公开(公告)号：US20240360092A1

公开(公告)日：2024-10-31

申请号：US18760458

申请日：2024-07-01

Applicant: Vivozon Inc.

Inventor： Dae Kyu CHOI ,  Hyo Jin KIM ,  Mi Seon BAE ,  Jin CHOI ,  Hyun Jin HEO ,  Yong Seok LEE ,  Geon Ho LEE ,  Mi Yon SHIM ,  Jin Sun PARK ,  Han Mi LEE

IPC: C07D295/135 ,  A61P25/04 ,  C07C233/66 ,  C07C233/70 ,  C07C233/72 ,  C07C233/78 ,  C07C233/86 ,  C07C237/34 ,  C07D213/40 ,  C07D213/56 ,  C07D305/06 ,  C07D307/14 ,  C07D309/06 ,  C07D309/14 ,  C07D319/12

CPC classification number: C07D295/135 ,  A61P25/04 ,  C07C233/66 ,  C07C233/70 ,  C07C233/72 ,  C07C233/78 ,  C07C233/86 ,  C07C237/34 ,  C07D213/40 ,  C07D213/56 ,  C07D305/06 ,  C07D307/14 ,  C07D309/06 ,  C07D309/14 ,  C07D319/12

Abstract: Disclosed are a dual modulator of mGluR5 and 5-HT2AR (5-HT2A receptor), and use thereof. More specifically, disclosed are a compound which acts as modulator of mGluR5 and an antagonist of 5-HT2AR at the same time, and use thereof as therapeutic agent for pain.

公开(公告)号：US12043631B2

公开(公告)日：2024-07-23

申请号：US17567737

申请日：2022-01-03

Applicant: Purdue Research Foundation

Inventor： Arun K. Ghosh ,  Andrew Mesecar ,  Margherita Brindisi ,  Emilio Leal Cardenas

IPC: C07D307/22 ,  A61K31/166 ,  A61K31/341 ,  A61K31/351 ,  A61P25/28 ,  C07C233/78 ,  C07D309/14 ,  C07D513/04 ,  C07D513/06 ,  C07D519/00

CPC classification number: C07D513/04 ,  C07C233/78 ,  C07D307/22 ,  C07D309/14 ,  C07D519/00

Abstract: Described herein are compounds of the formulae (I)-(III) as well as pharmaceutical compositions comprising such compounds and methods for using such compounds/pharmaceutical compositions for treating Alzheimer's disease.

公开(公告)号：US20240016799A1

公开(公告)日：2024-01-18

申请号：US18355811

申请日：2023-07-20

Applicant: MEDICON PHARMACEUTICALS, INC.

Inventor： Basil RIGAS

IPC: A61K31/495 ,  A61P27/02 ,  A61P35/00 ,  A61K9/00 ,  A61K31/166 ,  A61K31/664 ,  A61K45/06 ,  C07C233/78 ,  C07D241/04 ,  C07F9/22

CPC classification number: A61K31/495 ,  A61P27/02 ,  A61P35/00 ,  A61K9/0019 ,  A61K9/0048 ,  A61K31/166 ,  A61K31/664 ,  A61K45/06 ,  C07C233/78 ,  C07D241/04 ,  C07F9/222

Abstract: Compounds of the general Formula A-D-Y are disclosed with activity towards treating diseases related to inflammation, cancer, neurodegenerative diseases, and cardiovascular diseases. Pharmaceutical compositions, methods of making, and methods of use thereof are also described.

公开(公告)号：US09872852B2

公开(公告)日：2018-01-23

申请号：US14915782

申请日：2014-09-02

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： Louis S. Chupak ,  Xiaofan Zheng

IPC: A61K31/381 ,  A61K31/396 ,  A61K31/40 ,  A61K31/4427 ,  A61K31/496 ,  C07C217/58 ,  C07C229/22 ,  C07C233/36 ,  C07C235/76 ,  C07C311/05 ,  C07D205/04 ,  C07D207/14 ,  C07D211/32 ,  C07D213/57 ,  C07D213/69 ,  C07D217/02 ,  C07D233/06 ,  C07D249/08 ,  C07D265/30 ,  A61K31/397 ,  A61K31/5375 ,  A61K31/44 ,  A61K31/4523 ,  A61K31/445 ,  A61K31/551 ,  A61K31/55 ,  C07D309/14 ,  C07D311/14 ,  C07D317/50 ,  C07D223/06 ,  C07D319/18 ,  C07D333/20 ,  C07D333/32 ,  C07D333/36 ,  C07D233/61 ,  C07D401/06 ,  C07D401/12 ,  C07D405/12 ,  C07D487/10 ,  C07D205/08 ,  C07D207/08 ,  C07D207/16 ,  C07D207/27 ,  C07C279/12 ,  C07D211/34 ,  C07D211/44 ,  C07D295/12 ,  C07D211/48 ,  C07D211/56 ,  C07D211/60 ,  C07D211/62 ,  C07D295/14 ,  C07D295/18 ,  C07D295/185 ,  C07D211/76 ,  C07D211/78 ,  C07D213/63 ,  C07D213/64 ,  C07D213/65 ,  C07C255/54 ,  C07C271/20 ,  C07C279/14 ,  C07C229/14 ,  C07C233/38 ,  C07C233/47 ,  C07C233/78 ,  C07C237/06 ,  C07K5/083 ,  C07C275/40 ,  C07D217/04 ,  C07D295/13 ,  C07D295/16 ,  C07D311/08

CPC classification number: A61K31/381 ,  A61K31/396 ,  A61K31/397 ,  A61K31/40 ,  A61K31/44 ,  A61K31/4427 ,  A61K31/445 ,  A61K31/4523 ,  A61K31/496 ,  A61K31/5375 ,  A61K31/55 ,  A61K31/551 ,  C07C217/58 ,  C07C229/14 ,  C07C229/22 ,  C07C233/36 ,  C07C233/38 ,  C07C233/47 ,  C07C233/78 ,  C07C235/76 ,  C07C237/06 ,  C07C255/54 ,  C07C271/20 ,  C07C275/40 ,  C07C279/12 ,  C07C279/14 ,  C07C311/05 ,  C07C2601/02 ,  C07C2601/04 ,  C07C2601/08 ,  C07C2601/14 ,  C07C2602/08 ,  C07C2602/10 ,  C07D205/04 ,  C07D205/08 ,  C07D207/08 ,  C07D207/14 ,  C07D207/16 ,  C07D207/27 ,  C07D211/32 ,  C07D211/34 ,  C07D211/44 ,  C07D211/48 ,  C07D211/56 ,  C07D211/60 ,  C07D211/62 ,  C07D211/76 ,  C07D211/78 ,  C07D213/57 ,  C07D213/63 ,  C07D213/64 ,  C07D213/65 ,  C07D213/69 ,  C07D217/02 ,  C07D217/04 ,  C07D223/06 ,  C07D233/61 ,  C07D249/08 ,  C07D265/30 ,  C07D279/12 ,  C07D295/12 ,  C07D295/13 ,  C07D295/14 ,  C07D295/16 ,  C07D295/18 ,  C07D295/185 ,  C07D309/14 ,  C07D311/08 ,  C07D311/14 ,  C07D317/50 ,  C07D319/18 ,  C07D333/20 ,  C07D333/32 ,  C07D333/36 ,  C07D401/06 ,  C07D401/12 ,  C07D405/12 ,  C07D487/10 ,  C07K5/0806 ,  C07K5/0808

Abstract: Disclosed are compounds of Formula (I): (I). Also disclosed are methods of using such compounds as immunomodulators, and pharmaceutical compositions comprising such compounds. These compounds are useful in treating, preventing, or slowing the progression of virological diseases or disorders and cancer.

公开(公告)号：US20180009737A1

公开(公告)日：2018-01-11

申请号：US15706797

申请日：2017-09-18

Applicant: Dow AgroSciences LLC

Inventor： Paul R. LePlae, JR. ,  James E. Hunter ,  Gerald B. Watson ,  William C. Lo ,  John Herbert

IPC: C07C225/16 ,  A01N33/08 ,  C07C317/28 ,  C07C323/41

CPC classification number: C07C225/16 ,  A01N33/08 ,  A01N37/18 ,  A01N37/20 ,  A01N37/26 ,  A01N37/28 ,  A01N37/34 ,  A01N37/36 ,  A01N37/44 ,  A01N41/10 ,  A01N53/00 ,  C07B2200/07 ,  C07C233/78 ,  C07C233/83 ,  C07C243/38 ,  C07C255/19 ,  C07C255/46 ,  C07C317/28 ,  C07C317/44 ,  C07C323/41 ,  C07C323/60 ,  C07C2601/02

Abstract: This disclosure relates to the field of molecules having pesticidal utility against pests in Phyla Nematoda, Arthropoda, and/or Mollusca, processes to produce such molecules and intermediates used in such processes, compositions containing such molecules, and processes of using such molecules against such pests. These molecules may be used, for example, as nematicides, acaricides, insecticides, miticides, and/or molluscicides. This document discloses molecules having the following formula (“Formula One”).

公开(公告)号：US09839219B2

公开(公告)日：2017-12-12

申请号：US15222576

申请日：2016-07-28

Applicant: Curza Global, LLC ,  University of Utah Research Foundation

Inventor： Ryan Looper ,  Dustin Williams ,  Sujeevini Jeyapalina ,  Travis Haussener ,  Paul R. Sebahar ,  Hariprasada R. Kanna Reddy

IPC: A01N47/28 ,  A61K8/49 ,  A61L2/232 ,  A61L29/14 ,  A61L31/14 ,  A61Q5/02 ,  A61Q15/00 ,  A61Q19/00 ,  A61Q19/10 ,  C09D5/14 ,  A01N33/08 ,  A61K8/41 ,  A61K8/42 ,  A61K31/166 ,  A01N43/56 ,  A01N47/12 ,  A01N43/54 ,  A01N37/40 ,  A01N33/10 ,  A01N37/30 ,  C07C217/58 ,  C07C271/20 ,  C07C211/29 ,  C07C275/14 ,  A01N43/40 ,  A61K31/125 ,  C07C211/27 ,  A01N43/10 ,  C07D317/58 ,  C07C233/78 ,  A01N33/04 ,  A01N37/18 ,  A01N43/84 ,  A01N43/30 ,  C07D295/135 ,  A61K31/135 ,  A61L2/18 ,  A61L2/22 ,  A61L2/235 ,  A61L12/14 ,  C08K5/17

CPC classification number: A01N47/28 ,  A01N33/04 ,  A01N33/08 ,  A01N33/10 ,  A01N37/18 ,  A01N37/30 ,  A01N37/40 ,  A01N43/10 ,  A01N43/30 ,  A01N43/40 ,  A01N43/54 ,  A01N43/56 ,  A01N43/84 ,  A01N47/12 ,  A61K8/41 ,  A61K8/42 ,  A61K8/49 ,  A61K8/4926 ,  A61K8/494 ,  A61K8/4953 ,  A61K8/4973 ,  A61K8/4986 ,  A61K31/135 ,  A61K31/166 ,  A61L2/18 ,  A61L2/22 ,  A61L2/232 ,  A61L2/235 ,  A61L12/14 ,  A61L29/14 ,  A61L31/14 ,  A61L2202/21 ,  A61L2202/24 ,  A61Q5/02 ,  A61Q15/00 ,  A61Q19/007 ,  A61Q19/10 ,  C07C211/27 ,  C07C211/29 ,  C07C217/58 ,  C07C233/78 ,  C07C271/20 ,  C07C275/14 ,  C07C2601/14 ,  C07D295/135 ,  C07D317/58 ,  C08K5/17 ,  C09D5/14

Abstract: Compounds, compositions, and methods comprising a polyamine compound are described, which may be used to kill, disperse, treat, or reduce biofilms, or to inhibit or substantially prevent biofilm formation. In certain aspects, the present invention relates to compounds, compositions, and methods comprising polyamine compounds that have antimicrobial or dispersing activity against a variety of bacterial strains capable of forming biofilms.

公开(公告)号：US20170349537A1

公开(公告)日：2017-12-07

申请号：US15683348

申请日：2017-08-22

Applicant: Cortexyme, Inc.

Inventor： Andrei Konradi ,  Stephen S. Dominy ,  Casey Crawford Lynch ,  Craig Coburn ,  Joseph Vacca

IPC: C07C233/78 ,  C07D409/12 ,  C07D277/64 ,  C07D213/50 ,  C07C247/16 ,  C07D417/12 ,  C07C233/62

CPC classification number: C07D417/12 ,  C07B2200/07 ,  C07C233/62 ,  C07C233/78 ,  C07C247/16 ,  C07C247/18 ,  C07C2601/08 ,  C07D213/50 ,  C07D213/53 ,  C07D277/24 ,  C07D277/28 ,  C07D277/64 ,  C07D409/12

Abstract: The present invention relates generally to therapeutics targeting the bacterium Porphyromonas gingivalis, including its protease Lysine gingipain (Kgp), and their use for the treatment of disorders associated with P. gingivalis infection, including brain disorders such as Alzheimer's disease. In certain embodiments, the invention provides compounds according to Formula I, as described herein, and pharmaceutically acceptable salts thereof.

公开(公告)号：US20170320848A1

公开(公告)日：2017-11-09

申请号：US15523028

申请日：2015-10-26

Applicant: Bayer Animal Health GMBH

Inventor： Claudia WELZ ,  Adeline KÖHLER ,  Kirsten BÖRNGEN ,  Daniel KULKE ,  Ulrich GÖRGENS ,  Hans-Georg SCHWARZ ,  Kerstin ILG

IPC: C07D317/58 ,  C07D295/135 ,  C07D213/82 ,  C07C317/40 ,  C07C233/66 ,  C07C255/60 ,  C07C233/80 ,  C07C233/73 ,  C07D295/185 ,  C07C323/42

CPC classification number: C07D317/58 ,  C07C233/66 ,  C07C233/73 ,  C07C233/78 ,  C07C233/80 ,  C07C255/58 ,  C07C255/60 ,  C07C317/40 ,  C07C323/42 ,  C07D213/81 ,  C07D213/82 ,  C07D241/24 ,  C07D295/135 ,  C07D295/155 ,  C07D295/185 ,  C07D317/62

Abstract: Disclosed are compounds of formula (I) which possess anthelminthic properties wherein the structural elements have the meaning as indicated in the description. Further disclosed are such compounds for the control, treatment and/or prevention of infections with helminths in animals and humans.

公开(公告)号：US09730902B2

公开(公告)日：2017-08-15

申请号：US14962195

申请日：2015-12-08

Applicant: Otto Phanstiel, IV ,  Jennifer J. Archer

Inventor： Otto Phanstiel, IV ,  Jennifer J. Archer

IPC: A61K31/135 ,  A61K31/166 ,  C07C237/46 ,  C07D295/13 ,  A61K31/137 ,  C07C211/27 ,  C07C231/02 ,  C07C233/78 ,  C07C235/10 ,  A61K31/192 ,  A61K31/197 ,  A61K45/06

CPC classification number: A61K31/166 ,  A61K31/137 ,  A61K31/192 ,  A61K31/197 ,  A61K45/06 ,  C07C211/27 ,  C07C231/02 ,  C07C233/78 ,  C07C235/10 ,  C07C237/46 ,  C07D295/13

Abstract: Novel polyamine transport inhibitors have been synthesized and demonstrated to block the uptake of native polyamines into human cancer cells. A combination therapy of the transport inhibitor and DFMO (a drug which blocks polyamine biosynthesis) provided synergistic activity against a metastatic human colon cancer cell line. The strategy uses polyamine depletion and polyamine metabolism to generate reactive oxygen species within cells as a novel way to treat cancers. This approach may be implemented for widespread use in the treatment of diseases which rely upon polyamine transport activity for proliferation.

公开(公告)号：US20170217876A1

公开(公告)日：2017-08-03

申请号：US15488732

申请日：2017-04-17

Applicant: Dow AgroSciences LLC

Inventor： Paul R. LePlae, JR. ,  James E. Hunter ,  Gerald B. Watson ,  William C. Lo ,  John Herbert

IPC: C07C225/16 ,  C07C323/41 ,  A01N33/08 ,  C07C317/28

CPC classification number: C07C225/16 ,  A01N33/08 ,  A01N37/18 ,  A01N37/20 ,  A01N37/26 ,  A01N37/28 ,  A01N37/34 ,  A01N37/36 ,  A01N37/44 ,  A01N41/10 ,  A01N53/00 ,  C07B2200/07 ,  C07C233/78 ,  C07C233/83 ,  C07C243/38 ,  C07C255/19 ,  C07C255/46 ,  C07C317/28 ,  C07C317/44 ,  C07C323/41 ,  C07C323/60 ,  C07C2601/02

Abstract: This disclosure relates to the field of molecules having pesticidal utility against pests in Phyla Nematoda, Arthropoda, and/or Mollusca, processes to produce such molecules and intermediates used in such processes, compositions containing such molecules, and processes of using such molecules against such pests. These molecules may be used, for example, as nematicides, acaricides, insecticides, miticides, and/or molluscicides. This document discloses molecules having the following formula