公开(公告)号：US10054853B2

公开(公告)日：2018-08-21

申请号：US15483210

申请日：2017-04-10

Applicant: Shin-Etsu Chemical Co., Ltd.

Inventor： Takayuki Fujiwara

IPC: G03F7/004 ,  G03F7/039 ,  C07C381/12 ,  C07C311/49 ,  C07D307/00 ,  C07C307/02 ,  C08F220/18 ,  G03F7/038 ,  G03F7/16 ,  G03F7/20 ,  G03F7/38 ,  G03F7/32 ,  G03F7/11 ,  C08F220/20 ,  C08F220/38

CPC classification number: G03F7/0392 ,  C07C307/02 ,  C07C311/48 ,  C07C311/49 ,  C07C311/51 ,  C07C381/12 ,  C07C2601/14 ,  C07C2603/74 ,  C07D307/00 ,  C08F220/18 ,  C08F220/20 ,  C08F2220/1866 ,  C08F2220/387 ,  G03F7/0045 ,  G03F7/0046 ,  G03F7/0382 ,  G03F7/0397 ,  G03F7/11 ,  G03F7/162 ,  G03F7/168 ,  G03F7/2006 ,  G03F7/2041 ,  G03F7/322 ,  G03F7/325 ,  G03F7/38 ,  C08F2220/282

Abstract: A monomer having an onium salt structure represented by formula (1) gives a polymer which is fully compatible with resist components. A resist composition comprising the polymer has advantages including reduced acid diffusion, high sensitivity, high resolution, a good balance of lithography properties, and less defects, and is quite effective for precise micropatterning.

公开(公告)号：US20170044109A1

公开(公告)日：2017-02-16

申请号：US15305407

申请日：2015-04-14

Applicant: E. I. DU PONT DE NEMOURS AND COMPANY

Inventor： Kanu Maganbhai Patel

IPC: C07D231/12 ,  C07C303/36 ,  C07C311/49

CPC classification number: C07D231/12 ,  C07C303/36 ,  C07C311/49 ,  C07D213/61 ,  C07D213/71 ,  C07D231/16 ,  C07D239/26 ,  C07D239/38 ,  C07D261/08 ,  C07D261/10 ,  C07D277/28 ,  C07D277/32 ,  C07D277/36 ,  C07D307/52 ,  C07D307/64 ,  C07D333/06 ,  C07D333/28 ,  C07D333/34

Abstract: Disclosed are compounds of Formula I, including all stereoisomers, (N-oxides), and salts thereof, wherein A and R are as defined in the disclosure. Also disclosed is a method for preparing a compound of Formula I, comprising reacting a compound of Formula II with an aroyl enolate salt of Formula III in the presence of an acid in an aqueous solvent mixture, wherein A, R and M are as defined in the disclosure.Also disclosed is a method for preparing a compound of Formula IV, comprising reacting a compound of Formula I with an aldehyde of Formula V in the presence of a secondary amine salt, wherein A, B and R are as defined in the disclosure.

Abstract translation: 公开了式I的化合物，包括所有立体异构体，（N-氧化物）及其盐，其中A和R如本公开所定义。 还公开了制备式I化合物的方法，包括使式II化合物与式III的芳酰基烯醇盐在酸的存在下在水性溶剂混合物中反应，其中A，R和M如 披露。 还公开了制备式IV化合物的方法，包括在仲胺盐存在下使式I化合物与式V的醛反应，其中A，B和R如本发明所定义。

公开(公告)号：US09527878B2

公开(公告)日：2016-12-27

申请号：US14817690

申请日：2015-08-04

Applicant: THE REGENTS OF THE UNIVERSITY OF MICHIGAN ,  EASTERN MICHIGAN UNIVERSITY

Inventor： Daniel A. Lawrence ,  Cory Emal ,  Jacqueline Cale ,  Enming Joe Su ,  Mark Warnock ,  Shih-Hon Li ,  Jeanne Ann Cupp

IPC: C07H15/203 ,  A61K31/7034 ,  A61K38/17 ,  C07C69/94 ,  A61K31/235 ,  C07C271/22 ,  A61K31/27 ,  C07C311/29 ,  A61K31/18 ,  C07C235/68 ,  A61K31/166 ,  C07D213/82 ,  A61K31/444 ,  C07D295/192 ,  A61K31/495 ,  C07C311/49 ,  C07D295/26 ,  A61K31/50 ,  A61K31/5375 ,  C07C69/88 ,  C07C69/90 ,  C07C229/12 ,  C07C229/34 ,  C07C271/54 ,  C07H13/08 ,  A61K38/48 ,  C07D295/195

CPC classification number: C07H15/203 ,  A61K31/166 ,  A61K31/18 ,  A61K31/235 ,  A61K31/27 ,  A61K31/444 ,  A61K31/495 ,  A61K31/50 ,  A61K31/5375 ,  A61K31/7034 ,  A61K38/1741 ,  A61K38/482 ,  C07C69/88 ,  C07C69/90 ,  C07C69/94 ,  C07C229/12 ,  C07C229/34 ,  C07C235/68 ,  C07C271/22 ,  C07C271/54 ,  C07C311/29 ,  C07C311/49 ,  C07C2601/14 ,  C07D213/82 ,  C07D295/192 ,  C07D295/195 ,  C07D295/26 ,  C07H13/08 ,  C12Y304/21073

Abstract: The invention relates to plasminogen activator-1 (PAI-1) inhibitor compounds and uses thereof in the treatment of any disease or condition associated with elevated PAI-1. The invention includes, but is not limited to, the use of such compounds to modulate lipid metabolism and treat conditions associated with elevated PAI-1, cholesterol, or lipid levels.

公开(公告)号：US09408392B2

公开(公告)日：2016-08-09

申请号：US14375801

申请日：2013-02-14

Applicant: SYNGENTA PARTICIPATIONS AG

Inventor： Anthony Cornelius O'Sullivan ,  Olivier Loiseleur ,  Daniel Stierli ,  Torsten Luksch ,  Thomas Pitterna

IPC: C07C233/64 ,  C07C233/65 ,  C07C311/49 ,  C07D213/81 ,  C07D231/14 ,  C07D233/64 ,  C07D237/24 ,  C07D239/28 ,  C07D241/24 ,  C07D307/68 ,  A01N37/18 ,  A01N43/40 ,  A01N51/00 ,  A01N43/08 ,  A01N43/10 ,  A01N43/12 ,  A01N43/36 ,  A01N43/42 ,  A01N43/50 ,  A01N43/54 ,  A01N43/56 ,  A01N43/80 ,  A01N43/58 ,  A01N43/60

CPC classification number: A01N51/00 ,  A01N37/18 ,  A01N43/08 ,  A01N43/10 ,  A01N43/12 ,  A01N43/36 ,  A01N43/40 ,  A01N43/42 ,  A01N43/50 ,  A01N43/54 ,  A01N43/56 ,  A01N43/58 ,  A01N43/60 ,  A01N43/80 ,  C07C233/64 ,  C07C233/65 ,  C07C311/49 ,  C07D213/81 ,  C07D231/14 ,  C07D233/64 ,  C07D237/24 ,  C07D239/28 ,  C07D241/24 ,  C07D307/68

Abstract: Compounds of the formula (I), in which the substituents are as defined in claim 1, are suitable for use as nematicides.

Abstract translation: 其中取代基如权利要求1中所定义的式（I）化合物适合用作杀线虫剂。

公开(公告)号：US20150025042A1

公开(公告)日：2015-01-22

申请号：US14108162

申请日：2013-12-16

Applicant: Shoujun Chen ,  Keizo Koya ,  Zachary Demko ,  Lijun Sun

Inventor： Shoujun Chen ,  Keizo Koya ,  Zachary Demko ,  Lijun Sun

IPC: C07C327/56 ,  A61K31/16 ,  C07C257/22 ,  A61K31/277 ,  C07C311/55 ,  A61K31/18 ,  C07C243/34 ,  C07F9/22 ,  A61K31/664 ,  C07F9/46 ,  C07D307/66 ,  A61K31/341 ,  C07D207/34 ,  A61K31/40 ,  C07D271/113 ,  A61K31/4245 ,  A61K31/166

CPC classification number: C07C327/56 ,  A61K31/16 ,  A61K31/166 ,  A61K31/18 ,  A61K31/277 ,  A61K31/341 ,  A61K31/40 ,  A61K31/4245 ,  A61K31/664 ,  C07C243/28 ,  C07C243/34 ,  C07C255/66 ,  C07C257/22 ,  C07C261/04 ,  C07C281/06 ,  C07C307/04 ,  C07C311/49 ,  C07C311/51 ,  C07C311/55 ,  C07C337/06 ,  C07C2601/02 ,  C07D207/34 ,  C07D207/36 ,  C07D233/74 ,  C07D263/48 ,  C07D271/10 ,  C07D271/113 ,  C07D307/66 ,  C07F9/228 ,  C07F9/4423 ,  C07F9/4496 ,  C07F9/46

Abstract: Disclosed are compounds of formulae (I), (III), (IV), (VII), (X), (XI), (XII), (XIII) and (XIV), wherein the variables are as defined in the claims, and methods of using compounds of the invention for treating a subject with a proliferative disorder, such as cancer, and methods for treating disorders responsive to Hsp70 induction and/or natural killer induction. Also disclosed are pharmaceutical compositions comprising compounds of the invention and a pharmaceutically acceptable carrier.

Abstract translation: 公开了式（I），（III），（IV），（VII），（X），（XI），（XII），（XIII）和（XIV）的化合物，其中变量如权利要求 以及使用本发明化合物治疗患有增殖性疾病（例如癌症）的受试者的方法，以及用于治疗对Hsp70诱导和/或自然杀伤诱导反应的病症的方法。 还公开了包含本发明化合物和药学上可接受的载体的药物组合物。

公开(公告)号：US20140275037A1

公开(公告)日：2014-09-18

申请号：US14134165

申请日：2013-12-19

Applicant: Siga Technologies, Inc.

Inventor： Yijun Deng ,  Theodore J. Nitz ,  Thomas R. Bailey ,  Yanming Zhang ,  Sylvie Laquerre

IPC: C07C311/49 ,  C07D285/06 ,  C07D231/18 ,  C07D295/26 ,  C07D213/74 ,  C07D317/48 ,  C07D277/36 ,  C07D261/10 ,  C07D233/84 ,  C07D295/195 ,  C07C275/40 ,  C07D265/36 ,  C07D319/18

CPC classification number: C07C311/49 ,  A61K9/0014 ,  A61K9/0019 ,  A61K9/0031 ,  A61K9/0075 ,  A61K9/0078 ,  A61K9/0095 ,  A61K9/02 ,  A61K9/06 ,  A61K9/10 ,  A61K9/146 ,  A61K9/2027 ,  A61K9/2054 ,  A61K9/2059 ,  A61K9/4866 ,  A61K31/175 ,  C07C275/40 ,  C07D213/74 ,  C07D231/18 ,  C07D233/84 ,  C07D261/10 ,  C07D265/36 ,  C07D277/36 ,  C07D285/06 ,  C07D295/195 ,  C07D295/26 ,  C07D317/48 ,  C07D319/18 ,  C12N2760/12211 ,  Y02A50/387 ,  Y02A50/397

Abstract: Compounds, methods and pharmaceutical compositions for treating viral infections, by administering certain novel semicarbazides, sulfonyl carbazides, ureas and related compounds in therapeutically effective amounts are disclosed. Methods for preparing the compounds and methods of using the compounds and pharmaceutical compositions thereof are also disclosed. In particular, the treatment and prophylaxis of viral infections such as caused by hemorrhagic fever viruses is disclosed, i.e., including but not limited to Arenaviridae (Junin, Machupo, Guanavito, Sabia and Lassa), Filoviridae (ebola and Marburg viruses), Flaviviridae (yellow fever, omsk hemorrhagic fever and Kyasanur Forest disease viruses), and Bunyaviridae (Rift Valley fever).

Abstract translation: 公开了通过施用治疗有效量的某些新型氨基脲，磺酰基卡巴肼，脲和相关化合物来治疗病毒感染的化合物，方法和药物组合物。 还公开了制备化合物的方法和使用该化合物的方法及其药物组合物。 特别地，公开了治疗和预防由出血热病毒引起的病毒感染，即，包括但不限于：活细胞病毒科（Junin，Machupo，Guanavito，Sabia和Lassa），丝状病毒科（埃博拉病毒和马尔堡病毒），黄病毒科（Flaviviridae） 黄热病，o疮出血热和Kyasanur森林病毒）和布尼亚病毒科（裂谷热）。

公开(公告)号：US08778940B2

公开(公告)日：2014-07-15

申请号：US13487963

申请日：2012-06-04

Applicant: Jay Schneider ,  Jenny Hsieh ,  Douglas Frantz ,  Steven L. McKnight ,  Joseph M. Ready

Inventor： Jay Schneider ,  Jenny Hsieh ,  Douglas Frantz ,  Steven L. McKnight ,  Joseph M. Ready

IPC: A61K31/422 ,  A61K31/427 ,  A61K31/4439 ,  A61K31/496 ,  A61K31/5377 ,  A61K31/415 ,  A61K31/4155 ,  A61K31/42

CPC classification number: C07D413/04 ,  A61K31/415 ,  A61K31/4155 ,  A61K31/42 ,  A61K31/422 ,  A61K31/427 ,  A61K31/4439 ,  A61K31/496 ,  A61K31/5377 ,  C07C311/49 ,  C07D231/12 ,  C07D261/08 ,  C07D261/18 ,  C07D403/04 ,  C07D405/04 ,  C07D409/04 ,  C07D413/14 ,  C07D417/04 ,  C12N5/0618 ,  C12N5/0657 ,  C12N2501/999

Abstract: The present invention relates to compounds and methods for inducing neuronal differentiation in normal neural stem cells and brain cancer stem cells. The methods may take place in vitro, such as in isolates from the adult mammalian brain, or in vivo. Compounds and methods described herein may find use in the treatment of neurodegenerative and psychiatric diseases, the repair and regeneration of the nervous system, and in treatment of neurologic malignancy.

Abstract translation: 本发明涉及在正常神经干细胞和脑癌干细胞中诱导神经元分化的化合物和方法。 该方法可以在体外进行，例如在来自成年哺乳动物脑的分离物中，或在体内。 本文所述的化合物和方法可用于治疗神经变性和精神疾病，神经系统的修复和再生以及治疗神经恶性肿瘤。

公开(公告)号：US08410149B2

公开(公告)日：2013-04-02

申请号：US12914400

申请日：2010-10-28

Applicant: Dongcheng Dai ,  Tove Bolken ,  Sean M. Amberg ,  Dennis E. Hruby ,  Thomas R. Bailey

Inventor： Dongcheng Dai ,  Tove Bolken ,  Sean M. Amberg ,  Dennis E. Hruby ,  Thomas R. Bailey

IPC: A61K31/175 ,  A61K31/433 ,  C07C281/06 ,  C07D285/04

CPC classification number: C07C311/49 ,  A61K31/18 ,  A61K31/357 ,  A61K31/40 ,  A61K31/415 ,  A61K31/42 ,  A61K31/426 ,  A61K31/433 ,  A61K31/445 ,  A61K31/496 ,  A61K31/5377 ,  A61K31/538 ,  A61K31/55 ,  A61K31/63 ,  C07D265/36 ,  C07D285/06 ,  Y02A50/387 ,  Y02A50/397

Abstract: Compounds, methods and pharmaceutical compositions for treating viral infections, by administering certain novel semicarbazides, sulfonyl carbazides, ureas and related compounds in therapeutically effective amounts are disclosed. Methods for preparing the compounds and methods of using the compounds and pharmaceutical compositions thereof are also disclosed. In particular, the treatment and prophylaxis of viral infections such as caused by hemorrhagic fever viruses is disclosed, i.e., including but not limited to Arenaviridae (Junin, Machupo, Guanavito, Sabia and Lassa), Filoviridae (ebola and Marburg viruses), Flaviviridae (yellow fever, omsk hemorrhagic fever and Kyasanur Forest disease viruses), and Bunyaviridae (Rift Valley fever).

公开(公告)号：US08193247B2

公开(公告)日：2012-06-05

申请号：US12225572

申请日：2007-03-23

Applicant: Yousef Al-Abed

Inventor： Yousef Al-Abed

IPC: A61K31/13 ,  C07C249/00 ,  A61P29/00

CPC classification number: C07C251/86 ,  C07C281/02 ,  C07C311/49

Abstract: Provided are various compounds of Formula (I): Also provided are pharmaceutical compositions comprising the above compounds. Additionally, methods of inhibiting macrophage migration inhibitory factor (MIF) activity in a mammal are provided, as are methods of treating or preventing inflammation in a mammal. Further provided are methods of treating a mammal having sepsis, septicemia, and/or endotoxic shock. Also provided are methods of treating a mammal having an autoimmune disease, and methods of treating a mammal having a tumor.

Abstract translation: 提供式（I）的各种化合物：还提供包含上述化合物的药物组合物。 此外，提供了哺乳动物抑制巨噬细胞迁移抑制因子（MIF）活性的方法，以及治疗或预防哺乳动物炎症的方法。 还提供了治疗具有败血症，败血病和/或内毒素性休克的哺乳动物的方法。 还提供了治疗具有自身免疫疾病的哺乳动物的方法以及治疗具有肿瘤的哺乳动物的方法。

公开(公告)号：US08193225B2

公开(公告)日：2012-06-05

申请号：US11974479

申请日：2007-10-12

Applicant: Jay Schneider ,  Jenny Hsieh ,  Douglas Frantz ,  Steven L. McKnight ,  Joseph M. Ready

Inventor： Jay Schneider ,  Jenny Hsieh ,  Douglas Frantz ,  Steven L. McKnight ,  Joseph M. Ready

IPC: A61K31/422 ,  C07D261/18

CPC classification number: C07D413/04 ,  A61K31/415 ,  A61K31/4155 ,  A61K31/42 ,  A61K31/422 ,  A61K31/427 ,  A61K31/4439 ,  A61K31/496 ,  A61K31/5377 ,  C07C311/49 ,  C07D231/12 ,  C07D261/08 ,  C07D261/18 ,  C07D403/04 ,  C07D405/04 ,  C07D409/04 ,  C07D413/14 ,  C07D417/04 ,  C12N5/0618 ,  C12N5/0657 ,  C12N2501/999

Abstract: The present invention relates to compounds and methods for inducing neuronal differentiation in normal neural stem cells and brain cancer stem cells. The compounds are isoxazole amides and derivatives thereof. The methods may take place in vitro, such as in isolates from the adult mammalian brain, or in vivo. Compounds and methods described herein may find use in the treatment of neurodegenerative and psychiatric diseases, the repair and regeneration of the nervous system, and in treatment of neurologic malignancy.

Abstract translation: 本发明涉及在正常神经干细胞和脑癌干细胞中诱导神经元分化的化合物和方法。 化合物是异恶唑酰胺及其衍生物。 该方法可以在体外进行，例如在来自成年哺乳动物脑的分离物中，或在体内。 本文所述的化合物和方法可用于治疗神经变性和精神疾病，神经系统的修复和再生以及治疗神经恶性肿瘤。