公开(公告)号：US20240391884A1

公开(公告)日：2024-11-28

申请号：US18779915

申请日：2024-07-22

Applicant: Novartis AG

Inventor： Luigi FRANCHI ,  Shomir GHOSH ,  Gary GLICK ,  Jason KATZ ,  Anthony William OPIPARI, Jr. ,  William ROUSH ,  Hans Martin SEIDEL ,  Dong-Ming SHEN ,  Shankar VENKATRAMAN ,  David Guenther WINKLER

IPC: C07D265/30 ,  A61K45/06 ,  A61P1/00 ,  A61P11/00 ,  A61P19/08 ,  A61P35/00 ,  C07C381/10 ,  C07D209/26 ,  C07D211/78 ,  C07D215/06 ,  C07D231/12 ,  C07D239/26 ,  C07D239/36 ,  C07D261/08 ,  C07D263/46 ,  C07D277/36 ,  C07D317/50 ,  C07D333/34 ,  C07D401/12 ,  C07D409/12 ,  C07D417/12

Abstract: In one aspect, compounds of Formula AA, or a pharmaceutically acceptable salt thereof, are featured: or a pharmaceutically acceptable salt thereof, wherein the variables shown in Formula A can be as defined anywhere herein.

公开(公告)号：US20230295106A1

公开(公告)日：2023-09-21

申请号：US17768725

申请日：2020-10-14

Applicant: The Regents of the University of California ,  Delix Therapeutics, Inc.

Inventor： David E. Olson ,  Lee Dunlap ,  Florence Wagner ,  Milan Chytil ,  Noel Aaron Powell

IPC: C07D401/04 ,  C07D405/14 ,  C07D471/06 ,  C07D491/16 ,  C07D211/78 ,  C07D209/90 ,  A61P25/28

CPC classification number: C07D401/04 ,  C07D405/14 ,  C07D471/06 ,  C07D491/16 ,  C07D211/78 ,  C07D209/90 ,  A61P25/28

Abstract: Provided herein are ergoline-derived heterocyclic compounds which can be useful for methods of treating a disease or for increasing neural plasticity. The compounds can also be useful for increasing dendritic spine density.

公开(公告)号：US20230098847A1

公开(公告)日：2023-03-30

申请号：US17867233

申请日：2022-07-18

Applicant: California Institute of Technology

Inventor： Brian M. Stoltz ,  Scott C. Virgil ,  David E. White ,  Taiga Yurino ,  Yiyang Liu ,  Douglas C. Behenna ,  Douglas Duquette ,  Christian Eidamshaus

IPC: C07D211/78 ,  C07D265/32 ,  C07D211/60 ,  C07D207/16 ,  C07D223/10 ,  C07D309/04 ,  C07D223/04 ,  C07D241/04 ,  C07D241/08 ,  C07D241/52 ,  C07D207/06 ,  C07D265/30 ,  C07D207/08 ,  C07D207/10 ,  C07D207/26 ,  C07D207/263 ,  C07D207/27 ,  C07D207/46 ,  C07D211/16 ,  C07D211/18 ,  C07D211/22 ,  C07D211/34 ,  C07D211/38 ,  C07D211/76 ,  C07D211/88 ,  C07D211/94 ,  C07D211/96 ,  C07D309/30 ,  C07D207/267 ,  C07D207/273 ,  C07D207/277 ,  C07D211/90

Abstract: The invention provides heterocyclic compounds with quaternary centers and methods of preparing compounds. Methods include the method for the preparation of a compound of Formula (II): comprising treating a compound of Formula (I): with a transition metal catalyst and under alkylation conditions as valence and stability permit.

公开(公告)号：US20230079631A1

公开(公告)日：2023-03-16

申请号：US17662863

申请日：2022-05-11

Applicant: Novartis AG

Inventor： Luigi FRANCHI ,  Shomir GHOSH ,  Gary GLICK ,  Jason KATZ ,  Anthony William OPIPARI, JR. ,  William ROUSH ,  Hans Martin SEIDEL ,  Dong-Ming SHEN ,  Shankar VENKATRAMAN ,  David Guenther WINKLER

IPC: C07D265/30 ,  A61P1/00 ,  A61P11/00 ,  A61P19/08 ,  A61P35/00 ,  C07C381/10 ,  C07D209/26 ,  C07D211/78 ,  C07D215/06 ,  C07D231/12 ,  C07D239/26 ,  C07D239/36 ,  C07D261/08 ,  C07D263/46 ,  C07D277/36 ,  C07D317/50 ,  C07D333/34 ,  C07D401/12 ,  C07D409/12 ,  C07D417/12

Abstract: In one aspect, compounds of Formula AA, or a pharmaceutically acceptable salt thereof, are featured: or a pharmaceutically acceptable salt thereof, wherein the variables shown in Formula A can be as defined anywhere herein.

公开(公告)号：US11053195B2

公开(公告)日：2021-07-06

申请号：US16186275

申请日：2018-11-09

Applicant: Global Blood Therapeutics, Inc.

Inventor： Qing Xu ,  Zhe Li ,  Stephen L. Gwaltney, II

IPC: C07D207/08 ,  C07D265/30 ,  C07D401/12 ,  C07D211/30 ,  C07D403/12 ,  C07C271/16 ,  C07D207/34 ,  C07D207/48 ,  C07D211/16 ,  C07D211/22 ,  C07D211/60 ,  C07D211/78 ,  C07D213/81 ,  C07D241/04 ,  C07D279/12 ,  C07D309/08 ,  C07D309/28 ,  C07D333/38 ,  C07D335/02 ,  C07D401/06 ,  C07D403/06

Abstract: Provide herein are compounds and pharmaceutical compositions suitable as modulators of hemoglobin, methods and intermediates for their preparation, and methods for their use in treating disorders mediated by hemoglobin and disorders that would benefit from tissue and/or cellular oxygenation.

公开(公告)号：US20210163403A1

公开(公告)日：2021-06-03

申请号：US17145152

申请日：2021-01-08

Applicant: Cedars-Sinai Medical Center

Inventor： Michael FREEMAN ,  Mirja ROTINEN ,  Ramachandran MURALI ,  Sungyong YOU

IPC: C07C237/08 ,  A61K31/165 ,  A61K45/06 ,  A61K31/397 ,  A61K31/40 ,  A61K31/416 ,  A61K31/417 ,  A61K31/445 ,  A61K31/45 ,  C07D231/56 ,  C07D233/64 ,  C07D205/04 ,  C07D211/60 ,  C12Q1/68 ,  C07C237/22 ,  A61K31/4164 ,  C07C259/06 ,  C12Q1/6886 ,  C07D207/16 ,  C07D211/78 ,  A61P35/00 ,  C07C233/31 ,  C07D207/09 ,  C07D211/76

Abstract: Provided herein are compositions and methods for treating, inhibiting and/or reducing the severity of cancer in subjects in need thereof. The methods include providing an agent that inhibits expression or activity of ONECUT2 and administering a therapeutically effective amount of the agent so as to treat, inhibit and/or reduce the severity of cancer in the subject.

公开(公告)号：US20200223865A1

公开(公告)日：2020-07-16

申请号：US16828141

申请日：2020-03-24

Applicant: H. Lundbeck A/S

Inventor： Carla De Faveri ,  Florian Anton Martin Huber

IPC: C07D498/04 ,  C07C269/04 ,  C07C271/22 ,  C07C227/22 ,  C07D211/78 ,  C07C227/18 ,  C07C249/02 ,  C07C229/08 ,  C07D491/113

Abstract: The present invention relates to a process for synthesis of 4,5,6,7-tetrahydroisoxazolo[5,4-c]pyridin-3-ol abbreviated THIP, having the INN name gaboxadol, starting from pyrrolidin-2-one. The process comprises a new direct process to obtain the intermediate dimethyl 5-hydroxy-3,6-dihydropyridine-1,4(2H)-dicarboxylate or the intermediate diethyl 5-hydroxy-3,6-dihydropyridine-1,4(2H)-dicarboxylate.

公开(公告)号：US20200157049A1

公开(公告)日：2020-05-21

申请号：US16427629

申请日：2019-05-31

Applicant: California Institute of Technology

Inventor： Brian M. Stoltz ,  Scott C. Virgil ,  David E. White ,  Taiga Yurino ,  Yiyang Liu ,  Douglas C. Behenna ,  Douglas Duquette ,  Christian Eidamshaus

IPC: C07D211/78 ,  C07D265/32 ,  C07D211/60 ,  C07D207/16 ,  C07D223/10 ,  C07D309/04 ,  C07D223/04 ,  C07D241/04 ,  C07D241/08 ,  C07D241/52 ,  C07D207/06 ,  C07D265/30 ,  C07D207/08 ,  C07D207/10 ,  C07D207/26 ,  C07D207/263 ,  C07D207/27 ,  C07D207/46 ,  C07D211/16 ,  C07D211/18 ,  C07D211/22 ,  C07D211/34 ,  C07D211/38 ,  C07D211/76 ,  C07D211/88 ,  C07D211/94 ,  C07D211/96 ,  C07D309/30 ,  C07D207/267 ,  C07D207/273 ,  C07D207/277 ,  C07D211/90

Abstract: The invention provides heterocyclic compounds with quaternary centers and methods of preparing compounds. Methods include the method for the preparation of a compound of Formula (II): comprising treating a compound of Formula (I): with a transition metal catalyst and under alkylation conditions as valence and stability permit.

公开(公告)号：US20200010443A1

公开(公告)日：2020-01-09

申请号：US16340115

申请日：2017-09-29

Applicant: SYNGENTA PARTICIPATIONS AG

Inventor： Jonathan Wesley Paul DALLIMORE ,  Christopher John MATHEWS ,  James Alan MORRIS

IPC: C07D401/04 ,  C07D403/04 ,  C07D413/04 ,  C07D211/78 ,  A01N43/40 ,  A01N43/50 ,  A01N43/76 ,  A01N43/56 ,  A01N25/32

Abstract: The present invention provides a composition comprising (A) a compound of formula (I): wherein R1 is methyl or methoxy, R2 is hydrogen, methyl or ethoxy and A is a substituted heteroaryl group, or an N-oxide or salt form thereof, and (B) one or more further herbicides; as well as the use of such compositions in controlling plants or inhibiting plant growth.

公开(公告)号：US10301323B2

公开(公告)日：2019-05-28

申请号：US16046304

申请日：2018-07-26

Applicant: BIOMARIN PHARMACEUTICAL INC.

Inventor： Vincent Jacques ,  James R. Rusche ,  Norton P. Peet ,  Jasbir Singh

IPC: C07D205/06 ,  C07D211/70 ,  C07D451/02 ,  C07D471/04 ,  C07D471/08 ,  C07D305/10 ,  C07D513/04 ,  C07D231/12 ,  C07D403/06 ,  C07D401/06 ,  C07D261/08 ,  C07D263/32 ,  C07D277/34 ,  C07D277/30 ,  C07D211/78 ,  C07D403/10

Abstract: This invention relates to generally inhibiting histone deacetylase (“HDAC”) enzymes (e.g., HDAC1, HDAC2, and HDAC3).