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公开(公告)号：US11713316B2
公开(公告)日：2023-08-01
申请号：US17164009
申请日：2021-02-01
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Upender Velaparthi , Louis S. Chupak , Chetan Padmakar Darne , Min Ding , Robert G. Gentles , Yazhong Huang , Manjunatha Narayana Rao Kamble , Scott W. Martin , Raju Mannoori , Ivar M. McDonald , Richard E. Olson , Hasibur Rahaman , Prasada Rao Jalagam , Saumya Roy , Gopikishan Tonukunuru , Sivasudar Velaiah , Jayakumar Sankara Warrier , Xiaofan Zheng , John S. Tokarski , Bireshwar Dasgupta , Kotha Rathnakar Reddy , Thiruvenkadam Raja
IPC: C07D403/04 , C07D471/04 , C07D487/04 , A61K31/196
CPC classification number: C07D471/04
Abstract: Disclosed are compounds of Formula (I):
or a salt thereof, wherein: R1, R2, R3, R4, R5, and m are defined herein. Also disclosed are methods of using such compounds to inhibit the activity of one or both of diacylglycerol kinase alpha (DGKα) and diacylglycerol kinase zeta (DGKζ), and pharmaceutical compositions comprising such compounds. These compounds are useful in the treatment of viral infections and proliferative disorders, such as cancer.-
公开(公告)号：US20220324859A1
公开(公告)日：2022-10-13
申请号：US17164009
申请日：2021-02-01
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Upender Velaparthi , Louis S. Chupak , Chetan Padmakar Darne , Min Ding , Robert G. Gentles , Yazhong Huang , Manjunatha Narayana Rao Kamble , Scott W. Martin , Raju Mannoori , Ivar M. McDonald , Richard E. Olson , Hasibur Rahaman , Prasada Rao Jalagam , Saumya Roy , Gopikishan Tonukunuru , Sivasudar Velaiah , Jayakumar Sankara Warrier , Xiaofan Zheng , John S. Tokarski , Bireshwar Dasgupta , Kotha Rathnakar Reddy , Thiruvenkadam Raja
IPC: C07D471/04
Abstract: Disclosed are compounds of Formula (I): or a salt thereof, wherein: R1, R2, R3, R4, R5, and m are defined herein. Also disclosed are methods of using such compounds to inhibit the activity of one or both of diacylglycerol kinase alpha (DGKα) and diacylglycerol kinase zeta (DGKζ), and pharmaceutical compositions comprising such compounds. These compounds are useful in the treatment of viral infections and proliferative disorders, such as cancer.
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公开(公告)号：US09872852B2
公开(公告)日：2018-01-23
申请号：US14915782
申请日：2014-09-02
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Louis S. Chupak , Xiaofan Zheng
IPC: A61K31/381 , A61K31/396 , A61K31/40 , A61K31/4427 , A61K31/496 , C07C217/58 , C07C229/22 , C07C233/36 , C07C235/76 , C07C311/05 , C07D205/04 , C07D207/14 , C07D211/32 , C07D213/57 , C07D213/69 , C07D217/02 , C07D233/06 , C07D249/08 , C07D265/30 , A61K31/397 , A61K31/5375 , A61K31/44 , A61K31/4523 , A61K31/445 , A61K31/551 , A61K31/55 , C07D309/14 , C07D311/14 , C07D317/50 , C07D223/06 , C07D319/18 , C07D333/20 , C07D333/32 , C07D333/36 , C07D233/61 , C07D401/06 , C07D401/12 , C07D405/12 , C07D487/10 , C07D205/08 , C07D207/08 , C07D207/16 , C07D207/27 , C07C279/12 , C07D211/34 , C07D211/44 , C07D295/12 , C07D211/48 , C07D211/56 , C07D211/60 , C07D211/62 , C07D295/14 , C07D295/18 , C07D295/185 , C07D211/76 , C07D211/78 , C07D213/63 , C07D213/64 , C07D213/65 , C07C255/54 , C07C271/20 , C07C279/14 , C07C229/14 , C07C233/38 , C07C233/47 , C07C233/78 , C07C237/06 , C07K5/083 , C07C275/40 , C07D217/04 , C07D295/13 , C07D295/16 , C07D311/08
CPC classification number: A61K31/381 , A61K31/396 , A61K31/397 , A61K31/40 , A61K31/44 , A61K31/4427 , A61K31/445 , A61K31/4523 , A61K31/496 , A61K31/5375 , A61K31/55 , A61K31/551 , C07C217/58 , C07C229/14 , C07C229/22 , C07C233/36 , C07C233/38 , C07C233/47 , C07C233/78 , C07C235/76 , C07C237/06 , C07C255/54 , C07C271/20 , C07C275/40 , C07C279/12 , C07C279/14 , C07C311/05 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07C2601/14 , C07C2602/08 , C07C2602/10 , C07D205/04 , C07D205/08 , C07D207/08 , C07D207/14 , C07D207/16 , C07D207/27 , C07D211/32 , C07D211/34 , C07D211/44 , C07D211/48 , C07D211/56 , C07D211/60 , C07D211/62 , C07D211/76 , C07D211/78 , C07D213/57 , C07D213/63 , C07D213/64 , C07D213/65 , C07D213/69 , C07D217/02 , C07D217/04 , C07D223/06 , C07D233/61 , C07D249/08 , C07D265/30 , C07D279/12 , C07D295/12 , C07D295/13 , C07D295/14 , C07D295/16 , C07D295/18 , C07D295/185 , C07D309/14 , C07D311/08 , C07D311/14 , C07D317/50 , C07D319/18 , C07D333/20 , C07D333/32 , C07D333/36 , C07D401/06 , C07D401/12 , C07D405/12 , C07D487/10 , C07K5/0806 , C07K5/0808
Abstract: Disclosed are compounds of Formula (I): (I). Also disclosed are methods of using such compounds as immunomodulators, and pharmaceutical compositions comprising such compounds. These compounds are useful in treating, preventing, or slowing the progression of virological diseases or disorders and cancer.
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公开(公告)号：US10669272B2
公开(公告)日：2020-06-02
申请号：US16452679
申请日：2019-06-26
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Upender Velaparthi , Louis S. Chupak , Chetan Padmakar Darne , Min Ding , Robert G. Gentles , Yazhong Huang , Manjunatha Narayana Rao Kamble , Scott W. Martin , Raju Mannoori , Ivar M. McDonald , Richard E. Olson , Hasibur Rahaman , Prasada Rao Jalagam , Saumya Roy , Gopikishan Tonukunuru , Sivasudar Velaiah , Jayakumar Sankara Warrier , Xiaofan Zheng , John S. Tokarski , Bireshwar Dasgupta , Kotha Rathnakar Reddy , Thiruvenkadam Raja
IPC: C07D403/04 , C07D487/04 , C07D471/04
Abstract: Disclosed are compounds of Formula (I): or a salt thereof, wherein: R1, R2, R3, R4, R5, and m are defined herein. Also disclosed are methods of using such compounds to inhibit the activity of one or both of diacylglycerol kinase alpha (DGKα) and diacylglycerol kinase zeta (DGKζ), and pharmaceutical compositions comprising such compounds. These compounds are useful in the treatment of viral infections and proliferative disorders, such as cancer.
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公开(公告)号：US20200109140A1
公开(公告)日：2020-04-09
申请号：US16452679
申请日：2019-06-26
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Upender VELAPARTHI , Louis S. Chupak , Chetan Padmakar Darne , Min Ding , Robert G. Gentles , Yazhong Huang , Manjunatha Narayana Rao Kamble , Scott W. Martin , Raju Mannoori , Ivar M. McDonald , Richard E. Olson , Hasibur Rahaman , Prasada Rao Jalagam , Saumya Roy , Gopikishan Tonukunuru , Sivasudar Velaiah , Jayakumar Sankara Warrier , Xiaofan Zheng , John S. Tokarski , Bireshwar Dasgupta , Kotha Rathnakar Reddy , Thiruvenkadam Raja
IPC: C07D471/04
Abstract: Disclosed are compounds of Formula (I): or a salt thereof, wherein: R1, R2, R3, R4, R5, and m are defined herein. Also disclosed are methods of using such compounds to inhibit the activity of one or both of diacylglycerol kinase alpha (DGKα) and diacylglycerol kinase zeta (DGKζ), and pharmaceutical compositions comprising such compounds. These compounds are useful in the treatment of viral infections and proliferative disorders, such as cancer.
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Patent Agency Ranking
公开(公告)号：US20160194307A1
公开(公告)日：2016-07-07
申请号：US14915782
申请日：2014-09-02
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Louis S. Chupak , Xiaofan Zheng
IPC: C07D405/12 , C07D217/04 , C07C217/58 , C07D205/04 , C07C233/36 , C07D205/08 , C07D213/65 , C07C275/40 , C07D311/08 , C07C235/76 , C07D295/13 , C07D295/16 , C07D211/60 , C07D333/32
CPC classification number: A61K31/381 , A61K31/396 , A61K31/397 , A61K31/40 , A61K31/44 , A61K31/4427 , A61K31/445 , A61K31/4523 , A61K31/496 , A61K31/5375 , A61K31/55 , A61K31/551 , C07C217/58 , C07C229/14 , C07C229/22 , C07C233/36 , C07C233/38 , C07C233/47 , C07C233/78 , C07C235/76 , C07C237/06 , C07C255/54 , C07C271/20 , C07C275/40 , C07C279/12 , C07C279/14 , C07C311/05 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07C2601/14 , C07C2602/08 , C07C2602/10 , C07D205/04 , C07D205/08 , C07D207/08 , C07D207/14 , C07D207/16 , C07D207/27 , C07D211/32 , C07D211/34 , C07D211/44 , C07D211/48 , C07D211/56 , C07D211/60 , C07D211/62 , C07D211/76 , C07D211/78 , C07D213/57 , C07D213/63 , C07D213/64 , C07D213/65 , C07D213/69 , C07D217/02 , C07D217/04 , C07D223/06 , C07D233/61 , C07D249/08 , C07D265/30 , C07D279/12 , C07D295/12 , C07D295/13 , C07D295/14 , C07D295/16 , C07D295/18 , C07D295/185 , C07D309/14 , C07D311/08 , C07D311/14 , C07D317/50 , C07D319/18 , C07D333/20 , C07D333/32 , C07D333/36 , C07D401/06 , C07D401/12 , C07D405/12 , C07D487/10 , C07K5/0806 , C07K5/0808
Abstract: Disclosed are compounds of Formula (I): (I). Also disclosed are methods of using such compounds as immunomodulators, and pharmaceutical compositions comprising such compounds. These compounds are useful in treating, preventing, or slowing the progression of virological diseases or disorders and cancer.
Abstract translation: 公开了式（I）的化合物：（I）。 还公开了使用这些化合物作为免疫调节剂的方法和包含这些化合物的药物组合物。 这些化合物可用于治疗，预防或减缓病毒学疾病或病症和癌症的发展。
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公开(公告)号：US20230061608A1
公开(公告)日：2023-03-02
申请号：US17786239
申请日：2020-12-22
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Louis S. Chupak , Richard E. Olson , Upender Velaparthi , Xiaofan Zheng , Robert G. Gentles , Min Ding , Jayakumar Sankara Warrier
IPC: C07D401/04 , C07D401/14
Abstract: Disclosed are compounds of Formula (I) or a salt thereof, wherein: R1, R2, R3, R4, R5, R6, and m are defined herein. Also disclosed are methods of using such compounds to inhibit the activity of one or both of diacylglycerol kinase alpha (DGKα) and diacylglycerol kinase zeta (DGKξ), and pharmaceutical compositions comprising such compounds. These compounds are useful in the treatment of viral infections and proliferative disorders, such as cancer.
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公开(公告)号：US20210188845A1
公开(公告)日：2021-06-24
申请号：US17130022
申请日：2020-12-22
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Robert G. Gentles , Upender Velaparthi , Min Ding , Richard E. Olson , Scott W. Martin , Saumya Roy , Prasada Rao Jalagam , Jayakumar Sankara Warrier , Louis S. Chupak , Denise Christine Grunenfelder
IPC: C07D471/04 , C07D401/04
Abstract: Disclosed are compounds of Formula (I): or a salt thereof, wherein: X is CR6 or N; Y is CR3 or N; R1, R2, R3, R4, R5, R6, R7, and m are defined herein. Also disclosed are methods of using such compounds to inhibit the activity of one or both of diacylglycerol kinase alpha (DGKα) and diacylglycerol kinase zeta (DGKζ), and pharmaceutical compositions comprising such compounds. These compounds are useful in the treatment of viral infections and proliferative disorders, such as cancer.
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公开(公告)号：US20180214445A1
公开(公告)日：2018-08-02
申请号：US15747218
申请日：2016-07-28
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Xiaojun Zhang , Xiaofan Zheng , Louis S. Chupak
IPC: A61K31/498 , A61P7/02 , A61P9/10 , A61P31/20
Abstract: Disclosed is a compound of Formula (I) or a stereoisomer, tautomer, pharmaceutically acceptable salt, solvate or prodrug thereof, wherein one R3 is H and the other R3 is an aryl group substituted with zero to 3 R3a; and R1, R2, and R3a are defined herein. Also disclosed are methods of using such compounds as PAR4 inhibitors for the inhibition or prevention of platelet aggregation, and the treatment of a thromboembolic disorder or the primary prophylaxis of a thromboembolic disorder. Also disclosed are methods of using such compounds for the treatment of human papillomavirus. Additionally, pharmaceutical compositions comprising at least one compound of Formula (I) are disclosed.
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公开(公告)号：US11866430B2
公开(公告)日：2024-01-09
申请号：US17254914
申请日：2019-06-26
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Louis S. Chupak , Min Ding , Robert G. Gentles , Yazhong Huang , Scott W. Martin , Ivar M. Mcdonald , Stephen E. Mercer , Richard E. Olson , Upender Velaparthi , Michael Wichroski , Xiaofan Zheng
IPC: C07D471/04 , A61K31/4375 , A61P35/00
CPC classification number: C07D471/04 , A61K31/4375 , A61P35/00
Abstract: Disclosed are compounds of Formula (I): or a salt thereof, wherein: R1, R2, R3, and R4 are defined herein. Also disclosed are methods of using such compounds to inhibit the activity of one or both of diacylglycerol kinase alpha (DGK α) and diacylglycerol kinase zeta (DGKζ), and pharmaceutical compositions comprising such compounds. These compounds are useful in the treatment of viral infections and proliferative disorders, such as cancer.
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