公开(公告)号：US12071416B2

公开(公告)日：2024-08-27

申请号：US18058587

申请日：2022-11-23

申请人： H. Lundbeck A/S

发明人： Mikkel Fog Jacobsen ,  Morten Jørgensen

IPC分类号： C07D295/037

CPC分类号： C07D295/037

摘要： The present invention relates to prodrugs of 4-((1R,3S)-6-cloro-3-phenyl-2,3-dihydro-1H-inden-1-yl)-1,2,2-trimethylpiperazine in the form of 1a and 1b; and 4-((1R,3S)-6-chloro-3-(phenyl-d5)-2,3-dihydro-1H-inden-1-yl)-2,2′-dimethyl-1-(methyl-d3)piperazine in the form of 2a and 2b, wherein X− is a counter ion, or pharmaceutically acceptable salts thereof. The present invention also provides pharmaceutical composition comprising prodrugs, or pharmaceutically acceptable salts thereof, of the invention.

公开(公告)号：US20230159478A1

公开(公告)日：2023-05-25

申请号：US18058587

申请日：2022-11-23

申请人： H. Lundbeck A/S

发明人： Mikkel Fog Jacobsen ,  Morten Jørgensen

IPC分类号： C07D295/037

CPC分类号： C07D295/037

摘要： The present invention relates to prodrugs of 4-((1R,3S)-6-cloro-3-phenyl-2,3-dihydro-1H-inden-1-yl)-1,2,2-trimethylpiperazine in the form of 1a and 1b; and 4-((1R,3S)-6-chloro-3-(phenyl-d5)-2,3-dihydro-1H-inden-1-yl)-2,2′-dimethyl-1-(methyl-d3)piperazine in the form of 2a and 2b, wherein X− is a counter ion, or pharmaceutically acceptable salts thereof. The present invention also provides pharmaceutical composition comprising prodrugs, or pharmaceutically acceptable salts thereof, of the invention.

公开(公告)号：US20190048025A1

公开(公告)日：2019-02-14

申请号：US16075660

申请日：2017-01-27

申请人： GOTION, INC.

发明人： Nicole HOLUB ,  Juergen HERBEL

IPC分类号： C07F5/02 ,  C07D295/037 ,  C07D213/20 ,  C07C211/63 ,  H01M10/0525 ,  H01M10/0568

CPC分类号： C07F5/022 ,  C07C211/63 ,  C07D213/20 ,  C07D295/037 ,  H01G11/62 ,  H01M10/0525 ,  H01M10/0568 ,  H01M2300/0025 ,  Y02E60/13

摘要： A process for preparing a difluoro chelato borate salt comprising an anion A of formula (I) wherein is a bidentate radical derived from a 1,2-, 1,3- or 1,4-diol, from a 1,2-, 1,3- or 1,4-dicarboxylic acid or from a 1,2-, 1,3- or 1,4-hydroxycarboxylic acid by abstracting the two H atoms of pairs of adjacent OH groups of the respective diol, hydroxycarboxylic acid or dicarboxylic acid. The process includes step (i) reacting (a) one or more BF3 sources; (b) a dihydric compound selected from 1,2-, 1,3- and 1,4-diols, 1,2-, 1,3- and 1,4-dicarboxylic acids, and 1,2-, 1,3- and 1,4-hydroxycarboxylic acids; (c) one or more second boron sources which do not contain F; and (d) one or more proton acceptors.

公开(公告)号：US20180244826A1

公开(公告)日：2018-08-30

申请号：US15753004

申请日：2016-08-15

申请人： Covestro Deutschland AG

发明人： Frank Richter

IPC分类号： C08G18/02 ,  C08G18/20 ,  C07D295/037

CPC分类号： C08G18/022 ,  B01J31/0239 ,  B01J31/0282 ,  C07D295/037 ,  C08G18/2018

摘要： The invention relates to a process for modifying isocyanates where at least one organic isocyanate with NCO functionality >1 is oligomerized in the presence of at least one catalyst, characterized in that the catalyst comprises, as isocyanatemodification catalysts, at least one cyclic ammonium salt having a cation of the formula (I) (formula I), where the N-containing substituents R1 and R2 are mutually independently identical or different aliphatic, cycloaliphatic, aromatic or araliphatic C, to C20 moieties which are saturated or unsaturated, linear or branched, optionally substituted and/or interrupted by heteroatoms from the group of oxygen, sulphur and nitrogen, and Y is a substituted or unsubstituted, linear or branched C2 to C20 segment optionally interrupted by heteroatoms from the group of oxygen, sulphur and nitrogen or else intempted by aromatic rings, and optionally containing other rings. The invention further relates to the use of such a catalyst.

公开(公告)号：US20180078928A1

公开(公告)日：2018-03-22

申请号：US15667502

申请日：2017-08-02

申请人： ExxonMobil Chemical Patents Inc.

发明人： Allen W. Burton

IPC分类号： B01J29/40 ,  C07D295/037 ,  C01B39/40 ,  C01B39/38 ,  C01B37/02 ,  B01J35/02 ,  B01J37/08 ,  B01J37/00 ,  C01B39/12 ,  C07D207/06

CPC分类号： B01J29/40 ,  B01J35/02 ,  B01J37/0018 ,  B01J37/082 ,  C01B37/02 ,  C01B39/12 ,  C01B39/38 ,  C01B39/40 ,  C07D207/06 ,  C07D295/037

摘要： A molecular sieve having the framework structure of ZSM-5 is produced using one or more of 1,4-bis(N-pentylpyrrolidinium)butane dications, 1,5-bis(N-pentylpyrrolidinium)pentane dications, and 1,6-bis(N-pentylpyrrolidinium)hexane dications as a structure directing agent.

公开(公告)号：US09850265B2

公开(公告)日：2017-12-26

申请号：US14403167

申请日：2012-05-25

申请人： Georg Schlechtingen ,  Hans-Joachim Knölker ,  Tim Friedrichson ,  Gary Jennings ,  Tobias Braxmeier

发明人： Georg Schlechtingen ,  Hans-Joachim Knölker ,  Tim Friedrichson ,  Gary Jennings ,  Tobias Braxmeier

IPC分类号： C07F9/40 ,  C07D211/62 ,  C07D211/46 ,  C07D295/037 ,  C07C229/12 ,  A61K31/205 ,  C07F9/38 ,  C07C309/14 ,  A61K31/662 ,  A61K31/4425

CPC分类号： C07F9/4006 ,  A61K31/205 ,  A61K31/4425 ,  A61K31/662 ,  C07C229/12 ,  C07C309/14 ,  C07D211/06 ,  C07D211/46 ,  C07D211/60 ,  C07D211/62 ,  C07D295/037 ,  C07F9/3808

摘要： The present invention relates to amino- or ammonium-containing sulfonic acid, phosphonic acid and carboxylic acid derivatives, in particular the compounds of formula 1, 2, 3, 4, 5 or 6, and their medical use, including their use in the treatment, prevention or amelioration of an inflammatory, autoimmune and/or allergic disorder.

公开(公告)号：US09725456B2

公开(公告)日：2017-08-08

申请号：US14655781

申请日：2014-01-10

申请人： THE CHEMOURS COMPANY FC LLC ,  TRINITY WESTERN UNIVERSITY

发明人： Jon Lee Howell ,  Chadron Mark Friesen ,  Benson Jacob Jelier

IPC分类号： C07D487/08 ,  C10M169/06 ,  C07D213/74 ,  C07F9/54 ,  C07C209/00 ,  C07C209/68 ,  C07C211/63 ,  C07D487/18 ,  C07D295/037 ,  C07C29/00 ,  C08G65/22 ,  C08G65/00 ,  C08G65/26

CPC分类号： C07D487/08 ,  C07C29/00 ,  C07C209/00 ,  C07C209/68 ,  C07C211/63 ,  C07D213/74 ,  C07D295/037 ,  C07D487/18 ,  C07F9/5407 ,  C08G65/007 ,  C08G65/226 ,  C08G65/2621 ,  C08G65/2624 ,  C10M169/06 ,  C07C31/40

摘要： The present invention relates to anhydrous tetraalkyl pnictogen perfluoroalkoxy salts and a process to produce anhydrous tetraalkyl pnictogen perfluoroalkoxy salts. The process involves contacting a hydrofluoroether and an amine to produce a tetraalkyl pnictogen perfluoroalkoxy salt in the presence of a solvent. The present invention also relates to processes of preparing fluoroalkyl ether acid fluoride polymers using tetraalkyl pnictogen perfluoroalkoxy salt. The present invention further relates to some novel fluorinated alkyl polyether polymers.

公开(公告)号：US20160185720A1

公开(公告)日：2016-06-30

申请号：US15061931

申请日：2016-03-04

申请人： Pfizer Inc.

发明人： Anthony Michael Campeta ,  Joseph Francis Krzyzaniak ,  Jason Albert Leonard

IPC分类号： C07D207/34 ,  C07C215/08 ,  C07C229/26 ,  C07D295/027 ,  C07C211/07

CPC分类号： C07D207/34 ,  C07C211/07 ,  C07C215/08 ,  C07C229/26 ,  C07D295/027 ,  C07D295/037

摘要： Novel salt forms of [R—(R*,R*)]-2-(4-fluorophenyl)-β,δ-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1H-pyrrole-1-heptanoic acid characterized by their X-ray powder diffraction pattern and solid-state NMR spectra are described, as well as methods for the preparation and pharmaceutical composition of the same, which are useful as agents for treating hyperlipidemia, hypercholesterolemia, osteoporosis, benign prostatic hyperplasia, and Alzheimer's Disease.

公开(公告)号：US09331360B2

公开(公告)日：2016-05-03

申请号：US12964702

申请日：2010-12-09

申请人： Cedric M. Weiss ,  Simon Christopher Jones ,  Arunkumar Tiruvannamalai ,  Isabelle Darolles ,  Maksudul M. Alam ,  Sohrab Hossain

发明人： Cedric M. Weiss ,  Simon Christopher Jones ,  Arunkumar Tiruvannamalai ,  Isabelle Darolles ,  Maksudul M. Alam ,  Sohrab Hossain

IPC分类号： H01M10/0566 ,  H01M4/36 ,  H01M10/0569 ,  H01M10/0568 ,  H01M4/583 ,  H01M10/39

CPC分类号： H01M10/0568 ,  C07D295/037 ,  H01M4/36 ,  H01M4/5835 ,  H01M10/0525 ,  H01M10/0566 ,  H01M10/0569 ,  H01M10/399 ,  H01M2300/0045

摘要： A fluoride ion battery includes a substantially lithium-free anode and cathode. At least one of the anode or cathode contains fluorine, and a substantially lithium-free liquid electrolyte is used for charge transport. The electrolyte is liquid at temperatures below about 200 degrees Celsius, and can be formed from an organic-soluble fluoride salt dissolved in selected classes of solvents.

摘要翻译： 氟化物离子电池包括基本上无锂的阳极和阴极。 阳极或阴极中的至少一个含有氟，并且基本上不含锂的液体电解质用于电荷输送。 电解液在低于约200摄氏度的温度下是液体的，并且可以由溶解在选定类别的溶剂中的有机溶解的氟化物盐形成。

公开(公告)号：US20150328627A1

公开(公告)日：2015-11-19

申请号：US14648476

申请日：2013-11-22

申请人： EXXONMOBIL CHEMICALS PATENTS INC.

发明人： Allen W. Burton

IPC分类号： B01J29/40 ,  C07D207/06 ,  B01J37/08 ,  B01J35/02 ,  C01B39/40 ,  B01J37/00

CPC分类号： B01J29/40 ,  B01J35/02 ,  B01J37/0018 ,  B01J37/082 ,  C01B37/02 ,  C01B39/12 ,  C01B39/38 ,  C01B39/40 ,  C07D207/06 ,  C07D295/037

摘要： A molecular sieve having the framework structure of ZSM-5 is produced using one or more of 1,4-bis(N-pentylpyrrolidinium)butane dications, 1,5-bis(N-pentylpyrrolidinium)pentane dications, and 1,6-bis(N-pentylpyrrolidinium)hexane dications as a structure directing agent.

摘要翻译： 使用一种或多种1,4-双（N-戊基吡咯烷鎓）丁烷偶联剂，1,5-双（N-戊基吡咯烷鎓）戊烷二异氰酸酯和1,6-双（N-戊基吡咯烷鎓）戊烷偶联剂制备具有ZSM-5骨架结构的分子筛 （N-戊基吡咯烷鎓）己烷作为结构导向剂。