知搜-全球专利检索

  1. Login
  2. Sign Up

Search Results

65 records (took 0.028 seconds)

    Preparation of Diazo and Diazonium Compounds
    3.
    发明申请
    Preparation of Diazo and Diazonium Compounds 有权
    重氮和重氮化合物的制备

    公开(公告)号：US20130203974A1

    公开(公告)日：2013-08-08

    申请号：US13715842

    申请日：2012-12-14

    Applicant: Ronald Thaddeus RAINES ,  Eddie Leonard MYERS

    Inventor： Ronald Thaddeus RAINES ,  Eddie Leonard MYERS

    IPC: C07C245/18 ,  C07F9/28 ,  C07C251/00 ,  C07D223/16

    CPC classification number: C07C245/18 ,  C07C245/12 ,  C07C247/10 ,  C07C247/12 ,  C07C247/14 ,  C07C251/00 ,  C07C271/22 ,  C07C2601/14 ,  C07C2603/18 ,  C07C2603/24 ,  C07D223/16 ,  C07F9/28 ,  C07F9/5022 ,  C07F9/5325 ,  C07F9/572

    Abstract: A method for making diazo-compounds, diazonium salts thereof and other protected forms of these compounds. Diaz-compounds are prepared by reaction of a tertiary phosphine reagent carrying a reactive carbonyl group with an azide. The reaction can also generate an acyl triazene which can be converted thermally or by addition of base to form the diazo-compound or the acyl triazene can be isolated. The method is particularly useful for conversion of azides carrying one or more electron withdrawing groups to diazo-compounds. The method can be carried out in aqueous medium under mild conditions and is particularly useful for conversion of azido sugars to diazo-compound and diazonium salts thereof under physiological conditions. Tertiary phosphine reagents, particularly those that are water-soluble, and precursors for preparation of the reagents are provided.

    Abstract translation: 制备重氮化合物，其重氮盐和这些化合物的其它保护形式的方法。 通过使带有反应性羰基的叔膦试剂与叠氮化物反应来制备二嗪化合物。 反应也可以产生酰基三氮烯，其可以热转化或加入碱形成重氮化合物，或者可以分离酰基三氮烯。 该方法对于携带一个或多个吸电子基团的叠氮化物转化为重氮化合物是特别有用的。 该方法可以在温和条件下在水性介质中进行，特别适用于在生理条件下将叠氮基糖转化为重氮化合物和重氮盐。 提供了叔膦试剂，特别是水溶性试剂，以及制备试剂的前体。

    Process for the preparation of 2-diazo-3-trisubstituted silyloxy 3-butenoates
    6.
    发明授权
    Process for the preparation of 2-diazo-3-trisubstituted silyloxy 3-butenoates 失效
    2-重氮-3-三取代甲硅烷氧基-3-丁烯酸酯的制备方法

    公开(公告)号：US5340927A

    公开(公告)日：1994-08-23

    申请号：US846725

    申请日：1992-03-02

    Applicant: David L. Hughes

    Inventor： David L. Hughes

    IPC: C07F7/18 ,  C07C245/18

    CPC classification number: C07F7/188 ,  C07F7/1852

    Abstract: A novel process for preparing 2-diazo-3-trisubstituted silyloxy-3-butenoates, synthons useful in the conversion of 3-substituted-4-acetoxy azetidinones and penicillin to thienamycin, imipenem and other carbapenem antibiotic compounds is provided, comprising the reaction of the appropriate diazo acetoacetate with the substituted silane, base and salt.

    Abstract translation: 提供了一种用于制备2-重氮-3-三取代的甲硅烷氧基-3-丁烯酸酯的新方法，可用于将3-取代-4-乙酰氧基氮杂环丁酮和青霉素转化成硫霉素，亚胺培南和其他碳青霉烯类抗生素化合物的合成物，其包括 适当的重氮乙酰乙酸酯与取代的硅烷，碱和盐。

    Positively operating radiation-sensitive mixture containing a polyfunctional .alpha.-diazo-.beta.-keto ester and radiation-sensitive recording material containing this mixture
    7.
    发明授权
    Positively operating radiation-sensitive mixture containing a polyfunctional .alpha.-diazo-.beta.-keto ester and radiation-sensitive recording material containing this mixture 失效
    含有多官能（ALPHA）-DIAZO-（BETA）-KETO ESTER和含有该混合物的辐射敏感记录材料的正确操作的辐射敏感性混合物

    公开(公告)号：US5198322A

    公开(公告)日：1993-03-30

    申请号：US466007

    申请日：1990-01-12

    Applicant: Peter Wilharm ,  Hans-Joachim Merrem ,  Georg Pawlowski ,  Ralph Dammel

    Inventor： Peter Wilharm ,  Hans-Joachim Merrem ,  Georg Pawlowski ,  Ralph Dammel

    IPC: G03F7/039 ,  A61K8/00 ,  A61Q17/04 ,  C07C245/18 ,  C07C271/10 ,  C07C271/20 ,  C07C271/24 ,  C07C275/10 ,  C07C275/26 ,  C07C275/32 ,  C07C275/40 ,  C07C323/12 ,  C07D209/48 ,  C07D251/34 ,  C07D295/14 ,  C08F2/50 ,  C09K3/00 ,  G03C1/52 ,  G03F7/004 ,  G03F7/016 ,  H01L21/027 ,  H01L21/30

    CPC classification number: C07C245/18 ,  G03F7/0163 ,  C07C2101/14

    Abstract: A positively operating radiation-sensitive mixture comprising a binder which is insoluble in water but soluble or at least swellable in aqueous alkaline solution, and as a photoactive component a polyfunctional .alpha.-diazo-.beta.-keto ester of the general formula I ##STR1## in which R.sup.1 denotes an aliphatic, cycloaliphatic or araliphatic or aromatic radical having 4 to 20 carbon atoms, in which individual CH.sub.2 groups can be replaced by oxygen or sulfur atoms or by ##STR2## or NH groups and/or contain keto groups, X denotes an aliphatic, cycloaliphatic, carbocyclic, heterocyclic or araliphatic radical having 2 to 22 carbon atoms, in which individual CH.sub.2 groups can be replaced by oxygen or sulfur atoms or by the groups --NR.sup.2 --, --C(O)--O--, --C(O)--NR.sup.2 --, --C(O)-- ##STR3## --NR.sup.2 --C(O)--NR.sup.3 --, --O--C(O)--NR.sup.2 --, --C(O)-- ##STR4## or --O--C(O)--O--, or CH groups can be replaced by ##STR5## in which R.sup.2 and R.sup.3 independently of one another represent hydrogen or an aliphatic, carbocyclic or araliphatic radical,m denotes an integer from 2 to 10 andn denotes an integer from 0 to 2, whereinm-n is .gtoreq.2,is described.The radiation-sensitive mixture is particularly suitable for exposure using radiation of wavelength 190 to 300 nm.

    Abstract translation: 一种正面工作的辐射敏感性混合物，其包含不溶于水但在碱性水溶液中可溶或至少可溶胀的粘合剂，以及作为光活性组分的通式I的多官能α-重氮基β-酮酯（IMAGE）（ I），其中R1表示具有4至20个碳原子的脂族，脂环族或芳脂族或芳族基团，其中各个CH 2基团可以被氧或硫原子替代，或者通过<或>或/或含有酮基， X表示具有2至22个碳原子的脂族，脂环族，碳环，杂环或芳脂族基团，其中各个CH 2基团可被氧或硫原子替代，或由-NR 2 - ， - C（O）-O-， -C（O）-NR 2 - ， - C（O）-NR 2 -C（O）-NR 3 - ， - OC（O）-NR 2 - ， - C（O） （O）-O-或CH基团可以被其中R 2和R 3彼此独立地表示氢或脂族，碳环或芳脂族基团的“IMAGE”代替，m表示 s为2至10的整数，n表示0至2的整数，其中m-n为> / = 2。 辐射敏感的混合物特别适用于使用波长为190至300nm的辐射的曝光。

    Chelators whose affinity for calcium ion is increased by illumination
    8.
    发明授权
    Chelators whose affinity for calcium ion is increased by illumination 失效
    通过照明增加对钙离子的亲和力的螯合剂

    公开(公告)号：US5141627A

    公开(公告)日：1992-08-25

    申请号：US412852

    申请日：1989-09-25

    Applicant: Roger Y. Tsien ,  Stephen R. Adams

    Inventor： Roger Y. Tsien ,  Stephen R. Adams

    IPC: C07C245/18

    CPC classification number: C07C245/18

    Abstract: The present invention relates to a group of organic chelators whose affinity for calcium ion in solution is increased by electromagnetic radiation. Specifically, the chelators are related to BAPTA and utilize the addition of an electron-withdrawing group (e.g., diazocarbonyl) to a ring of BAPTA, para to the amino group. Photochemical rearrangement of the diazoacetyl group converts the group to the electron-donating carboxymethyl group, causing the calcium ion efficiency to increase 25 to 50 fold. These chelators when incorporated into rat fibroblasts either by microinjection or by incubation as the membrane-permeable, enzymatically-labile tetraacetoxymethyl ester and flash-photolyzed cause a drop in intracellular free calcine ion to or below resting valves of about 10.sup.-7 M. These chelators are used to generate controlled fast removal of intracellular free calcium ion to mimic or modulate a number of important cellular responses, especially in nerve or muscle.

    Abstract translation: 本发明涉及通过电磁辐射增加溶液中对钙离子的亲和力的一组有机螯合剂。 具体地说，螯合剂与BAPTA有关，并利用向吸附对氨基的BAPTA环中加入吸电子基团（如重氮羰基）。 重氮乙酰基的光化学重排将该基团转移到给电子的羧甲基基团，导致钙离子效率增加25-50倍。 这些螯合剂通过显微注射或通过孵育作为膜可渗透的，酶促不稳定的四乙酰氧基甲基酯并且闪光光引发而引入大鼠成纤维细胞时，导致细胞内游离的煅烧离子降至约10-7M的静止阀或其下面。这些螯合剂 用于产生受控的快速去除细胞内游离钙离子以模拟或调节许多重要的细胞反应，特别是在神经或肌肉中。

Patent Agency Ranking