公开(公告)号：US09988329B1

公开(公告)日：2018-06-05

申请号：US15427691

申请日：2017-02-08

申请人： Eastman Chemical Company

发明人： Mesfin Ejerssa Janka ,  Robert Thomas Hembre ,  Scott Donald Barnicki ,  Robert Scott Huss ,  Xiaopeng Shan ,  Stephanie Rollins Testerman ,  Timothy Alan Upshaw ,  Dewey Wayne Fuller, Jr.

IPC分类号： C07C29/14 ,  C07C29/50 ,  C07C45/62 ,  C07C51/00 ,  C07C29/80 ,  C07C45/82 ,  C07C51/44 ,  B01J23/755 ,  B01J23/883 ,  B01J23/887

CPC分类号： C07C29/14 ,  B01J23/755 ,  B01J23/883 ,  B01J23/8878 ,  C07C29/143 ,  C07C29/80 ,  C07C45/29 ,  C07C45/62 ,  C07C45/74 ,  C07C45/82 ,  C07C51/00 ,  C07C51/44 ,  C07C49/08 ,  C07C49/10 ,  C07C31/125 ,  C07C47/02 ,  C07C31/12 ,  C07C47/21

摘要： A transfer-hydrogenation process for preparing a carbonyl compound and an alcohol compound comprises the steps of (a) contacting a first carbonyl compound with a first alcohol compound in the presence of a transfer-hydrogenation catalyst in a first reaction zone at conditions effective to form a second carbonyl compound from the first alcohol compound and a second alcohol compound from the first carbonyl compound, and (b) removing the second carbonyl compound from the first reaction zone during step (a). The first carbonyl compound is a saturated aldehyde or ketone, or an α,β-unsaturated aldehyde or ketone. The first alcohol compound is a primary or secondary alcohol. The second alcohol compound is α,β-saturated. The transfer-hydrogenation catalyst includes a Group 8 to 11 metal. This process is useful for preparing and higher value alcohols, such as butanol or 2-ethylhexanol, from the corresponding carbonyl compounds by engaging lower alcohol (C2-C4) feedstocks instead of hydrogen (H2).

公开(公告)号：US09845304B2

公开(公告)日：2017-12-19

申请号：US15014598

申请日：2016-02-03

申请人： Shin-Etsu Chemical Co., Ltd.

发明人： Yuki Miyake ,  Takeshi Kinsho ,  Miyoshi Yamashita ,  Naoki Ishibashi ,  Yusuke Nagae ,  Akihiro Baba

IPC分类号： C07C17/266 ,  C07C17/269 ,  C07C2/86 ,  C07C29/10 ,  C07C29/32 ,  C07C41/48 ,  C07C45/26 ,  C07C45/51 ,  C07C67/08 ,  C07C67/40 ,  C07D309/12

CPC分类号： C07D309/12 ,  C07B2200/09 ,  C07C2/861 ,  C07C17/266 ,  C07C17/269 ,  C07C29/103 ,  C07C29/32 ,  C07C41/48 ,  C07C45/26 ,  C07C45/515 ,  C07C67/08 ,  C07C67/40 ,  C07C2527/122 ,  C07C33/04 ,  C07C21/22 ,  C07C43/303 ,  C07C43/30 ,  C07C47/21 ,  C07C33/02 ,  C07C69/145 ,  C07C11/22 ,  C07C2/32

摘要： Provided are a method for efficiently producing an asymmetric conjugated diyne from an inexpensive and safe alternative compound to hydroxylamine hydrochloride and a method for producing a Z,Z-conjugated diene compound from the asymmetric conjugated diyne compound thus obtained. More specifically, provided is a method for producing an asymmetric conjugated diyne compound comprising a step of subjecting a terminal alkyne compound (1): HC≡C—Z1—Y1 to a coupling reaction with an alkynyl halide (2): Y2—Z2—C≡C—X by using sodium borohydride in water and an organic solvent in the presence of a copper catalyst and a base to obtain the asymmetric conjugated diyne compound (3): Y2—Z2—C≡C—C≡C—Z1—Y1. In addition, provided is a method for producing a Z,Z-conjugated diene compound by reducing the resulting asymmetric conjugated diyne compound, or the like.

公开(公告)号：US20170297987A1

公开(公告)日：2017-10-19

申请号：US15473150

申请日：2017-03-29

申请人： SHIN-ETSU CHEMICAL CO., LTD.

发明人： Akihiro Baba ,  Yuki MIYAKE ,  Takeshi KINSHO

IPC分类号： C07C43/315 ,  C07C41/48

CPC分类号： C07C43/315 ,  C07C41/20 ,  C07C41/30 ,  C07C41/48 ,  C07C43/178 ,  C07C45/42 ,  C07C45/81 ,  C07C45/82 ,  C07C47/21 ,  C07C303/28 ,  C07C47/02 ,  C07C43/313 ,  C07C43/303 ,  C07C309/66

摘要： Provided are a method for producing a terminal conjugated dienal compound without an oxidation reaction and a terminal hydroxyacetal compound useful as an intermediate in the method. More specifically, provided are a method for producing an (E)-dienal compound comprising the steps of: a metalation reaction of an alkynal acetal compound (1) to obtain an organic metal compound (2), an addition reaction of (2) to ethylene oxide to obtain a hydroxyalkynal acetal compound (3), a reduction reaction of (3) to obtain an (E)-hydroxyalkenal acetal compound (4), a functional group conversion reaction of (4) to obtain an (E)-alkenal acetal compound (5) having a leaving group X, an elimination reaction of (5) to obtain an (E)-dienal acetal compound (6), and a hydrolysis reaction of (6) to obtain the (E)-dienal compound (7); and others.

公开(公告)号：US09765003B2

公开(公告)日：2017-09-19

申请号：US15308755

申请日：2015-05-04

申请人： BASF SE

发明人： Nicolas Vautravers ,  Joaquim H. Teles ,  Ralf Pelzer ,  Daniel Schneider

IPC分类号： C07C45/28 ,  C07C45/00 ,  C07C45/82

CPC分类号： C07C45/002 ,  C07B2200/07 ,  C07C45/28 ,  C07C45/82 ,  C07C47/21

摘要： The present invention relates to a process for producing 2,6-dimethyl-5-hepten-1-al, which comprises reacting 3,7-dimethyl-1,6-octadiene (dihydromyrcene, beta-citronellene) with N2O in a solvent or solvent mixture containing at least one solvent having a proton-donating functional group.

公开(公告)号：US09758499B2

公开(公告)日：2017-09-12

申请号：US15398094

申请日：2017-01-04

申请人： The Florida State University Research Foundation, Inc.

发明人： Dinesh V. Vidhani ,  Marie E. Krafft ,  Igor Alabugin

IPC分类号： C07D307/46 ,  C07C41/08 ,  C07C45/51 ,  C07C253/30 ,  C07D307/42

CPC分类号： C07D307/46 ,  C07C41/08 ,  C07C45/513 ,  C07C253/30 ,  C07D307/42 ,  C07C255/56 ,  C07C255/54 ,  C07C47/21 ,  C07C43/16 ,  C07C43/164 ,  C07C43/162 ,  C07C47/232 ,  C07C47/225

摘要： A novel Rh(I)-catalyzed approach to synthesizing functionalized (E,Z) dienal compounds has been developed via tandem transformation where a stereoselective hydrogen transfer follows a propargyl Claisen rearrangement. Z-Stereochemistry of the first double bond suggests the involvement of a six-membered cyclic intermediate whereas the E-stereochemistry of the second double bond stems from the subsequent protodemetallation step giving an (E,Z)-dienal. The reaction may be represented by the following sequence.

公开(公告)号：US20170137365A1

公开(公告)日：2017-05-18

申请号：US15354916

申请日：2016-11-17

申请人： PROVIVI, INC.

发明人： KEITH M. WAMPLER ,  PETER MEINHOLD ,  PEDRO COELHO ,  VU BUI ,  LEVENTE ONDI ,  HASAN MEHDI

IPC分类号： C07C67/293 ,  B01J31/22 ,  C07C69/533

CPC分类号： B01J31/2278 ,  B01J2231/543 ,  B01J2531/64 ,  B01J2531/66 ,  C07B2200/09 ,  C07C6/04 ,  C07C29/147 ,  C07C45/41 ,  C07C67/08 ,  C07C67/293 ,  C07C67/343 ,  C07C2531/22 ,  C07C69/533 ,  C07C33/025 ,  C07C69/145 ,  C07C47/21 ,  C07C11/21

摘要： In one aspect, the invention provides a method for synthesizing a fatty olefin derivative. The method includes: a) contacting an olefin according to Formula I with a metathesis reaction partner according to Formula IIb in the presence of a metathesis catalyst under conditions sufficient to form a metathesis product according to Formula IIIb: and b) converting the metathesis product to the fatty olefin derivative. Each R1 is independently selected from H, C1-18 alkyl, and C2-18 alkenyl; R2b is C1-8 alkyl; subscript y is an integer ranging from 0 to 17; and subscript z is an integer ranging from 0 to 17. In certain embodiments, the metathesis catalyst is a tungsten catalyst or a molybdenum catalyst. In various embodiments, the fatty olefin derivative is a pheromone. Pheromone compositions and methods of using them are also described.

公开(公告)号：US20170129865A1

公开(公告)日：2017-05-11

申请号：US15398094

申请日：2017-01-04

申请人： The Florida State University Research Foundation, Inc.

发明人： Dinesh V. Vidhani ,  Marie E. Krafft ,  Igor Alabugin

IPC分类号： C07D307/46 ,  C07D307/42 ,  C07C253/30 ,  C07C45/51 ,  C07C41/08

CPC分类号： C07D307/46 ,  C07C41/08 ,  C07C45/513 ,  C07C253/30 ,  C07D307/42 ,  C07C255/56 ,  C07C255/54 ,  C07C47/21 ,  C07C43/16 ,  C07C43/164 ,  C07C43/162 ,  C07C47/232 ,  C07C47/225

摘要： A novel Rh(I)-catalyzed approach to synthesizing functionalized (E,Z) dienal compounds has been developed via tandem transformation where a stereoselective hydrogen transfer follows a propargyl Claisen rearrangement. Z-Stereochemistry of the first double bond suggests the involvement of a six-membered cyclic intermediate whereas the E-stereochemistry of the second double bond stems from the subsequent protodemetallation step giving an (E,Z)-dienal. The reaction may be represented by the following sequence.

公开(公告)号：US09554990B2

公开(公告)日：2017-01-31

申请号：US14984752

申请日：2015-12-30

申请人： J-OIL MILLS, INC.

发明人： Hiroshi Hara ,  Tohru Hira ,  Chigusa Nishiyama ,  Noriko Tokura ,  Takatoshi Yamashita ,  Jun Imagi

IPC分类号： A61K31/11 ,  A61K31/19 ,  C07C47/21 ,  A61K9/00

CPC分类号： A61K9/0056 ,  A23L33/10 ,  A23V2002/00 ,  A61K31/11 ,  A61K31/19 ,  C07C47/21

摘要： A method is provided to promote secretion of cholecystokinin (CCK) by administering an active component. The active component includes acrylic acid and/or an unsaturated aldehyde having a main chain of 4 to 12 carbon atoms having a double bond in at least position 2 or 4, where the main chain has 4 to 9 carbon atoms when there is a double bond in only position 2, and the main chain has 9 to 12 carbon atoms when there is a double bond in only position 4. The cholecystokinin secretion-promoting composition can be used as an appetite suppressant. By adding this cholecystokinin secretion-promoting composition to food, appetite-suppressing food products can be provided.

摘要翻译： 提供一种通过施用活性成分促进胆囊收缩素（CCK）分泌的方法。 活性组分包括丙烯酸和/或具有4-12个碳原子的主链的不饱和醛，其在至少2或4位具有双键，当存在双键时，主链具有4至9个碳原子 仅在位置2，当仅在位置4存在双键时，主链具有9至12个碳原子。缩胆囊素分泌促进组合物可以用作食欲抑制剂。 通过将该缩胆囊素分泌促进组合物加入到食品中，可以提供食欲抑制食品。

公开(公告)号：US20160280625A1

公开(公告)日：2016-09-29

申请号：US15033709

申请日：2014-11-14

申请人： OXEA GMBH

发明人： Jens THEUERKAUF ,  Heinz STRUTZ

IPC分类号： C07C51/235 ,  C07C45/75 ,  C07C45/50

CPC分类号： C07C51/235 ,  C07C45/50 ,  C07C45/62 ,  C07C45/66 ,  C07C45/75 ,  C07C47/02 ,  C07C47/19 ,  C07C47/21 ,  C07C53/126

摘要： A process for preparing isomeric hexanoic acids comprising 2-methylpentanoic acid from the secondary streams obtained in the preparation of pentanals, characterized in that a) a mixture comprising linear butenes is reacted to give a pentanal mixture; b) the mixture obtained in step a) is separated into a stream enriched with 2-methylbutanal and 3-methyl-butanal, and a stream enriched with n-pentanal; c) the stream enriched with 2-methylbutanal and 3-methylbutanal of step b) is reacted with formaldehyde; d) the reaction mixture obtained after step c) is selectively reacted to give a mixture comprising 2-methylbutanal and isomeric hexanals; e) the reaction mixture is separated into a stream enriched with 2-methylbutanal and a stream enriched with a mixture of isomeric hexanals; and f) the mixture of isomeric hexanals obtained in step e) is oxidized to a mixture of isomeric hexanoic acids comprising 2-methylpentanoic acid.

摘要翻译： 从戊醛制备中获得的二次流中制备包含2-甲基戊酸的异构己酸的方法，其特征在于a）包含线性丁烯的混合物反应得到戊醛混合物; b）将步骤a）中获得的混合物分离成富含2-甲基丁醛和3-甲基 - 丁醛的物流和富含正戊醛的物流; c）将富含步骤b）的2-甲基丁醛和3-甲基丁醛的料流与甲醛反应; d）将步骤c）后获得的反应混合物选择性地反应，得到包含2-甲基丁醛和异构己醛的混合物; e）将反应混合物分离成富含2-甲基丁醛的流和富含异构己醛混合物的流; 和f）将步骤e）中获得的异构己醛的混合物氧化成包含2-甲基戊酸的异构己酸的混合物。

公开(公告)号：US09416082B2

公开(公告)日：2016-08-16

申请号：US14768222

申请日：2014-02-07

申请人： FIRMENICH SA

发明人： Ramez Boshra ,  Koenraad Vanhessche ,  Anatoly Alexander

IPC分类号： C07C45/67

CPC分类号： C07C45/67 ,  C07C2601/10 ,  C07C2601/14 ,  C07C49/597 ,  C07C47/21

摘要： The present invention concerns a process for the isomerization of an exo double bond toward an endo double bond being performed in the presence of a catalyst system comprising palladium (Pd) or platinum (Pt) and molecular hydrogen or a hydrogen source.

摘要翻译： 本发明涉及在包含钯（Pd）或铂（Pt）和分子氢或氢源的催化剂体系的存在下进行的外双键向内双键异构化的方法。