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    Substituted Phenethylamines with Serotoninergic and/or Norepinephrinergic Activity
    2.
    发明申请
    Substituted Phenethylamines with Serotoninergic and/or Norepinephrinergic Activity 有权

    公开(公告)号：US20210101863A1

    公开(公告)日：2021-04-08

    申请号：US16999367

    申请日：2020-08-21

    申请人： Auspex Pharmaceuticals, Inc.

    发明人： Thomas G. Gant ,  Sepehr Sarshar ,  Soon Hyung Woo

    IPC分类号： C07C211/64 ,  C07B59/00 ,  C07C215/64 ,  C07C217/74 ,  C07D265/16

    摘要： Chemical syntheses and medical uses of novel inhibitors of the uptake of monoamine neurotransmitters and pharmaceutically acceptable salts and prodrugs thereof, for the treatment and/or management of psychotropic disorders, anxiety disorder, generalized anxiety disorder, depression, post-traumatic stress disorder, obsessive-compulsive disorder, panic disorder, hot flashes, senile dementia, migraine, hepatopulmonary syndrome, chronic pain, nociceptive pain, neuropathic pain, painful diabetic retinopathy, bipolar depression, obstructive sleep apnea, psychiatric disorders, premenstrual dysphoric disorder, social phobia, social anxiety disorder, urinary incontinence, anorexia, bulimia nervosa, obesity, ischemia, head injury, calcium overload in brain cells, drug dependence, attention deficit hyperactivity disorder, fibromyalgia, irritable bowel syndrome, and/or premature ejaculation are described.

    Crystalline salts and/or co-crystals of O-desmethyltramadol
    9.
    发明申请
    Crystalline salts and/or co-crystals of O-desmethyltramadol 审中-公开
    O-去甲基曲马多的结晶盐和/或共晶体

    公开(公告)号：US20110251286A1

    公开(公告)日：2011-10-13

    申请号：US13044069

    申请日：2011-03-09

    申请人： Michael GRUSS ,  Oswald Zimmer

    发明人： Michael GRUSS ,  Oswald Zimmer

    IPC分类号： A61K31/135 ,  A61P29/00 ,  A61P13/10 ,  A61P1/12 ,  A61P21/00 ,  A61P11/14 ,  C07C215/64 ,  A61P25/30

    CPC分类号： C07C215/64 ,  C07C53/126 ,  C07C55/20 ,  C07C57/15 ,  C07C57/44 ,  C07C2601/14

    摘要： Salts and/or co-crystals of (+)-3-[2-(dimethylamino)-methyl-1-hydroxycyclohexyl]-phenol or of (−)-3-[2-(dimethylamino)methyl-1-hydroxy-cyclohexyl]phenol, present in crystalline form, with cinnamic acid, C8- to C10-alkane-monocarboxylic acids, C6- to C10-alkanedicarboxylic acids, C15- to C17-alkane-monocarboxylic acids, fumaric acid, tartaric acid, mandelic acid, hippuric acid and/or embonic acid, a process for their production, and the use of such salts and/or co-crystals as medicaments.

    摘要翻译： （+） - 3- [2-（二甲基氨基） - 甲基-1-羟基环己基] - 苯酚或（ - ） - 3- [2-（二甲基氨基）甲基-1-羟基 - ]苯酚，以肉桂酸，C 8〜C 10烷烃一元羧酸，C 6〜C 10烷基二羧酸，C 15〜C 17 - 烷烃 - 一元羧酸，富马酸，酒石酸，扁桃酸，马尿酸 酸和/或乌头酸，它们的生产方法，以及这些盐和/或共晶体作为药物的用途。