公开(公告)号：US20190194124A1

公开(公告)日：2019-06-27

申请号：US16307702

申请日：2017-05-26

Applicant: Cedars-Sinai Medical Center

Inventor： Michael FREEMAN ,  Mirja ROTINEN ,  Ramachandran MURALI ,  Sungyong YOU

IPC: C07C237/08 ,  A61K45/06 ,  A61K31/165 ,  A61K31/416 ,  C07D231/56 ,  C07D205/04 ,  A61K31/397 ,  A61K31/40 ,  C07D207/09 ,  A61P35/00 ,  A61K31/445 ,  C07D211/60 ,  C07D211/76 ,  A61K31/45 ,  C07C233/31 ,  C07D233/64 ,  A61K31/417

CPC classification number: C07C237/08 ,  A61K31/165 ,  A61K31/397 ,  A61K31/40 ,  A61K31/416 ,  A61K31/4164 ,  A61K31/417 ,  A61K31/445 ,  A61K31/45 ,  A61K45/06 ,  A61P35/00 ,  C07B2200/07 ,  C07C233/31 ,  C07C237/22 ,  C07C259/06 ,  C07D205/04 ,  C07D207/09 ,  C07D207/16 ,  C07D211/60 ,  C07D211/76 ,  C07D211/78 ,  C07D231/56 ,  C07D233/64 ,  C12Q1/68 ,  C12Q1/6886 ,  C12Q2600/106 ,  C12Q2600/158 ,  A61K2300/00

Abstract: Provided herein are compositions and methods for treating, inhibiting and/or reducing the severity of cancer in subjects in need thereof The methods include providing an agent that inhibits expression or activity of ONECUT2 and administering a therapeutically effective amount of the agent so as to treat, inhibit and/or reduce the severity of cancer in the subject.

公开(公告)号：US20210163403A1

公开(公告)日：2021-06-03

申请号：US17145152

申请日：2021-01-08

Applicant: Cedars-Sinai Medical Center

Inventor： Michael FREEMAN ,  Mirja ROTINEN ,  Ramachandran MURALI ,  Sungyong YOU

IPC: C07C237/08 ,  A61K31/165 ,  A61K45/06 ,  A61K31/397 ,  A61K31/40 ,  A61K31/416 ,  A61K31/417 ,  A61K31/445 ,  A61K31/45 ,  C07D231/56 ,  C07D233/64 ,  C07D205/04 ,  C07D211/60 ,  C12Q1/68 ,  C07C237/22 ,  A61K31/4164 ,  C07C259/06 ,  C12Q1/6886 ,  C07D207/16 ,  C07D211/78 ,  A61P35/00 ,  C07C233/31 ,  C07D207/09 ,  C07D211/76

Abstract: Provided herein are compositions and methods for treating, inhibiting and/or reducing the severity of cancer in subjects in need thereof. The methods include providing an agent that inhibits expression or activity of ONECUT2 and administering a therapeutically effective amount of the agent so as to treat, inhibit and/or reduce the severity of cancer in the subject.