公开(公告)号：US20240360075A1

公开(公告)日：2024-10-31

申请号：US18640931

申请日：2024-04-19

Applicant: ALCON INC.

Inventor： Heeren M. Gordhan ,  Mitchell A. deLong ,  Jill M. Sturdivant ,  David Archer Ellis ,  Cynthia L. Lichorowic

IPC: C07C233/60 ,  A61K9/00 ,  A61K31/16 ,  A61K31/165 ,  A61K31/167 ,  A61K31/175 ,  A61K31/192 ,  A61K31/27 ,  A61K31/277 ,  A61K31/337 ,  A61K31/341 ,  A61K31/343 ,  A61K31/351 ,  A61K31/382 ,  A61K31/397 ,  A61K31/40 ,  A61K31/415 ,  A61K31/425 ,  A61K31/4465 ,  A61K31/495 ,  A61K31/5375 ,  A61K31/69 ,  A61K47/12 ,  A61K47/18 ,  A61K47/38 ,  C07C231/02 ,  C07C233/58 ,  C07C233/59 ,  C07C233/62 ,  C07C233/63 ,  C07C235/14 ,  C07C235/56 ,  C07C237/24 ,  C07C271/20 ,  C07C271/24 ,  C07C279/22 ,  C07C315/04 ,  C07C317/30 ,  C07D205/04 ,  C07D207/09 ,  C07D209/54 ,  C07D211/58 ,  C07D213/75 ,  C07D213/79 ,  C07D231/40 ,  C07D239/42 ,  C07D263/04 ,  C07D263/56 ,  C07D265/36 ,  C07D275/03 ,  C07D277/46 ,  C07D295/088 ,  C07D295/135 ,  C07D295/32 ,  C07D305/06 ,  C07D305/08 ,  C07D305/14 ,  C07D307/22 ,  C07D307/94 ,  C07D309/14 ,  C07D311/58 ,  C07D335/02 ,  C07F5/02

CPC classification number: C07C233/60 ,  A61K9/0048 ,  A61K31/16 ,  A61K31/165 ,  A61K31/167 ,  A61K31/175 ,  A61K31/192 ,  A61K31/27 ,  A61K31/277 ,  A61K31/337 ,  A61K31/341 ,  A61K31/343 ,  A61K31/351 ,  A61K31/382 ,  A61K31/397 ,  A61K31/40 ,  A61K31/415 ,  A61K31/425 ,  A61K31/4465 ,  A61K31/495 ,  A61K31/5375 ,  A61K31/69 ,  A61K47/12 ,  A61K47/183 ,  A61K47/186 ,  A61K47/38 ,  C07C231/02 ,  C07C233/58 ,  C07C233/59 ,  C07C233/62 ,  C07C233/63 ,  C07C235/14 ,  C07C235/56 ,  C07C237/24 ,  C07C271/20 ,  C07C271/24 ,  C07C279/22 ,  C07C315/04 ,  C07C317/30 ,  C07D205/04 ,  C07D207/09 ,  C07D209/54 ,  C07D211/58 ,  C07D213/75 ,  C07D213/79 ,  C07D231/40 ,  C07D239/42 ,  C07D263/04 ,  C07D263/56 ,  C07D265/36 ,  C07D275/03 ,  C07D277/46 ,  C07D295/088 ,  C07D295/135 ,  C07D295/32 ,  C07D305/06 ,  C07D305/08 ,  C07D305/14 ,  C07D307/22 ,  C07D307/94 ,  C07D309/14 ,  C07D311/58 ,  C07D335/02 ,  C07F5/025 ,  C07C2601/02 ,  C07C2601/04 ,  C07C2601/08 ,  C07C2601/14 ,  C07C2602/18 ,  C07C2602/38 ,  C07C2602/42 ,  C07C2602/50

Abstract: Described herein are modified monoterpene TRPM8 activating compounds. In particular, provided herein are compounds that affect the function of ion channels in a cell, and are useful as therapeutic agents or with therapeutic agents. The compounds provided herein are useful in the treatment of a variety of diseases and conditions including inflammatory eye diseases such as uveitis, cardiovascular diseases, inflammatory diseases, and diseases characterized by abnormal growth, such as cancers.

公开(公告)号：US12043636B2

公开(公告)日：2024-07-23

申请号：US16950901

申请日：2020-11-17

Applicant: Covestro Deutschland AG

Inventor： Thomas Rölle ,  Horst Berneth ,  Dennis Hönel ,  Friedrich-Karl Bruder ,  Jürgen Kintrup

IPC: C07F5/02 ,  C07C211/63 ,  C07C211/64 ,  C07C217/08 ,  C07C219/10 ,  C07C219/28 ,  C07C219/30 ,  C07C271/12 ,  C07C271/16 ,  C07C271/20 ,  C07C271/24 ,  C07C271/28 ,  C07D213/20 ,  C07D233/02 ,  C07D233/58 ,  C07D247/00 ,  C07D295/037 ,  C07D309/34 ,  C07D335/02 ,  C07D347/00 ,  C07D413/06 ,  C07F5/04 ,  C07F9/54 ,  G03F7/00

CPC classification number: C07F5/027 ,  C07C211/63 ,  C07C211/64 ,  C07C217/08 ,  C07C219/10 ,  C07C219/28 ,  C07C219/30 ,  C07C271/12 ,  C07C271/16 ,  C07C271/20 ,  C07C271/24 ,  C07C271/28 ,  C07D213/20 ,  C07D233/02 ,  C07D233/58 ,  C07D247/00 ,  C07D295/037 ,  C07D309/34 ,  C07D335/02 ,  C07D347/00 ,  C07D413/06 ,  C07F5/04 ,  C07F9/54 ,  C07F9/5407 ,  C07F9/5442 ,  G03F7/001 ,  C07C2601/14

Abstract: The invention relates to a process for preparing triaryl organo borates proceeding from organoboronic esters in the presence of an n-valent cation 1/n Kn+, comprising the anhydrous workup of the reaction mixture and the use of the triaryl organoborates obtained as co-initiator in photopolymer formulations, holographic media and holograms.

公开(公告)号：US20230337677A1

公开(公告)日：2023-10-26

申请号：US17635631

申请日：2020-08-28

Applicant: University of Florida Research Foundation, Incorporated

Inventor： Jeffrey R. Bloomquist ,  Quentin R. Coquerel ,  Gary M. Richoux ,  Maia Tsikolia ,  Liu Yang

IPC: A01N47/20 ,  C07C311/08 ,  A01N53/00 ,  A01N43/647 ,  A01N37/16 ,  A01N37/22 ,  C07C69/017 ,  C07D209/48 ,  C07C233/25 ,  A01P17/00 ,  A01N43/18 ,  C07D213/74 ,  C07C69/747 ,  A01N43/82 ,  C07D271/12 ,  C07D213/75 ,  A01N25/18 ,  C07C233/91 ,  A01N37/10 ,  C07D213/76 ,  C07D335/02 ,  A01N43/40 ,  C07C271/64 ,  C07D249/18 ,  A01N43/38 ,  A01N41/10 ,  C07C233/43 ,  C07C271/28 ,  C07C233/15 ,  C07C255/29 ,  C07C233/05 ,  A01N37/26 ,  C07C233/44 ,  C07C233/66

CPC classification number: A01N47/20 ,  C07C311/08 ,  A01N53/00 ,  A01N43/647 ,  A01N37/16 ,  A01N37/22 ,  C07C69/017 ,  C07D209/48 ,  C07C233/25 ,  A01P17/00 ,  A01N43/18 ,  C07D213/74 ,  C07C69/747 ,  A01N43/82 ,  C07D271/12 ,  C07D213/75 ,  A01N25/18 ,  C07C233/91 ,  A01N37/10 ,  C07D213/76 ,  C07D335/02 ,  A01N43/40 ,  C07C271/64 ,  C07D249/18 ,  A01N43/38 ,  A01N41/10 ,  C07C233/43 ,  C07C271/28 ,  C07C233/15 ,  C07C255/29 ,  C07C233/05 ,  A01N37/26 ,  C07C233/44 ,  C07C233/66 ,  C07C2601/10 ,  C07C2601/02

Abstract: The subject matter described herein is directed to compounds, synergistic compositions, and methods for repelling arthropods, such as insects. The compositions comprise aryl and pyridyl-type compounds. The compounds demonstrate strong vapor and topical repellency when applied alone and in synergistic compositions.

公开(公告)号：US20230075188A1

公开(公告)日：2023-03-09

申请号：US17948838

申请日：2022-09-20

Applicant: FUJIFILM Corporation

Inventor： Taro MIYOSHI ,  Eiji FUKUZAKI

IPC: G03F7/039 ,  G03F7/004 ,  G03F7/038 ,  C08F212/14 ,  C08F220/28 ,  C08F220/30 ,  C07C381/12 ,  C07C309/04 ,  C07D307/00 ,  C07D309/30 ,  C07D327/06 ,  C07D333/46 ,  C07D335/02 ,  C07D333/76 ,  C07C43/225 ,  C07C25/18

Abstract: The present invention provides an actinic ray-sensitive or radiation-sensitive resin composition containing (A) a resin having a polarity that increases by an action of an acid, and (B) a compound that generates an acid upon irradiation with actinic rays or radiation, represented by a specific general formula, is which the resin (A) includes a repeating unit represented by a specific general formula; and an actinic ray-sensitive or radiation-sensitive film formed of the actinic ray-sensitive or radiation-sensitive resin composition, a pattern forming method, and a method for manufacturing an electronic device.

公开(公告)号：US11487203B2

公开(公告)日：2022-11-01

申请号：US15858129

申请日：2017-12-29

Applicant: Rohm and Haas Electronic Materials Korea Ltd.

Inventor： Eui Hyun Ryu ,  Myung-Yeol Kim ,  Woo-Hyung Lee ,  Haemi Jeong ,  Kwang-Hwyi Im

IPC: G03F7/039 ,  G03F7/38 ,  C08F220/28 ,  C08F220/38 ,  C08F220/68 ,  G03F7/038 ,  C07C323/13 ,  C07C69/54 ,  C08L33/10 ,  C07D327/06 ,  C07D331/00 ,  C07D327/00 ,  C07D335/02 ,  C09D133/06 ,  C07D307/20 ,  C07C323/17 ,  C07D309/10

Abstract: Monomers and polymers are provided that comprise a carbon alicyclic group or heteroalicyclic group that comprises 1) one or more acid-labile ring substituents and 2) one or more ether or thioether ring substituents. Photoresists that comprise such polymers also are provided.

公开(公告)号：US20220055985A1

公开(公告)日：2022-02-24

申请号：US17463011

申请日：2021-08-31

Applicant: The Liver Company Inc.

Inventor： Julie FARAND ,  Joshua A. KAPLAN ,  Gregory NOTTE ,  Casey Lockwood OLEN ,  Michael SANGI ,  David SPERANDIO

IPC: C07C323/25 ,  C07C323/30 ,  C07C323/31 ,  C07D205/04 ,  C07D207/48 ,  C07D213/89 ,  C07D231/18 ,  C07D235/00 ,  C07D239/26 ,  C07D257/04 ,  C07D275/02 ,  C07D277/36 ,  C07D295/116 ,  C07D305/08 ,  C07D309/08 ,  C07D335/02 ,  C07D451/02 ,  C07D493/08 ,  C07F9/50 ,  C07C313/06 ,  A61K31/18 ,  C07C311/08 ,  C07C311/21 ,  C07C311/39 ,  C07C311/29 ,  C07C311/46 ,  C07C311/14 ,  C07C311/13

Abstract: Provided is a compound of Formula (I): wherein the variable groups are defined herein.

公开(公告)号：US20220054486A1

公开(公告)日：2022-02-24

申请号：US17185278

申请日：2021-02-25

Applicant: InventisBio LLC

Inventor： Xing DAI ,  Yaolin Wang

IPC: A61K31/505 ,  A61K31/196 ,  A61K31/351 ,  A61K31/382 ,  A61K31/41 ,  A61K31/415 ,  A61K31/4155 ,  A61K31/4184 ,  C07C275/42 ,  C07D233/88 ,  C07D239/42 ,  C07D257/04 ,  C07D261/14 ,  C07D309/08 ,  C07D309/14 ,  C07D335/02 ,  C07D413/12

Abstract: The present disclosure provides compounds of Formula (I). The compounds described herein may be useful in treating a disease associated with IDO, for example, cancer or an infectious disease (e.g., viral or bacterial infectious diseases). Also, provided in the present disclosure are pharmaceutical compositions, kits, methods, and uses including or using a compound described herein.

公开(公告)号：US10899754B2

公开(公告)日：2021-01-26

申请号：US16464858

申请日：2017-12-15

Applicant: GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED

Inventor： Martha Alicia De La Rosa ,  Wieslaw Mieczyslaw Kazmierski ,  Vicente Samano

IPC: C07D417/12 ,  C07D417/14 ,  C07D405/12 ,  C07D285/08 ,  C07D241/06 ,  C07D233/88 ,  C07D233/90 ,  C07D213/04 ,  C07D249/14 ,  C07D237/20 ,  C07C229/42 ,  C07D207/50 ,  C07D213/74 ,  C07D235/00 ,  C07D235/30 ,  C07D241/20 ,  C07D257/06 ,  C07D263/48 ,  C07D271/113 ,  C07D277/42 ,  C07D277/82 ,  C07D305/08 ,  C07D333/36 ,  C07D335/02 ,  C07D413/12 ,  C07D417/04 ,  C07D471/04

Abstract: Provided are IDO inhibitor compounds of Formula I and pharmaceutically acceptable salts thereof, their pharmaceutical compositions, their methods of preparation, and methods for their use in the prevention and/or treatment of diseases such as chronic viral infection, chronic bacterial infections, cancer, sepsis or a neurological disorder.

公开(公告)号：US10881656B2

公开(公告)日：2021-01-05

申请号：US15431967

申请日：2017-02-14

Applicant: The General Hospital Corporation

Inventor： Othon Iliopoulos ,  Michael Albert Zimmer

IPC: A61K31/381 ,  A61K31/38 ,  A61K31/473 ,  A61K31/138 ,  A61K31/166 ,  A61K31/167 ,  A61K31/366 ,  A61K31/382 ,  A61K31/5575 ,  A61K45/06 ,  C07C225/16 ,  C07C235/38 ,  C07C237/46 ,  C07D219/14 ,  C07D309/38 ,  C07D333/22 ,  C07D333/38 ,  C07D335/02 ,  A61K31/137

Abstract: The present invention is directed to HIF inhibitors and methods of preventing cell proliferation, reducing inflammation, and treating an angiogenic disease or disorders.

公开(公告)号：US10858317B2

公开(公告)日：2020-12-08

申请号：US16383049

申请日：2019-04-12

Applicant: Global Blood Therapeutics, Inc.

Inventor： Qing Xu ,  Zhe Li

IPC: C07D207/08 ,  C07C271/16 ,  C07D207/34 ,  C07D211/22 ,  C07D211/60 ,  C07D211/78 ,  C07D213/81 ,  C07D241/04 ,  C07D265/30 ,  C07D279/12 ,  C07D309/08 ,  C07D309/28 ,  C07D333/38 ,  C07D335/02 ,  C07D401/06 ,  C07D211/16 ,  C07D401/12 ,  C07D207/48 ,  C07D403/06

Abstract: Provide herein are compounds and pharmaceutical compositions suitable as modulators of hemoglobin, methods and intermediates for their preparation, and methods for their use in treating disorders mediated by hemoglobin and disorders that would benefit from tissue and/or cellular oxygenation.