请日：2014-07-30

申请人： Semiconductor Energy Laboratory Co., Ltd.

发明人： Momoko KATO ,  Yasuhiro Niikura ,  Tetsuji Ishitani ,  Yuko Kawata

IPC分类号： C07D317/30 ,  C09K19/58 ,  C07D317/20

CPC分类号： C07D317/20 ,  C07D317/18 ,  C07D317/22 ,  C07D317/24 ,  C07D317/30 ,  C09K19/3405 ,  C09K19/588

摘要： A dioxolane derivative represented by formula (G1) is provided. The explanation of the substituents is given in the specification. The use of the dioxolane derivative enables the production of a liquid crystal composition and a liquid crystal display device including the liquid crystal composition.

摘要翻译： 提供由式（G1）表示的二氧杂环戊烷衍生物。 取代基的说明在说明书中给出。 使用二氧戊环衍生物能够制备液晶组合物和包括该液晶组合物的液晶显示装置。

公开(公告)号：US20140135455A1

公开(公告)日：2014-05-15

申请号：US14159068

申请日：2014-01-20

申请人： SEGETIS, INC.

发明人： Sergey Selifonov ,  Adam Edward Goetz ,  Feng Jing

IPC分类号： C07D493/16 ,  C07D493/04 ,  C07D493/14 ,  C08G69/28 ,  C07D407/04 ,  C07D407/12 ,  C08G69/26 ,  C08G69/48 ,  C07D493/10 ,  C07D407/14

CPC分类号： C07D407/14 ,  C07D317/12 ,  C07D317/22 ,  C07D317/30 ,  C07D407/04 ,  C07D407/12 ,  C07D493/04 ,  C07D493/10 ,  C07D493/14 ,  C07D493/16 ,  C07D493/18 ,  C07D493/22 ,  C08G63/668 ,  C08G69/26 ,  C08G69/28 ,  C08G69/44 ,  C08G69/48 ,  C08L77/06 ,  C08L77/12

摘要： The present disclosure relates to the preparation of ketal compounds from polyols and oxocarboxylates, and uses thereof.

摘要翻译： 本公开涉及由多元醇和氧代羧酸盐制备缩酮化合物及其应用。