公开(公告)号：US4492762B1

公开(公告)日：1991-08-13

申请号：US39357782

申请日：1982-06-30

Applicant: ABBOTT LAB

Inventor： CHAO-HUEI J WANG ,  STEPHEN D STROUPE ,  MICHAEL E JOLLEY

IPC: C07D311/82 ,  C07D405/12 ,  C07D473/08 ,  C07J41/00 ,  G01N33/533 ,  G01N33/58 ,  G01N33/542

CPC classification number: C07D405/12 ,  C07D311/82 ,  C07D473/08 ,  C07J41/0005 ,  G01N33/533 ,  G01N33/582 ,  Y10S436/80 ,  Y10S436/825

公开(公告)号：US4326083A

公开(公告)日：1982-04-20

申请号：US26016081

申请日：1981-05-04

Applicant: ABBOTT LAB

Inventor： MCKELLIN WILBUR H

IPC: C07C45/46 ,  C07C49/84

CPC classification number: C07C45/46 ,  C07C49/84

公开(公告)号：US3928582A

公开(公告)日：1975-12-23

申请号：US47203074

申请日：1974-05-21

Applicant: ABBOTT LAB

Inventor： PRASAD RAJ NANDAN

IPC: C07H19/16 ,  A61K31/70

CPC classification number: C07H19/16

Abstract: WHEREIN R1 is loweralkyl, lowerhydroxyalkyl or lowerhaloalkyl, and R2 and R3 each are hydrogen or acyl or when taken together form an isopropylidene or a benzylidene moiety, and the pharmaceutically acceptable acid addition salts thereof. The compounds are useful as anti-anginal agents.

N1-Oxides of adenosine-5''-alkyl carboxylates represented by the structural formula

Abstract translation: 由结构式为WHEREIN R1表示的腺苷-5'-烷基羧酸盐的N1氧化物为低级烷基，低级羟基烷基或低级卤代烷基，R2和R3各自为氢或酰基，或者一起形成异亚丙基或亚苄基部分，其药学上可接受的 其酸加成盐。 该化合物可用作抗心绞痛剂。

公开(公告)号：US3910988A

公开(公告)日：1975-10-07

申请号：US40890173

申请日：1973-10-23

Applicant: ABBOTT LAB

Inventor： JONES PETER HADLEY ,  KYNCL JAROSLAV ,  OURS CARROLL WAYNE ,  SOMANI PITAMBAR

IPC: A61K31/195 ,  A01N37/44 ,  A61K31/198 ,  A61K31/22 ,  A61P9/08 ,  C07C237/08 ,  C07C103/50

CPC classification number: A01N37/44 ,  Y10S514/929

Abstract: Covers the esters of gamma -glutamyl amide of dopamine selected from the group consisting of

where R is a C1-C20 alkyl radical, and a pharmaceutically acceptable acid addition salt thereof. Also covers the use of said esters of gamma -glutamyl amide of dopamine to increase renal blood flow by administering said amide to warm-blooded mammals by clinically acceptable routes of administration such as oral, parenteral, rectal, etc.

Abstract translation: 包括选自-CH 2 -CH 2 -NH 2 |平行C-CH 2 -CH 2 -CH-C-OR PARALLEL | ONH 2的多巴胺的γ-谷氨酰胺的酯，其中R是C 1 -C 20烷基， 其药学上可接受的酸加成盐。 还涵盖使用所述多巴胺的γ-谷氨酰胺的酯通过临床上可接受的给药途径（例如口服，胃肠外，直肠等）将所述酰胺施用于温血哺乳动物来增加肾血流量。

公开(公告)号：US3906107A

公开(公告)日：1975-09-16

申请号：US28730472

申请日：1972-09-08

Applicant: ABBOTT LAB

Inventor： SOMANI PITAMBAR ,  MARTIN DONALD LYONS

IPC: A61K20060101 ,  A61K31/00 ,  A61K31/185 ,  A61K31/255 ,  C07C20060101

CPC classification number: A61K31/185 ,  Y10S514/869

Abstract: The present invention is directed to the provision of a therapeutically active composition having diuretic and renal vasodialator properties. The composition contains as its active ingredient a (substituted) aminoalkylsulfate ester. Such an ester is of extremely low toxicity and has a high therapeutic index.

Abstract translation: 本发明涉及提供具有利尿和肾血管扩张剂性质的治疗活性组合物。 该组合物含有（取代的）氨基烷基硫酸酯作为其活性成分。 这种酯的毒性极低，治疗指数高。

公开(公告)号：US3890972A

公开(公告)日：1975-06-24

申请号：US40057373

申请日：1973-09-25

Applicant: ABBOTT LAB

Inventor： STANDLEY WENDELL EVERT ,  BEALL GLENN LEE

IPC: A61M5/24 ,  B65D83/10

CPC classification number: A61M5/2429

Abstract: A syringe assembly including a vial in which a unit dose of an injectable medicament can be prepackaged and an injector portion comprising a solid post molded along a substantial portion of the cannula to provide support and a pair of longitudinally extending wings projecting from the hub of the injector. A threaded stem extends from the post for receiving the thread stopper of the vial, the threads on the stem being intermittent. A cap for covering the threaded stem prior to use includes a flange which mates with finger grips on the wings whereby the cap can be removed by pressure applied to the wings. Possible contact with the threaded stem or cannula which could contaminate the system is thereby minimized.

Abstract translation: 一种注射器组件，其包括小瓶，其中可以预先包装单位剂量的可注射药物，以及包括沿着套管的大部分模制的固体柱的注射器部分，以提供支撑和一对纵向延伸的翼， 注射器。 螺纹杆从柱子延伸，用于接收小瓶的螺纹塞子，杆上的螺纹是间歇的。 用于在使用之前覆盖螺纹杆的帽包括与翅膀上的手指夹配合的凸缘，由此可以通过施加到翼的压力来移除盖。 因此可能与可能污染系统的螺纹杆或套管的接触最小化。

公开(公告)号：US3878223A

公开(公告)日：1975-04-15

申请号：US34062273

申请日：1973-03-12

Applicant: ABBOTT LAB

Inventor： GARMAISE DAVID LYON ,  PARIS GERARD YVON

IPC: C07D231/40 ,  C07D261/14 ,  C07D49/20

CPC classification number: C07D231/40 ,  C07D261/14 ,  Y10S514/87

Abstract: Acrylamides of N-containing heterocyclic moieties that optionally carry a further hetero atom adjacent to the said N and/or methyl substituent(s) on said hetero ring and at least one chlorine atom adjacent to the double bond of the acrylic moiety have been found to have anti-inflammatory properties at reasonably low dosage levels.

Abstract translation: 已经发现，含氮杂环部分的丙烯酰胺任选地在所述杂环上邻近所述N和/或甲基取代基和与丙烯酸部分的双键相邻的至少一个氯原子携带另外的杂原子， 在相当低的剂量水平下具有抗炎性质。

公开(公告)号：US3859170A

公开(公告)日：1975-01-07

申请号：US3048860

申请日：1960-05-20

Applicant: ABBOTT LAB

Inventor： GOLDSTEIN ALMA W

IPC: C12P17/18 ,  A61K21/00

CPC classification number: A61K36/06 ,  C12P17/181 ,  Y10S435/886

Abstract: A method of producing antimicrobial agent M-141 by cultivating the organism Streptomyces flavopersicus NRRL 2820 under submerged aerobic conditions. The antimicrobial agent is active against a variety of bacteria and protozoan organisms, as for example, Eimeria tenella.

公开(公告)号：US3855214A

公开(公告)日：1974-12-17

申请号：US29325372

申请日：1972-09-28

Applicant: ABBOTT LAB

Inventor： RODERICK W

IPC: C07D513/04 ,  C07D93/12

CPC classification number: C07D513/04 ,  Y10S514/916

Abstract: 2,3-Dihydro-1H-pyridino-(2,3-b)(1,4)-thiazin-2-one 4-oxide has been found to possess excellent anti-inflammatory, analgesic and anti-pyretic activity when administered in small doses to warmblooded animals.

Abstract translation: 已经发现2,3-二氢-1H-吡啶并[2,3-b] [1,4] - 噻嗪-2-酮4-氧化物在施用时具有优异的抗炎，止痛和抗热解活性 温血动物的小剂量。

公开(公告)号：US3855205A

公开(公告)日：1974-12-17

申请号：US29469972

申请日：1972-10-03

Applicant: ABBOTT LAB

Inventor： PRASAD R ,  FISCHER F

IPC: C07H19/16 ,  C07D51/54

CPC classification number: C07H19/16

Abstract: An improved process for synthesizing esters of adenosine-5''carboxylic acid comprising reacting the acid with thionyl chloride and an appropriate alcohol at a temperature of less than 0*.

Abstract translation: 一种合成腺苷-5'-羧酸酯的改进方法，包括使酸与亚硫酰氯和适当的醇在低于0℃的温度下反应。