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    Chemical compounds
    7.
    发明申请
    Chemical compounds 审中-公开

    公开(公告)号：US20060128752A1

    公开(公告)日：2006-06-15

    申请号：US10520143

    申请日：2003-07-02

    Applicant: Giuseppe Alvaro ,  Francesca Cardullo ,  Romano Di Fabio ,  Riccardo Giovannini ,  Elisabeth Piga ,  Maria Tranquillini

    Inventor： Giuseppe Alvaro ,  Francesca Cardullo ,  Romano Di Fabio ,  Riccardo Giovannini ,  Elisabeth Piga ,  Maria Tranquillini

    IPC: A61K31/445 ,  C07D211/06

    CPC classification number: C07D211/34 ,  C07D211/64 ,  C07D223/04 ,  C07D223/06

    Abstract: The present invention relates to cyclic amine derivatives of formula(l) wherein R represents halogen, C1-4 alkyl, cyano, C1-4 alkoxy, trifluoromethyl or trifluoromethoxy; R1 represents hydrogen, halogen, C3-7cycloalkyl, hydroxy, nitro, cyano or C1-4 alkyl optionally substituted by halogen, cyano or C1-4 alkoxy; R2 represents hydrogen or C1-4 alkyl; R3 and R4 independently represent hydrogen, cyano, C1-4 alkyl or R3 together with R4 represents C3-7 cycloalkyl; R5 represents trifluoromethyl, S(O)t C1-4 alkyl, C1-4 alkyl, C1-4 alkoxy, trifluoromethoxy, halogen or cyano; R6 represents hydrogen or (CH2)rR7; R7 represents hydrogen, C37 cycloalkyl, NH(C1-4alkylOC1-4alkoxy), NH(C1-4alkyl), N(C1-4alkyl)2, OC(O)NR9R8, NR8C(O)R9 or C(O)NR9R8; R9 and R8 independently represent hydrogen, C1-4 alkyl or C3-7 cycloalkyl; m represents zero or an integer from 1 to 4; n represents 1 or 2; p is zero or an integer from 1 to 3; q is an integer from 1 to 3; r is an integer from 1 to 4; t is 0, 1 or 2; provided that when m is 0, p is 2, q , r and n represent 1, R1, R2,R3, R4, R5 and R7 are hydrogen and R is chlorine, R5 is not iodine; and pharmaceutically acceptable salts and solvates thereof; process for their preparation and their use in the treatment of conditions mediated by tackykinins and/or by selective inhibition of serotonin reuptake transporter protein.

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