公开(公告)号：US11905232B2

公开(公告)日：2024-02-20

申请号：US17429183

申请日：2020-02-10

申请人： Nogra Pharma Limited

发明人： Salvatore Demartis ,  Francesca Viti ,  Marie McNulty

IPC分类号： C07C231/10 ,  C07C201/12 ,  C07C205/56 ,  C07C231/18 ,  C07C233/54 ,  C07C231/02 ,  C07C227/04 ,  C07C303/28

CPC分类号： C07C231/10 ,  C07C201/12 ,  C07C205/56 ,  C07C227/04 ,  C07C231/02 ,  C07C231/18 ,  C07C233/54 ,  C07C303/28 ,  C07C201/12 ,  C07C205/56 ,  C07C303/28 ,  C07C309/66 ,  C07C227/04 ,  C07C229/42 ,  C07C231/02 ,  C07C233/54

摘要： The disclosure provides a process for the preparation of 3-(4′-aminophenyl)-2-methoxypropionic acid, and analogs and intermediates thereof, contemplated to be capable of modulating the activity of receptors, e.g., PPARs receptors.

公开(公告)号：US20240051915A1

公开(公告)日：2024-02-15

申请号：US18256308

申请日：2021-12-06

申请人： GNT PHARMA CO., LTD.

发明人： Xinliang XU ,  Chenghan ZHUANG ,  Lei WANG ,  Xin LU ,  Bo ZHANG ,  Byoung Joo GWAG ,  Chun San AHN ,  Jing Yu JIN

IPC分类号： C07C227/18 ,  C07C303/28

CPC分类号： C07C227/18 ,  C07C303/28

摘要： A method for preparing 2-hydroxy-5-[2-(4-(trifluoromethylphenyl)ethylamino)]benzoic acid is proposed. The method may include protection, condensation, and hydrolysis. By means of the screening of a hydroxyl protecting reagent for a starting material, for example, 2-(4-trifluoromethyl)phenethylalcohol and the optimization of other process parameters, the contents of meta-isomer impurities and disubstituted impurities in a target product are effectively controlled. Accordingly, the quality of the product is significantly improved, the reaction yield is also greatly improved, and the improved product quality can satisfy related requirements of preparation research.

公开(公告)号：US11492318B2

公开(公告)日：2022-11-08

申请号：US15985616

申请日：2018-05-21

申请人： Etna-TEC, Ltd.

发明人： Michael P. Greuel

IPC分类号： C08F22/38 ,  C07C231/12 ,  C07C311/04 ,  C07C319/20 ,  C07C323/01 ,  C07C323/12 ,  C08F8/18 ,  C08F14/18 ,  C08F222/08 ,  C08F22/02 ,  C08F22/18 ,  C07C43/13 ,  C07C303/28 ,  C07C227/10 ,  C07C67/03 ,  C07C41/03 ,  C07C67/26 ,  C07C69/63 ,  C07C235/08 ,  C07C303/40 ,  C07C41/16 ,  C07C67/08 ,  C07C213/02 ,  C08G59/14 ,  C08G64/02 ,  C08G63/91 ,  C08G64/42 ,  C07C41/24 ,  C07C43/12 ,  C08G63/42 ,  C08G63/682 ,  C08G64/22 ,  C08G65/26 ,  C08G85/00 ,  C08L27/12

摘要： A method of making a functionalized fluorinated monomer for use in making oligomers and polymers that can be used to improve surface properties of polymer-derived systems, such as coatings. The method of making a functionalized fluorinated monomer includes reacting at least one fluorinated nucleophilic reactant, such as a fluorinated alcohol, with at least one compound containing at least one epoxide group. Other methods include reaction of a fluorinated alcohol with a cyclic carboxylic anhydride. In another embodiment, a method includes reacting a fluorinated mesylate, tosylate or triflate with an amine, alkoxide or phenoxide. In other embodiments, the method includes reacting a fluorinated alcohol with an alkyl halide, or reacting a fluorinated alkyl halide with an amine. The functionalized fluorinated monomers may be used as intermediates and reacted to modify the functional groups thereon. Further, the functionalized fluorinated monomers may be reacted to form polymers or oligomers, or with polymers or oligomers having functional groups to modify the polymer or oligomer through the functional group thereon.

公开(公告)号：US20220213016A1

公开(公告)日：2022-07-07

申请号：US17701620

申请日：2022-03-22

申请人： ETNA-Tec, Ltd.

发明人： Michael P. Greuel

IPC分类号： C07C41/03 ,  C08F22/38 ,  C07C67/26 ,  C07C69/63 ,  C07C231/12 ,  C07C235/08 ,  C07C303/40 ,  C07C311/04 ,  C07C319/20 ,  C07C323/01 ,  C07C323/12 ,  C08F8/18 ,  C08F14/18 ,  C08F222/08 ,  C08F22/02 ,  C08F22/18 ,  C07C43/13 ,  C07C303/28 ,  C07C227/10 ,  C07C67/03 ,  C07C41/16 ,  C07C67/08 ,  C07C213/02 ,  C08G59/14 ,  C08G64/02 ,  C08G63/91 ,  C08G64/42 ,  C07C41/24 ,  C07C43/12 ,  C08G63/42 ,  C08G63/682 ,  C08G64/22 ,  C08G65/26 ,  C08G85/00 ,  C08L27/12

摘要： A method of making a functionalized fluorinated monomer for use in making oligomers and polymers that can be used to improve surface properties of polymer-derived systems, such as coatings. The method of making a functionalized fluorinated monomer includes reacting at least one fluorinated nucleophilic reactant, such as a fluorinated alcohol, with at least one compound containing at least one epoxide group. Other methods include reaction of a fluorinated alcohol with a cyclic carboxylic anhydride. In another embodiment, a method includes reacting a fluorinated mesylate, tosylate or triflate with an amine, alkoxide or phenoxide. In other embodiments, the method includes reacting a fluorinated alcohol with an alkyl halide, or reacting a fluorinated alkyl halide with an amine. The functionalized fluorinated monomers may be used as intermediates and reacted to modify the functional groups thereon. Further, the functionalized fluorinated monomers may be reacted to form polymers or oligomers, or with polymers or oligomers having functional groups to modify the polymer or oligomer through the functional group thereon.

公开(公告)号：US10647667B2

公开(公告)日：2020-05-12

申请号：US16466273

申请日：2017-11-28

申请人： BAYER CROPSCIENCE AKTIENGESELLSCHAFT

发明人： Daniel Gallenkamp ,  Mark James Ford ,  Dirk Brohm ,  Florian Erver

IPC分类号： C07C303/28 ,  C07D319/08 ,  C07C37/00

摘要： The present invention relates to a method for preparing 3-substituted 2-vinylphenyl sulfonates.

公开(公告)号：US10364229B2

公开(公告)日：2019-07-30

申请号：US15812524

申请日：2017-11-14

申请人： ADVERIO PHARMA GMBH

发明人： Peter Fey ,  Alfons Grunenberg ,  Donald Bierer

IPC分类号： C07D239/02 ,  C07D295/104 ,  C07D265/30 ,  C07D471/04 ,  C07C309/04 ,  C07C317/04 ,  C07D295/067 ,  C07C303/28 ,  A61P9/00

摘要： The present application relates to a novel and efficient process for preparing novel substituted 5-fluoro-1H-pyrazolopyridines of the formula (VI) which are suitable as an intermediate for production of medicaments and for production of medicaments for treatment and/or prophylaxis of cardiovascular disorders. More particularly, the 5-fluoro-1H-pyrazolopyridines of the formula (VI) are suitable for preparation of the compound of the formula (I) which serves for production of medicaments, for production of medicaments for treatment and/or prophylaxis of cardiovascular disorders.

公开(公告)号：US20190177288A1

公开(公告)日：2019-06-13

申请号：US16278813

申请日：2019-02-19

申请人： ADVERIO PHARMA GMBH

发明人： Peter FEY

IPC分类号： C07D295/104 ,  A61P9/00 ,  C07D471/04 ,  C07D295/067 ,  C07D265/30 ,  C07C317/04 ,  C07C309/04 ,  C07C303/28

摘要： The present application relates to a novel and efficient process for preparing novel substituted 5-fluoro-1H-pyrazolopyridines of the formula (VI) which are suitable as an intermediate for production of medicaments and for production of medicaments for treatment and/or prophylaxis of cardiovascular disorders. More particularly, the 5-fluoro-1H-pyrazolopyridines of the formula (VI) are suitable for preparation of the compound of the formula (I) which serves for production of medicaments, for production of medicaments for treatment and/or prophylaxis of cardiovascular disorders.

公开(公告)号：US10252972B2

公开(公告)日：2019-04-09

申请号：US15739533

申请日：2016-06-27

申请人： Bizen Chemical Co., Ltd.

发明人： Naomichi Bamba ,  Yoshihisa Misawa ,  Hiroshi Tabata ,  Yoshio Shimizu

IPC分类号： C07C33/02 ,  C07C67/32 ,  C07C29/147 ,  C07C303/28 ,  C07C309/66 ,  C07C67/343 ,  C07C69/587 ,  C07C69/602

摘要： A method of chemically extending a carbon chain of an unsaturated fatty acid for conversion into a different unsaturated fatty acid has been reported. The present invention shortens reaction steps of conventional methods, and completes a carbon chain extending reaction in a shorter time. The present invention provides a method of extending a carbon chain of an unsaturated fatty acid by two carbons, comprising steps of four stages including a short-path conversion reaction of an unsaturated fatty chain obtained from an unsaturated fatty acid into a malonic ester derivative, and heating of the malonic ester derivative to reflux in a lower fatty acid solution. The method of the present invention can complete a carbon chain extending reaction in a shorter time.

公开(公告)号：US20180355386A1

公开(公告)日：2018-12-13

申请号：US16107349

申请日：2018-08-21

申请人： Shin-Etsu Chemical Co., Ltd.

发明人： Miyoshi Yamashita ,  Takeshi Kinsho

IPC分类号： C12P7/62 ,  C07C69/78 ,  C07C67/08 ,  C07C303/28 ,  C07C29/80 ,  C07C67/10 ,  C07C67/54 ,  C07C29/09 ,  C07C309/66 ,  C07C309/73 ,  C07C33/025 ,  C07C69/145

CPC分类号： C12P7/62 ,  C07B2200/07 ,  C07B2200/09 ,  C07C29/095 ,  C07C29/80 ,  C07C67/08 ,  C07C67/10 ,  C07C67/54 ,  C07C69/78 ,  C07C303/28 ,  C07C309/66 ,  C07C309/73 ,  C07C33/025 ,  C07C69/145

摘要： Provided are methods including a method for industrially producing (2S,12Z)-2-acetoxy-12-heptadecene, which is, for example, a sex pheromone of pistachio twig borer. The methods can include a production method comprising a step of reacting racemic (2RS,12Z)-2-hydroxy-12-heptadecene with vinyl benzoate in the presence of a lipase to obtain a mixture of optically active (2R,12Z)-2-benzoyloxy-12-heptadecene of Formula (R,Z-2) and optically active (2S,12Z)-2-hydroxy-12-heptadecene of Formula (S,Z-1), a step of heating the mixture to distill out the optically active (2S,12Z)-2-hydroxy-12-heptadecene (S,Z-1), and a step of acetylating the optically active (2S,12Z)-2-hydroxy-12-heptadecene (S,Z-1) to obtain optically active (2S,12Z)-2-acetoxy-12-heptadecene of Formula (S,Z-3).

公开(公告)号：US20180009745A1

公开(公告)日：2018-01-11

申请号：US15545435

申请日：2016-01-25

申请人： Avexxin AS

发明人： Marcel Sanderberg ,  Inger-Reidun Aukrust

IPC分类号： C07C319/14 ,  C07C319/28 ,  C07C319/02 ,  C07C327/22 ,  C07C303/28

CPC分类号： C07C319/14 ,  C07C303/28 ,  C07C319/02 ,  C07C319/28 ,  C07C327/22 ,  C07C309/66 ,  C07C323/14 ,  C07C321/08

摘要： A process for the preparation of a polyunsaturated thiol comprising: (1) reacting a polyunsaturated alcohol in the presence of a compound of formula R2—SO2Hal wherein R2 is a C1-20 hydrocarbyl group, such an C1-10 alkyl group, to form a polyunsaturated sulphonyl ester; (2) converting the polyunsaturated sulphonyl ester to a polyunsaturated thioester by reacting with an anion of formula −SC(═O)R4 wherein R4 is a C1-20 hydrocarbyl group; (3) converting the polyunsaturated thioester to form a polyunsaturated thiol optionally in the presence of an antioxidant, e.g. using a metal carbonate. (4) reacting said polyunsaturated thiol with a compound (LG)R3COX wherein X is an electron withdrawing group and R3 is an alkylene group carrying a leaving group (LG), such as LG-CH2— forming where X is an electron withdrawing group and LG is a leaving group; optionally in the presence of an antioxidant, so as to form a polyunsaturated ketone compound.