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    Trifunctional agents useful as irreversible inhibitors of A1-adenosine receptors
    3.
    发明授权
    Trifunctional agents useful as irreversible inhibitors of A1-adenosine receptors 失效
    可用作A1-腺苷受体的不可逆抑制剂的功能性试剂

    公开(公告)号：US5310916A

    公开(公告)日：1994-05-10

    申请号：US572410

    申请日：1990-08-24

    Applicant: Kenneth A. Jacobson ,  Gary L. Stiles ,  Daniel L. Boring

    Inventor： Kenneth A. Jacobson ,  Gary L. Stiles ,  Daniel L. Boring

    IPC: C07D473/06 ,  C07H19/16 ,  C07D331/00 ,  A61K31/505 ,  A61K31/52

    CPC classification number: C07D473/06 ,  C07H19/16

    Abstract: Trifunctional agents useful as inhibitors of A.sub.1 -Adenosine receptors may be formulated into pharmaceutical compositions. These agents are represented by formula (I): ##STR1## wherein X is CH or N, R is an isothiocyanate group, an amino group or --NHCO.sub.2 C(CH.sub.3).sub.3 and R.sup.1 is hydrogen, carboxyl, lower alkoxycarbonyl, aminocarbonyl, ##STR2## lower alkyl, optionally substituted with: --OH, --COOH, lower ester of COOH, carboxamide, NHCOCH.sub.3, NHCOCH.sub.2 Br, halo, dimethylamino, triethylammonium, NHCONH.sub.2, SO.sub.2 NH.sub.2, --SO.sub.3 H, or a reporter group, particularly a spectroscopic reporter group such as a fluorescent dye, photoaffinity probe, or spin label probe, coupled through an amide, sulfonamide, amine or thiourea linkage, biotinylamino- (optionally containing an .epsilon.-aminocaproyl spacer chain or similar spacer chain) or; R.sup.1 is CONH--R.sup.2 or NHCSNH--R.sup.2, wherein R.sup.2 is lower alkyl, optionally substituted with: --OH, --COOH, lower ester of COOH, carboxamide, NHCOCH.sub.3, NHCOCH.sub.2 Br, halo, dimethylamino, triethylammonium, NHCONH.sub.2, SO.sub.2 NH.sub.2, --SO.sub.3 H, or a reporter group, particularly a spectroscopic reporter group such as a fluorescent dye, photoaffinity probe, or spin label probe, coupled through an amide, sulfonamide, amine, or thiourea linkage, biotinylamino- (optionally containing an .epsilon.-aminocaproyl spacer chain or similar spacer chain).

    Abstract translation: 可用作A1-腺苷受体抑制剂的功能剂可以配制成药物组合物。 这些试剂由式（I）表示：其中X是CH或N，R是异硫氰酸酯基，氨基或-NHCO 2 C（CH 3）3，R 1是氢，羧基，低级烷氧基羰基 ，氨基羰基，低级烷基，任选被：-OH，-COOH，COOH的低级酯，羧酰胺，NHCOCH 3，NHCOCH 2 Br，卤素，二甲基氨基，三乙基铵，NHCONH 2，SO 2 NH 2，-SO 3 H或报道基团取代， 通过酰胺，磺酰胺，胺或硫脲键偶联的荧光染料，光亲和探针或自旋标记探针的光谱报告基团，生物素基氨基 - （任选地含有ε-氨基己酰基间隔链或类似的间隔链） R 1是CONH-R 2或NHCSNH-R 2，其中R 2是低级烷基，任选地被以下基团取代：-OH，-COOH，COOH的低级酯，甲酰胺，NHCOCH 3，NHCOCH 2 Br，卤素，二甲基氨基，三乙基铵，NHCONH 2，SO 2 NH 2，-SO 3 H， 或报告基团，特别是通过酰胺，磺酰胺，胺或硫脲键偶联的荧光染料，光亲和探针或自旋标记探针的光谱报道基团，生物素基氨基 - （任选地含有ε-氨基己酰基间隔链或类似物 间隔链）。

    Sulphoxides
    5.
    发明授权
    Sulphoxides 失效
    亚砜

    公开(公告)号：US4108866A

    公开(公告)日：1978-08-22

    申请号：US804638

    申请日：1977-06-08

    Applicant: Bernard Tramier ,  Raymond Delourme ,  Philippe Fresnel

    Inventor： Bernard Tramier ,  Raymond Delourme ,  Philippe Fresnel

    IPC: C07D331/00 ,  C07D333/02 ,  C07D333/48 ,  C07D337/04

    CPC classification number: C07D333/48 ,  C07C317/00 ,  C07D331/00 ,  C07D337/04 ,  Y10S203/06

    Abstract: An improved method of producing dialkyl-sulfoxides by oxidizing corresponding dialkyl-sulfides with hydrogen peroxide in aqueous acidic medium. It remedies the drawback of the similar prior art as concerns the separation of the sulfoxide formed from its reaction medium. The new method permits of easily recovering the sulfoxides in the state of good purity.The improvement consists in mixing the reaction medium with a large proportion of a solvent capable of yielding an azeotropic mixture with water. Then, after oxidization, the water is removed by distillation as azeotropic mixture. Preferably solvents are used which dissolve the dialkyl-sulfide but do not dissolve the sulfoxide formed; heptane is a particularly useful solvent. When an excess of the solvent is used, there is obtained, after distilling off the azeotropic mixture, a slurry of sulfoxide and solvent, easy to separate.

    Abstract translation: 通过在酸性介质水溶液中用过氧化氢氧化相应的二烷基硫化物来制备二烷基 - 亚砜的改进方法。 它解决了相似的现有技术关于从其反应介质形成的亚砜的分离的缺点。 新方法允许在纯度良好的状态下容易地回收亚砜。

    Polar nematic compounds
    9.
    发明授权
    Polar nematic compounds 有权
    极性向列化合物

    公开(公告)号：US08709280B2

    公开(公告)日：2014-04-29

    申请号：US13456727

    申请日：2012-04-26

    Applicant: Bryan Ringstrand ,  Piotr Kaszynski

    Inventor： Bryan Ringstrand ,  Piotr Kaszynski

    IPC: C09K19/34 ,  C09K19/52 ,  C09K19/06 ,  C09K19/00 ,  C09K19/08 ,  G02F1/1333 ,  C07D331/02 ,  C07D331/00 ,  C07D327/00

    CPC classification number: C07F5/027 ,  C09K19/404

    Abstract: Polar nematic compounds having the following structure: where is a caged boron structure. The sphere of the caged boron structure is C and each non-sphere vertex of the caged boron structure is B—H. R is H, an alkyl, a cycloalkyl, a bicycloalkyl, an alkenyl, a cycloalkenyl, a bicycloalkenyl, an alkynyl, an acyl, an aryl, an alkylaryl, a halogen, a cyano group, an isothiocyanoto group, or a group that forms an ether, a ketone, an ester, a thioester, a sulfide, or a sulfone. R′ is H, an alkyl, a cycloalkyl, a bicycloalkyl, an alkenyl, a cycloalkenyl, a bicycloalkenyl, an alkynyl, an aryl, an alkylaryl, or a halogen. The compounds may be used in liquid crystal displays, and in television sets, laptop computers, computer monitors, hand-held communication devices, gaming devices, watches, cash registers, clocks, and calculators having liquid crystal displays.

    Abstract translation: 极性向列化合物具有以下结构：其中是笼状硼结构。 笼状硼结构的球体为C，笼状硼结构的每个非球形顶点为B-H。 R为H，烷基，环烷基，双环烷基，烯基，环烯基，双环烯基，炔基，酰基，芳基，烷基芳基，卤素，氰基，异硫氰基或基团 醚，酮，酯，硫酯，硫化物或砜。 R'是H，烷基，环烷基，双环烷基，烯基，环烯基，双环烯基，炔基，芳基，烷基芳基或卤素。 该化合物可用于液晶显示器，电视机，笔记本电脑，计算机显示器，手持通信设备，游戏设备，手表，收银机，时钟和具有液晶显示器的计算器中。

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