公开(公告)号：US11691956B2

公开(公告)日：2023-07-04

申请号：US17623405

申请日：2020-07-06

Applicant: NDSU RSEARCH FOUNDATION

Inventor： Dean C. Webster ,  Mukund P. Sibi ,  Catherine A. Sutton ,  Deep J. Kalita ,  Eric M. Serum

IPC: C07D307/42 ,  C07D407/14 ,  C09D163/00 ,  C08G59/04 ,  C08G59/26

CPC classification number: C07D307/42 ,  C07D407/14 ,  C08G59/04 ,  C08G59/26 ,  C09D163/00

Abstract: The invention relates to diols derived from 5-hydroxymethyl furfural, diformyl furan, or derivatives thereof. The invention further relates to diglycidyl ethers derived from the diols of the invention, curable coating compositions containing the diglycidyl ethers, and objects coated with the curable coating compositions. The invention also relates to composites, composites, adhesives, and films containing the diglycidyl ethers of the invention. The invention also relates to methods of making the diols, diglycidyl ethers, and curable coating compositions.

公开(公告)号：US20230192908A1

公开(公告)日：2023-06-22

申请号：US17926337

申请日：2021-05-18

Applicant: Bowling Green State University

Inventor： Jayaraman Sivaguru ,  Ravichandranath Singathi

IPC: C08F2/50 ,  C08F120/14 ,  C08F120/28 ,  C08F122/20 ,  C07C49/84 ,  C07D307/42

CPC classification number: C08F2/50 ,  C08F120/14 ,  C08F120/28 ,  C08F122/20 ,  C07C49/84 ,  C07D307/42

Abstract: Biomass derived benzophenone derivatives, and methods of making and using the same, are described. In accordance with the present disclosure, biomass derived benzophenone derivatives are useful as visible light photoinitiators.

公开(公告)号：US20180163016A1

公开(公告)日：2018-06-14

申请号：US15374314

申请日：2016-12-09

Applicant: International Business Machines Corporation

Inventor： Scott B. KING ,  Brandon M. KOBILKA ,  Joseph KUCZYNSKI ,  Jason T. WERTZ

IPC: C08K5/00 ,  C07D307/66 ,  C07D307/68 ,  C07D307/42 ,  C08K5/1535 ,  C08K5/378 ,  C08K5/5435 ,  C08K5/17

CPC classification number: C08K5/0025 ,  C07D307/42 ,  C07D307/66 ,  C07D307/68 ,  C08K5/1535 ,  C08K5/17 ,  C08K5/378 ,  C08K5/5435

Abstract: A class of bio-based bifuran cross-linkers are disclosed. Polymers cross-linked using the cross-linkers are also disclosed.

公开(公告)号：US09845317B2

公开(公告)日：2017-12-19

申请号：US15142418

申请日：2016-04-29

Applicant: The Board of Trustees of the University of Illinois

Inventor： Martin D. Burke ,  David M. Knapp ,  Eric P. Gillis

IPC: C07F5/02 ,  C07F5/04 ,  C07D413/04 ,  C07C1/32 ,  C07C41/30 ,  C07D207/325 ,  C07D213/73 ,  C07D241/42 ,  C07D263/56 ,  C07D307/42 ,  C07D401/04 ,  C07D405/12 ,  C07D409/04 ,  C07B61/00 ,  C07D207/333 ,  C07D209/12 ,  C07D307/36 ,  C07D307/80 ,  C07D333/16 ,  C07D405/04 ,  C07D207/34 ,  C07D209/30 ,  C07D213/16 ,  C07D213/50 ,  C07D213/57

CPC classification number: C07D413/04 ,  C07B61/00 ,  C07C1/321 ,  C07C41/30 ,  C07C2527/173 ,  C07C2531/12 ,  C07C2531/24 ,  C07C2601/02 ,  C07D207/325 ,  C07D207/333 ,  C07D207/34 ,  C07D209/12 ,  C07D209/30 ,  C07D213/16 ,  C07D213/50 ,  C07D213/57 ,  C07D213/73 ,  C07D241/42 ,  C07D263/56 ,  C07D307/36 ,  C07D307/42 ,  C07D307/80 ,  C07D333/16 ,  C07D401/04 ,  C07D405/04 ,  C07D405/12 ,  C07D409/04 ,  Y02P20/55 ,  C07C15/46 ,  C07C15/58 ,  C07C13/28 ,  C07C43/2055

Abstract: A method of performing a chemical reaction includes reacting a compound selected from the group consisting of an organohalide and an organo-pseudohalide, and a protected organoboronic acid represented by formula (I) in a reaction mixture: R1—B-T  (I); where R1 represents an organic group, T represents a conformationally rigid protecting group, and B represents boron having sp3 hybridization. When unprotected, the corresponding organoboronic acid is unstable by the boronic acid neat stability test. The reaction mixture further includes a base having a pKB of at least 1 and a palladium catalyst. The method further includes forming a cross-coupled product in the reaction mixture.

公开(公告)号：US20170355658A1

公开(公告)日：2017-12-14

申请号：US15535289

申请日：2015-11-19

Applicant: Archer Daniels Midland Company

Inventor： Chi Cheng Ma ,  Kenneth Stensrud ,  Padmesh Venkitasubramanian

IPC: C07C68/06 ,  C07C68/04 ,  C07C41/16 ,  C07D493/04 ,  C07D307/42 ,  C07D307/12 ,  C07C43/10 ,  C07C43/12

CPC classification number: C07C68/06 ,  C07C41/16 ,  C07C43/10 ,  C07C43/12 ,  C07C68/04 ,  C07D307/12 ,  C07D307/42 ,  C07D493/04 ,  Y02P20/142 ,  C07C43/13

Abstract: A method of etherifying glycols or other diols by employing renewable reagents is disclosed. In particular, the method involves contacting a diol with an alkylating agent in an alcoholic solvent, catalyzed with a catalyst (carbonic acid) generated in situ (from CO2). The mono- and di-ether products can serve as valued precursors to an array of renewable surfactants, dispersants, and lubricants, among others.

公开(公告)号：US20170275224A1

公开(公告)日：2017-09-28

申请号：US15620395

申请日：2017-06-12

Applicant: Unigen, Inc.

Inventor： Sandip K. Nandy ,  Jiyun Liu ,  Alexandre Mikhailovitch Nesterov ,  Carmen Hertel ,  Abeysinghe Arrachchigae Papmapiya

IPC: C07C43/295 ,  C07D317/54 ,  A23L3/3481 ,  A61K8/34 ,  A61K8/49 ,  A61K31/09 ,  A61K31/341 ,  A61K31/357 ,  A61K31/4406 ,  A61Q19/02 ,  A61Q19/08 ,  C07C39/11 ,  C07C39/15 ,  C07C43/23 ,  C07C45/67 ,  C07C45/74 ,  C07C49/83 ,  C07D213/30 ,  C07D213/64 ,  C07D263/57 ,  C07D307/12 ,  C07D307/42 ,  C07C49/84 ,  A23B7/154

CPC classification number: C07C43/295 ,  A23B7/154 ,  A23L3/3481 ,  A61K8/345 ,  A61K8/347 ,  A61K8/4926 ,  A61K8/4973 ,  A61K31/09 ,  A61K31/341 ,  A61K31/357 ,  A61K31/4406 ,  A61K2800/782 ,  A61Q19/02 ,  A61Q19/08 ,  C07C39/11 ,  C07C39/15 ,  C07C43/23 ,  C07C45/673 ,  C07C45/74 ,  C07C49/83 ,  C07D213/30 ,  C07D213/64 ,  C07D263/57 ,  C07D307/12 ,  C07D307/42 ,  C07D317/54 ,  C07C49/84

Abstract: The present invention is directed to inhibitors of tyrosinase, pharmaceutical compositions comprising such tyrosinase inhibitors, and methods of making and using the same. Specifically, included in the present invention are compositions of matter comprised of at least one 2,4-dihydroxybenzene analog, which inhibit the activity of tyrosinase and which inhibit the overproduction of melanin.

公开(公告)号：US09765085B2

公开(公告)日：2017-09-19

申请号：US14772731

申请日：2014-02-27

Applicant: Aquinox Pharmaceuticals (Canada) Inc.

Inventor： Lloyd F. Mackenzie ,  Thomas B. MacRury ,  Curtis Harwig ,  David Bogucki ,  Jeffery R. Raymond ,  Jeremy D. Pettigrew

IPC: C07D231/54 ,  A61K31/416 ,  C07D493/10 ,  C07D213/75 ,  C07D213/82 ,  C07D215/227 ,  C07C275/22 ,  C07D221/18 ,  C07C215/26 ,  C07C215/38 ,  C07C335/10 ,  C07C233/23 ,  C07D261/20 ,  C07D277/24 ,  C07D277/28 ,  C07C255/30 ,  C07D211/58 ,  C07D213/30 ,  C07D307/42 ,  C07D333/16 ,  C07D231/56 ,  C07D277/64 ,  C07C35/21 ,  C07C35/23 ,  C07D213/38 ,  C07D221/16 ,  C07D307/52 ,  C07D333/20

CPC classification number: C07D493/10 ,  A61K31/416 ,  C07C35/21 ,  C07C35/23 ,  C07C215/26 ,  C07C215/38 ,  C07C233/23 ,  C07C255/30 ,  C07C275/22 ,  C07C335/10 ,  C07C2601/14 ,  C07C2602/24 ,  C07D211/58 ,  C07D213/30 ,  C07D213/38 ,  C07D213/75 ,  C07D213/82 ,  C07D215/227 ,  C07D221/16 ,  C07D221/18 ,  C07D231/54 ,  C07D231/56 ,  C07D261/20 ,  C07D277/24 ,  C07D277/28 ,  C07D277/64 ,  C07D307/42 ,  C07D307/52 ,  C07D333/16 ,  C07D333/20

Abstract: Compounds of formula (II): wherein A, R1, R2, R5 and R13 are described herein, or a stereoisomer, enantiomer or tautomer thereof or mixtures thereof, or a pharmaceutically acceptable salt or solvate thereof, are described herein, as well as other compounds. These compounds have activity as SHIP1 modulators, and thus may be useful in treating a variety of diseases, disorders or conditions that would benefit from SHIP1 modulation. Compositions comprising a compound of the invention are also disclosed, as are methods of SHIP1 modulation by administration of such compounds to an animal in need thereof.

公开(公告)号：US20170247389A2

公开(公告)日：2017-08-31

申请号：US14772731

申请日：2014-02-27

Applicant: Aquinox Pharmaceuticals (Canada) Inc.

Inventor： Lloyd F. Mackenzie ,  Thomas B. MacRury ,  Curtis Harwig ,  David Bogucki ,  Jeffery R. Raymond ,  Jeremy D. Pettigrew

IPC: C07D493/10 ,  C07D211/58 ,  C07C255/30 ,  C07D213/75 ,  C07C275/22 ,  C07C335/10 ,  C07D231/54 ,  C07D215/227 ,  C07D221/16 ,  C07C215/38 ,  C07D307/52 ,  C07D333/20 ,  C07D213/38 ,  C07D277/28 ,  C07D231/56 ,  C07D261/20 ,  C07D277/64 ,  C07C35/21 ,  C07C35/23 ,  C07D307/42 ,  C07C233/23 ,  C07D213/82

CPC classification number: C07D493/10 ,  A61K31/416 ,  C07C35/21 ,  C07C35/23 ,  C07C215/26 ,  C07C215/38 ,  C07C233/23 ,  C07C255/30 ,  C07C275/22 ,  C07C335/10 ,  C07C2601/14 ,  C07C2602/24 ,  C07D211/58 ,  C07D213/30 ,  C07D213/38 ,  C07D213/75 ,  C07D213/82 ,  C07D215/227 ,  C07D221/16 ,  C07D221/18 ,  C07D231/54 ,  C07D231/56 ,  C07D261/20 ,  C07D277/24 ,  C07D277/28 ,  C07D277/64 ,  C07D307/42 ,  C07D307/52 ,  C07D333/16 ,  C07D333/20

Abstract: Compounds of formula (II): wherein R1, R2, R5 and R13 are described herein, or a stereoisomer, enantiomer or tautomer thereof or mixtures thereof, or a pharmaceutically acceptable salt or solvate thereof, are described herein, as well as other compounds. These compounds have activity as SHIP1 modulators, and thus may be useful in treating a variety of diseases, disorders or conditions that would benefit from SHIP1 modulation. Compositions comprising a compound of the invention are also disclosed, as are methods of SHIP1 modulation by administration of such compounds to an animal in need thereof.

公开(公告)号：US20170233386A1

公开(公告)日：2017-08-17

申请号：US15494798

申请日：2017-04-24

Applicant: Commissariat a l'Energie Atomique et aux Energies Alternatives

Inventor： Roman Lopez ,  Séverine Hebbe ,  Daniel Gillet ,  Julien Barbier

IPC: C07D453/02 ,  C07C211/38 ,  C07C217/58 ,  C07C233/58 ,  C07C317/14 ,  C07D215/12 ,  C07D209/14 ,  C07D451/02 ,  C07C229/14 ,  C07C271/56 ,  C07C251/24 ,  C07D317/46 ,  C07D213/38 ,  C07D233/64 ,  C07C275/28 ,  C07C335/02 ,  C07D243/12 ,  C07D243/24 ,  C07D333/20 ,  C07D307/52

CPC classification number: C07D453/02 ,  A61K31/167 ,  A61K31/341 ,  A61K31/5513 ,  C07C211/27 ,  C07C211/38 ,  C07C215/10 ,  C07C215/42 ,  C07C215/44 ,  C07C217/16 ,  C07C217/58 ,  C07C229/14 ,  C07C229/22 ,  C07C229/38 ,  C07C229/48 ,  C07C233/06 ,  C07C233/58 ,  C07C233/65 ,  C07C237/40 ,  C07C251/24 ,  C07C271/56 ,  C07C275/28 ,  C07C317/14 ,  C07C335/02 ,  C07C2601/08 ,  C07C2602/46 ,  C07C2603/74 ,  C07D209/14 ,  C07D213/38 ,  C07D215/12 ,  C07D233/10 ,  C07D233/58 ,  C07D233/61 ,  C07D233/64 ,  C07D235/08 ,  C07D243/12 ,  C07D243/24 ,  C07D245/06 ,  C07D249/06 ,  C07D307/42 ,  C07D307/52 ,  C07D317/46 ,  C07D317/58 ,  C07D317/62 ,  C07D317/66 ,  C07D333/20 ,  C07D401/04 ,  C07D451/02 ,  C07D471/08 ,  C07D487/04 ,  Y02A50/471 ,  Y02A50/473

Abstract: The subject matter of the present invention is novel families of compounds which are aromatic amine, imine, aminoadamantane and benzodiazepine derivatives, medicaments comprising same and the use thereof as inhibitors of the toxic effects of toxins with intracellular activity, such as, for example, ricin, and of viruses that use the internalization pathway for infecting cells.

公开(公告)号：US20170183300A1

公开(公告)日：2017-06-29

申请号：US15460910

申请日：2017-03-16

Applicant: UNIVERSITY COLLEGE DUBLIN, NATIONAL UNIVERSITY OF IRELAND, DUBLIN

Inventor： B. Therese Kinsella ,  Patrick Guiry ,  Helen Reid ,  Barry O'Connor

IPC: C07C313/06

CPC classification number: C07D213/71 ,  A61K31/18 ,  A61K31/215 ,  A61K31/64 ,  C07C311/58 ,  C07C311/59 ,  C07C2601/14 ,  C07D205/04 ,  C07D213/34 ,  C07D213/53 ,  C07D213/85 ,  C07D213/89 ,  C07D231/12 ,  C07D261/08 ,  C07D263/48 ,  C07D277/34 ,  C07D295/192 ,  C07D305/08 ,  C07D307/42 ,  C07D307/52 ,  A61K2300/00

Abstract: The invention generally relates to compounds that function as TP antagonists for treating thrombosis and other cardiovascular, renal, or pulmonary diseases. In some embodiments, the invention provides a compound including a substituted nitro phenoxy phenyl, a sulfonylurea, and an alkyl group. In some embodiments, the invention provides a method of treating thrombosis by administering an antithrombotic compound that preferentially binds to a thromboxane receptor, has preferential binding for either TPalpha (TPα) or TPbeta (TPβ) receptor subtype.