公开(公告)号：US12110263B2

公开(公告)日：2024-10-08

申请号：US17740260

申请日：2022-05-09

申请人： CORTEXYME, INC.

发明人： Andrei W. Konradi ,  Robert A. Galemmo, Jr. ,  Stephen S. Dominy ,  Casey C. Lynch ,  Leslie J. Holsinger

IPC分类号： C07C233/62 ,  A61K31/165 ,  A61K31/167 ,  A61K31/41 ,  A61K31/42 ,  A61K31/44 ,  A61K31/4402 ,  A61K31/4406 ,  A61K31/4409 ,  A61K31/4439 ,  A61K31/505 ,  A61K31/513 ,  A61K31/655 ,  A61K45/06 ,  A61P25/00 ,  A61P31/04 ,  C07B59/00 ,  C07C233/78 ,  C07C235/10 ,  C07C235/50 ,  C07C237/42 ,  C07C245/08 ,  C07C247/16 ,  C07C247/18 ,  C07C317/28 ,  C07C323/40 ,  C07C323/42 ,  C07C381/00 ,  C07D213/65 ,  C07D213/68 ,  C07D213/70 ,  C07D213/81 ,  C07D213/82 ,  C07D239/34 ,  C07D239/36 ,  C07D239/38 ,  C07D257/04 ,  C07D261/12 ,  C07D401/12 ,  C07D413/12 ,  C07F5/02

CPC分类号： C07C233/62 ,  A61K31/165 ,  A61K31/167 ,  A61K31/41 ,  A61K31/42 ,  A61K31/44 ,  A61K31/4402 ,  A61K31/4406 ,  A61K31/4409 ,  A61K31/4439 ,  A61K31/505 ,  A61K31/513 ,  A61K31/655 ,  A61K45/06 ,  A61P25/00 ,  A61P31/04 ,  C07B59/001 ,  C07C233/78 ,  C07C235/10 ,  C07C235/50 ,  C07C237/42 ,  C07C245/08 ,  C07C247/16 ,  C07C247/18 ,  C07C317/28 ,  C07C323/40 ,  C07C323/42 ,  C07C381/00 ,  C07D213/65 ,  C07D213/68 ,  C07D213/70 ,  C07D213/81 ,  C07D213/82 ,  C07D239/34 ,  C07D239/36 ,  C07D239/38 ,  C07D257/04 ,  C07D261/12 ,  C07D401/12 ,  C07D413/12 ,  C07F5/02 ,  C07C2601/08

摘要： The present invention provides compounds according to Formula I as described herein, and their use for inhibiting the lysine gingipain protease (Kgp) from the bacterium Porphyromonas gingivalis. Also described are gingipain activity probe compounds and methods for assaying gingipain activity are also described, as well as methods for the treatment of disorders associated with P. gingivalis infection, including brain disorders such as Alzheimer's disease.

公开(公告)号：US11926575B2

公开(公告)日：2024-03-12

申请号：US17628980

申请日：2020-06-22

申请人： Sumitomo Chemical Company, Limited

发明人： Keisuke Takahashi

IPC分类号： C07C245/08 ,  C07D277/30 ,  C07D277/66 ,  C07D333/16 ,  C07D333/60 ,  C07D513/04 ,  C08F220/34 ,  G02B5/30

CPC分类号： C07C245/08 ,  C07D277/30 ,  C07D277/66 ,  C07D333/16 ,  C07D333/60 ,  C07D513/04 ,  C08F220/346 ,  G02B5/30

摘要： Provided is a compound represented by formula (1). In formula (1), Ar1, Ar2, and Ar3 represent a 1,4-phenylene group or a divalent sulfur-containing aromatic heterocyclic group optionally having a substituent, and at least one of Ar1 and Ar2 has a fluorine atom as a substituent; n represents 1 or 2; R1 represents a single bond or a group selected from the group consisting of —OC(═O)—, —C(═O)O—, —C≡C—, —CH═CH—, —CH═N—, and —N═CH—; R2 represents an alkylamino group or an alkoxy group; R3 represents a group selected from the group consisting of an alkanediyl group, an alkanediyloxy group, an alkanediyloxycarbonyl group, and an alkanediylcarbonyloxy group; and R4 represents a polymerizable group or a hydrogen atom.

R4—R3—Ar1—(—R1—Ar2—)n-N═N-Ar3—R2  (1)

公开(公告)号：US20230142714A1

公开(公告)日：2023-05-11

申请号：US17740260

申请日：2022-05-09

申请人： CORTEXYME, INC.

发明人： Andrei W. Konradi ,  Robert A. Galemmo, JR. ,  Stephen S. Dominy ,  Casey C. Lynch ,  Leslie J. Holsinger

IPC分类号： C07C233/62 ,  C07D401/12 ,  A61K31/655 ,  A61K31/165 ,  C07C245/08 ,  C07C323/42 ,  C07C247/18 ,  C07D261/12 ,  C07C237/42 ,  C07D213/82 ,  A61K31/513 ,  C07D239/34 ,  C07D239/36 ,  A61P31/04 ,  C07F5/02 ,  A61K31/4402 ,  A61K31/4439 ,  A61K31/4409 ,  C07D413/12 ,  C07C323/40 ,  A61K31/4406 ,  A61K31/505 ,  C07C233/78 ,  C07C235/50 ,  A61K31/44 ,  C07D257/04 ,  A61K45/06 ,  C07D239/38 ,  C07C317/28 ,  A61K31/42 ,  C07C381/00 ,  C07D213/81 ,  A61K31/41 ,  C07D213/65 ,  C07C247/16 ,  C07D213/70 ,  C07B59/00 ,  A61K31/167 ,  C07C235/10 ,  C07D213/68 ,  A61P25/00

CPC分类号： C07C233/62 ,  C07D401/12 ,  A61K31/655 ,  A61K31/165 ,  C07C245/08 ,  C07C323/42 ,  C07C247/18 ,  C07D261/12 ,  C07C237/42 ,  C07D213/82 ,  A61K31/513 ,  C07D239/34 ,  C07D239/36 ,  A61P31/04 ,  C07F5/02 ,  A61K31/4402 ,  A61K31/4439 ,  A61K31/4409 ,  C07D413/12 ,  C07C323/40 ,  A61K31/4406 ,  A61K31/505 ,  C07C233/78 ,  C07C235/50 ,  A61K31/44 ,  C07D257/04 ,  A61K45/06 ,  C07D239/38 ,  C07C317/28 ,  A61K31/42 ,  C07C381/00 ,  C07D213/81 ,  A61K31/41 ,  C07D213/65 ,  C07C247/16 ,  C07D213/70 ,  C07B59/001 ,  A61K31/167 ,  C07C235/10 ,  C07D213/68 ,  A61P25/00 ,  C07C2601/08

摘要： The present invention provides compounds according to Formula I as described herein, and their use for inhibiting the lysine gingipain protease (Kgp) from the bacterium Porphyromonas gingivalis. Also described are gingipain activity probe compounds and methods for assaying gingipain activity are also described, as well as methods for the treatment of disorders associated with P. gingivalis infection, including brain disorders such as Alzheimer's disease.

公开(公告)号：US11325884B2

公开(公告)日：2022-05-10

申请号：US16899376

申请日：2020-06-11

申请人： CORTEXYME, INC.

发明人： Andrei W. Konradi ,  Robert A. Galemmo, Jr. ,  Stephen S. Dominy ,  Casey C. Lynch ,  Leslie J. Holsinger

IPC分类号： C07C233/62 ,  C07D213/82 ,  C07D239/34 ,  C07D239/36 ,  C07D413/12 ,  C07D257/04 ,  C07D261/12 ,  C07D213/70 ,  C07C317/28 ,  C07C233/78 ,  C07C235/10 ,  C07C235/50 ,  C07B59/00 ,  C07C237/42 ,  C07D401/12 ,  C07C381/00 ,  C07C323/42 ,  C07D213/65 ,  C07D213/68 ,  C07D239/38 ,  C07C247/18 ,  C07F5/02 ,  A61P31/04 ,  A61P25/00 ,  A61K31/165 ,  A61K31/167 ,  A61K31/41 ,  A61K31/42 ,  A61K31/44 ,  A61K31/4402 ,  A61K31/4406 ,  A61K31/4409 ,  A61K31/4439 ,  A61K31/505 ,  A61K31/513 ,  A61K31/655 ,  A61K45/06 ,  C07C245/08 ,  C07C247/16 ,  C07C323/40 ,  C07D213/81

摘要： The present invention provides compounds according to Formula I as described herein, and their use for inhibiting the lysine gingipain protease (Kgp) from the bacterium Porphyromonas gingivalis. Also described are gingipain activity probe compounds and methods for assaying gingipain activity are also described, as well as methods for the treatment of disorders associated with P. gingivalis infection, including brain disorders such as Alzheimer's disease.

公开(公告)号：US10689480B2

公开(公告)日：2020-06-23

申请号：US16073107

申请日：2016-03-01

申请人： TOYO TIRE & RUBBER CO., LTD.

发明人： Yuki Hidaka

IPC分类号： C08G18/48 ,  C07C43/23 ,  C07C245/08 ,  C09K19/14 ,  C09K19/24 ,  C09K19/12 ,  C09K19/22 ,  C07C251/24 ,  C07C235/56 ,  C08G18/32 ,  C08G18/38 ,  C08G18/72 ,  C08G18/73 ,  C08G18/76

摘要： One purpose of the present invention is to provide a liquid-crystal compound which exhibits liquid crystallinity at low temperatures. Another purpose of the present invention is to provide a thermally responsive material which exhibits liquid crystallinity and rubber elasticity at low temperatures (around room temperature) ever, though a large amount of a liquid-crystal compound is contained therein, and a method for producing this thermally responsive material. A liquid-crystal compound according to the present invention is obtained by adding an alkylene oxide and/or styrene oxide to a mesogenic group-containing compound that has an active hydrogen group.

公开(公告)号：US10301430B2

公开(公告)日：2019-05-28

申请号：US15715414

申请日：2017-09-26

申请人： The United States of America, as represented by the Secretary of the Air Force

发明人： Loon-Seng Tan ,  David Huabin Wang ,  Jeong Jae Wie ,  Timothy J. White

IPC分类号： C08G73/10 ,  C07C323/48 ,  C07C245/08 ,  C08G69/32 ,  C09B35/021 ,  C09B69/10 ,  C09B43/16

摘要： Bis(azo-benzene) diamine monomers and a method of synthesizing the monomers are provided. The bis(azo-benzene) diamine monomers, in combination with amine reactive monomers, form polymers, such as polyimides and copolyimides, having photomechanical and thermomechanical properties.

公开(公告)号：US20180230385A1

公开(公告)日：2018-08-16

申请号：US15954045

申请日：2018-04-16

申请人： DIC Corporation

发明人： Fumiaki Kodera ,  Yoshitaka Saito ,  Hiroshi Hasebe ,  Masanao Takashima ,  Shuuhei Yamamoto ,  Kouzi Satou ,  Sayaka Nose ,  Kazuki Obi ,  Hiroyuki Itou

IPC分类号： C09K19/56 ,  C07C245/08 ,  C08F220/30 ,  C08F222/20 ,  G02F1/1337

摘要： A compound and a polymer which can each form a photo-alignment film having excellent ability of controlling alignment, a photo-alignment film obtained using the polymer and an optically anisotropic body and a liquid crystal display element each having the photo-alignment film are provided. A compound represented by the general formula (1). In the formula, P represents a polymerizable group, Z and Z1 represent divalent linking groups, A and A1 represent divalent cyclic groups, and X1 to X5 each independently represent a hydrogen atom, a fluorine atom, a chlorine atom, a hydroxy group, a nitro group, a cyano group or an alkyl group having 1 to 40 carbon atoms which may have a substituent, provided that X1, X2, X4 and X5 are not simultaneously hydrogen atoms.

公开(公告)号：US09758469B2

公开(公告)日：2017-09-12

申请号：US14926178

申请日：2015-10-29

申请人： Noxell Corporation

发明人： Garry Steven Garrett ,  Heike Gertrud Abel ,  Armin Osan ,  John Michael Gardlik ,  Bryan Patrick Murphy ,  Markus Speckbacher ,  Ingo Reinhold Weber

IPC分类号： C07C213/02 ,  C07C245/20 ,  C07C245/24 ,  C07C245/08

CPC分类号： C07C213/02 ,  C07C245/08 ,  C07C245/20 ,  C07C245/24 ,  C07C217/76

摘要： A process for the preparation of 2-substituted-1,4-benzenediamines, a cosmetically acceptable salt thereof, or mixture thereof. The process according to the present invention is a particularly cost effective process in that it avoids sophisticated chemical steps which requires special equipment or expensive catalysts and in that it comprises a recycling step of one of the starting materials, namely the 2-substituted aniline.

公开(公告)号：US20170240504A1

公开(公告)日：2017-08-24

申请号：US15518679

申请日：2015-12-02

申请人： LG Chem, Ltd. ,  IUCF-HYU (Industry-University Cooperation Foundation Hanyang University)

发明人： Yang Kyoo Han ,  In-Joon Byun ,  Sung Soo Yoon ,  Je Gwon Lee

IPC分类号： C07C245/08 ,  G01N33/20 ,  C08F120/36

CPC分类号： C07C245/08 ,  C08F20/34 ,  C08F120/36 ,  G01N33/1813 ,  G01N33/20

摘要： According to one embodiment of the present invention, an azo polymer forms a complex with a lithium ion and a sodium ion among alkali metal ions, but does not form a complex with a potassium ion. Therefore, the azo polymer is expected to be utilized as a material for a sensor capable of selectively detecting a specific alkali metal ion, or as a novel material capable of selectively trapping a specific alkali metal ion from a solution in which metal ions are mixed.

公开(公告)号：US20170226052A1

公开(公告)日：2017-08-10

申请号：US15205083

申请日：2016-07-08

申请人： NATIONAL CHUNG SHAN INSTITUTE OF SCIENCE AND TECHNOLOGY

发明人： WEN-CHIUNG SU ,  RU-JONG JENG ,  CHIEN-HSIN WU ,  YU-WEN LAI ,  SHIH-CHIEH YEH

IPC分类号： C07C245/08

CPC分类号： C07C245/08 ,  C08G69/00

摘要： Epoxy/MMT composite material and a crosslinking method for epoxy/MMT composite material with second order nonlinear optical properties are introduced. Chromophore-containing intercalating agents are applied to modify montmorillonites (MMTs) to form organoclays by an ion-exchange process, wherein the chrmophores are neatly packed on exfoliated epoxy/organoclay nanocomposites. As a result, optical nonlinearity, i.e. the Pockels effect is observed for the nanocomposites without resorting to the poling process due to self-assembly process. Furthermore, a series of epoxy/MMT nanocomposites comprising thermally reversible furan-norbornene Diels-Alder adducts are prepared to establish a crosslinking feature. Self-alignment behavior, electro-optical (EO) coefficient and temporal stability of the epoxy/MMT nanocomposites are improved by the Diels-Alders crosslinking.