公开(公告)号：US20180282817A1

公开(公告)日：2018-10-04

申请号：US15764185

申请日：2016-10-05

Applicant: Cedars-Sinai Medical Center

Inventor： Sungyong YOU ,  Michael FREEMAN ,  Jayoung KIM ,  Beatrice KNUDSEN

IPC: C12Q1/6886 ,  A61K33/24 ,  A61K31/337 ,  A61K31/4166 ,  A61K31/506 ,  G06F19/20

Abstract: The invention provides various methods for classifying prostate cancers into subtypes. The classification methods may be used to diagnose or prognose prostate cancers. In one embodiment, the subtypes are PCS1, PCS2, or PCS3. In one embodiment, the PCS1 subtype is most likely to progress to metastatic disease or prostate cancer specific mortality when compared to the PCS2 subtype or PCS3 subtype. In one embodiment, the PCS1 subtype is resistant to enzalutamide.

公开(公告)号：US20190194124A1

公开(公告)日：2019-06-27

申请号：US16307702

申请日：2017-05-26

Applicant: Cedars-Sinai Medical Center

Inventor： Michael FREEMAN ,  Mirja ROTINEN ,  Ramachandran MURALI ,  Sungyong YOU

IPC: C07C237/08 ,  A61K45/06 ,  A61K31/165 ,  A61K31/416 ,  C07D231/56 ,  C07D205/04 ,  A61K31/397 ,  A61K31/40 ,  C07D207/09 ,  A61P35/00 ,  A61K31/445 ,  C07D211/60 ,  C07D211/76 ,  A61K31/45 ,  C07C233/31 ,  C07D233/64 ,  A61K31/417

CPC classification number: C07C237/08 ,  A61K31/165 ,  A61K31/397 ,  A61K31/40 ,  A61K31/416 ,  A61K31/4164 ,  A61K31/417 ,  A61K31/445 ,  A61K31/45 ,  A61K45/06 ,  A61P35/00 ,  C07B2200/07 ,  C07C233/31 ,  C07C237/22 ,  C07C259/06 ,  C07D205/04 ,  C07D207/09 ,  C07D207/16 ,  C07D211/60 ,  C07D211/76 ,  C07D211/78 ,  C07D231/56 ,  C07D233/64 ,  C12Q1/68 ,  C12Q1/6886 ,  C12Q2600/106 ,  C12Q2600/158 ,  A61K2300/00

Abstract: Provided herein are compositions and methods for treating, inhibiting and/or reducing the severity of cancer in subjects in need thereof The methods include providing an agent that inhibits expression or activity of ONECUT2 and administering a therapeutically effective amount of the agent so as to treat, inhibit and/or reduce the severity of cancer in the subject.

公开(公告)号：US20210163403A1

公开(公告)日：2021-06-03

申请号：US17145152

申请日：2021-01-08

Applicant: Cedars-Sinai Medical Center

Inventor： Michael FREEMAN ,  Mirja ROTINEN ,  Ramachandran MURALI ,  Sungyong YOU

IPC: C07C237/08 ,  A61K31/165 ,  A61K45/06 ,  A61K31/397 ,  A61K31/40 ,  A61K31/416 ,  A61K31/417 ,  A61K31/445 ,  A61K31/45 ,  C07D231/56 ,  C07D233/64 ,  C07D205/04 ,  C07D211/60 ,  C12Q1/68 ,  C07C237/22 ,  A61K31/4164 ,  C07C259/06 ,  C12Q1/6886 ,  C07D207/16 ,  C07D211/78 ,  A61P35/00 ,  C07C233/31 ,  C07D207/09 ,  C07D211/76

Abstract: Provided herein are compositions and methods for treating, inhibiting and/or reducing the severity of cancer in subjects in need thereof. The methods include providing an agent that inhibits expression or activity of ONECUT2 and administering a therapeutically effective amount of the agent so as to treat, inhibit and/or reduce the severity of cancer in the subject.