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公开(公告)号：US10669272B2
公开(公告)日：2020-06-02
申请号：US16452679
申请日：2019-06-26
发明人： Upender Velaparthi , Louis S. Chupak , Chetan Padmakar Darne , Min Ding , Robert G. Gentles , Yazhong Huang , Manjunatha Narayana Rao Kamble , Scott W. Martin , Raju Mannoori , Ivar M. McDonald , Richard E. Olson , Hasibur Rahaman , Prasada Rao Jalagam , Saumya Roy , Gopikishan Tonukunuru , Sivasudar Velaiah , Jayakumar Sankara Warrier , Xiaofan Zheng , John S. Tokarski , Bireshwar Dasgupta , Kotha Rathnakar Reddy , Thiruvenkadam Raja
IPC分类号： C07D403/04 , C07D487/04 , C07D471/04
摘要： Disclosed are compounds of Formula (I): or a salt thereof, wherein: R1, R2, R3, R4, R5, and m are defined herein. Also disclosed are methods of using such compounds to inhibit the activity of one or both of diacylglycerol kinase alpha (DGKα) and diacylglycerol kinase zeta (DGKζ), and pharmaceutical compositions comprising such compounds. These compounds are useful in the treatment of viral infections and proliferative disorders, such as cancer.
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公开(公告)号：US20200109140A1
公开(公告)日：2020-04-09
申请号：US16452679
申请日：2019-06-26
发明人： Upender VELAPARTHI , Louis S. Chupak , Chetan Padmakar Darne , Min Ding , Robert G. Gentles , Yazhong Huang , Manjunatha Narayana Rao Kamble , Scott W. Martin , Raju Mannoori , Ivar M. McDonald , Richard E. Olson , Hasibur Rahaman , Prasada Rao Jalagam , Saumya Roy , Gopikishan Tonukunuru , Sivasudar Velaiah , Jayakumar Sankara Warrier , Xiaofan Zheng , John S. Tokarski , Bireshwar Dasgupta , Kotha Rathnakar Reddy , Thiruvenkadam Raja
IPC分类号： C07D471/04
摘要： Disclosed are compounds of Formula (I): or a salt thereof, wherein: R1, R2, R3, R4, R5, and m are defined herein. Also disclosed are methods of using such compounds to inhibit the activity of one or both of diacylglycerol kinase alpha (DGKα) and diacylglycerol kinase zeta (DGKζ), and pharmaceutical compositions comprising such compounds. These compounds are useful in the treatment of viral infections and proliferative disorders, such as cancer.
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公开(公告)号：US11866430B2
公开(公告)日：2024-01-09
申请号：US17254914
申请日：2019-06-26
发明人： Louis S. Chupak , Min Ding , Robert G. Gentles , Yazhong Huang , Scott W. Martin , Ivar M. Mcdonald , Stephen E. Mercer , Richard E. Olson , Upender Velaparthi , Michael Wichroski , Xiaofan Zheng
IPC分类号： C07D471/04 , A61K31/4375 , A61P35/00
CPC分类号： C07D471/04 , A61K31/4375 , A61P35/00
摘要： Disclosed are compounds of Formula (I): or a salt thereof, wherein: R1, R2, R3, and R4 are defined herein. Also disclosed are methods of using such compounds to inhibit the activity of one or both of diacylglycerol kinase alpha (DGK α) and diacylglycerol kinase zeta (DGKζ), and pharmaceutical compositions comprising such compounds. These compounds are useful in the treatment of viral infections and proliferative disorders, such as cancer.
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公开(公告)号：US20210277004A1
公开(公告)日：2021-09-09
申请号：US17254914
申请日：2019-06-26
发明人： Louis S. Chupak , Min Ding , Robert G. Gentles , Yazhong Huang , Scott W. Martin , Ivar M. Mcdonald , Stephen E. Mercer , Richard E. Olson , Upender Velaparthi , Michael Wichroski , Xiaofan Zheng
IPC分类号： C07D471/04 , A61P35/00
摘要： Disclosed are compounds of Formula (I): or a salt thereof, wherein: R1, R2, R3, and R4 are defined herein. Also disclosed are methods of using such compounds to inhibit the activity of one or both of diacylglycerol kinase alpha (DGK α) and diacylglycerol kinase zeta (DGKζ), and pharmaceutical compositions comprising such compounds. These compounds are useful in the treatment of viral infections and proliferative disorders, such as cancer.
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公开(公告)号：US20160257645A1
公开(公告)日：2016-09-08
申请号：US15031352
申请日：2014-10-23
发明人： Annapurna Pendri , Guo Li , John A. Bender , Zhong Yang , Alan Xiangdong Wang , Brett R. Beno , Robert A. Fridell , Makonen Belema , Nicholas A. Meanwell , Robert G. Gentles
IPC分类号： C07C311/58 , C07D317/66 , C07D409/12 , C07D405/12 , C07D317/46 , C07D407/12 , C07D271/06 , C07D307/38 , C07D333/18 , C07D231/12 , C07D333/54 , C07D209/10 , C07D333/28 , C07D261/08 , C07D215/08 , C07D209/08 , C07D277/82 , C07D495/04 , C07D491/08 , C07D205/04 , C07D401/04 , C07D213/56 , C07D249/08 , C07D265/36
CPC分类号： C07C311/58 , C07C2601/08 , C07C2601/14 , C07C2602/08 , C07D205/04 , C07D209/08 , C07D209/10 , C07D213/56 , C07D215/08 , C07D231/12 , C07D249/08 , C07D261/08 , C07D265/36 , C07D271/06 , C07D277/82 , C07D307/38 , C07D317/46 , C07D317/66 , C07D333/18 , C07D333/28 , C07D333/54 , C07D401/04 , C07D405/12 , C07D407/12 , C07D409/12 , C07D491/08 , C07D495/04
摘要： Compounds of Formula I with activity against HIV, including pharmaceutical compositions and methods for using these compounds in treating human immunodeficiency virus (HIV) infection, are set forth: Formula: (I)
摘要翻译： 阐述了具有抗HIV活性的式I化合物，包括药物组合物和使用这些化合物治疗人类免疫缺陷病毒（HIV）感染的方法：式（I）
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公开(公告)号：US20230061608A1
公开(公告)日：2023-03-02
申请号：US17786239
申请日：2020-12-22
发明人： Louis S. Chupak , Richard E. Olson , Upender Velaparthi , Xiaofan Zheng , Robert G. Gentles , Min Ding , Jayakumar Sankara Warrier
IPC分类号： C07D401/04 , C07D401/14
摘要： Disclosed are compounds of Formula (I) or a salt thereof, wherein: R1, R2, R3, R4, R5, R6, and m are defined herein. Also disclosed are methods of using such compounds to inhibit the activity of one or both of diacylglycerol kinase alpha (DGKα) and diacylglycerol kinase zeta (DGKξ), and pharmaceutical compositions comprising such compounds. These compounds are useful in the treatment of viral infections and proliferative disorders, such as cancer.
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公开(公告)号：US20210188845A1
公开(公告)日：2021-06-24
申请号：US17130022
申请日：2020-12-22
发明人： Robert G. Gentles , Upender Velaparthi , Min Ding , Richard E. Olson , Scott W. Martin , Saumya Roy , Prasada Rao Jalagam , Jayakumar Sankara Warrier , Louis S. Chupak , Denise Christine Grunenfelder
IPC分类号： C07D471/04 , C07D401/04
摘要： Disclosed are compounds of Formula (I): or a salt thereof, wherein: X is CR6 or N; Y is CR3 or N; R1, R2, R3, R4, R5, R6, R7, and m are defined herein. Also disclosed are methods of using such compounds to inhibit the activity of one or both of diacylglycerol kinase alpha (DGKα) and diacylglycerol kinase zeta (DGKζ), and pharmaceutical compositions comprising such compounds. These compounds are useful in the treatment of viral infections and proliferative disorders, such as cancer.
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公开(公告)号：US11713316B2
公开(公告)日：2023-08-01
申请号：US17164009
申请日：2021-02-01
发明人： Upender Velaparthi , Louis S. Chupak , Chetan Padmakar Darne , Min Ding , Robert G. Gentles , Yazhong Huang , Manjunatha Narayana Rao Kamble , Scott W. Martin , Raju Mannoori , Ivar M. McDonald , Richard E. Olson , Hasibur Rahaman , Prasada Rao Jalagam , Saumya Roy , Gopikishan Tonukunuru , Sivasudar Velaiah , Jayakumar Sankara Warrier , Xiaofan Zheng , John S. Tokarski , Bireshwar Dasgupta , Kotha Rathnakar Reddy , Thiruvenkadam Raja
IPC分类号： C07D403/04 , C07D471/04 , C07D487/04 , A61K31/196
CPC分类号： C07D471/04
摘要： Disclosed are compounds of Formula (I):
or a salt thereof, wherein: R1, R2, R3, R4, R5, and m are defined herein. Also disclosed are methods of using such compounds to inhibit the activity of one or both of diacylglycerol kinase alpha (DGKα) and diacylglycerol kinase zeta (DGKζ), and pharmaceutical compositions comprising such compounds. These compounds are useful in the treatment of viral infections and proliferative disorders, such as cancer.-
公开(公告)号：US20220324859A1
公开(公告)日：2022-10-13
申请号：US17164009
申请日：2021-02-01
发明人： Upender Velaparthi , Louis S. Chupak , Chetan Padmakar Darne , Min Ding , Robert G. Gentles , Yazhong Huang , Manjunatha Narayana Rao Kamble , Scott W. Martin , Raju Mannoori , Ivar M. McDonald , Richard E. Olson , Hasibur Rahaman , Prasada Rao Jalagam , Saumya Roy , Gopikishan Tonukunuru , Sivasudar Velaiah , Jayakumar Sankara Warrier , Xiaofan Zheng , John S. Tokarski , Bireshwar Dasgupta , Kotha Rathnakar Reddy , Thiruvenkadam Raja
IPC分类号： C07D471/04
摘要： Disclosed are compounds of Formula (I): or a salt thereof, wherein: R1, R2, R3, R4, R5, and m are defined herein. Also disclosed are methods of using such compounds to inhibit the activity of one or both of diacylglycerol kinase alpha (DGKα) and diacylglycerol kinase zeta (DGKζ), and pharmaceutical compositions comprising such compounds. These compounds are useful in the treatment of viral infections and proliferative disorders, such as cancer.
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公开(公告)号：US20140186299A1
公开(公告)日：2014-07-03
申请号：US14197343
申请日：2014-03-05
IPC分类号： C07D487/08 , A61K31/55 , A61K45/06
CPC分类号： C07D487/08 , A61K31/55 , A61K45/06 , C07D471/08 , C07D487/04 , C07D519/00
摘要： The invention encompasses compounds of formula I as well as compositions and methods of using the compounds. The compounds have activity against hepatitis C virus (HCV) and are useful in treating those infected with HCV.
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