公开(公告)号：US12091386B2

公开(公告)日：2024-09-17

申请号：US17500680

申请日：2021-10-13

申请人： Zevra Therapeutics, Inc.

发明人： Sven Guenther ,  Guochen Chi ,  Travis Mickle

IPC分类号： C07D213/56 ,  A61K9/00 ,  A61K31/44 ,  A61K31/4458 ,  A61K31/4545 ,  A61K47/55 ,  C07D213/79 ,  C07D213/80 ,  C07D213/81 ,  C07D401/06 ,  C07D413/06 ,  A61K9/02

CPC分类号： C07D213/79 ,  A61K9/0019 ,  A61K9/0043 ,  A61K31/4458 ,  A61K31/4545 ,  A61K47/55 ,  C07D213/80 ,  C07D213/81 ,  C07D401/06 ,  C07D413/06 ,  A61K9/0053 ,  A61K9/02

摘要： Disclosed are d-amphetamine compounds and compositions comprising at least one organic acid covalently bound to d-amphetamine, having the structure of




a salt thereof, a derivative thereof, or a combination thereof. Methods of making and using the same are also disclosed.

公开(公告)号：US12090226B2

公开(公告)日：2024-09-17

申请号：US18588687

申请日：2024-02-27

申请人： Cristcot LLC

发明人： Jennifer J. Davagian ,  Raj Devarajan

IPC分类号： A61K9/02 ,  A61K9/00 ,  A61K31/573 ,  A61K47/02 ,  A61K47/10 ,  A61K47/14 ,  A61K47/20 ,  A61M31/00

CPC分类号： A61K9/025 ,  A61K9/0031 ,  A61K9/02 ,  A61K31/573 ,  A61K47/02 ,  A61K47/10 ,  A61K47/14 ,  A61K47/20 ,  A61M31/007 ,  A61M2210/1064 ,  A61M2210/1067

摘要： The present invention relates, in various embodiments, to formulations comprising hydrocortisone and silicon dioxide. In additional embodiments, the invention relates to suppositories comprising hydrocortisone and silicon dioxide. The formulations of the present invention are useful for administration to patients who have gastrointestinal diseases and disorders such as, for example, inflammatory bowel disease.

公开(公告)号：US20240197630A1

公开(公告)日：2024-06-20

申请号：US18588996

申请日：2024-02-27

申请人： Cristcot LLC

发明人： Jennifer J. Davagian ,  Raj Devarajan

IPC分类号： A61K9/02 ,  A61K9/00 ,  A61K31/573 ,  A61K47/02 ,  A61K47/10 ,  A61K47/14 ,  A61K47/20 ,  A61M31/00

CPC分类号： A61K9/025 ,  A61K9/0031 ,  A61K9/02 ,  A61K31/573 ,  A61K47/02 ,  A61K47/10 ,  A61K47/14 ,  A61K47/20 ,  A61M31/007 ,  A61M2210/1064 ,  A61M2210/1067

摘要： The present invention relates, in various embodiments, to formulations comprising hydrocortisone and silicon dioxide. In additional embodiments, the invention relates to suppositories comprising hydrocortisone and silicon dioxide. The formulations of the present invention are useful for administration to patients who have gastrointestinal diseases and disorders such as, for example, inflammatory bowel disease.

公开(公告)号：US20240165168A1

公开(公告)日：2024-05-23

申请号：US18523002

申请日：2023-11-29

申请人： President and Fellows of Harvard College

发明人： Peter Q. Nguyen ,  Neel Satish Joshi

IPC分类号： A61K35/74 ,  A61K9/00 ,  A61K9/02 ,  A61K9/20 ,  A61K9/48 ,  A61P1/00 ,  C07K14/245 ,  C07K19/00 ,  C12P21/02

CPC分类号： A61K35/74 ,  A61K9/0031 ,  A61K9/0056 ,  A61K9/02 ,  A61K9/20 ,  A61K9/48 ,  A61P1/00 ,  C07K14/245 ,  C07K19/00 ,  C12P21/02 ,  C07K2317/622 ,  C07K2319/02 ,  C07K2319/036 ,  C07K2319/21

摘要： Engineered bacteria that secrete therapeutic polypeptides, pharmaceutical compositions comprising the bacteria, methods for producing recombinant polypeptides, and methods for using the bacteria for diagnostic and therapeutic purposes are provided.

公开(公告)号：US20240076300A1

公开(公告)日：2024-03-07

申请号：US18144800

申请日：2023-05-08

申请人： C4 Therapeutics, Inc.

发明人： Christopher G. Nasveschuk ,  Martin Duplessis ,  Jae Young Ahn ,  Alexander W. Hird ,  Ryan E. Michael ,  Kiel Lazarski ,  Yanke Liang ,  Georg Jaeschke ,  Antonio Ricci ,  Annick Goergler ,  Daniel Rueher

IPC分类号： C07D519/00 ,  A61K9/00 ,  A61K9/02 ,  A61K9/08 ,  A61K9/20 ,  A61K9/48 ,  A61K47/10 ,  A61K47/12 ,  A61K47/26 ,  A61K47/32 ,  A61K47/38 ,  C07D487/04

CPC分类号： C07D519/00 ,  A61K9/009 ,  A61K9/02 ,  A61K9/08 ,  A61K9/2013 ,  A61K9/2018 ,  A61K9/2054 ,  A61K9/4825 ,  A61K9/485 ,  A61K9/4858 ,  A61K9/4866 ,  A61K47/10 ,  A61K47/12 ,  A61K47/26 ,  A61K47/32 ,  A61K47/38 ,  C07D487/04

摘要： The invention provides compounds that degrade the epidermal growth factor receptor (EGFR) including mutant forms via the ubiquitination of the EGFR protein and subsequent proteasomal degradation. The compounds are useful for the treatment of various cancers.

公开(公告)号：US11905248B2

公开(公告)日：2024-02-20

申请号：US16653475

申请日：2019-10-15

申请人： CalciMedica, Inc.

发明人： Jeffrey P. Whitten ,  Yazhong Pei ,  Jianguo Cao ,  Zhijun Wang ,  Evan Rogers ,  Brian Dyck ,  Jonathan Grey

IPC分类号： C07D213/74 ,  C07D213/75 ,  C07D241/20 ,  C07D401/04 ,  C07D405/04 ,  C07D405/14 ,  C07D409/04 ,  C07D409/14 ,  C07D413/04 ,  C07D413/14 ,  C07D417/04 ,  C07D417/14 ,  A61K31/00 ,  A61K47/02 ,  A61K47/10 ,  A61K47/12 ,  A61K47/14 ,  A61K47/20 ,  A61K47/38 ,  C07D471/04 ,  C07D495/04 ,  A61K9/02 ,  A61K9/00 ,  A61K9/20 ,  C07D493/10 ,  A61K9/06

CPC分类号： C07D213/74 ,  A61K9/0014 ,  A61K9/0019 ,  A61K9/0031 ,  A61K9/0048 ,  A61K9/0056 ,  A61K9/0078 ,  A61K9/0095 ,  A61K9/02 ,  A61K9/06 ,  A61K9/2018 ,  A61K9/2054 ,  A61K9/2059 ,  A61K31/00 ,  A61K47/02 ,  A61K47/10 ,  A61K47/12 ,  A61K47/14 ,  A61K47/20 ,  A61K47/38 ,  C07D213/75 ,  C07D241/20 ,  C07D401/04 ,  C07D405/04 ,  C07D405/14 ,  C07D409/04 ,  C07D409/14 ,  C07D413/04 ,  C07D413/14 ,  C07D417/04 ,  C07D417/14 ,  C07D471/04 ,  C07D493/10 ,  C07D495/04

摘要： Described herein are compounds and pharmaceutical compositions containing such compounds, which modulate the activity of store-operated calcium (SOC) channels. Also described herein are methods of using such SOC channel modulators, alone and in combination with other compounds, for treating diseases or conditions that would benefit from inhibition of SOC channel activity.

公开(公告)号：US11850268B2

公开(公告)日：2023-12-26

申请号：US17698596

申请日：2022-03-18

申请人： President and Fellows of Harvard College

发明人： Peter Q. Nguyen ,  Neel Satish Joshi

IPC分类号： C12P21/06 ,  A61K35/74 ,  C07K14/245 ,  C12P21/02 ,  A61P1/00 ,  A61K9/00 ,  A61K9/02 ,  A61K9/20 ,  A61K9/48 ,  C07K19/00

CPC分类号： A61K35/74 ,  A61K9/0031 ,  A61K9/0056 ,  A61K9/02 ,  A61K9/20 ,  A61K9/48 ,  A61P1/00 ,  C07K14/245 ,  C07K19/00 ,  C12P21/02 ,  C07K2317/622 ,  C07K2319/02 ,  C07K2319/036 ,  C07K2319/21

摘要： Engineered bacteria that secrete therapeutic polypeptides, pharmaceutical compositions comprising the bacteria, methods for producing recombinant polypeptides, and methods for using the bacteria for diagnostic and therapeutic purposes are provided.

公开(公告)号：US11738032B2

公开(公告)日：2023-08-29

申请号：US17094233

申请日：2020-11-10

申请人： Dr. Falk Pharma GmbH

发明人： Rudolph Wilhelm ,  Markus Pröls ,  Roland Greinwald ,  Ralf Mohrbacher

IPC分类号： A01N37/00 ,  A61K31/215 ,  A01N37/12 ,  A01N37/44 ,  A61K31/24 ,  A01N25/00 ,  A61K31/58 ,  A61K9/02 ,  A61K31/606 ,  A61P29/00

CPC分类号： A61K31/58 ,  A61K9/02 ,  A61K31/606 ,  A61P29/00 ,  A61K31/58 ,  A61K2300/00 ,  A61K31/606 ,  A61K2300/00

摘要： Disclosed is a storage-stable pharmaceutical formulation for rectal administration, containing budesonide or a pharmaceutically compatible salt or derivative thereof, and at least 80 wt % of a solid fat or a mixture of different solid fats, based on the total weight of the formulation, as well as at least one anti-oxidation agent that is compatible therewith.

公开(公告)号：US20230218636A1

公开(公告)日：2023-07-13

申请号：US18053120

申请日：2022-11-07

申请人： TherapeuticsMD, Inc.

发明人： Brian A. BERNICK ,  Janice Louise CACACE ,  Peter H.R. PERSICANER ,  Neda IRANI ,  Julia M. AMADIO ,  Frederick D. SANCILIO

IPC分类号： A61K31/57 ,  A61K9/48 ,  A61K9/107 ,  A61K31/565 ,  A61K47/10 ,  A61K47/14 ,  A61K9/00 ,  A61K47/44 ,  A61K9/02

CPC分类号： A61K31/57 ,  A61K9/02 ,  A61K9/0034 ,  A61K9/48 ,  A61K9/1075 ,  A61K9/4858 ,  A61K9/4866 ,  A61K31/565 ,  A61K47/10 ,  A61K47/14 ,  A61K47/44

摘要： Estrogen and progesterone replacement therapies are provided herein. Among others, the following formulations are provided herein: solubilized estradiol without progesterone; micronized progesterone without estradiol; micronized progesterone with partially solubilized progesterone; solubilized estradiol with micronized progesterone; solubilized estradiol with micronized progesterone in combination with partially solubilized progesterone; and solubilized estradiol with solubilized progesterone.

公开(公告)号：US20230174579A1

公开(公告)日：2023-06-08

申请号：US17782336

申请日：2020-12-04

申请人： AJOU UNIVERSITY INDUSTRY-ACADEMIC COOPERATION FOUNDATION

发明人： Seonghyang SOHN

IPC分类号： C07K7/08 ,  A61P19/02 ,  A61K9/00 ,  A61K9/02

CPC分类号： C07K7/08 ,  A61K9/02 ,  A61K9/0019 ,  A61K9/0056 ,  A61P19/02

摘要： The present invention relates to a composition for preventing or treating Behcet’s disease and rheumatoid arthritis, the composition containing a peptide or a mixture thereof as an active ingredient. More specifically, an intraperitoneal injection or application of P1 to P5 peptides or a mixture thereof as a skin external preparation to a mouse animal model having Behcet’s disease caused by autoimmune response was found to ameliorate skin ulcers and skin inflammation in the Behcet’s disease mouse model, and an arthritis amelioration effect on a rheumatoid arthritis animal model was also observed. Accordingly, the composition containing P1 to P5 peptides or mixtures thereof as active ingredients can be provided as medicine for Behcet’s disease and rheumatoid arthritis.