公开(公告)号：US20240300907A1

公开(公告)日：2024-09-12

申请号：US18497891

申请日：2023-10-30

申请人： Escient Pharmaceuticals, Inc.

发明人： Adam Yeager ,  Brandon Selfridge ,  Marcos Sainz ,  Esther Martinborough ,  Marcus Boehm ,  Liming Huang

IPC分类号： C07D265/30 ,  A61K45/06 ,  C07C69/78 ,  C07C255/41 ,  C07D213/79 ,  C07D241/24 ,  C07D261/18 ,  C07D277/64 ,  C07D333/38

CPC分类号： C07D265/30 ,  C07C69/78 ,  C07C255/41 ,  C07D213/79 ,  C07D241/24 ,  C07D261/18 ,  C07D277/64 ,  C07D333/38 ,  A61K45/06

摘要： Methods are provided for modulating MRGPR X4 generally, or for treating a MRGPR X4 dependent condition more specifically, by contacting the MRGPR X4 or administering to a subject in need thereof, respectively, an effective amount of a compound having the structure of Formula (I):




or a pharmaceutically acceptable isomer, racemate, hydrate, solvate, isotope, or salt thereof, wherein n, x, A, Q1, Q2, Z, R, R1, R2, R3, R4 and R5 are as defined herein. Pharmaceutical compositions containing such compounds, as well as to compounds themselves, are also provided.

公开(公告)号：US20240210824A1

公开(公告)日：2024-06-27

申请号：US18510889

申请日：2023-11-16

申请人： SUMITOMO CHEMICAL COMPANY, LIMITED

发明人： Shohei TERAHIGASHI ,  Haruka HOMMA ,  Koji ICHIKAWA

IPC分类号： G03F7/004 ,  C07C69/757 ,  C07C69/78 ,  C07C381/12 ,  C07D333/76 ,  G03F7/038 ,  G03F7/039

CPC分类号： G03F7/0045 ,  C07C69/757 ,  C07C69/78 ,  C07C381/12 ,  C07D333/76 ,  G03F7/038 ,  G03F7/039 ,  C07C2601/14 ,  C07C2602/42

摘要： Disclosed are a carboxylate represented by formula (I), a carboxylic acid generator and a resist composition:




wherein W represents a cyclic hydrocarbon group, a hydrogen atom included in the cyclic hydrocarbon group may be substituted with a substituent, —CH2— included in the cyclic hydrocarbon group may be replaced by —O—, —S—, —CO— or —SO2—, X1 represents *—CO—O—, *—O—CO—, *—O—CO—O— or *—O— (in which * represents a bonding site to W), L1 represents a single bond or a hydrocarbon group which may have a substituent, —CH2— included in the hydrocarbon group may be replaced by —O—, —S—, —SO2— or —CO—, R4 represents a halogen atom, a haloalkyl group or a hydrocarbon group, the group may have a substituent, —CH2— included in the group may be replaced by —O—, —CO—, —S— or —SO2—, m4 represents an integer of 0 to 3, and Z+ represents an organic cation.

公开(公告)号：US20240167922A1

公开(公告)日：2024-05-23

申请号：US18281175

申请日：2022-03-11

申请人： KYOTO UNIVERSITY

发明人： Takenobu OGAWA ,  Yasuki MATSUMURA

IPC分类号： G01N1/34 ,  C07C39/08 ,  C07C39/10 ,  C07C69/78 ,  C07C69/80 ,  C07C309/29 ,  G01N21/64 ,  G01N33/10

CPC分类号： G01N1/34 ,  C07C39/08 ,  C07C39/10 ,  C07C69/78 ,  C07C69/80 ,  C07C309/29 ,  G01N21/6428 ,  G01N33/10 ,  G01N2021/6439

摘要： Provided are a reagent for transparentizing a carbohydrate- or protein-containing material, the reagent including a compound selected from the group consisting of a benzene carboxylic acid compound, a hydroxybenzene compound, a benzene sulfonic acid compound, a homosulfamine compound, and a benzenesulfohydroxamic acid compound; and a method for transparentizing said material, including processing the carbohydrate- or protein-containing material in said reagent.

公开(公告)号：US20240067597A1

公开(公告)日：2024-02-29

申请号：US18268090

申请日：2021-12-21

申请人： MITSUI CHEMICALS, INC.

发明人： Takaaki YANO ,  Wataru YAMADA ,  Shotaro TAKANO ,  Takashi KIMURA ,  Makoto ISOGAI ,  Takashi NAKANO ,  Sunil Krzysztof MOORTHI

IPC分类号： C07C69/78 ,  C07C35/31 ,  C07C49/553 ,  C07C49/573 ,  C07C49/82 ,  C07C69/76 ,  C07C69/92 ,  C07D317/70

CPC分类号： C07C69/78 ,  C07C35/31 ,  C07C49/553 ,  C07C49/573 ,  C07C49/82 ,  C07C69/76 ,  C07C69/92 ,  C07D317/70 ,  C07C2602/10 ,  C07C2602/44

摘要： [Problem] To provide an internal donor component capable of producing, with high productivity, a propylene polymer having extremely high stereoregularity when used mainly as a solid titanium catalyst component.
[Solution] A polyol ester compound having a specific polycyclic structure represented by formula (1). This ester compound is characterized in that sites including a C-R3 structure and a C-R4 structure satisfy a specific relationship.

公开(公告)号：US20240019779A1

公开(公告)日：2024-01-18

申请号：US17749880

申请日：2022-05-20

申请人： ROHM AND HAAS ELECTRONIC MATERIALS LLC

发明人： Li Cui ,  Emad Aqad ,  Yinjie Cen ,  Conner A. Hoelzel ,  James F. Cameron ,  Jong Keun Park ,  Suzanne M. Coley ,  Choong-Bong Lee

IPC分类号： G03F7/004 ,  C07C317/22 ,  C07C69/78

CPC分类号： G03F7/0045 ,  C07C317/22 ,  C07C2601/16 ,  C07C2601/08 ,  C07C69/78

摘要： A compound represented by Formula (1):




wherein X is a group having a valency of r; each R1 is independently an organic group comprising an acid-labile group; m is an integer greater than or equal to 1; k is an integer from 1 to 5; and r is an integer from 2 to 10, wherein the compound is non-polymeric, and wherein Ar1, L1, L2, R2, and R3 are as defined herein.

公开(公告)号：US11796915B2

公开(公告)日：2023-10-24

申请号：US17196988

申请日：2021-03-09

申请人： Kioxia Corporation

发明人： Norikatsu Sasao ,  Koji Asakawa ,  Shinobu Sugimura

IPC分类号： G03F7/11 ,  C07C69/78 ,  C08F12/22 ,  H01L21/311 ,  H01L21/027 ,  H10B41/27 ,  H10B43/27

CPC分类号： G03F7/11 ,  C07C69/78 ,  C08F12/22 ,  H01L21/0271 ,  H01L21/31116 ,  H01L21/31144 ,  H10B41/27 ,  H10B43/27

摘要： A pattern forming material used for forming an organic film on a film to be processed of a substrate having the film to be processed, the organic film being patterned and then impregnated with a metallic compound to form a composite film which is used as a mask pattern when processing the film to be processed, the pattern forming material contains a polymer including a monomer unit represented by the following general formula (3),






where, R1 is H or CH3, R2 is a C2-14 hydrocarbon group, Q is a C1-20 hydrocarbon group, or an organic group containing an oxygen atom, a nitrogen atom, or a sulfur atom between carbon-carbon atoms or at a bond terminal of a C1-20 hydrocarbon group, and X and Y are independently a hydrogen atom or a C1-4 hydrocarbon group, at least one of them being the C1-4 hydrocarbon group.

公开(公告)号：US11738000B2

公开(公告)日：2023-08-29

申请号：US16988525

申请日：2020-08-07

申请人： Biomedical Analysis Center, Academy Of Military Medical Sciences ,  Institute Of Pharmacology And Toxicology, Academy Of Military Medical Sciences

发明人： Xuemin Zhang ,  Xinhua He ,  Tao Zhou ,  Zhenggang Liu ,  Tao Li

IPC分类号： A61K31/09 ,  A61K31/23 ,  A61K31/325 ,  C07C69/78 ,  C07C271/44 ,  C07C69/28 ,  C07D265/30 ,  C07C271/56 ,  A61K31/222 ,  C07C69/16 ,  A61P37/04 ,  A61P35/04 ,  A61K31/135

CPC分类号： A61K31/325 ,  A61K31/09 ,  A61K31/135 ,  A61K31/222 ,  A61K31/23 ,  A61P35/04 ,  A61P37/04 ,  C07C69/16 ,  C07C69/28 ,  C07C69/78 ,  C07C271/44 ,  C07C271/56 ,  C07D265/30

摘要： Disclosed are hydroquinone compounds, preparation methods therefor, and uses thereof in anti-tumor or immunomodulation. The structural formula of the hydroquinone compounds are shown by formula I,




wherein X is C═O or CH2; Y is NH, O or absent; R is: a substituted or unsubstituted alkyl group having at least one carbon atom, a substituted or unsubstituted cycloalkyl group having at least three carbon atoms, a substituted or unsubstituted alkenyl group or alkynyl group having at least two carbon atoms; and a substituted or unsubstituted aryl group or heteroaryl group containing at least four carbon atoms. The compounds provided slowly release 2-tert-butyl-4-methoxyphenol in vivo and maintain stable plasma concentration of 2-tert-butyl-4-methoxyphenol (T1/2=12-24 h). The compounds provided by the present invention protect the phenolic hydroxyl group of 2-tert-butyl-4-methoxyphenol, avoids environmental oxidation and increase the environmental stability of drugs containing the compounds.

公开(公告)号：US20230242572A1

公开(公告)日：2023-08-03

申请号：US17801514

申请日：2020-08-19

申请人： JIANGXI NORMAL UNIVERSITY

发明人： Junfeng ZHAO ,  Zhengning WANG ,  Xuewei WANG

IPC分类号： C07K1/06 ,  C07C69/145 ,  C07C67/08 ,  C07C69/753 ,  C07C69/78 ,  C07D307/68 ,  C07D231/56 ,  C07D333/70 ,  C07C69/618 ,  C07C69/606 ,  C07C229/22 ,  C07C227/18 ,  C07D209/20 ,  C07C233/05 ,  C07C231/12 ,  C07D233/64 ,  C07D207/16 ,  C07C279/24 ,  C07C277/08 ,  C07C231/14 ,  C07C233/11 ,  C07C233/09 ,  C07D295/185 ,  C07K5/062 ,  C07K5/065 ,  C07K7/06 ,  C07K1/22

CPC分类号： C07K1/064 ,  C07C69/145 ,  C07C67/08 ,  C07C69/753 ,  C07C69/78 ,  C07D307/68 ,  C07D231/56 ,  C07D333/70 ,  C07C69/618 ,  C07C69/606 ,  C07C229/22 ,  C07C227/18 ,  C07D209/20 ,  C07C233/05 ,  C07C231/12 ,  C07D233/64 ,  C07D207/16 ,  C07C279/24 ,  C07C277/08 ,  C07C231/14 ,  C07C233/11 ,  C07C233/09 ,  C07D295/185 ,  C07K5/0606 ,  C07K5/06043 ,  C07K5/06052 ,  C07K5/06078 ,  C07K5/06069 ,  C07K7/06 ,  C07K1/22

摘要： There is provided an α-carbonyl alkenyl ester and a preparation method therefor, and the α-carbonyl alkenyl ester is further used to react with a primary or secondary amine to prepare an amide. The two reactions are combined to develop an amide bond and peptide bond formation method that directly use carboxylic acids and amines as starting materials and allenones as a condensing reagent. The α-carbonyl alkenyl ester corresponding to an α-amino acid serves as a peptide synthesis building block and is used in solid phase peptide synthesis. The method is carried out under mild reaction conditions, simple to operate, and has a high yield. Compared with existing amide bond condensation reagents, the allenones have the advantages of being simple to prepare, having good stability, a low molecular weight, not racemizing when activating α-chiral carboxylic acids, and is a novel amide bond and peptide bond condensing reagent.

公开(公告)号：US20190200609A1

公开(公告)日：2019-07-04

申请号：US16311847

申请日：2017-06-20

申请人： UNIVERSITÄT BASEL ,  FORSCHUNGSINSTITUT FÜR BIOLOGISCHEN LANDBAU (FIBL)

发明人： Matthias HAMBURGER ,  Olivier POTTERAT ,  Justine RAMSEYER ,  Hans-Jakob SCHÄRER ,  Barbara THÜRIG ,  Lucius TAMM ,  Thomas OBERHÄNSLI

IPC分类号： A01N37/10 ,  A01N65/08 ,  C07C69/78 ,  C07C69/618 ,  A01N37/06

CPC分类号： A01N37/10 ,  A01N37/06 ,  A01N65/00 ,  A01N65/08 ,  A01N65/20 ,  C07C69/618 ,  C07C69/78

摘要： The present invention relates to the use of a composition as a fungicide, wherein said composition comprises at least one compound of formula (I) or formula (II), wherein R1=formula (IV) or Formula (V), wherein R2, R3, R4; R5, R6 and R7 are independently of each other H, OH or OCH3.

公开(公告)号：US20190194120A1

公开(公告)日：2019-06-27

申请号：US15762559

申请日：2016-09-22

申请人： XW LABORATORIES INC.

发明人： Jia-Ning Xiang ,  Xuesong Xu ,  Xuan Zhang

IPC分类号： C07C69/78 ,  C07D207/16 ,  C07C255/57 ,  C07C69/618 ,  C07C69/612 ,  C07C69/22 ,  C07C69/74 ,  C07C317/14 ,  C07D213/80 ,  C07D277/30 ,  C07D307/68 ,  C07D333/38 ,  C07C229/08 ,  C07C229/34 ,  C07C233/47 ,  C07D207/12 ,  C07D317/64 ,  C07D309/12 ,  C07D211/44 ,  C07C69/34 ,  C07C69/96 ,  C07D213/79 ,  C07C271/22 ,  C07C271/34

CPC分类号： C07C69/78 ,  C07B59/001 ,  C07C69/22 ,  C07C69/24 ,  C07C69/28 ,  C07C69/34 ,  C07C69/608 ,  C07C69/612 ,  C07C69/618 ,  C07C69/738 ,  C07C69/74 ,  C07C69/76 ,  C07C69/96 ,  C07C229/08 ,  C07C229/34 ,  C07C229/36 ,  C07C233/47 ,  C07C255/57 ,  C07C271/22 ,  C07C271/34 ,  C07C317/14 ,  C07C317/44 ,  C07C2601/06 ,  C07C2601/08 ,  C07C2601/14 ,  C07C2601/16 ,  C07D207/12 ,  C07D207/16 ,  C07D211/44 ,  C07D211/46 ,  C07D213/79 ,  C07D213/80 ,  C07D277/30 ,  C07D277/56 ,  C07D307/68 ,  C07D309/12 ,  C07D317/64 ,  C07D333/38

摘要： The present disclosure discloses prodrugs of gamma-hydroxybutyric acid as well as compositions and uses thereof.