公开(公告)号：US20240124402A1

公开(公告)日：2024-04-18

申请号：US18395979

申请日：2023-12-26

Applicant: AVANIR PHARMACEUTICALS, INC.

Inventor： Matt Johnson ,  Cunxiang Zhao ,  Weihua Meng ,  Zhijun Lu ,  Yan Li

IPC: C07D221/28 ,  C07B59/00

CPC classification number: C07D221/28 ,  C07B59/002 ,  A61P25/24

Abstract: The application describes methods for making a deuterated dextromethorphan of Formula (I), deuterated dextromethorphan produced by these methods, and pharmaceutically acceptable salts thereof.

公开(公告)号：US20240067608A1

公开(公告)日：2024-02-29

申请号：US18388041

申请日：2023-11-08

Applicant: AVANIR PHARMACEUTICALS, INC.

Inventor： Matt Johnson ,  Cunxiang Zhao ,  Weihua Meng ,  Zhijun Lu ,  Yan Li

IPC: C07D221/28 ,  C07B59/00

CPC classification number: C07D221/28 ,  C07B59/002 ,  A61P25/28

Abstract: The application describes methods for making a deuterated dextromethorphan of Formula (I), deuterated dextromethorphan produced by these methods, and pharmaceutically acceptable salts thereof.

公开(公告)号：US11613547B2

公开(公告)日：2023-03-28

申请号：US16924037

申请日：2020-07-08

Applicant: University of Health Sciences & Pharmacy in St. Louis ,  University of Southern California ,  The University of North Carolina at Chapel Hill ,  Memorial Sloan Kettering Cancer Center ,  University of Florida Research Foundation, Incorporated ,  Memorial Sloan Kettering Cancer Center

Inventor： Susruta Majumdar ,  Vsevolod Katritch ,  Bryan Roth ,  Jay McLaughlin ,  Saheem Zaidi ,  Gavril W. Pasternak ,  Rajendra Uprety

IPC: C07D489/00 ,  C07D221/28

Abstract: In some aspects, the present disclosure provides compounds of the formula: wherein the variables are as defined herein. In some embodiments, these compounds may be used to reduce the pain of a patient. These compounds may be used in pain relief and show an improved pharmaceutical profile relative to other commonly used opiates and opioid derivatives.

公开(公告)号：US11351166B2

公开(公告)日：2022-06-07

申请号：US17071166

申请日：2020-10-15

Applicant: Alkermes Pharma Ireland Limited

Inventor： Daniel R. Deaver ,  Mark Todtenkopf

IPC: A61K31/485 ,  A61K31/439 ,  A61K31/496 ,  A61K31/519 ,  A61K31/5513 ,  A61K31/554 ,  C07D221/28 ,  C07D405/06 ,  A61K9/20 ,  A61K31/551

Abstract: The present invention relates to the discovery of a novel opioid modulator effective in reducing pharmacologically induced weight gain associated with atypical antipsychotic use. The present invention provides methods of reducing antipsychotic induced weight gain, methods for suppressing food intake and reducing ghrelin levels induced by atypical antipsychotic medications in a patient.

公开(公告)号：US11214545B2

公开(公告)日：2022-01-04

申请号：US16644084

申请日：2018-09-06

Applicant: OTSUKA PHARMACEUTICAL CO., LTD.

Inventor： Yuya Nakai ,  Masashi Hayashi ,  Wataru Mitsuhashi

IPC: C07D221/28

Abstract: The present invention relates to a method of mono-alkylating a piperidine nitrogen in a piperidine derivative with a deuterated lower-alkyl, which comprises protecting the piperidine nitrogen with an aralkyl protective group, lower-alkylating the piperidine nitrogen with a deuterated-lower-alkylating agent under neutral or basic condition, and then deprotecting the aralkyl protective group.

公开(公告)号：US10736890B2

公开(公告)日：2020-08-11

申请号：US16272654

申请日：2019-02-11

Applicant: Alkermes Pharma Ireland Limited

Inventor： Laura Cook Blumberg ,  Daniel R. Deaver ,  David J. Eyerman ,  Thomas Andrew Wynn

IPC: A61K31/485 ,  C07D211/62 ,  C07D217/04 ,  C07D221/22 ,  C07D221/28 ,  C07D223/04 ,  C07D401/12 ,  C07D405/12 ,  C07D489/00 ,  C07D489/09

Abstract: The present application relates methods for treating a depressive symptom comprising administering an effective amount of a μ opioid receptor agonist or a pharmaceutically acceptable salt thereof to a subject in need thereof. Non-limiting examples of such agonist include the compounds of Formulas I, II, III, and IV, as well as the compounds of Table A.

公开(公告)号：US20200109119A1

公开(公告)日：2020-04-09

申请号：US16151798

申请日：2018-10-04

Applicant: AMPAC Fine Chemicals LLC

Inventor： William DUBAY ,  Alex NICHOLS ,  Wei CHEN ,  Alec BROZELL ,  Ajay RYERSON

IPC: C07D221/28 ,  C07C59/255

Abstract: A method for producing substantially pure levorphanol and related compounds, when compared to the conventional process, is provided. In particular, a method for producing substantially pure levorphanol tartrate dihydrate is described. Also described are compositions comprising levorphanol and related compounds, particularly compositions comprising levorphanol tartrate dihydrate, levomethorphan, and norlevorphanol in which the levomethorphan and norlevorphanol are present in the composition in reduced levels.

公开(公告)号：US10463660B2

公开(公告)日：2019-11-05

申请号：US16054578

申请日：2018-08-03

Applicant: KemPharm, Inc.

Inventor： Travis Mickle ,  Sven Guenther ,  Sanjib Bera ,  Jaroslaw Kanski ,  Andrea Martin

IPC: A61K31/485 ,  C07D489/08 ,  A61K47/54 ,  A61K47/55 ,  C07D221/28

Abstract: The presently described technology provides compositions comprising aryl carboxylic acids and, for example NSAIDs, chemically conjugated to oxymorphone (4,5-α-epoxy-3,14-dihydroxy-17-methylmorphinan-6-one) to form novel prodrugs/compositions of oxymorphone, including benzoates, salicylates, propionates, fenamates, and acetates, which have a decreased potential for abuse of oxymorphone. The present technology also provides methods of treating patients, pharmaceutical kits and methods of synthesizing conjugates of the present technology.

公开(公告)号：US20190241525A1

公开(公告)日：2019-08-08

申请号：US16312439

申请日：2017-07-03

Applicant: AVANIR PHARMACEUTICALS, INC.

Inventor： Matt Johnson ,  Cunxiang Zhao ,  Weihua Meng ,  Zhijun Lu ,  Yan Li

IPC: C07D221/28 ,  C07B59/00

Abstract: The application describes methods for making a deuterated dextromethorphan of Formula (I), deuterated dextromethorphan produced by these methods, and pharmaceutically acceptable salts thereof.

公开(公告)号：US20190167666A1

公开(公告)日：2019-06-06

申请号：US16272654

申请日：2019-02-11

Applicant: Alkermes Pharma Ireland Limited

Inventor： Laura Cook Blumberg ,  Daniel R. Deaver ,  David J. Eyerman ,  Thomas Andrew Wynn

IPC: A61K31/485 ,  C07D223/04 ,  C07D217/04 ,  C07D221/22 ,  C07D489/09 ,  C07D221/28 ,  C07D405/12 ,  C07D489/00 ,  C07D211/62 ,  C07D401/12

Abstract: The present application relates methods for treating a depressive symptom comprising administering an effective amount of a μ opioid receptor agonist or a pharmaceutically acceptable salt thereof to a subject in need thereof. Non-limiting examples of such agonist include the compounds of Formulas I, II, III, and IV, as well as the compounds of Table A.