公开(公告)号：US11129834B2

公开(公告)日：2021-09-28

申请号：US16541490

申请日：2019-08-15

Applicant: Novira Therapeutics, Inc. ,  Janssen Sciences Ireland Unlimited Company

Inventor： George Hartman ,  Osvaldo Flores ,  Klaus Klumpp ,  Man Iu Lam ,  Jan Martin Berke

IPC: A01N43/04 ,  A61K31/70 ,  A61K31/52 ,  A61K31/40 ,  A61K31/445 ,  A61K31/522 ,  A61K31/675 ,  A61K31/7072 ,  A61K31/03 ,  A61K31/095 ,  A61K31/18 ,  A61K31/706 ,  C12N7/06

Abstract: The present disclosure is directed to capsid assembly inhibitor compositions and methods for use in the treatment of hepatitis B virus infection.

公开(公告)号：US10544141B2

公开(公告)日：2020-01-28

申请号：US16118760

申请日：2018-08-31

Applicant: Novira Therapeutics, Inc.

Inventor： George D. Hartman ,  Scott Kuduk

IPC: C07D471/04 ,  A61K38/21 ,  A61K39/29 ,  C12N7/00 ,  A61K31/437 ,  A61K31/5377 ,  A61K45/06 ,  A61K31/4545 ,  A61P31/12 ,  A61K31/501

Abstract: Provided herein are compounds useful for the treatment of HBV infection in a subject in need thereof, pharmaceutical compositions thereof, and methods of inhibiting, suppressing, or preventing HBV infection in the subject.

公开(公告)号：US10428041B2

公开(公告)日：2019-10-01

申请号：US16191199

申请日：2018-11-14

Applicant: Novira Therapeutics, Inc.

Inventor： Ryan C. Clark ,  Yen Truong ,  Nicholas Stock ,  Jason Jacintho

IPC: A61K45/06 ,  C07D213/81 ,  C07D231/18 ,  C07D333/26

Abstract: The present invention includes a method of inhibiting, suppressing or preventing HBV infection in an individual in need thereof, comprising administering to the individual a therapeutically effective amount of at least one compound of the invention.

公开(公告)号：US20190209541A1

公开(公告)日：2019-07-11

申请号：US16235210

申请日：2018-12-28

Applicant: Novira Therapeutics Inc.

Inventor： George D. Hartman

IPC: A61K31/45 ,  A61K31/40 ,  A61K31/397 ,  A61K38/21 ,  A61K31/445

CPC classification number: A61K31/45 ,  A61K31/397 ,  A61K31/40 ,  A61K31/445 ,  A61K38/21 ,  A61K38/212 ,  A61K2300/00

Abstract: Provided herein is a combination therapy comprising a compound of Formula I and peginterferon alfa-2a, or another interferon analog. The combination therapy is useful for the treatment of HBV infection. Also provided herein are compositions comprising a compound of Formula I and peginterferon alfa-2a, or another interferon analog.

公开(公告)号：US20190194191A1

公开(公告)日：2019-06-27

申请号：US16226780

申请日：2018-12-20

Applicant: Novira Therapeutics, Inc.

Inventor： George D. Hartman ,  Scott Kuduk

IPC: C07D471/04 ,  A61K31/437 ,  A61K31/5377 ,  A61K31/4545 ,  A61K31/501 ,  A61K45/06 ,  A61K39/29 ,  A61P31/12 ,  C12N7/00 ,  A61K38/21

CPC classification number: C07D471/04 ,  A61K31/437 ,  A61K31/4545 ,  A61K31/501 ,  A61K31/5377 ,  A61K38/212 ,  A61K39/292 ,  A61K45/06 ,  A61P31/12 ,  C12N7/00 ,  C12N2730/10111 ,  C12N2730/10134 ,  C12N2730/10171 ,  A61K2300/00

Abstract: Provided herein are compounds useful for the treatment of HBV infection in a subject in need thereof, pharmaceutical compositions thereof, and methods of inhibiting, suppressing, or preventing HBV infection in the subject.

公开(公告)号：US20190031653A1

公开(公告)日：2019-01-31

申请号：US16024954

申请日：2018-07-02

Applicant: Novira Therapeutics, Inc.

Inventor： George D. Hartman ,  Scott Kuduk

IPC: C07D471/04 ,  A61K31/501 ,  A61K31/437 ,  A61K45/06 ,  A61K31/5377 ,  A61K38/21 ,  A61K39/29 ,  C12N7/00 ,  A61P31/12 ,  A61K31/4545

CPC classification number: C07D471/04 ,  A61K31/437 ,  A61K31/4545 ,  A61K31/501 ,  A61K31/5377 ,  A61K38/212 ,  A61K39/292 ,  A61K45/06 ,  A61P31/12 ,  C12N7/00 ,  C12N2730/10111 ,  C12N2730/10134 ,  C12N2730/10171 ,  A61K2300/00

Abstract: Provided herein are compounds useful for the treatment of HBV infection in a subject in need thereof, pharmaceutical compositions thereof, and methods of inhibiting, suppressing, or preventing HBV infection in the subject.

公开(公告)号：US09873671B2

公开(公告)日：2018-01-23

申请号：US15277421

申请日：2016-09-27

Applicant: Novira Therapeutics, Inc.

Inventor： George D. Hartman ,  Scott Kuduk

IPC: C07D223/08 ,  A61K31/55 ,  A61K45/06 ,  C07D267/10 ,  A61K31/553 ,  C07D223/32 ,  A61K31/439 ,  A61K31/551 ,  C07D221/22 ,  C07D223/06 ,  C07D243/08 ,  A61K38/21 ,  A61K47/48 ,  A61K31/554 ,  C07D283/00 ,  C07D295/26 ,  C07D403/12

CPC classification number: C07D223/08 ,  A61K31/439 ,  A61K31/55 ,  A61K31/551 ,  A61K31/553 ,  A61K31/554 ,  A61K38/21 ,  A61K45/06 ,  A61K47/60 ,  C07D221/22 ,  C07D223/06 ,  C07D223/32 ,  C07D243/08 ,  C07D267/10 ,  C07D283/00 ,  C07D295/26 ,  C07D403/12 ,  A61K2300/00

Abstract: Provided herein are compounds useful for the treatment of HBV infection in a subject in need thereof, pharmaceutical compositions thereof, and methods of inhibiting, suppressing, or preventing HBV infection in the subject.

公开(公告)号：US20170340642A1

公开(公告)日：2017-11-30

申请号：US15488368

申请日：2017-04-14

Applicant: Novira Therapeutics, Inc. ,  Janssen Sciences Ireland UC

Inventor： George HARTMAN ,  Osvaldo FLORES ,  Klaus KLUMPP ,  Man Iu LAM ,  Jan Martin BERKE

IPC: A61K31/52 ,  A61K31/03 ,  A61K31/095 ,  A61K31/18 ,  A61K31/40 ,  C12N7/06

Abstract: The present disclosure is directed to capsid assembly inhibitor compositions and methods for use in the treatment of hepatitis B virus infection.

公开(公告)号：US09400280B2

公开(公告)日：2016-07-26

申请号：US14670001

申请日：2015-03-26

Applicant: Novira Therapeutics, Inc.

Inventor： George D. Hartman

IPC: C07D211/96 ,  G01N33/569 ,  A61K31/445 ,  A61K31/5375 ,  A61K31/54 ,  C07D491/048 ,  A61K31/4355 ,  A61K45/06 ,  A61K31/4453 ,  A61K31/506

CPC classification number: G01N33/56988 ,  A61K31/4355 ,  A61K31/445 ,  A61K31/4453 ,  A61K31/506 ,  A61K31/5375 ,  A61K31/54 ,  A61K45/06 ,  C07D211/96 ,  C07D491/048 ,  A61K2300/00

Abstract: Provided herein are compounds useful for the treatment of HBV infection in a subject in need thereof, pharmaceutical compositions thereof, and methods of inhibiting, suppressing, or preventing HBV infection in the subject.

Abstract translation: 本文提供了可用于治疗有需要的受试者的HBV感染的化合物，其药物组合物，以及抑制，抑制或预防受试者中HBV感染的方法。

公开(公告)号：US20160185748A1

公开(公告)日：2016-06-30

申请号：US14957008

申请日：2015-12-02

Applicant: NOVIRA THERAPEUTICS, INC.

Inventor： Ryan C. Clark ,  Yen Truong ,  Nicholas Stock ,  Jason Jacintho

IPC: C07D333/26 ,  A61K31/44 ,  A61K45/06 ,  A61K31/415 ,  A61K31/381 ,  C07D213/81 ,  C07D231/18

CPC classification number: C07D333/26 ,  A61K45/06 ,  C07D213/81 ,  C07D231/18

Abstract: The present invention includes a method of inhibiting, suppressing or preventing HBV infection in an individual in need thereof, comprising administering to the individual a therapeutically effective amount of at least one compound of the invention.

Abstract translation: 本发明包括在有需要的个体中抑制，抑制或预防HBV感染的方法，包括向个体施用治疗有效量的至少一种本发明的化合物。