公开(公告)号：US3930024A

公开(公告)日：1975-12-30

申请号：US52793474

申请日：1974-11-27

申请人： PARKE DAVIS & CO

发明人： CREGER PAUL L

IPC分类号： C07F9/09 ,  A61K31/045

CPC分类号： C07F9/091

摘要： Pharmaceutical compositions comprising a pharmaceutical carrier and a Beta , Beta , Beta '' Beta ''-tetramethylalkanediol having a total of 14 to 18 carbon atoms, or an ester of such an alkanediol. Methods for the lowering of serum triglyceride and cholesterol levels by administering a Beta , Beta , Beta '', Beta ''-tetramethylalkanediol having a total of 14 to 18 carbon atoms, or an ester of such an alkanediol.

摘要翻译： 包含药物载体和总共14-18个碳原子的β，β，β'-四甲基烷二醇或这种链烷二醇的酯的药物组合物。 通过施用总共14-18个碳原子的β，β，β'，β'-四甲基烷二醇或这种链烷二醇的酯来降低血清甘油三酯和胆固醇水平的方法。

公开(公告)号：US3814931A

公开(公告)日：1974-06-04

申请号：US25576672

申请日：1972-05-22

申请人： PARKE DAVIS & CO

发明人： KURODA T ,  SHIMIZU T

IPC分类号： A61J3/07 ,  B07C5/10 ,  B07C5/342 ,  G01B11/04 ,  H01J39/12

CPC分类号： B07C5/10

摘要： Apparatus and means are provided for the quality control of hard shell pharmaceutical capsules comprising a set of collets or holders arranged side-by-side in a row for supporting and moving successive sets of individual capsule shells open-end foremost in timed relation from a work station, photosensor means for scanning a light beam projected across the path of the conveyed capsule parts, control means for activating the scanning mode during a predetermined time segment in the motion cycle such that during the time segment the light beam bypasses the leading edge of advancing standard-length capsule parts but is blocked and prevented from being scanned by the intervention of any overlength capsule parts, and means responsive to the scanning means for signalling and/or rejecting capsule parts thus found blocking the beam.

摘要翻译： 提供了用于硬壳药物胶囊的质量控制的装置和装置，其包括一排并排布置的一组夹头或保持器，用于支撑并移动连续的一组单独的胶囊壳，所述胶囊壳的开口端最开始于工作时间关系 用于扫描投射在所输送的胶囊部件的路径上的光束的光传感器装置，用于在运动周期中的预定时间段期间激活扫描模式的控制装置，使得在时间段期间光束绕过前进的前缘 标准长度的胶囊部件，但是被任何超过长度的胶囊部件的干预而被阻止和防止扫描，以及响应于扫描装置的装置，用于信令和/或拒绝由此发现的阻挡光束的胶囊部件。

公开(公告)号：US3794650A

公开(公告)日：1974-02-26

申请号：US3794650D

申请日：1972-08-14

申请人： PARKE DAVIS & CO

发明人： MEYER R ,  STRATTON C

IPC分类号： C07D215/12 ,  C07D215/14 ,  C07D217/16 ,  C07D221/12 ,  C07D39/02

CPC分类号： C07C255/00 ,  C07D215/12 ,  C07D215/14 ,  C07D217/16 ,  C07D221/12 ,  Y10S514/821

摘要： A- AMINOMETHYL-2-QUINOLINEETHANOLS, A-AMIOMETHYL-1ISOQUINOLINEETHANOLS, A-AMINOMETHYL-6-PHENANTHRIDINEETHANOLS AND THEIR KETONIC ANALOGUES; AND ACID-ADITION SALTS. THE AMINO GROUP IS SUBSTITUTED BY TERT-BUTYL, ISOPROPYL,OR 3,4-DIMETHOXYPHENETHYL. THE 2-QUINOLYL GROUP IS OPTIONALLY SUBSTITUTED BY METHYL OR PHENYL. THE COMPOUNDS ARE PHARMACOLOGICAL AGENTS ESPECIALLY BETA-ADRENERGIC BLOCKING AGENTS. THE AMINOALKANOLS CAN BE PRODUCED BY REDUCTION OF THE CORRESPONDING AMINOKETONES OR BY CATALYTIC HYDROGENATION OF AN N-BENZYL DERIVATIVE. THE AMINOKETONES CAN BE PRODUCED BY THE ACIDIC HYDROLYSIS OF A CORRESPOMDING ENEAMINE DERIVATIVE OR BY CATALYTIC HYDROGENATION OF AN N-BENZYL DERIVATIVE. STARTING MATERIALS FOR USE IN THOSE PROCESSES ARE OBTAINED BY DETAILED PROCEDURES GENERALLY STARTAING FROM A METHYL-SUBSTITUTED HETEROCYCLIC NUCLEUS.

公开(公告)号：US3758491A

公开(公告)日：1973-09-11

申请号：US3758491D

申请日：1972-01-07

申请人： PARKE DAVIS & CO

发明人： CAPPS D

IPC分类号： C07D277/46 ,  C07D99/06

摘要： NOVEL THIAZOLIUM SALTS (I) HAVING PHARMACOLOGICAL

2-((3-R3,4-R5-2,3-DIHYDROTHIAZOL-2-YLIDENE)=N-C(-S-R1)=N-)

,3-R2,4-R4-THIAZOLIUM A(-)

ACTIVITY AND BEING PARTICULARLY USEFUL AS ANTI-INFECTIVE AGENTS, ARE PROVIDED BY: (A) REACTING THE CORRESPONDING 2-((BIS(METHYLTHIO)METHYLENE)AMINO)THIAZOLIUM SALT AND 2-IMINO-4THIAZOLINE, (B) REACTING METHYL IODIDE AND A SALT OF THE CORRESPONDING DITHIO-4-THIAZOLINE-$2, N-CARBAMIC ACID WITH 2-IMINO-4-THIAZOLINE, (C) REACTING A COMPOUND R3X AND THE CORRESPONDING 3-(4-THIAZOLIN-2-YLIDENE)-2-R1-1-(2-THIAZOLYL)-2-THIOPSEUDOUREA, (D) REACTING A COMPOUND R1X AND THE CORRESPONDING 1, 3-BIS(3-SUBSTITUTED-4-THIAZOLIN)-2-THIOUREA, OR (E) CONVERTING A SALT (I) OR HYDROXIDE THEREOF BY MEANS OF ANION EXCHANGE; WHERE R1 IS A C1-C10 ALKYL, -CH2CON(LOWER ALKYL)2, -CH2COO(LOWER ALKYL), PHENETHYL, 2-PHENOXYETHYL, BENZYL, A-METHYLBENZYL, MONO- OR DICHLOROBENZYL, OR ALLYL GROUP; R2 AND R3 ARE THE SAME OR DIFFERENT AND INDEPENDENTLY REPRESENT A C1-C10 ALKYL, -CH2CH2OCH3, -CH2CH2OH, BENZYL, MONO- OR DICHLOROBENZYL, PHENETHYL, OR 2-PHENOXYETHYL GROUP, ONE OF R2 AND R3 ADDITIONALLY REPRESENTING A -CH2CON(LOWER ALKYL)2 OR -CH2COO(LOWER ALKYL GROUP); R4 AND R5 ARE THE SAME OR DIFFERENT AND INDEPENDENTLY REPRESENT H OR CH3; A IS AN ANION; AND X IS A CHLORIDE, BROMIDE OR IODIDE ION OR A TOSYLATE OR METHANESULFONATE GROUP.

公开(公告)号：US3756759A

公开(公告)日：1973-09-04

申请号：US3756759D

申请日：1972-11-30

申请人： PARKE DAVIS & CO

发明人： WEYERS H

IPC分类号： A61J3/07 ,  B29C41/14 ,  B29C13/00

CPC分类号： A61J3/077 ,  B29C41/14 ,  B29L2031/7174

摘要： An improved apparatus is provided for producing pharmaceutical capsules by the dipping technique. For the conventional bottom feed dipping pan the improvement comprises open-end tunnel means below the pan whereby overflow dipping solution from opposite sides of the dipping pan is selectively channeled to opposite ends of the pan reservoir for lengthwise and depthwise recycling to the dipping pan by way of the tunnel.

摘要翻译： 提供了一种通过浸渍技术制备药物胶囊的改进装置。 对于常规的底部进料浸渍锅，改进包括在锅底下方的开放式隧道装置，由此将浸渍盘的相对侧的溢出浸渍溶液选择性地引导到锅储存器的相对端，以纵向和深度方式循环到浸渍锅 的隧道。

公开(公告)号：US3739909A

公开(公告)日：1973-06-19

申请号：US3739909D

申请日：1971-10-06

申请人： PARKE DAVIS & CO

发明人： GARLAND C ,  KWARSICK E ,  NOREN O

IPC分类号： B07B13/07 ,  A61J3/07 ,  B65G35/00 ,  B65G47/14 ,  B07B13/04

CPC分类号： A61J3/074 ,  B65G35/00 ,  B65G47/1492

摘要： Apparatus and means are provided for handling articles, particularly tubular, cylindrical or elongated articles such as pharmaceutical capsules and the like, comprising an inclined slide or trough formed by trough-defining surfaces including the circumferential surfaces of rotating roll means adapted to move the articles lengthwise in single file down the trough and, if desired, for rectification and/or for gravity-sorting with respect to width and/or length size at one or more points along the trough. The apparatus can be used for any of various operational steps or combinations of steps such as conveying, sorting, rectifying, etc.

摘要翻译： 提供装置和装置，用于处理物品，特别是管状的圆柱形或细长的制品，例如药物胶囊等，包括由槽形限定表面形成的倾斜的滑动槽或槽，该表面包括用于纵向移动物品的旋转辊装置的周向表面 如果需要，在沿着槽的一个或多个点处的整流和/或重力分选相对于宽度和/或长度尺寸的单个文件中。 该装置可以用于各种操作步骤或步骤的组合中的任何一个，例如输送，分类，整流等

公开(公告)号：US3737029A

公开(公告)日：1973-06-05

申请号：US3737029D

申请日：1971-08-09

申请人： PARKE DAVIS & CO

发明人： SERRELL J ,  SPARKS G ,  TROWERN H

IPC分类号： B65D75/34 ,  B65D83/04

CPC分类号： B65D75/327 ,  B65D2575/3245 ,  B65D2585/56 ,  Y10S206/82

摘要： A pharmacal package wherein a pair of blister sheets are closed by respective backing sheets, the backing sheets being hingedly connected together and the blister sheets being held in adjacent relation.

摘要翻译： 一种药物包装，其中一对泡罩片由相应的背衬片封闭，背衬片被铰接地连接在一起，并且泡罩片保持相邻的关系。

公开(公告)号：US3707566A

公开(公告)日：1972-12-26

申请号：US3707566D

申请日：1970-03-30

申请人： PARKE DAVIS & CO

发明人： CREGER PAUL L ,  NEUKLIS WINIFRED A

IPC分类号： C07C45/51 ,  C07C47/277 ,  C07C59/68 ,  C07C43/20

CPC分类号： C07C59/68 ,  C07C45/516 ,  C07C47/277

摘要： A SERIES OF 2,2-DIMETHYL-5-(2,5-XYLYLOXY)- AND (3,5XYLYOXY)-1-PENTANOLS, ETHER AND ESTER DERIVATIVES, AND STRUCTURALLY RELATED NITRILES AND ALDEHYDES. THE COMPOUNDS LOWER SERUM TRIGLYCERIDE LEVELS. THE 1-PENTANOL COMPOUNDS CAN BE PRODUCED BY REDUCING THE CORRESPONDING VALERIC ACIDS OR THEIR SALTS OR ESTERS. THE ETHER AND ESTER DERIVATIVES CAN BE PRODUCED BY REACTING THE 1-PENTANOL COMPOUNDS WITH AN ETHERIFIYING AGENT OR ESTERIFYING AGENT. THE NITRILES CAN BE PRODUCED BY REACTING A 3-ARYLOXYPROPYL HALIDE WITH ISOBUTYRONITRILE IN THE PRESENCE OF A BASE. THE ALDEHYDES CAN BE PRODUCED BY REACTING A SUBSTITUTED IMINE WITH A HYDROLYTIC AGENT.

公开(公告)号：US3674836A

公开(公告)日：1972-07-04

申请号：US81912669

申请日：1969-04-24

申请人： PARKE DAVIS & CO

发明人： CREGER PAUL L

IPC分类号： C07C51/09 ,  C07C51/367 ,  C07C59/68 ,  C07C69/76

CPC分类号： C07C59/68 ,  C07C51/09 ,  C07C51/367

摘要： A series of 2,2-dimethyl- omega -phenoxyalkanoic acids and 2,2dimethyl- omega -(disubstituted phenoxy)alkanoic acids having 3 to 6 methylene groups between the phenoxy group or 0 phenoxy group and the carbon atom substituted by two methyl groups; and their salts and esters. The compounds reduce serum triglyceride levels and can be produced by (a) reacting an alkali metal derivative of an isobutyric acid, salt, or ester with a phenoxyalkyl halide or a disubstituted phenoxyalkyl halide; (b) esterifying a carboxylic acid; or (c) hydrolyzing a carboxylate ester.

摘要翻译： 在苯氧基或苯氧基之间具有3至6个亚甲基的一系列2,2-二甲基-ω-苯氧基链烷酸和2,2-二甲基-ω-（二取代的苯氧基）链烷酸和被两个甲基 团体 及其盐和酯。 所述化合物降低血清甘油三酯水平，并且可以通过（a）使异丁酸，盐或酯的碱金属衍生物与苯氧基烷基卤化物或二取代的苯氧基烷基卤化物反应来制备; （b）酯化羧酸; 或（c）水解羧酸酯。

公开(公告)号：US3668205A

公开(公告)日：1972-06-06

申请号：US3668205D

申请日：1970-04-20

申请人： PARKE DAVIS & CO

发明人： ELSLAGER EDWARD F ,  WORTH DONALD F

IPC分类号： C07D239/95 ,  C07D51/48

CPC分类号： C07D239/95 ,  Y10S514/895

摘要： Benzylamino quinazolinyl formamidine compounds (I) and their acid salts ARE PROVIDED BY AMIDINATION OF THE CORRESPONDING 2,4-DIAMINO OR 2-AMINO-4-DIMETHYLAMIDINO COMPOUNDS WHERE R1 is hydrogen or methyl; R2 is hydrogen, nitroso, formyl, acetyl, propionyl or lower alkyl; R3 represents amino or dimethylformamidino; and X, Y and Z are hydrogen, chloro or methyl. The compounds are pharmacological agents having useful antiparasitic properties, especially antimalarial properties.

摘要翻译： 苄基氨基喹唑啉基甲脒化合物（I）及其酸式盐是通过相应的2,4-二氨基或2-氨基-4-二甲基氨基甲酸酯化合物的化合物而提供的，其中R1是氢或甲基; R2是氢，亚硝基，甲酰基，乙酰基，丙酰基或低级烷基; R3表示氨基或二甲基甲脒基; X，Y和Z是氢，氯或甲基。 这些化合物是具有有用的抗寄生虫性质，特别是抗疟疾性质的药理学试剂。