公开(公告)号：US20180355386A1

公开(公告)日：2018-12-13

申请号：US16107349

申请日：2018-08-21

申请人： Shin-Etsu Chemical Co., Ltd.

发明人： Miyoshi Yamashita ,  Takeshi Kinsho

IPC分类号： C12P7/62 ,  C07C69/78 ,  C07C67/08 ,  C07C303/28 ,  C07C29/80 ,  C07C67/10 ,  C07C67/54 ,  C07C29/09 ,  C07C309/66 ,  C07C309/73 ,  C07C33/025 ,  C07C69/145

CPC分类号： C12P7/62 ,  C07B2200/07 ,  C07B2200/09 ,  C07C29/095 ,  C07C29/80 ,  C07C67/08 ,  C07C67/10 ,  C07C67/54 ,  C07C69/78 ,  C07C303/28 ,  C07C309/66 ,  C07C309/73 ,  C07C33/025 ,  C07C69/145

摘要： Provided are methods including a method for industrially producing (2S,12Z)-2-acetoxy-12-heptadecene, which is, for example, a sex pheromone of pistachio twig borer. The methods can include a production method comprising a step of reacting racemic (2RS,12Z)-2-hydroxy-12-heptadecene with vinyl benzoate in the presence of a lipase to obtain a mixture of optically active (2R,12Z)-2-benzoyloxy-12-heptadecene of Formula (R,Z-2) and optically active (2S,12Z)-2-hydroxy-12-heptadecene of Formula (S,Z-1), a step of heating the mixture to distill out the optically active (2S,12Z)-2-hydroxy-12-heptadecene (S,Z-1), and a step of acetylating the optically active (2S,12Z)-2-hydroxy-12-heptadecene (S,Z-1) to obtain optically active (2S,12Z)-2-acetoxy-12-heptadecene of Formula (S,Z-3).

公开(公告)号：US20170275262A1

公开(公告)日：2017-09-28

申请号：US15509026

申请日：2014-09-19

申请人： Tingwei Cai ,  Adam P. Closson ,  Adam Jan Janczuk ,  Ryan D. Oesterle ,  International Flavors & Fragrances Inc.

发明人： Tingwei Cai ,  Adam P. Closson ,  Adam Jan Janczuk ,  Ryan D. Oesterle

IPC分类号： C07D307/20 ,  C07C35/21 ,  C07C69/753 ,  A23L27/20 ,  C11B9/00 ,  A23L33/10 ,  A23G4/06 ,  C07C35/04 ,  C07C43/13

CPC分类号： C07D307/20 ,  A23G4/06 ,  A23L27/20 ,  A23L33/10 ,  A23V2002/00 ,  C07C35/04 ,  C07C35/21 ,  C07C43/13 ,  C07C69/14 ,  C07C69/145 ,  C07C69/753 ,  C07C2601/02 ,  C11B9/003 ,  C11B9/0076

摘要： The present invention relates to novel cyclopropane derivatives represented by Formula I: wherein R represents a hydrocarbon group containing 1-20 carbon atoms or an ester containing 1-20 carbon atoms;wherein R′ represents a C1-C6 acyclic carboxylic acid ester, a C4-C6 cyclic carboxylic acid ester or —OR″, and R″ is selected from the group consisting of H, a C1-C6 acyclic hydrocarbon group, a C3-C6 carbocyclic ring and a C4-C5 heterocyclic ring; andwherein the composition is selected from the group consisting of a flavor composition and a fragrance composition.

公开(公告)号：US09688622B1

公开(公告)日：2017-06-27

申请号：US15436320

申请日：2017-02-17

申请人： Shin-Etsu Chemical Co., Ltd.

发明人： Takeshi Kinsho ,  Naoki Ishibashi ,  Yusuke Nagae

IPC分类号： C07C69/52 ,  C07C309/66 ,  C07C309/73

CPC分类号： C07C309/66 ,  C07C67/287 ,  C07C67/293 ,  C07C67/297 ,  C07C69/63 ,  C07C69/65 ,  C07C309/73 ,  C07C315/04 ,  C07C317/04 ,  C07C317/14 ,  C07C2601/02 ,  C07C69/24 ,  C07C69/145

摘要： Provided is a 1-(2-acyloxyethyl)cyclopropyl sulfonate compound of General Formula (2): wherein R1 is a monovalent hydrocarbon group having 1 to 10 carbon atoms and optionally containing one or more unsaturated bonds and Z is a monovalent hydrocarbon group having 1 to 10 carbon atoms and optionally containing one or more unsaturated bonds.

公开(公告)号：US20170174607A1

公开(公告)日：2017-06-22

申请号：US15382782

申请日：2016-12-19

申请人： International Flavors & Fragrances Inc.

发明人： Ian R. Baxendale ,  James S. Sharley ,  Amadeo Fernández Miranda ,  Ana Maria Collado Pérez

IPC分类号： C07C67/317 ,  C07C67/00 ,  C07C45/27

CPC分类号： C07C67/317 ,  C07C45/27 ,  C07C45/54 ,  C07C67/00 ,  C07C67/313 ,  C07C2101/08 ,  C07C2101/10 ,  C07C2101/14 ,  C07C2101/16 ,  C07C2102/08 ,  C07C2601/08 ,  C07C2601/10 ,  C07C2601/14 ,  C07C2601/16 ,  C07C2602/08 ,  C07C69/73 ,  C07C69/145 ,  C07C69/157 ,  C07C69/757 ,  C07C69/738 ,  C07C49/597 ,  C07C49/683 ,  C07C49/687 ,  C07C49/457 ,  C07C49/697 ,  C07C49/227 ,  C07C47/353

摘要： Copper(II) bromide mediated oxidation of acylated enol and use of the reaction in the synthesis of α,β-unsaturated or α-bromo ketones or aldehydes are disclosed. The method provides an efficient and practical process for manufacturing dehydrohedione (DHH) and many other versatile α,β-unsaturated or α-bromo ketones or aldehydes in large scales to avoid using precious metal compounds.

公开(公告)号：US09676676B2

公开(公告)日：2017-06-13

申请号：US14789848

申请日：2015-07-01

申请人： CALIFORNIA INSTITUTE OF TECHNOLOGY

发明人： John Hartung, Jr. ,  Brendan L. Quigley ,  Peter K. Dornan ,  Robert H. Grubbs

IPC分类号： C07F15/00 ,  C07B37/02 ,  B01J31/22 ,  C07C67/293 ,  C07D207/46 ,  C07F7/18 ,  C07D211/94 ,  C07D471/04 ,  C07D317/12 ,  C07C6/04 ,  C07C29/32 ,  C07C67/343 ,  C07C67/475

CPC分类号： C07B37/02 ,  B01J31/2208 ,  B01J31/2278 ,  B01J2231/54 ,  B01J2231/543 ,  B01J2531/821 ,  C07B2200/09 ,  C07C6/04 ,  C07C29/32 ,  C07C67/293 ,  C07C67/343 ,  C07C67/475 ,  C07C2531/22 ,  C07C2601/08 ,  C07C2601/14 ,  C07C2602/08 ,  C07D207/46 ,  C07D211/94 ,  C07D317/12 ,  C07D471/04 ,  C07F7/1892 ,  C07F15/0046 ,  C07C69/145 ,  C07C69/63 ,  C07C69/78 ,  C07C33/025 ,  C07C69/593 ,  C07C69/608 ,  C07C15/50

摘要： This invention relates generally to C—H activated ruthenium olefin metathesis catalyst compounds which are stereogenic at the ruthenium center, to their preparation, and the use of such catalysts in the metathesis of olefins and olefin compounds. In particular, the invention relates to the use of C—H activated ruthenium olefin metathesis catalyst compounds in Z-selective olefin metathesis reactions, enantio-selective olefin metathesis reactions, and enantio-Z-selective olefin metathesis reactions. The invention has utility in the fields of catalysis, organic synthesis, polymer chemistry, and industrial and fine chemicals chemistry.

公开(公告)号：US09611211B2

公开(公告)日：2017-04-04

申请号：US14974052

申请日：2015-12-18

申请人： Shin-Etsu Chemical Co., Ltd.

发明人： Takeshi Kinsho ,  Naoki Ishibashi ,  Yusuke Nagae

IPC分类号： C07C69/65 ,  C07C309/66 ,  C07C309/73 ,  C07C67/287 ,  C07C67/293 ,  C07C69/63 ,  C07C67/297 ,  C07C315/04 ,  C07C317/04 ,  C07C317/14

CPC分类号： C07C309/66 ,  C07C67/287 ,  C07C67/293 ,  C07C67/297 ,  C07C69/63 ,  C07C69/65 ,  C07C309/73 ,  C07C315/04 ,  C07C317/04 ,  C07C317/14 ,  C07C2601/02 ,  C07C69/24 ,  C07C69/145

摘要： Provided is a simple, selective and efficient method for producing 4-alkyl-3-methylenebutyl carboxylates such as 7-methyl-3-methylene-7-octenyl propionate. More specifically, provided is, for example, a method for producing a 4-alkyl-3-methylenebutyl carboxylate compound, comprising an acyloxylation step of subjecting a 1-(2-haloethyl)cyclopropyl sulfonate compound (1) to acyloxylation to obtain a 1-(2-acyloxyethyl)cyclopropyl sulfonate compound (2), a halogenation step of subjecting the compound (2) to halogenation involving cyclopropyl-allyl rearrangement to obtain a 3-halomethyl-3-butenyl carboxylate compound (3), and a coupling step of subjecting the compound (3) to a coupling reaction with an organometallic reagent (4) to obtain the 4-alkyl-3-methylenebutyl carboxylate compound (5).

公开(公告)号：US09550720B2

公开(公告)日：2017-01-24

申请号：US14984343

申请日：2015-12-30

申请人： Shin-Etsu Chemical Co., Ltd.

发明人： Miyoshi Yamashita ,  Takehiko Fukumoto ,  Takeshi Kinsho

IPC分类号： C07C45/43 ,  C07C67/10 ,  C07C45/42 ,  C07C47/24 ,  C07C67/11 ,  C07C17/263

CPC分类号： C07C67/10 ,  C07C17/2635 ,  C07C45/42 ,  C07C45/43 ,  C07C47/24 ,  C07C67/11 ,  C07C69/145 ,  C07C21/22

摘要： Provided is a method for industrially producing a conjugated Z-alken-yn-yl acetate such as Z-13-hexadecen-11-yn-yl acetate which is a sex pheromone component of a pine processionary moth, and an intermediate for the conjugated Z-alken-yn-yl acetate under mild conditions at a high yield. More specifically, provided is a method for producing a conjugated Z-alken-yn-yl acetate (5) comprising the steps of: reacting an ω-halo-2-alkynal (1) with an alkylidene triphenylphosphorane (3) through a Wittig reaction to obtain a conjugated Z-alken-yn-yl halide (4), and acetoxylating the conjugated Z-alken-yn-yl halide (4) into a conjugated Z-alken-yn-yl acetate (5).

摘要翻译： 本发明提供了工业上制造Z-联烯基乙酸酯的共轭Z-烯酸乙酯的方法，例如作为松木酰蛾的性信息素成分的Z-13-十六碳烯-11-炔酸乙酯，和共轭Z - 烯酸乙酯在温和条件下以高产率。 更具体地，提供了一种制备共轭Z-烯酸乙酯（5）的方法，包括以下步骤：使-卤-2-炔（1）与亚烷基三苯基正膦（3）通过Wittig反应 得到共轭的Z-烯烃基卤化物（4），并将共轭的Z-烯烃基卤化物（4）乙酰氧化成共轭的Z-烯酸乙酯（5）。

公开(公告)号：US09505699B2

公开(公告)日：2016-11-29

申请号：US14889291

申请日：2014-05-07

申请人： DSM IP ASSETS B. V.

发明人： Werner Bonrath ,  Johannes Tschumi ,  Fabrice Aquino

IPC分类号： C07C67/08 ,  C07C69/145 ,  B01J31/02 ,  B01J31/26

CPC分类号： C07C67/08 ,  B01J31/0225 ,  B01J31/0232 ,  B01J31/26 ,  C07C69/145

摘要： The present invention is related to a novel and improved process for the production of dehydrolinalyl acetate (DLA), which IUPAC name is acetic acid 1-ethynyl-1,5-dimethyl-hex-4-enyl ester, starting from dehydrolinalool (DLL), which IUPAC name is 3,7-dimethyloct-6-en-1-yn-3-ol, by catalytic acetylation.

摘要翻译： 本发明涉及一种新型改进的乙酸脱乙酰醋酸酯（DLA）的制备方法，IUPAC的名称是乙酸1-乙炔基-1,5-二甲基 - 己-4-烯酯，由脱氢罗兰尼醇（DLL）开始， ，其IUPAC名称是3,7-二甲基-6-烯-1-基-3-醇，通过催化乙酰化。

公开(公告)号：US09415374B2

公开(公告)日：2016-08-16

申请号：US14395150

申请日：2013-04-17

申请人： DSM IP ASSETS B.V.

发明人： Werner Bonrath

IPC分类号： C07C33/02 ,  B01J19/24 ,  B01J23/44 ,  B01J10/00 ,  B01J12/00 ,  B01J19/00 ,  B01J19/02 ,  B01J35/00 ,  B01J35/04 ,  C07C29/17 ,  C10G45/40 ,  B01J23/889 ,  B01J23/883 ,  B01J23/885 ,  B01J23/887 ,  B01J23/89 ,  B01J37/02 ,  C07C67/283 ,  C10G3/00 ,  B01J23/60 ,  B01J21/04 ,  B01J23/06

CPC分类号： B01J23/44 ,  B01J10/007 ,  B01J12/007 ,  B01J19/0093 ,  B01J19/02 ,  B01J19/2415 ,  B01J19/2485 ,  B01J21/04 ,  B01J23/06 ,  B01J23/60 ,  B01J23/883 ,  B01J23/885 ,  B01J23/8876 ,  B01J23/8878 ,  B01J23/8892 ,  B01J23/8993 ,  B01J35/0006 ,  B01J35/006 ,  B01J35/04 ,  B01J37/0201 ,  B01J2219/00094 ,  B01J2219/00792 ,  B01J2219/00822 ,  B01J2219/00824 ,  B01J2219/00835 ,  B01J2219/0086 ,  B01J2219/00873 ,  B01J2219/0277 ,  B01J2219/2403 ,  B01J2219/2411 ,  B01J2219/2428 ,  B01J2219/2435 ,  B01J2219/2437 ,  B01J2219/2444 ,  C07C29/17 ,  C07C67/283 ,  C10G3/47 ,  C10G3/50 ,  C10G45/40 ,  Y02P30/20 ,  C07C33/03 ,  C07C33/02 ,  C07C69/145

摘要： The present invention relates to a device for treatment of material transported through the device comprising at least one porous element consisting of specific solid metallic structure which allows cross-flow of the material through the porous element and wherein the porous element is coated by a non-acidic metal oxide which is impregnated by palladium (Pd).

摘要翻译： 本发明涉及一种用于处理通过该装置输送的材料的装置，包括至少一个由特定固体金属结构组成的多孔元件，该多孔元件允许材料跨过多孔元件的交叉流动，并且其中多孔元件被非金属结构涂覆， 用钯（Pd）浸渍的酸性金属氧化物。

公开(公告)号：US20160229829A1

公开(公告)日：2016-08-11

申请号：US15014598

申请日：2016-02-03

申请人： Shin-Etsu Chemical Co., Ltd.

发明人： Yuki Miyake ,  Takeshi Kinsho ,  Miyoshi Yamashita ,  Naoki Ishibashi ,  Yusuke Nagae ,  Akihiro Baba

IPC分类号： C07D309/12 ,  C07C45/26 ,  C07C67/40 ,  C07C41/48

CPC分类号： C07D309/12 ,  C07B2200/09 ,  C07C2/861 ,  C07C17/266 ,  C07C17/269 ,  C07C29/103 ,  C07C29/32 ,  C07C41/48 ,  C07C45/26 ,  C07C45/515 ,  C07C67/08 ,  C07C67/40 ,  C07C2527/122 ,  C07C33/04 ,  C07C21/22 ,  C07C43/303 ,  C07C43/30 ,  C07C47/21 ,  C07C33/02 ,  C07C69/145 ,  C07C11/22 ,  C07C2/32

摘要： Provided are a method for efficiently producing an asymmetric conjugated diyne from an inexpensive and safe alternative compound to hydroxylamine hydrochloride and a method for producing a Z,Z-conjugated diene compound from the asymmetric conjugated diyne compound thus obtained. More specifically, provided is a method for producing an asymmetric conjugated diyne compound comprising a step of subjecting a terminal alkyne compound (1): HC≡C—Z1—Y1 to a coupling reaction with an alkynyl halide (2) Y2—Z2—C≡C—X by using sodium borohydride in water and an organic solvent in the presence of a copper catalyst and a base to obtain the asymmetric conjugated diyne compound (3): Y2—Z2—C≡C—C≡C—Z1—Y1. In addition, provided is a method for producing a Z,Z-conjugated diene compound by reducing the resulting asymmetric conjugated diyne compound, or the like.

摘要翻译： 提供了从廉价且安全的替代化合物到盐酸羟胺有效地制备不对称共轭二炔的方法和由此获得的不对称共轭二炔化合物制备Z，Z-共轭二烯化合物的方法。 更具体地说，提供了一种制备不对称共轭二炔化合物的方法，包括使末端炔化合物（1）：HC≡C-Z1-Y1与炔基卤（2）Y2-Z2-C的偶联反应 ≡C-X通过使用硼氢化钠在水和有机溶剂中，在铜催化剂和碱的存在下，得到不对称共轭二炔化合物（3）：Y2-Z2-C≡C-C≡C-Z1-Y1 。 此外，提供了通过还原所得的不对称共轭二炔化合物等制备Z，Z-共轭二烯化合物的方法。