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公开(公告)号：US11058696B2
公开(公告)日：2021-07-13
申请号：US16879824
申请日：2020-05-21
发明人： Alaric J. Dyckman , T. G. Murali Dhar , Hai-Yun Xiao , John L. Gilmore , Michael G. Yang , Zili Xiao , David Marcoux
IPC分类号： A61K31/695 , C07F7/08 , A61K31/135 , C07D215/14 , C07D241/04 , C07C323/29 , C07C251/38 , C07C251/42 , C07C251/44 , C07D209/46 , C07D213/38 , C07C275/26 , C07C217/74 , C07C323/25 , C07C235/46 , C07F9/54 , C07F9/572 , C07F9/09 , C07C215/42 , C07C217/52 , C07C217/58 , C07C219/24 , C07C233/41 , C07C233/65 , C07C251/50 , C07C251/52 , C07C251/54 , C07C271/34 , C07C317/28 , C07C317/32 , C07C321/16 , C07C321/22 , C07C321/28 , C07D213/32 , C07D213/69 , C07D213/70 , C07D215/12 , C07D217/24 , C07D231/12 , C07D231/20 , C07D239/26 , C07D241/12 , C07D277/24 , C07D305/08 , C07D309/06 , C07D309/12 , C07D311/58 , C07D311/76 , C07D319/20 , C07D333/16 , C07F9/117 , C07F9/62 , C07F9/6503 , C07F9/6509 , C07F9/655 , C07F9/6553 , A61K31/137 , A61K31/15 , A61K31/165 , A61K31/166 , A61K31/17 , A61K31/222 , A61K31/24 , A61K31/27 , A61K31/337 , A61K31/351 , A61K31/352 , A61K31/381 , A61K31/415 , A61K31/4174 , A61K31/426 , A61K31/44 , A61K31/4402 , A61K31/4406 , A61K31/4409 , A61K31/47 , A61K31/4965 , A61K31/505 , A61K31/661
摘要： Disclosed are compounds of Formulas (I), (II), (III), (IV), and (V): and/or a salt thereof, wherein R1 is —OH or —OP(O)(OH)2, and X1, X2, X3, R2, R2a, Ra, Rb, and Rc are defined herein. Also disclosed are methods of using such compounds as selective agonists for G protein-coupled receptor S1P1, and pharmaceutical compositions comprising such compounds. These compounds are useful in treating, preventing, or slowing the progression of diseases or disorders in a variety of therapeutic areas, such as autoimmune diseases and vascular disease.
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公开(公告)号：US20170304332A1
公开(公告)日：2017-10-26
申请号：US15648250
申请日：2017-07-12
发明人： Alaric J. Dyckman , T.G. Murali Dhar , Hai-Yun Xiao , John L. Gilmore , Michael G. Yang , Zili Xiao , David Marcoux
IPC分类号： A61K31/695 , C07F9/6553 , C07F9/655 , C07F9/6509 , C07F9/6503 , C07F9/62 , C07F9/572 , C07F9/54 , C07F9/117 , C07F9/09 , C07F7/08 , C07D333/16 , C07D319/20 , C07D311/76 , C07D311/58 , C07D309/12 , C07D309/06 , C07D305/08 , C07D277/24 , C07D241/12 , C07D241/04 , C07D239/26 , C07D231/20 , C07D231/12 , C07D217/24 , C07D215/14 , C07D215/12 , C07D213/70 , C07D213/69 , C07D213/38 , C07D213/32 , C07D209/46 , C07C323/29 , C07C323/25 , C07C321/28 , C07C321/22 , C07C321/16 , C07C317/32 , C07C317/28 , C07C275/26 , C07C271/34 , C07C251/54 , C07C251/52 , C07C251/50 , C07C251/44 , C07C251/42 , C07C251/38 , C07C235/46 , C07C233/65 , C07C233/41 , C07C219/24 , C07C217/74 , C07C217/58 , C07C217/52 , C07C215/42 , A61K31/661 , A61K31/505 , A61K31/4965 , A61K31/47 , A61K31/4409 , A61K31/4406 , A61K31/4402 , A61K31/44 , A61K31/426 , A61K31/4174 , A61K31/415 , A61K31/381 , A61K31/352 , A61K31/351 , A61K31/337 , A61K31/27 , A61K31/24 , A61K31/222 , A61K31/17 , A61K31/166 , A61K31/165 , A61K31/15 , A61K31/137 , A61K31/135 , C07C2601/04 , C07C2601/08 , C07C2603/74 , C07C2602/10 , C07C2601/02
CPC分类号： A61K31/695 , A61K31/135 , A61K31/137 , A61K31/15 , A61K31/165 , A61K31/166 , A61K31/17 , A61K31/222 , A61K31/24 , A61K31/27 , A61K31/337 , A61K31/351 , A61K31/352 , A61K31/381 , A61K31/415 , A61K31/4174 , A61K31/426 , A61K31/44 , A61K31/4402 , A61K31/4406 , A61K31/4409 , A61K31/47 , A61K31/4965 , A61K31/505 , A61K31/661 , C07B2200/05 , C07C215/42 , C07C217/52 , C07C217/58 , C07C217/74 , C07C219/24 , C07C233/41 , C07C233/65 , C07C235/46 , C07C251/38 , C07C251/42 , C07C251/44 , C07C251/50 , C07C251/52 , C07C251/54 , C07C271/34 , C07C275/26 , C07C317/28 , C07C317/32 , C07C321/16 , C07C321/22 , C07C321/28 , C07C323/25 , C07C323/29 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07C2602/10 , C07C2603/74 , C07D209/46 , C07D213/32 , C07D213/38 , C07D213/69 , C07D213/70 , C07D215/12 , C07D215/14 , C07D217/24 , C07D231/12 , C07D231/20 , C07D239/26 , C07D241/04 , C07D241/12 , C07D277/24 , C07D305/08 , C07D309/06 , C07D309/12 , C07D311/58 , C07D311/76 , C07D319/20 , C07D333/16 , C07F7/081 , C07F9/091 , C07F9/117 , C07F9/5442 , C07F9/5728 , C07F9/62 , C07F9/65031 , C07F9/650952 , C07F9/65522 , C07F9/655345
摘要： Disclosed are compounds of Formulas (I), (II), (III), (IV), and (V): and/or a salt thereof, wherein R1 is —OH or —OP(O)(OH)2, and X1, X2, X3, R2, R2a, Ra, Rb, and Rc are defined herein. Also disclosed are methods of using such compounds as selective agonists for G protein-coupled receptor S1P1, and pharmaceutical compositions comprising such compounds. These compounds are useful in treating, preventing, or slowing the progression of diseases or disorders in a variety of therapeutic areas, such as autoimmune diseases and vascular disease.
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公开(公告)号：US09770459B2
公开(公告)日：2017-09-26
申请号：US15337843
申请日：2016-10-28
发明人： Alaric J. Dyckman , T.G. Murali Dhar , Hai-Yun Xiao , John L. Gilmore , Michael G. Yang , Zili Xiao , David Marcoux
IPC分类号： C07D217/00 , A61K31/695 , C07C215/42 , C07C217/52 , C07C217/58 , C07C219/24 , C07C233/41 , C07C233/65 , C07C251/50 , C07C251/52 , C07C251/54 , C07C271/34 , C07C317/28 , C07C317/32 , C07C321/16 , C07C321/22 , C07C321/28 , C07D213/32 , C07D213/69 , C07D213/70 , C07D215/12 , C07D217/24 , C07D231/12 , C07D231/20 , C07D239/26 , C07D241/12 , C07D277/24 , C07D305/08 , C07D309/06 , C07D309/12 , C07D311/58 , C07D311/76 , C07D319/20 , C07D333/16 , C07F7/08 , C07F9/117 , C07F9/62 , C07F9/6503 , C07F9/6509 , C07F9/655 , C07F9/6553 , A61K31/135 , C07D215/14 , C07D241/04 , C07C323/29 , C07C251/38 , C07C251/42 , C07C251/44 , C07D209/46 , C07D213/38 , C07C275/26 , C07C217/74 , C07C323/25 , C07C235/46 , C07F9/54 , C07F9/572 , C07F9/09 , A61K31/137 , A61K31/15 , A61K31/165 , A61K31/166 , A61K31/17 , A61K31/222 , A61K31/24 , A61K31/27 , A61K31/337 , A61K31/351 , A61K31/352 , A61K31/381 , A61K31/415 , A61K31/4174 , A61K31/426 , A61K31/44 , A61K31/4402 , A61K31/4406 , A61K31/4409 , A61K31/47 , A61K31/4965 , A61K31/505 , A61K31/661
CPC分类号： A61K31/695 , A61K31/135 , A61K31/137 , A61K31/15 , A61K31/165 , A61K31/166 , A61K31/17 , A61K31/222 , A61K31/24 , A61K31/27 , A61K31/337 , A61K31/351 , A61K31/352 , A61K31/381 , A61K31/415 , A61K31/4174 , A61K31/426 , A61K31/44 , A61K31/4402 , A61K31/4406 , A61K31/4409 , A61K31/47 , A61K31/4965 , A61K31/505 , A61K31/661 , C07B2200/05 , C07C215/42 , C07C217/52 , C07C217/58 , C07C217/74 , C07C219/24 , C07C233/41 , C07C233/65 , C07C235/46 , C07C251/38 , C07C251/42 , C07C251/44 , C07C251/50 , C07C251/52 , C07C251/54 , C07C271/34 , C07C275/26 , C07C317/28 , C07C317/32 , C07C321/16 , C07C321/22 , C07C321/28 , C07C323/25 , C07C323/29 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07C2602/10 , C07C2603/74 , C07D209/46 , C07D213/32 , C07D213/38 , C07D213/69 , C07D213/70 , C07D215/12 , C07D215/14 , C07D217/24 , C07D231/12 , C07D231/20 , C07D239/26 , C07D241/04 , C07D241/12 , C07D277/24 , C07D305/08 , C07D309/06 , C07D309/12 , C07D311/58 , C07D311/76 , C07D319/20 , C07D333/16 , C07F7/081 , C07F9/091 , C07F9/117 , C07F9/5442 , C07F9/5728 , C07F9/62 , C07F9/65031 , C07F9/650952 , C07F9/65522 , C07F9/655345
摘要： Disclosed are compounds of Formulas (I), (II), (III), (IV), and (V): and/or a salt thereof, wherein R1 is —OH or —OP(O)(OH)2, and X1, X2, X3, R2, R2a, Ra, Rb, and Rc are defined herein. Also disclosed are methods of using such compounds as selective agonists for G protein-coupled receptor S1P1, and pharmaceutical compositions comprising such compounds. These compounds are useful in treating, preventing, or slowing the progression of diseases or disorders in a variety of therapeutic areas, such as autoimmune diseases and vascular disease.
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公开(公告)号：US09725405B2
公开(公告)日：2017-08-08
申请号：US14967896
申请日：2015-12-14
发明人： Geert-Jan Boons , Jun Guo , Xinghai Ning , Margaretha Wolfert
IPC分类号： C07C271/34 , C07C35/37 , C07C49/683 , C07C211/42 , C07C251/44 , C07C251/58 , C07D249/16 , C07D261/20 , C07D271/12 , C07D307/94 , C07D311/90 , C07D495/04 , A61K47/48 , A61K49/00 , C07H21/00 , C07K2/00 , C07K14/00 , G01N33/58
CPC分类号： C07C251/58 , A61K47/54 , A61K47/542 , A61K47/61 , A61K47/62 , A61K47/64 , A61K47/6803 , A61K47/6921 , A61K49/0021 , A61K49/0043 , A61K49/0052 , C07C35/37 , C07C49/683 , C07C211/42 , C07C251/44 , C07C271/34 , C07C2603/36 , C07D249/16 , C07D261/20 , C07D271/12 , C07D307/94 , C07D311/90 , C07D495/04 , C07H21/00 , C07K2/00 , C07K14/00 , G01N33/582
摘要： 1,3-Dipole-functional compounds (e.g., azide functional compounds) can be reacted with certain alkynes in a cyclization reaction to form heterocyclic compounds. Useful alkynes (e.g., strained, cyclic alkynes) and methods of making such alkynes are also disclosed. The reaction of 1,3-dipole-functional compounds with alkynes can be used for a wide variety of applications including the immobilization of biomolecules on a substrate.
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公开(公告)号：US20160157485A1
公开(公告)日：2016-06-09
申请号：US14903169
申请日：2014-07-01
发明人： Anthony Cornelius O-Sullivan , Regis Jean Georges Mondiere , Olivier Loiseleur , Tomas Smejkal , Torsten Luksch , Andre Jeanguenat , Raphael Dumeunier , Edouard Godineau , Thomas Pittema
IPC分类号： A01N37/18 , A01N43/20 , C07C251/44 , C07C233/66 , C07D213/82 , A01N43/40 , C07C211/37 , C07C233/32 , C07C233/23 , C07C233/14 , C07C233/90 , C07D263/52 , C07C291/10 , C07C265/10 , C07C317/32 , C07D305/08
CPC分类号： A01N37/18 , A01N37/34 , A01N37/40 , A01N43/20 , A01N43/40 , C07B2200/07 , C07C211/37 , C07C233/14 , C07C233/23 , C07C233/32 , C07C233/66 , C07C233/81 , C07C233/90 , C07C235/54 , C07C235/62 , C07C251/44 , C07C255/57 , C07C265/10 , C07C291/10 , C07C317/32 , C07C323/62 , C07C2601/04 , C07D213/81 , C07D213/82 , C07D231/14 , C07D239/28 , C07D263/52 , C07D305/08
摘要： Compounds of the formula (I), in which the substituents are as defined in claim 1, are suitable for use as nematicides.
摘要翻译： 其中取代基如权利要求1中所定义的式（I）化合物适合用作杀线虫剂。
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公开(公告)号：US20160039741A1
公开(公告)日：2016-02-11
申请号：US14918729
申请日：2015-10-21
申请人： BAYER CROPSCIENCE AG
发明人： Simon MAECHLING , Mazen ES-SAYED , Peter DAHMEN , Ulrike WACHENDORFF-NEUMANN , David BERNIER , Lionel CARLES , Christophe DUBOST , Jean-Pierre VORS , Stephane BRUNET , Helene LACHAISE
IPC分类号： C07C211/60 , C07C251/44
CPC分类号： C07C211/60 , A01N43/56 , C07C251/44 , C07C251/50 , C07D231/14 , C07D231/16
摘要： The present invention relates to novel pyrazole(thio)tetrahydronaphthyl carboxamides, to processes for preparing these compounds, to compositions comprising these compounds, and to the use thereof as biologically active compounds, especially for control of harmful microorganisms in crop protection and in the protection of materials.
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公开(公告)号：US09227923B2
公开(公告)日：2016-01-05
申请号：US13390302
申请日：2010-08-03
申请人： Jun Mihara , Koichi Araki , Takuma Mori , Tetsuya Murata , Yasushi Yoneta , Yukiyoshi Watanabe , Eiichi Shimojo , Teruyuki Ichihara , Masashi Ataka , Katsuhiko Shibuya , Ulrich Gorgens
发明人： Jun Mihara , Koichi Araki , Takuma Mori , Tetsuya Murata , Yasushi Yoneta , Yukiyoshi Watanabe , Eiichi Shimojo , Teruyuki Ichihara , Masashi Ataka , Katsuhiko Shibuya , Ulrich Gorgens
IPC分类号： C07C233/65 , A01N37/18 , C07C233/66 , A01N37/42 , A01N37/44 , A01N37/48 , A01N37/50 , A01N43/40 , A01N43/56 , C07C235/84 , C07C237/40 , C07C237/42 , C07C237/48 , C07C251/44 , C07C251/48 , C07C255/19 , C07C255/57 , C07C271/22 , C07C275/24 , C07C309/66 , C07C311/06 , C07C323/60 , C07D209/48 , C07D213/61 , C07D213/81 , C07D213/82 , C07D213/84 , C07D213/85 , C07D231/12 , C07D231/16 , C07D249/08 , C07D249/18 , C07D249/20 , C07D257/04 , C07D295/155 , C07D401/12
CPC分类号： C07C233/66 , A01N37/42 , A01N37/44 , A01N37/48 , A01N37/50 , A01N43/40 , A01N43/56 , C07C235/84 , C07C237/40 , C07C237/42 , C07C237/48 , C07C251/44 , C07C251/48 , C07C255/19 , C07C255/57 , C07C271/22 , C07C275/24 , C07C309/66 , C07C311/06 , C07C323/60 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07C2601/10 , C07C2601/14 , C07C2602/08 , C07C2602/10 , C07D209/48 , C07D213/61 , C07D213/81 , C07D213/82 , C07D213/84 , C07D213/85 , C07D231/12 , C07D231/16 , C07D249/08 , C07D249/18 , C07D249/20 , C07D257/04 , C07D295/155 , C07D401/12
摘要： The object of the present invention is to provide novel carboxamides which exhibit an excellent pesticidal activity as pesticides. Disclosed are the carboxamides represented by the following Formula (I): wherein each substituent is as defined in the specification, and use thereof as pesticides and animal parasite controlling agents.
摘要翻译： 本发明的目的是提供一种作为农药具有优良杀虫活性的新型甲酰胺。 公开了由下式（I）表示的羧酰胺：其中每个取代基如说明书中所定义，以及其作为农药和动物寄生虫控制剂的用途。
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公开(公告)号：US09212163B2
公开(公告)日：2015-12-15
申请号：US14132977
申请日：2013-12-18
申请人： Dow AgroSciences LLC
发明人： William C. Lo , James E. Hunter , Gerald B. Watson , Akshay Patny , Pravin S. Iyer , Joshodeep Boruwa
IPC分类号： C07D401/10 , A01N37/10 , A01N37/34 , A01N37/18 , A01N43/84 , A01N43/40 , A01N43/36 , A01N43/20 , C07C255/57 , C07C233/65 , C07D295/12 , C07D213/61 , C07D207/16 , C07D331/04 , A01N43/50 , A01N43/08 , A01N43/78 , A01N43/60 , A01N43/16 , A01N43/82 , A01N43/48 , A01N43/90 , C07C233/66 , C07C63/70 , A01N43/54 , A01N43/653 , A01N47/32 , A01N53/00 , A61K31/166 , A61K31/17 , A61K31/4196 , A61K31/4245 , A61K31/426 , A61K31/4965 , A61K31/505 , A61K31/5375 , C07C243/14 , C07C335/14 , C07D239/26 , C07D241/12 , C07D249/14 , C07D271/10 , C07D277/32 , C07D295/192 , A01N37/20 , A01N37/28 , A01N41/10 , A01N47/22 , A01N47/38 , A01N37/46 , A01N47/10 , A01N47/28 , A01N47/36 , A61K45/06 , A61K31/167 , C07C255/46 , C07C259/08 , C07C271/22 , C07C271/24 , C07C275/24 , C07C211/27 , C07C211/29 , C07C211/30 , C07C211/42 , C07C233/13 , C07C233/56 , C07C233/83 , C07C237/06 , C07C237/24 , C07C239/08 , C07C243/22 , C07C243/32 , C07C251/44 , C07C327/46
CPC分类号： C07C233/66 , A01N37/10 , A01N37/18 , A01N37/20 , A01N37/28 , A01N37/34 , A01N37/46 , A01N41/10 , A01N43/08 , A01N43/10 , A01N43/16 , A01N43/20 , A01N43/36 , A01N43/40 , A01N43/50 , A01N43/54 , A01N43/56 , A01N43/60 , A01N43/653 , A01N43/78 , A01N43/82 , A01N43/84 , A01N47/10 , A01N47/22 , A01N47/28 , A01N47/32 , A01N47/36 , A01N47/38 , A01N53/00 , A01N61/00 , A61K31/166 , A61K31/167 , A61K31/17 , A61K31/4196 , A61K31/4245 , A61K31/426 , A61K31/4965 , A61K31/505 , A61K31/5375 , A61K45/06 , C07C63/70 , C07C211/27 , C07C211/29 , C07C211/30 , C07C211/42 , C07C233/13 , C07C233/56 , C07C233/65 , C07C233/83 , C07C237/06 , C07C237/24 , C07C239/08 , C07C243/14 , C07C243/22 , C07C243/32 , C07C251/44 , C07C255/46 , C07C255/57 , C07C259/08 , C07C271/22 , C07C271/24 , C07C275/24 , C07C327/46 , C07C335/14 , C07C2601/02 , C07C2601/04 , C07C2602/08 , C07C2602/10 , C07D207/16 , C07D207/26 , C07D209/08 , C07D209/48 , C07D211/58 , C07D213/40 , C07D213/61 , C07D237/32 , C07D239/26 , C07D241/12 , C07D249/08 , C07D249/14 , C07D271/10 , C07D277/28 , C07D277/32 , C07D277/64 , C07D295/108 , C07D295/12 , C07D295/192 , C07D307/06 , C07D307/52 , C07D331/04 , C07D401/10 , C07D405/04
摘要： This document discloses molecules having the following formula (“Formula One”): and processes associated therewith.
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公开(公告)号：US20150018566A1
公开(公告)日：2015-01-15
申请号：US14240985
申请日：2012-08-27
申请人： The Provost, Fellows, Foundation Scholars, & the other Members of Board, of the College of the Holy
发明人： John Jarlath Walsh , Richard Shah , Emmet Martin McCormack , Gillian Joy Hudson , Martina White , Gary Daniel Stack , Brian William Moran , Adrian Coogan , Elaine Carmel Breen
IPC分类号： C07C43/23 , C07D313/08 , C07D311/16 , C07C237/22 , C07C259/06 , C07C225/22 , C07C251/44 , C07C49/755 , C07F9/655
CPC分类号： C07C43/23 , C07C41/26 , C07C45/455 , C07C49/255 , C07C49/753 , C07C49/755 , C07C69/734 , C07C217/74 , C07C217/84 , C07C225/22 , C07C237/22 , C07C251/44 , C07C251/60 , C07C255/47 , C07C259/06 , C07C259/08 , C07C271/24 , C07C309/65 , C07C309/66 , C07C2602/12 , C07D311/16 , C07D311/18 , C07D313/08 , C07D493/18 , C07F7/1804 , C07F9/094 , C07F9/65522 , C07F9/65527 , C07K5/0202
摘要： The invention provides combretastatin A-4 like compounds that are modified to have enhanced tubulin binding activity and in some embodiments the ability to promote accumulation in the vasculature undergoing angiogenesis (homing activity). The compounds are based on the combretastatin A-4 skeletal structure having a tubulin-binding pharmacophore comprising two fused rings (A and B rings) in which the B ring is substituted with (a) an aromatic ring structure (C ring) and (b) a second substituent/functional group that comes off the B ring. The aromatic ring structure is typically a six membered ring phenolic or aniline structure, or may also be a fused ring structure such as a substituted or unsubstituted naphthalene. The second substituent on the B ring may for example be a substituent which has been found to provide enhanced tubulin binding activity (for example a carbonyl group), or may be a substituent that facilitates functionalisation of the B ring (for example an hydroxyl or amine group), or it may be a binding agent for a target that is preferentially expressed on vasculature undergoing angiogenesis, and not expressed on quiescent vasculature.
摘要翻译： 本发明提供了修饰为具有增强的微管蛋白结合活性的科曲他汀A-4类化合物，并且在一些实施方案中是促进经历血管生成（归巢活性）的脉管系统中的积累的能力。 该化合物基于具有微管蛋白结合药效团的考布他汀A-4骨架结构，其包含两个稠环（A和B环），其中B环被（a）芳环结构（C环）和（b ）脱离B环的第二取代基/官能团。 芳环结构通常是六元环酚或苯胺结构，或者也可以是稠环结构，例如取代或未取代的萘。 B环上的第二取代基可以是例如已经发现提供增强的微管蛋白结合活性的取代基（例如羰基），或者可以是促进B环官能化的取代基（例如羟基或胺 或者它可以是优先在经历血管生成的脉管系统上表达并且不在静止脉管系统上表达的靶标的结合剂。
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公开(公告)号：US08278487B2
公开(公告)日：2012-10-02
申请号：US12700280
申请日：2010-02-04
IPC分类号： C07C249/04 , C07C251/44
CPC分类号： C07C249/04
摘要： The present disclosure pertains to a process for preparing an oxime in which a carbonyl compound is reacted in the liquid phase with NH3 and H2O2 in the presence of a catalyst to form the corresponding oxime, wherein the catalyst comprises a catalytic component selected from the oxides of metals of group 5 and group 6. The use of a niobia catalyst is particularly preferred. The process according to the disclosure is suitable for the manufacture of numerous oximes, in particular cyclohexanone oxime.
摘要翻译： 本公开涉及一种制备肟的方法，其中羰基化合物在液相中与NH 3和H 2 O 2在催化剂存在下反应形成相应的肟，其中催化剂包含选自以下的催化剂组分： 第5组和第6组的金属。特别优选使用铌酸催化剂。 根据本公开的方法适用于制造许多肟，特别是环己酮肟。
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