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公开(公告)号：US20250059440A1
公开(公告)日：2025-02-20
申请号：US18804551
申请日：2024-08-14
Inventor： Charles J. HAGES , Alexander D. JESS , Ruiquan YANG
Abstract: Disclosed herein are methods to synthesize perovskite nanoparticles in solution and at a relatively low temperature (110-300 C). This synthesis of low-temperature, solution-based chalcogenide perovskites were shown to produce materials with excellent optoelectronic properties. Furthermore, disclosed is a technique to stabilize the desired phase of these perovskites (particularly those phases which can not be fabricated in existing techniques). In addition, the material of the composition BaZrS3 (barium zirconium sulfide) has been synthesized in the perovskite crystal structure as nanoparticles for the first time.
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2.发明申请公开(公告)号：US20250049744A1
公开(公告)日：2025-02-13
申请号：US18931828
申请日：2024-10-30
Inventor： Sadasivan VIDYASAGAR , Stephen J. GATTO , Daniel B. DENNISON
IPC: A61K31/198 , A61K31/00 , A61K31/197 , A61K31/405 , A61P1/00 , A61P1/12 , A61P3/12 , A61P29/00 , A61P31/12 , A61P31/18 , A61P35/00
Abstract: The subject invention provides therapeutic compositions and uses thereof for the treatment or amelioration of symptoms of a disease selected from the group consisting of: Ebola virus infection, HIV infection, ataxia, environmental enteropathy, cancer, hangover, inflammatory disease, and porcine epidemic diarrhea. In preferred embodiments, the composition includes a combination of one or more amino acids selected from the group comprising lysine, aspartic acid, glycine, isoleucine, threonine, tyrosine, valine, tryptophan, asparagine and/or serine.
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公开(公告)号：US12220400B2
公开(公告)日：2025-02-11
申请号：US17289374
申请日：2019-10-30
Inventor： Sadasivan Vidyasagar , Astrid Grosche , Xiaodong Xu , Shanshan Lin , Sreekala Prabhakaran
IPC: A61K31/401 , A61K31/198 , A61K31/47 , A61K45/06 , A61P11/00
Abstract: Provided herein are amino acid compositions useful for increasing the translocation of the cystic fibrosis transmembrane conductance (CFTR) protein from the cytoplasm to the plasma membrane, particularly in epithelial cells. Methods for increasing the concentration of CFTR in the plasma membrane, increasing chloride ion transport, and increasing water transport are also provided. These compositions and methods are useful in treating cystic fibrosis in subjects bearing one or more mutations in the CFTR protein. Use of these compositions for the treatment of cystic fibrosis and in the preparation of a medicament for the treatment of cystic fibrosis are also encompassed herein.
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公开(公告)号：US20250041453A1
公开(公告)日：2025-02-06
申请号：US18717532
申请日：2022-12-09
Inventor： Barry John Byrne , Pedro Cruz , Irene Zolotukhin , Widler Casy , Manuela Corti
Abstract: In several embodiments, the present disclosure relates to nucleic acids, compositions, and methods for the delivery of a therapeutic gene to a subject. In several embodiments, the therapeutic gene is through the use of a viral vector. In several embodiments, the viral vector is an adeno-associated virus. In several embodiments, the therapeutic gene is delivered to treat a cardiac disease, injury or other disorder.
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5.发明申请公开(公告)号：US20250041452A1
公开(公告)日：2025-02-06
申请号：US18717502
申请日：2022-12-09
Inventor： Barry John Byrne , Pedro Cruz , Irene Zolotukhin , Widler Casy , Manuela Corti
Abstract: In several embodiments, the present disclosure relates to nucleic acids, compositions, and methods for the delivery of a therapeutic gene to a subject. In several embodiments, the therapeutic gene is through the use of a viral vector. In several embodiments, the viral vector is an adeno-associated virus. In several embodiments, the therapeutic gene is delivered to treat a cardiac disease, injury or other disorder.
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Patent Agency Ranking
公开(公告)号：US12213929B2
公开(公告)日：2025-02-04
申请号：US17449159
申请日：2021-09-28
Inventor： Warren E. Dixon , Kimberly J. Stubbs , Brendon Allen
Abstract: Provided herein is a method, apparatus, and system for teleoperated, functional electric stimulation actuated rehabilitative cycling. Methods may include: receiving, at a master system, rotational input generating master system sensor input having a master system cadence; providing the master system sensor input including the master system cadence to a controller based on the rotational input from a rehabilitation participant or a remote therapist received at the master system; receiving, at a slave system, rotational input from the rehabilitation participant generating slave sensor input having a slave system cadence; providing the slave system sensor input including the slave system cadence to the controller based on the rotational input from the participant received at the slave system; and providing, from the controller, feedback through the master system in response to a difference between the master system cadence and the slave system cadence.
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公开(公告)号：US20250032624A1
公开(公告)日：2025-01-30
申请号：US18704712
申请日：2022-10-27
Inventor： Matthew D. Disney
Abstract: Described are small molecule embodiments, ALS compounds, that bind with the r(G4C2)exp RNA repeat expansion present in chromosome 9 open reading frame 72 involved in amyotrophic lateral sclerosis and frontotemporal dementia (ALS/FTD). These ALS compounds comprise a pyridocarbazole moiety having at least one substituent and an RNase-recruiting moiety linked to the pyridocarbazole moiety by a polyethylene glycol group.
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8.发明授权公开(公告)号：US12204685B2
公开(公告)日：2025-01-21
申请号：US17457498
申请日：2021-12-03
Inventor： Mark M. Tehranipoor , Farimah Farahmandi , Huanyu Wang
IPC: G06F21/72 , G06F21/55 , G06F21/57 , G06F21/75 , G06F30/337 , G06F30/398
Abstract: Various embodiments provide methods, systems, computer program products, apparatuses, and/or the like for assessing vulnerability of an IC design to fault injection attacks, such as through a security property-driven vulnerability assessment framework for efficiently evaluating faults with respect to certain security properties associated with the IC design. In one embodiment, a method is provided. The method includes generating, using a fault-injection technique specification, one or more fault models describing attributes of one or more faults. The method further includes selecting, using the fault models and executable security properties associated with a design file of an IC design, a fault list identifying a plurality of possible faults for the IC design. The method further includes identifying, based at least in part on performing a fault simulation on the design file with the fault list, critical locations of the IC design. The method further includes implementing protections at the critical locations.
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公开(公告)号：US12193931B2
公开(公告)日：2025-01-14
申请号：US17639046
申请日：2020-08-27
Inventor： Nancy Jean Ruzycki , Gavin Carter , Brenda A. Burke
IPC: A61F2/18
Abstract: Methods for producing a custom-made stapes prosthesis for a patient and stapes prostheses so produced. The methods may include obtaining a three-dimensional image of a natural stapes bone of the patient; and forming a stapes prosthesis that closely approximates a three-dimensional shape of the natural stapes bone via an additive manufacturing technique based on the three-dimensional image. The stapes prosthesis comprises a suitable material that is not osteogenic and is not cytotoxic. The stapes prosthesis may include a plurality of pores having an average size of from about 5 to about 100 micrometers and may exhibit a frequency of sound transmission in a range of from about 2 to about 30 kilohertz.
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10.发明申请公开(公告)号：US20240386174A1
公开(公告)日：2024-11-21
申请号：US18667408
申请日：2024-05-17
Inventor： Prabhat Mishra , Emma Andrews , Jayasena Ranhotige
IPC: G06F30/3308 , G06F21/55 , G06F30/333
Abstract: Embodiments provide for side-channel leakage evaluation of asymmetric key cryptography algorithms. An example method includes identifying inputs, constraints, and a sequence of steps involved in an algorithm of a design specification; generating input test vectors, wherein the input test vectors are associated with a secrecy guarantee of the algorithm; generating a testbench for simulation of the design specification; generating power traces by simulating the design specification; performing a leakage assessment on generated power profiles; generating a divergence factor; and determining whether the design specification has a side-channel vulnerability.
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