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公开(公告)号：US20230061608A1
公开(公告)日：2023-03-02
申请号：US17786239
申请日：2020-12-22
发明人： Louis S. Chupak , Richard E. Olson , Upender Velaparthi , Xiaofan Zheng , Robert G. Gentles , Min Ding , Jayakumar Sankara Warrier
IPC分类号： C07D401/04 , C07D401/14
摘要： Disclosed are compounds of Formula (I) or a salt thereof, wherein: R1, R2, R3, R4, R5, R6, and m are defined herein. Also disclosed are methods of using such compounds to inhibit the activity of one or both of diacylglycerol kinase alpha (DGKα) and diacylglycerol kinase zeta (DGKξ), and pharmaceutical compositions comprising such compounds. These compounds are useful in the treatment of viral infections and proliferative disorders, such as cancer.
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公开(公告)号：US20210188845A1
公开(公告)日：2021-06-24
申请号：US17130022
申请日：2020-12-22
发明人： Robert G. Gentles , Upender Velaparthi , Min Ding , Richard E. Olson , Scott W. Martin , Saumya Roy , Prasada Rao Jalagam , Jayakumar Sankara Warrier , Louis S. Chupak , Denise Christine Grunenfelder
IPC分类号： C07D471/04 , C07D401/04
摘要： Disclosed are compounds of Formula (I): or a salt thereof, wherein: X is CR6 or N; Y is CR3 or N; R1, R2, R3, R4, R5, R6, R7, and m are defined herein. Also disclosed are methods of using such compounds to inhibit the activity of one or both of diacylglycerol kinase alpha (DGKα) and diacylglycerol kinase zeta (DGKζ), and pharmaceutical compositions comprising such compounds. These compounds are useful in the treatment of viral infections and proliferative disorders, such as cancer.
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公开(公告)号：US11866430B2
公开(公告)日：2024-01-09
申请号：US17254914
申请日：2019-06-26
发明人： Louis S. Chupak , Min Ding , Robert G. Gentles , Yazhong Huang , Scott W. Martin , Ivar M. Mcdonald , Stephen E. Mercer , Richard E. Olson , Upender Velaparthi , Michael Wichroski , Xiaofan Zheng
IPC分类号： C07D471/04 , A61K31/4375 , A61P35/00
CPC分类号： C07D471/04 , A61K31/4375 , A61P35/00
摘要： Disclosed are compounds of Formula (I): or a salt thereof, wherein: R1, R2, R3, and R4 are defined herein. Also disclosed are methods of using such compounds to inhibit the activity of one or both of diacylglycerol kinase alpha (DGK α) and diacylglycerol kinase zeta (DGKζ), and pharmaceutical compositions comprising such compounds. These compounds are useful in the treatment of viral infections and proliferative disorders, such as cancer.
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公开(公告)号：US20210277004A1
公开(公告)日：2021-09-09
申请号：US17254914
申请日：2019-06-26
发明人： Louis S. Chupak , Min Ding , Robert G. Gentles , Yazhong Huang , Scott W. Martin , Ivar M. Mcdonald , Stephen E. Mercer , Richard E. Olson , Upender Velaparthi , Michael Wichroski , Xiaofan Zheng
IPC分类号： C07D471/04 , A61P35/00
摘要： Disclosed are compounds of Formula (I): or a salt thereof, wherein: R1, R2, R3, and R4 are defined herein. Also disclosed are methods of using such compounds to inhibit the activity of one or both of diacylglycerol kinase alpha (DGK α) and diacylglycerol kinase zeta (DGKζ), and pharmaceutical compositions comprising such compounds. These compounds are useful in the treatment of viral infections and proliferative disorders, such as cancer.
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公开(公告)号：US10669272B2
公开(公告)日：2020-06-02
申请号：US16452679
申请日：2019-06-26
发明人： Upender Velaparthi , Louis S. Chupak , Chetan Padmakar Darne , Min Ding , Robert G. Gentles , Yazhong Huang , Manjunatha Narayana Rao Kamble , Scott W. Martin , Raju Mannoori , Ivar M. McDonald , Richard E. Olson , Hasibur Rahaman , Prasada Rao Jalagam , Saumya Roy , Gopikishan Tonukunuru , Sivasudar Velaiah , Jayakumar Sankara Warrier , Xiaofan Zheng , John S. Tokarski , Bireshwar Dasgupta , Kotha Rathnakar Reddy , Thiruvenkadam Raja
IPC分类号： C07D403/04 , C07D487/04 , C07D471/04
摘要： Disclosed are compounds of Formula (I): or a salt thereof, wherein: R1, R2, R3, R4, R5, and m are defined herein. Also disclosed are methods of using such compounds to inhibit the activity of one or both of diacylglycerol kinase alpha (DGKα) and diacylglycerol kinase zeta (DGKζ), and pharmaceutical compositions comprising such compounds. These compounds are useful in the treatment of viral infections and proliferative disorders, such as cancer.
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公开(公告)号：US20200109140A1
公开(公告)日：2020-04-09
申请号：US16452679
申请日：2019-06-26
发明人： Upender VELAPARTHI , Louis S. Chupak , Chetan Padmakar Darne , Min Ding , Robert G. Gentles , Yazhong Huang , Manjunatha Narayana Rao Kamble , Scott W. Martin , Raju Mannoori , Ivar M. McDonald , Richard E. Olson , Hasibur Rahaman , Prasada Rao Jalagam , Saumya Roy , Gopikishan Tonukunuru , Sivasudar Velaiah , Jayakumar Sankara Warrier , Xiaofan Zheng , John S. Tokarski , Bireshwar Dasgupta , Kotha Rathnakar Reddy , Thiruvenkadam Raja
IPC分类号： C07D471/04
摘要： Disclosed are compounds of Formula (I): or a salt thereof, wherein: R1, R2, R3, R4, R5, and m are defined herein. Also disclosed are methods of using such compounds to inhibit the activity of one or both of diacylglycerol kinase alpha (DGKα) and diacylglycerol kinase zeta (DGKζ), and pharmaceutical compositions comprising such compounds. These compounds are useful in the treatment of viral infections and proliferative disorders, such as cancer.
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7.发明授权公开(公告)号：US09738642B2
公开(公告)日：2017-08-22
申请号：US15022072
申请日：2014-09-18
发明人： Lawrence R. Marcin , Mendi A. Higgins , Joanne J. Bronson , F. Christopher Zusi , John E. Macor , Min Ding
IPC分类号： C07D471/04 , A61K31/437 , C07B59/00
CPC分类号： C07D471/04 , C07B59/002 , C07B2200/05
摘要： The disclosure generally relates to compounds of formula I, including their salts, as well as compositions and methods of using the compounds. The compounds modulate the mGluR2 receptor and may be useful for the treatment of various disorders of the central nervous system.
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8.发明申请TRIAZOLOPYRIDINE ETHER DERIVATIVES AND THEIR USE IN NEUROLOGICAL AND PYSCHIATRIC DISORDERS 审中-公开三唑并噻吩衍生物及其在神经病学和麻醉病中的应用公开(公告)号：US20160237081A1
公开(公告)日：2016-08-18
申请号：US15022072
申请日：2014-09-18
发明人： Lawrence R. Marcin , Mendi A. Higgins , Joanne J. Bronson , F. Christopher Zusi , John E. Macor , Min Ding
IPC分类号： C07D471/04 , C07B59/00
CPC分类号： C07D471/04 , C07B59/002 , C07B2200/05
摘要： The disclosure generally relates to compounds of formula I, including their salts, as well as compositions and methods of using the compounds. The compounds modulate the mGluR2 receptor and may be useful for the treatment of various disorders of the central nervous system.
摘要翻译： 本公开内容通常涉及式I化合物，包括其盐，以及使用该化合物的组合物和方法。 该化合物调节mGluR2受体并且可用于治疗中枢神经系统的各种疾病。
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公开(公告)号：US11964973B2
公开(公告)日：2024-04-23
申请号：US17130022
申请日：2020-12-22
发明人： Robert G. Gentles , Upender Velaparthi , Min Ding , Richard E. Olson , Scott W. Martin , Saumya Roy , Prasada Rao Jalagam , Jayakumar Sankara Warrier , Louis S. Chupak , Denise Christine Grunenfelder
IPC分类号： C07D471/04 , C07D401/04
CPC分类号： C07D471/04 , C07D401/04
摘要： Disclosed are compounds of Formula (I):
or a salt thereof, wherein: X is CR6 or N; Y is CR3 or N; R1, R2, R3, R4, R5, R6, R7, and m are defined herein. Also disclosed are methods of using such compounds to inhibit the activity of one or both of diacylglycerol kinase alpha (DGKα) and diacylglycerol kinase zeta (DGKζ), and pharmaceutical compositions comprising such compounds. These compounds are useful in the treatment of viral infections and proliferative disorders, such as cancer.-
公开(公告)号：US10954238B1
公开(公告)日：2021-03-23
申请号：US16843024
申请日：2020-04-08
发明人： Upender Velaparthi , Louis S. Chupak , Chetan Padmakar Darne , Min Ding , Robert G. Gentles , Yazhong Huang , Manjunatha Narayana Rao Kamble , Scott W. Martin , Raju Mannoori , Ivar M. McDonald , Richard E. Olson , Hasibur Rahaman , Prasada Rao Jalagam , Saumya Roy , Gopikishan Tonukunuru , Sivasudar Velaiah , Jayakumar Sankara Warrier , Xiaofan Zheng , John S. Tokarski , Bireshwar Dasgupta , Kotha Rathnakar Reddy , Thiruvenkadam Raja
IPC分类号： C07D403/04 , C07D487/04 , A61K31/196 , C07D471/04
摘要： Disclosed are compounds of Formula (I): or a salt thereof, wherein: R1, R2, R3, R4, R5, and m are defined herein. Also disclosed are methods of using such compounds to inhibit the activity of one or both of diacylglycerol kinase alpha (DGKα) and diacylglycerol kinase zeta (DGKζ), and pharmaceutical compositions comprising such compounds. These compounds are useful in the treatment of viral infections and proliferative disorders, such as cancer.
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