公开(公告)号：US20170174607A1

公开(公告)日：2017-06-22

申请号：US15382782

申请日：2016-12-19

Applicant: International Flavors & Fragrances Inc.

Inventor： Ian R. Baxendale ,  James S. Sharley ,  Amadeo Fernández Miranda ,  Ana Maria Collado Pérez

IPC: C07C67/317 ,  C07C67/00 ,  C07C45/27

CPC classification number: C07C67/317 ,  C07C45/27 ,  C07C45/54 ,  C07C67/00 ,  C07C67/313 ,  C07C2101/08 ,  C07C2101/10 ,  C07C2101/14 ,  C07C2101/16 ,  C07C2102/08 ,  C07C2601/08 ,  C07C2601/10 ,  C07C2601/14 ,  C07C2601/16 ,  C07C2602/08 ,  C07C69/73 ,  C07C69/145 ,  C07C69/157 ,  C07C69/757 ,  C07C69/738 ,  C07C49/597 ,  C07C49/683 ,  C07C49/687 ,  C07C49/457 ,  C07C49/697 ,  C07C49/227 ,  C07C47/353

Abstract: Copper(II) bromide mediated oxidation of acylated enol and use of the reaction in the synthesis of α,β-unsaturated or α-bromo ketones or aldehydes are disclosed. The method provides an efficient and practical process for manufacturing dehydrohedione (DHH) and many other versatile α,β-unsaturated or α-bromo ketones or aldehydes in large scales to avoid using precious metal compounds.

公开(公告)号：US11198667B2

公开(公告)日：2021-12-14

申请号：US16499626

申请日：2018-03-30

Applicant: International Flavors & Fragrances Inc.

Inventor： James S. Sharley ,  Ian R. Baxendale ,  Estela Espinos Ferri ,  Ana Maria Collado Perez ,  Isabelle Fernandez Fernandez

IPC: C07C67/307 ,  C07C67/317 ,  C07C69/738

Abstract: Disclosed is a chemical process of preparing dehydrohedione from Hedione via α-chlorination and elimination steps. The process can be conducted in a one-pot process or in a continuous reactor system. Accordingly, a simple and cost effective process of preparing cis-Hedione enriched products is developed through reduction of dehydrohedione in the presence of a chiral catalyst system.

公开(公告)号：US10717701B2

公开(公告)日：2020-07-21

申请号：US16604227

申请日：2018-04-05

Applicant: International Flavors & Fragrances Inc.

Inventor： Estela Espinos Ferri ,  Ana Maria Collado Perez ,  Ian R. Baxendale ,  James S. Sharley

IPC: C07C205/03

Abstract: Amine-catalyzed formation of cyclic allylic nitro compounds via nitro-aldol reaction is disclosed. A greener solvent and a cheaper, more robust catalyst than in previous reports are used in the nitro-aldol reaction. After screening a range of catalysts the reaction is developed as a selective method of synthesis of α-dehydroherbac and the scope is demonstrated with a small collection of additional substrates.