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    Antiinflammatory 2-imino-indolines and their pharmaceutical compositions
    7.
    发明授权
    Antiinflammatory 2-imino-indolines and their pharmaceutical compositions 失效
    抗炎2-亚氨基 - 吲哚啉及其药物组合物

    公开(公告)号：US3984563A

    公开(公告)日：1976-10-05

    申请号：US504205

    申请日：1974-09-09

    申请人： Giorgio Winters ,  Nunzio Di Mola

    发明人： Giorgio Winters ,  Nunzio Di Mola

    IPC分类号： B01J27/00 ,  C07B61/00 ,  C07C243/36 ,  C07D209/40 ,  C07D209/96 ,  C07D209/14 ,  A61K31/40

    CPC分类号： C07C243/00 ,  C07C243/36 ,  C07D209/40 ,  C07D209/96

    摘要： Compounds with antiinflammatory, analgesic and CNS depressant activity having the following general formula ##SPC1##WhereinR represents hydrogen or methoxy;R.sub.1 represents hydrogen; lower alkyl; lower alkyl substituted with a group carboxy, carbo(lower alkoxy) or carbamyl; phenyl; benzyl, lower aliphatic acyl; benzoyl; benzoyl substituted with a halo group;R.sub.2 represents hydrogen; lower alkyl; carbo(lower alkoxy); carbamyl; phenylcarbamyl; lower aliphatic acyl; benzoyl; benzoyl substituted with a halo group,R.sub.3 represents halo; lower alkyl; lower alkyl substituted with a group selected from carboxy, carbo(lower alkoxy), carbamyl, halo, amino, mono and di-lower alkylamino, phthalimido and morpholino; phenyl; phenyl substituted with a group selected from lower alkoxy, halo, nitro, amino and acetamido;R.sub.4 represents hydrogen or lower alkyl; with the proviso that when simultaneously R.sub.1 represents hydrogen, methyl, phenyl, benzyl, acetyl or benzoyl, R.sub.2 represents hydrogen, lower alkyl or acetyl,R.sub.3 represents lower alkyl or phenyl, R.sub.4 must be different from hydrogen and methyl;Or R.sub.3 and R.sub.4 taken together with the adjacent carbon atom may represent a 5-6 membered alicyclic ring.

    摘要翻译： 具有抗炎，镇痛和CNS抑制活性的化合物具有以下通式，其中R表示氢或甲氧基; R1表示氢; 低级烷基 被羧基取代的低级烷基，碳（低级烷氧基）或氨基甲酰基; 苯基; 苄基，低级脂族酰基; 苯甲酰 用卤代基取代的苯甲酰基; R2表示氢; 低级烷基 碳（低级烷氧基）; 氨基甲酰 苯基氨基甲酰基; 低级脂肪族酰基; 苯甲酰 被卤素取代的苯甲酰基，R3代表卤素; 低级烷基 被选自羧基，碳（低级烷氧基），氨基甲酰基，卤素，氨基，单和二低级烷基氨基，苯二甲酰亚氨基和吗啉代的基团取代的低级烷基; 苯基; 被选自低级烷氧基，卤素，硝基，氨基和乙酰氨基的基团取代的苯基; R4代表氢或低级烷基; 条件是当R 1代表氢，甲基，苯基，苄基，乙酰基或苯甲酰基时，R 2表示氢，低级烷基或乙酰基，R 3表示低级烷基或苯基，R 4必须不同于氢和甲基; OR 3和R 4与相邻碳原子一起可以表示5-6元脂环。