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公开(公告)号：US20240360092A1
公开(公告)日：2024-10-31
申请号：US18760458
申请日：2024-07-01
申请人： Vivozon Inc.
发明人： Dae Kyu CHOI , Hyo Jin KIM , Mi Seon BAE , Jin CHOI , Hyun Jin HEO , Yong Seok LEE , Geon Ho LEE , Mi Yon SHIM , Jin Sun PARK , Han Mi LEE
IPC分类号： C07D295/135 , A61P25/04 , C07C233/66 , C07C233/70 , C07C233/72 , C07C233/78 , C07C233/86 , C07C237/34 , C07D213/40 , C07D213/56 , C07D305/06 , C07D307/14 , C07D309/06 , C07D309/14 , C07D319/12
CPC分类号： C07D295/135 , A61P25/04 , C07C233/66 , C07C233/70 , C07C233/72 , C07C233/78 , C07C233/86 , C07C237/34 , C07D213/40 , C07D213/56 , C07D305/06 , C07D307/14 , C07D309/06 , C07D309/14 , C07D319/12
摘要： Disclosed are a dual modulator of mGluR5 and 5-HT2AR (5-HT2A receptor), and use thereof. More specifically, disclosed are a compound which acts as modulator of mGluR5 and an antagonist of 5-HT2AR at the same time, and use thereof as therapeutic agent for pain.
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公开(公告)号：US11952353B2
公开(公告)日：2024-04-09
申请号：US17311021
申请日：2019-12-06
发明人： Philip Reigan , Donald S. Backos , Christopher J. Matheson , Steffanie L. Furtek , Craig T. Jordan , Maria L. Amaya
IPC分类号： C07D263/57 , C07C205/43 , C07C233/66 , C07C235/64 , C07D233/26 , C07D263/32 , C07D307/16 , C07D307/54 , C07D307/56 , C07D307/58 , C07D307/66 , C07D307/68 , C07D307/80
CPC分类号： C07D263/57 , C07C205/43 , C07C235/64 , C07D233/26 , C07D263/32 , C07D307/16 , C07D307/54 , C07D307/56
摘要： Compounds that inhibit the activity of Signal transducer and activator of transcription 3 (STAT3), or pharmaceutically acceptable salts or prodrugs thereof, and methods of using these compounds to treat cancer and other diseases.
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公开(公告)号：US11130743B2
公开(公告)日：2021-09-28
申请号：US16827147
申请日：2020-03-23
申请人： Marquette University
IPC分类号： C07D307/68 , C07C233/80 , C07C233/66 , C07D263/34 , C07D277/587 , C07D233/90 , A61P29/00
摘要： The present invention provides novel compounds with increased plasma stability that modulate PAR1 signaling, and methods of using them. The present invention provides methods of using the novel PAR1 modulators for the treatment of a number of disorders, including, inflammation, thrombosis, kidney disease, sepsis, stroke, as well as proliferation-related diseases. Furthermore, the PAR1 modulators of the present invention provide cytoprotection for certain cells and tissues, for example, in coronary blood vessels and tissues after a heart attack.
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公开(公告)号：US20210002209A1
公开(公告)日：2021-01-07
申请号：US16969261
申请日：2019-02-11
发明人： Mazen HANNA , Manomi PERERA , Jiyu YAN , Andrew HANNA
IPC分类号： C07C233/66 , C07C53/126 , C07C55/12 , C07C55/14 , C07C57/145 , C07C57/15 , C07C57/30 , C07C59/265 , C07C65/03 , C07C63/331
摘要： Synthesis and characterization of novel tamibarotene forms suitable for pharmaceutical compositions in drug delivery systems to treat human or warm-blooded mammal diseases.
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公开(公告)号：US10301255B2
公开(公告)日：2019-05-28
申请号：US15216124
申请日：2016-07-21
发明人： Yao-Ling Qiu , Wei Li , Hui Cao , Meizhong Jin , Jorden Kass , Xuri Gao , Xiaowen Peng , Yat Sun Or
IPC分类号： C07D233/88 , C07D233/64 , C07C271/28 , C07C271/12 , C07C255/60 , C07C255/58 , C07C235/56 , C07C235/42 , C07C233/66 , A61K45/06
摘要： The present invention discloses compounds of Formula (I), or pharmaceutically acceptable salts, esters, or prodrugs thereof: X-A1-Y-A2-Z-L-R (I) which inhibit the protein(s) encoded by hepatitis B virus (HBV) or interfere with the function of the HBV life cycle of the hepatitis B virus and are also useful as antiviral agents. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject suffering from HBV infection. The invention also relates to methods of treating an HBV infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention.
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公开(公告)号：US10238654B2
公开(公告)日：2019-03-26
申请号：US15479972
申请日：2017-04-05
发明人： John Paul Kilburn , Lars Kyhn Rasmussen , Mikkel Jessing , Eman Mohamed Eldemenky , Bin Chen , Yu Jiang , Allen T. Hopper
IPC分类号： A61K31/505 , C07C233/66 , C07C233/75 , C07C233/78 , C07D211/26 , C07D213/40 , C07D233/64 , C07D237/08 , C07D239/26 , C07D241/12 , C07D309/04 , C07D401/06 , C07D403/06 , C07D405/04 , C07D405/06 , C07D231/12 , C07D403/04 , C07D213/61 , C07C233/73
摘要： The present invention is directed to benzamide-containing compounds of formula I or pharmaceutically acceptable salts thereof which inhibit the P2X7 receptor, and their use in the treatment of epilepsy.
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公开(公告)号：US20170320848A1
公开(公告)日：2017-11-09
申请号：US15523028
申请日：2015-10-26
发明人： Claudia WELZ , Adeline KÖHLER , Kirsten BÖRNGEN , Daniel KULKE , Ulrich GÖRGENS , Hans-Georg SCHWARZ , Kerstin ILG
IPC分类号： C07D317/58 , C07D295/135 , C07D213/82 , C07C317/40 , C07C233/66 , C07C255/60 , C07C233/80 , C07C233/73 , C07D295/185 , C07C323/42
CPC分类号： C07D317/58 , C07C233/66 , C07C233/73 , C07C233/78 , C07C233/80 , C07C255/58 , C07C255/60 , C07C317/40 , C07C323/42 , C07D213/81 , C07D213/82 , C07D241/24 , C07D295/135 , C07D295/155 , C07D295/185 , C07D317/62
摘要： Disclosed are compounds of formula (I) which possess anthelminthic properties wherein the structural elements have the meaning as indicated in the description. Further disclosed are such compounds for the control, treatment and/or prevention of infections with helminths in animals and humans.
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公开(公告)号：US09701620B2
公开(公告)日：2017-07-11
申请号：US14880739
申请日：2015-10-12
申请人： Dow AgroSciences LLC
发明人： William C. Lo , James E. Hunter , Gerald B. Watson , Akshay Patny , Pravin S. Iyer , Joshodeep Boruwa
IPC分类号： C07C233/66 , C07C327/46 , A01N61/00 , A01N37/18 , A01N53/00 , A01N37/34 , C07C237/24 , C07C255/46 , C07D401/10 , A01N43/08 , A01N43/16 , A01N43/20 , A01N43/40 , A01N43/50 , A01N43/60 , A01N43/78 , A01N43/82 , C07C233/65 , C07C255/57 , C07C63/70 , C07D207/16 , C07D213/61 , C07D295/12 , C07D331/04 , A01N43/54 , A01N43/653 , A01N47/32 , A61K31/166 , A61K31/17 , A61K31/4196 , A61K31/4245 , A61K31/426 , A61K31/4965 , A61K31/505 , A61K31/5375 , C07C243/14 , C07C335/14 , C07D239/26 , C07D241/12 , C07D249/14 , C07D271/10 , C07D277/32 , C07D295/192 , A01N37/20 , A01N37/28 , A01N41/10 , A01N47/22 , A01N47/38 , A01N37/46 , A01N47/10 , A01N47/28 , A01N47/36 , A61K45/06 , A61K31/167 , C07C259/08 , C07C271/22 , C07C271/24 , C07C275/24 , C07C211/27 , C07C211/29 , C07C211/30 , C07C211/42 , C07C233/13 , C07C233/56 , C07C233/83 , C07C237/06 , C07C239/08 , C07C243/22 , C07C243/32 , C07C251/44 , A01N43/10 , A01N43/56
CPC分类号： C07C233/66 , A01N37/10 , A01N37/18 , A01N37/20 , A01N37/28 , A01N37/34 , A01N37/46 , A01N41/10 , A01N43/08 , A01N43/10 , A01N43/16 , A01N43/20 , A01N43/36 , A01N43/40 , A01N43/50 , A01N43/54 , A01N43/56 , A01N43/60 , A01N43/653 , A01N43/78 , A01N43/82 , A01N43/84 , A01N47/10 , A01N47/22 , A01N47/28 , A01N47/32 , A01N47/36 , A01N47/38 , A01N53/00 , A01N61/00 , A61K31/166 , A61K31/167 , A61K31/17 , A61K31/4196 , A61K31/4245 , A61K31/426 , A61K31/4965 , A61K31/505 , A61K31/5375 , A61K45/06 , C07C63/70 , C07C211/27 , C07C211/29 , C07C211/30 , C07C211/42 , C07C233/13 , C07C233/56 , C07C233/65 , C07C233/83 , C07C237/06 , C07C237/24 , C07C239/08 , C07C243/14 , C07C243/22 , C07C243/32 , C07C251/44 , C07C255/46 , C07C255/57 , C07C259/08 , C07C271/22 , C07C271/24 , C07C275/24 , C07C327/46 , C07C335/14 , C07C2601/02 , C07C2601/04 , C07C2602/08 , C07C2602/10 , C07D207/16 , C07D207/26 , C07D209/08 , C07D209/48 , C07D211/58 , C07D213/40 , C07D213/61 , C07D237/32 , C07D239/26 , C07D241/12 , C07D249/08 , C07D249/14 , C07D271/10 , C07D277/28 , C07D277/32 , C07D277/64 , C07D295/108 , C07D295/12 , C07D295/192 , C07D307/06 , C07D307/52 , C07D331/04 , C07D401/10 , C07D405/04
摘要： This document discloses molecules having the following formula (“Formula One”): and processes associated therewith.
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公开(公告)号：US20170158675A1
公开(公告)日：2017-06-08
申请号：US15435332
申请日：2017-02-17
申请人： Dow AgroSciences LLC
发明人： William C. Lo , James E. Hunter , Gerald B. Watson , Akshay Patny , Pravin S. Iyer , Joshodeep Boruwa
IPC分类号： C07D405/04 , C07C63/74 , A01N37/10 , C07C255/57 , A01N37/34 , C07C233/65 , A01N37/18 , C07C233/66 , C07D295/192 , A01N43/84 , C07D213/61 , A01N43/40 , C07D207/27 , A01N43/36 , C07D331/04 , A01N43/20 , C07D213/40 , C07D277/32 , A01N43/80 , C07C243/38 , C07D239/26 , A01N43/54 , C07D307/14 , A01N43/08 , C07D307/52 , C07D277/64 , C07D241/12 , A01N43/60 , C07C243/36 , C07D233/64 , A01N43/50 , C07D309/14 , A01N43/16 , C07D213/75 , C07D271/10 , A01N43/82 , C07C327/48 , C07D213/74 , C07D213/64 , C07D211/58 , C07C259/06 , C07C243/34 , C07C335/14 , A01N47/32 , C07C233/14 , C07C233/59 , C07D213/56 , C07C211/42 , C07D209/08 , C07D237/32 , C07D209/48 , C07C211/29 , C07C323/59 , A01N37/36 , C07C275/24 , C07C271/14 , C07C235/80 , C07C237/06 , C07D295/073 , C07D295/096 , C07D249/08 , C07D249/14 , C07D249/10 , C07D295/155 , C07C327/42 , C07C317/32
CPC分类号： C07D405/04 , A01N25/08 , A01N33/04 , A01N37/10 , A01N37/18 , A01N37/28 , A01N37/32 , A01N37/34 , A01N37/36 , A01N37/46 , A01N41/10 , A01N43/08 , A01N43/16 , A01N43/20 , A01N43/36 , A01N43/38 , A01N43/40 , A01N43/50 , A01N43/54 , A01N43/58 , A01N43/60 , A01N43/653 , A01N43/78 , A01N43/80 , A01N43/82 , A01N43/84 , A01N47/18 , A01N47/28 , A01N47/32 , A01N47/36 , A01N47/38 , A01N53/00 , C07C63/70 , C07C63/74 , C07C211/27 , C07C211/29 , C07C211/42 , C07C233/13 , C07C233/14 , C07C233/56 , C07C233/59 , C07C233/65 , C07C233/66 , C07C233/76 , C07C233/83 , C07C235/80 , C07C237/06 , C07C237/22 , C07C243/34 , C07C243/36 , C07C243/38 , C07C255/57 , C07C255/58 , C07C259/06 , C07C259/08 , C07C271/14 , C07C275/24 , C07C317/32 , C07C317/44 , C07C323/59 , C07C323/60 , C07C323/62 , C07C323/63 , C07C327/42 , C07C327/46 , C07C327/48 , C07C335/12 , C07C335/14 , C07C2601/02 , C07C2602/08 , C07C2602/10 , C07D207/16 , C07D207/27 , C07D209/08 , C07D209/48 , C07D209/50 , C07D211/58 , C07D213/40 , C07D213/56 , C07D213/61 , C07D213/64 , C07D213/74 , C07D213/75 , C07D233/64 , C07D237/32 , C07D239/26 , C07D241/12 , C07D249/08 , C07D249/10 , C07D249/14 , C07D271/10 , C07D277/30 , C07D277/32 , C07D277/64 , C07D295/073 , C07D295/096 , C07D295/155 , C07D295/192 , C07D307/14 , C07D307/16 , C07D307/52 , C07D309/14 , C07D331/04 , C07D401/10
摘要： This document discloses molecules having the following formula (“Formula One”): and processes associated therewith.
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公开(公告)号：US20170158674A1
公开(公告)日：2017-06-08
申请号：US15435328
申请日：2017-02-17
申请人： Dow AgroSciences LLC
发明人： James E. Hunter , William C. Lo , Gerald B. Watson , Akshay Patny , Gary D. Gustafson , Dan Pernich , William K. Brewster , Debra L. Camper , Beth Lorsbach , Michael R. Loso , Thomas C. Sparks , Hemant Joshi , Adiraj Mandaleswaran , Ramadevi Sanam , Rambabu Gundla , Pravin S. Iyer
IPC分类号： C07D405/04 , A01N37/10 , C07C255/57 , A01N37/34 , C07C233/65 , A01N37/18 , C07C233/66 , C07D295/192 , A01N43/84 , C07D213/61 , A01N43/40 , C07D207/27 , A01N43/36 , C07D331/04 , A01N43/20 , C07D213/40 , C07D277/32 , A01N43/80 , C07C243/38 , C07D239/26 , A01N43/54 , C07D307/14 , A01N43/08 , C07D307/52 , C07D277/64 , C07D241/12 , A01N43/60 , C07C243/36 , C07D233/64 , A01N43/50 , C07D309/14 , A01N43/16 , C07D213/75 , C07D271/10 , A01N43/82 , C07C327/48 , C07D213/74 , C07D213/64 , C07D211/58 , C07C259/06 , C07C243/34 , C07C335/14 , A01N47/32 , C07C233/14 , C07C233/59 , C07D213/56 , C07C211/42 , C07D209/08 , C07D237/32 , C07D209/48 , C07C211/29 , C07C323/59 , A01N37/36 , C07C275/24 , C07C271/14 , C07C235/80 , C07C237/06 , C07D295/073 , C07D295/096 , C07D249/08 , C07D249/14 , C07D249/10 , C07D295/155 , C07C63/74
CPC分类号： C07D405/04 , A01N33/04 , A01N35/06 , A01N37/10 , A01N37/18 , A01N37/28 , A01N37/34 , A01N37/36 , A01N37/40 , A01N37/46 , A01N43/08 , A01N43/16 , A01N43/20 , A01N43/36 , A01N43/38 , A01N43/40 , A01N43/50 , A01N43/54 , A01N43/58 , A01N43/60 , A01N43/653 , A01N43/78 , A01N43/80 , A01N43/82 , A01N43/84 , A01N47/12 , A01N47/18 , A01N47/28 , A01N47/32 , A01N47/36 , A01N47/38 , C07C63/74 , C07C69/78 , C07C211/29 , C07C211/42 , C07C233/14 , C07C233/56 , C07C233/59 , C07C233/65 , C07C233/66 , C07C233/83 , C07C235/80 , C07C237/06 , C07C237/22 , C07C243/28 , C07C243/34 , C07C243/36 , C07C243/38 , C07C255/57 , C07C259/06 , C07C271/14 , C07C271/46 , C07C275/24 , C07C323/59 , C07C327/48 , C07C335/14 , C07C2601/02 , C07C2602/08 , C07C2602/10 , C07D207/27 , C07D209/08 , C07D209/48 , C07D211/58 , C07D213/40 , C07D213/56 , C07D213/61 , C07D213/64 , C07D213/74 , C07D213/75 , C07D233/64 , C07D237/32 , C07D239/26 , C07D241/12 , C07D249/08 , C07D249/10 , C07D249/14 , C07D271/10 , C07D277/32 , C07D277/64 , C07D295/073 , C07D295/096 , C07D295/155 , C07D295/192 , C07D307/14 , C07D307/52 , C07D309/14 , C07D331/04 , C07D401/06
摘要： This document discloses molecules having the following formula (“Formula One”): and processes associated therewith.
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