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公开(公告)号：US09725405B2
公开(公告)日：2017-08-08
申请号：US14967896
申请日：2015-12-14
发明人： Geert-Jan Boons , Jun Guo , Xinghai Ning , Margaretha Wolfert
IPC分类号： C07C271/34 , C07C35/37 , C07C49/683 , C07C211/42 , C07C251/44 , C07C251/58 , C07D249/16 , C07D261/20 , C07D271/12 , C07D307/94 , C07D311/90 , C07D495/04 , A61K47/48 , A61K49/00 , C07H21/00 , C07K2/00 , C07K14/00 , G01N33/58
CPC分类号： C07C251/58 , A61K47/54 , A61K47/542 , A61K47/61 , A61K47/62 , A61K47/64 , A61K47/6803 , A61K47/6921 , A61K49/0021 , A61K49/0043 , A61K49/0052 , C07C35/37 , C07C49/683 , C07C211/42 , C07C251/44 , C07C271/34 , C07C2603/36 , C07D249/16 , C07D261/20 , C07D271/12 , C07D307/94 , C07D311/90 , C07D495/04 , C07H21/00 , C07K2/00 , C07K14/00 , G01N33/582
摘要： 1,3-Dipole-functional compounds (e.g., azide functional compounds) can be reacted with certain alkynes in a cyclization reaction to form heterocyclic compounds. Useful alkynes (e.g., strained, cyclic alkynes) and methods of making such alkynes are also disclosed. The reaction of 1,3-dipole-functional compounds with alkynes can be used for a wide variety of applications including the immobilization of biomolecules on a substrate.
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公开(公告)号：US20170320815A1
公开(公告)日：2017-11-09
申请号：US15657601
申请日：2017-07-24
发明人： Geert-Jan Boons , Jun Guo , Xinghai Ning , Margaretha Wolfert
IPC分类号： C07C251/58 , C07K14/00 , C07K2/00 , C07H21/00 , C07D495/04 , C07D311/90 , C07D307/94 , C07D271/12 , C07D261/20 , C07D249/16 , C07C271/34 , C07C251/44 , C07C211/42 , C07C49/683 , C07C35/37 , A61K49/00 , A61K47/68 , A61K47/54 , A61K47/61 , G01N33/58 , C07C2603/36
CPC分类号： C07C251/58 , A61K47/54 , A61K47/542 , A61K47/61 , A61K47/62 , A61K47/64 , A61K47/6803 , A61K47/6921 , A61K49/0021 , A61K49/0043 , A61K49/0052 , C07C35/37 , C07C49/683 , C07C211/42 , C07C251/44 , C07C271/34 , C07C2603/36 , C07D249/16 , C07D261/20 , C07D271/12 , C07D307/94 , C07D311/90 , C07D495/04 , C07H21/00 , C07K2/00 , C07K14/00 , G01N33/582
摘要： 1,3-Dipole-functional compounds (e.g., azide functional compounds) can be reacted with certain alkynes in a cyclization reaction to form heterocyclic compounds. Useful alkynes (e.g., strained, cyclic alkynes) and methods of making such alkynes are also disclosed. The reaction of 1,3-dipole-functional compounds with alkynes can be used for a wide variety of applications including the immobilization of biomolecules on a substrate.
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公开(公告)号：US09932297B2
公开(公告)日：2018-04-03
申请号：US15657601
申请日：2017-07-24
发明人： Geert-Jan Boons , Jun Guo , Xinghai Ning , Margaretha Wolfert
IPC分类号： C07C251/58 , A61K47/54 , G01N33/58 , C07C271/34 , A61K47/61 , C07K14/00 , C07K2/00 , C07D495/04 , C07D311/90 , C07D307/94 , C07D271/12 , C07D261/20 , C07D249/16 , C07C251/44 , C07C211/42 , C07C49/683 , C07C35/37 , A61K49/00 , A61K47/68 , C07H21/00
CPC分类号： C07C251/58 , A61K47/54 , A61K47/542 , A61K47/61 , A61K47/62 , A61K47/64 , A61K47/6803 , A61K47/6921 , A61K49/0021 , A61K49/0043 , A61K49/0052 , C07C35/37 , C07C49/683 , C07C211/42 , C07C251/44 , C07C271/34 , C07C2603/36 , C07D249/16 , C07D261/20 , C07D271/12 , C07D307/94 , C07D311/90 , C07D495/04 , C07H21/00 , C07K2/00 , C07K14/00 , G01N33/582
摘要： 1,3-Dipole-functional compounds (e.g., azide functional compounds) can be reacted with certain alkynes in a cyclization reaction to form heterocyclic compounds. Useful alkynes (e.g., strained, cyclic alkynes) and methods of making such alkynes are also disclosed. The reaction of 1,3-dipole-functional compounds with alkynes can be used for a wide variety of applications including the immobilization of biomolecules on a substrate.
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公开(公告)号：US20160159732A1
公开(公告)日：2016-06-09
申请号：US14967896
申请日：2015-12-14
发明人： Geert-Jan Boons , Jun Guo , Xinghai Ning , Margaretha Wolfert
IPC分类号： C07C251/58 , G01N33/58 , C07C271/34 , A61K47/48 , C07D495/04 , C07D307/94
CPC分类号： C07C251/58 , A61K47/54 , A61K47/542 , A61K47/61 , A61K47/62 , A61K47/64 , A61K47/6803 , A61K47/6921 , A61K49/0021 , A61K49/0043 , A61K49/0052 , C07C35/37 , C07C49/683 , C07C211/42 , C07C251/44 , C07C271/34 , C07C2603/36 , C07D249/16 , C07D261/20 , C07D271/12 , C07D307/94 , C07D311/90 , C07D495/04 , C07H21/00 , C07K2/00 , C07K14/00 , G01N33/582
摘要： 1,3-Dipole-functional compounds (e.g., azide functional compounds) can be reacted with certain alkynes in a cyclization reaction to form heterocyclic compounds. Useful alkynes (e.g., strained, cyclic alkynes) and methods of making such alkynes are also disclosed. The reaction of 1,3-dipole-functional compounds with alkynes can be used for a wide variety of applications including the immobilization of biomolecules on a substrate.
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公开(公告)号：US09227943B2
公开(公告)日：2016-01-05
申请号：US14591290
申请日：2015-01-07
发明人： Geert-Jan Boons , Jun Guo , Xinghai Ning , Margaretha Wolfert
IPC分类号： C07K14/00 , C07C35/37 , C07C49/683 , C07C211/42 , C07C251/44 , C07D261/20 , C07D271/12 , C07D307/94 , C07D311/90 , C07D495/04 , C07D249/16 , A61K47/48 , A61K49/00 , C07H21/00 , C07K2/00
CPC分类号： C07C251/58 , A61K47/54 , A61K47/542 , A61K47/61 , A61K47/62 , A61K47/64 , A61K47/6803 , A61K47/6921 , A61K49/0021 , A61K49/0043 , A61K49/0052 , C07C35/37 , C07C49/683 , C07C211/42 , C07C251/44 , C07C271/34 , C07C2603/36 , C07D249/16 , C07D261/20 , C07D271/12 , C07D307/94 , C07D311/90 , C07D495/04 , C07H21/00 , C07K2/00 , C07K14/00 , G01N33/582
摘要： 1,3-Dipole-functional compounds (e.g., azide functional compounds) can be reacted with certain alkynes in a cyclization reaction to form heterocyclic compounds. Useful alkynes (e.g., strained, cyclic alkynes) and methods of making such alkynes are also disclosed. The reaction of 1,3-dipole-functional compounds with alkynes can be used for a wide variety of applications including the immobilization of biomolecules on a substrate.
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