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    Sulfonamide carboxamide compounds
    2.
    发明授权
    Sulfonamide carboxamide compounds 有权

    公开(公告)号：US11518739B2

    公开(公告)日：2022-12-06

    申请号：US16638708

    申请日：2018-08-15

    Applicant: Inflazome Limited

    Inventor： David Miller ,  Angus Macleod ,  Jimmy Van Wiltenburg ,  Stephen Thom ,  Stephen St-Gallay ,  Jonathan Shannon

    IPC: C07C311/55 ,  C07D213/40 ,  C07D213/64 ,  C07D213/84

    Abstract: The present invention relates to compounds of formula (I): wherein Q is selected from O or S; R1 is a saturated or unsaturated, optionally substituted C1-C15 hydrocarbyl group, wherein the atom of R1 which is attached to the sulfur atom of the sulfonylurea group is not a ring atom of a cyclic group; and R2 is a cyclic group substituted at the α-position, wherein R2 may optionally be further substituted. The present invention further relates to salts, solvates and prodrugs of such compounds, to pharmaceutical compositions comprising such compounds, and to the use of such compounds in the treatment and prevention of medical disorders and diseases, most especially by the inhibition of NLRP3.

    Sulfonamide derivates as NLRP3 inhibitors
    7.
    发明授权
    Sulfonamide derivates as NLRP3 inhibitors 有权

    公开(公告)号：US12168653B2

    公开(公告)日：2024-12-17

    申请号：US16977464

    申请日：2019-03-01

    Applicant: Inflazome Limited

    Inventor： Matthew Cooper ,  David Miller ,  Jimmy Van Wiltenburg ,  Jonathan Shannon ,  Stephen St-Gallay

    IPC: C07D401/12 ,  C07C311/51 ,  C07D207/14 ,  C07D213/64

    Abstract: The present invention relates to compounds of formula (I): (I) wherein Q is selected from O or S; R1 is an optionally substituted hydrocarbyl group which may optionally include one or more heteroatoms N, O or S in its carbon skeleton, provided that the hydrocarbyl group includes at least one heteroatom N, O or S in its carbon skeleton or is substituted with a substituent comprising at least one heteroatom N, O or S, and provided that the atom of R1 which is attached to the sulfur atom of the remainder of the molecule is not a ring atom of a cyclic group; R2 is an α,α′-substituted cyclic group which may optionally be further substituted; R3 and R4 are each independently hydrogen, halogen, —OH, —NH2, —CN, —R5, —OR5, —NHRs or —N(R5)2; or R3 and R4 together with the carbon atom to which they are attached may form a 3- to 7-membered saturated or unsaturated, optionally substituted cyclic group; and R5 is independently optionally substituted C1-C4 alkyl. The present invention further relates to salts, solvates and prodrugs of such compounds, to pharmaceutical compositions comprising such compounds, and to the use of such compounds in the treatment and prevention of medical disorders and diseases, most especially by the inhibition of NLRP3.

    Sulfonamide carboxamide compounds
    9.
    发明授权
    Sulfonamide carboxamide compounds 有权

    公开(公告)号：US11773058B2

    公开(公告)日：2023-10-03

    申请号：US16638646

    申请日：2018-08-15

    Applicant: Inflazome Limited

    Inventor： David Miller ,  Angus MacLeod ,  Jimmy Van Wiltenburg ,  Stephen Thom ,  Stephen St-Gallay ,  Jonathan Shannon

    IPC: C07C311/55 ,  C07D205/04 ,  C07D205/12 ,  C07D207/09 ,  C07D211/24 ,  C07D211/58 ,  C07D213/34 ,  C07D213/40 ,  C07D231/12 ,  C07D295/088

    CPC classification number: C07C311/55 ,  C07D205/04 ,  C07D205/12 ,  C07D207/09 ,  C07D211/24 ,  C07D211/58 ,  C07D213/34 ,  C07D213/40 ,  C07D231/12 ,  C07D295/088

    Abstract: The present invention relates to compounds of formula (I): Formula (I) wherein Q is selected from O or S; L is a saturated or unsaturated, optionally substituted C1-C12 hydrocarbylene group optionally including one or more heteroatoms N, O or S; R1 is —NR3R4, —OR5, —(C═NR6)R7, —(CO)R8, —CN, —N3, a quaternary ammonium group or an optionally substituted heterocycle; R3, R4, R5, R6, R7 and R8 are each independently hydrogen or a saturated or unsaturated, optionally substituted C1-C10 hydrocarbyl group optionally including one or more heteroatoms N, O or S; wherein optionally L and R3, or L and R4, or R3 and R4, or L and R5, or L and R6, or L and R7, or R6 and R7, or L and R8 together with the atom(s) to which they are attached may form a 3- to 12-membered, saturated or unsaturated, optionally substituted cyclic group; and R2 is a cyclic group substituted at the a-position, wherein R2 may optionally be further substituted; provided that the atom of L which is attached to the sulfur atom of the sulfonylurea group is a carbon atom and is not a ring atom of a heterocyclic or aromatic group. The present invention further relates to salts, solvates and prodrugs of such compounds, to pharmaceutical compositions comprising such compounds, and to the use of such compounds in the treatment and prevention of medical disorders and diseases, most especially by the inhibition of NLRP3.

    Compounds
    10.
    发明授权
    Compounds 有权

    公开(公告)号：US11623922B2

    公开(公告)日：2023-04-11

    申请号：US16753239

    申请日：2018-10-03

    Applicant: INFLAZOME LIMITED

    Inventor： David Miller ,  Stephen Thom ,  Stephen St-Gallay ,  Jonathan Shannon ,  Paul Leeson

    IPC: C07D401/12 ,  C07C381/10 ,  C07D205/04 ,  C07D231/18

    Abstract: The present invention relates to compounds of formula (I): wherein Q is selected from O or S; R1 is a saturated or unsaturated hydrocarbyl group, wherein the hydrocarbyl group may be straight-chained or branched, or be or include cyclic groups, wherein the hydrocarbyl group may optionally be substituted, and wherein the hydrocarbyl group may optionally include one or more heteroatoms N, O or S in its carbon skeleton; and R2 is a cyclic group substituted at the a-position, wherein R2 may optionally be further substituted. The present invention further relates to salts, solvates and prodrugs of such compounds, to pharmaceutical compositions comprising such compounds, and to the use of such compounds in the treatment and prevention of medical disorders and diseases, most especially by the inhibition of NLRP3.

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