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公开(公告)号:US12115253B2
公开(公告)日:2024-10-15
申请号:US18588996
申请日:2024-02-27
申请人: Cristcot LLC
IPC分类号: A61K9/02 , A61K9/00 , A61K31/573 , A61K47/02 , A61K47/10 , A61K47/14 , A61K47/20 , A61M31/00
CPC分类号: A61K9/025 , A61K9/0031 , A61K9/02 , A61K31/573 , A61K47/02 , A61K47/10 , A61K47/14 , A61K47/20 , A61M31/007 , A61M2210/1064 , A61M2210/1067
摘要: The present invention relates, in various embodiments, to formulations comprising hydrocortisone and silicon dioxide. In additional embodiments, the invention relates to suppositories comprising hydrocortisone and silicon dioxide. The formulations of the present invention are useful for administration to patients who have gastrointestinal diseases and disorders such as, for example, inflammatory bowel disease.
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公开(公告)号:US11376217B2
公开(公告)日:2022-07-05
申请号:US16856806
申请日:2020-04-23
申请人: Cristcot LLC
IPC分类号: A61K9/02 , A61K47/02 , A61K9/00 , A61M31/00 , A61K31/573 , A61K47/10 , A61K47/14 , A61K47/20
摘要: The present invention relates, in various embodiments, to formulations comprising hydrocortisone and silicon dioxide. In additional embodiments, the invention relates to suppositories comprising hydrocortisone and silicon dioxide. The formulations of the present invention are useful for administration to patients who have gastrointestinal diseases and disorders such as, for example, inflammatory bowel disease.
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公开(公告)号:US10149967B2
公开(公告)日:2018-12-11
申请号:US14436359
申请日:2013-10-18
申请人: Cristcot LLC
IPC分类号: A61M31/00 , A61J3/08 , A61B50/30 , A45D40/16 , A61K9/02 , A61K9/00 , A45D40/00 , A45D40/08 , A45D40/12 , A45D40/20
摘要: Today's suppositories are typically packaged individually for digital administration into the anal canal of a patient. A suppository applicator described herein, which works with individually packaged suppositories, can alternatively be shipped in a prepackaged operational arrangement with a suppository to enable the patient to administer the suppository through use of the applicator in a single operation after opening a hygienic wrapper containing the applicator-suppository combination. A method for manufacturing a suppository includes manufacturing the suppository in the presence of and in contact with an element configured to be used to insert the suppository into a body cavity. The method may include using the element to define a shape of the suppository during the manufacturing. The resulting applicator-suppository combination is more hygienic and easier to handle than the separate applicator and suppository and provides more efficiency from time of opening the packaging to time of commencing administration of the suppository.
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公开(公告)号:US12109306B2
公开(公告)日:2024-10-08
申请号:US18588892
申请日:2024-02-27
申请人: Cristcot LLC
IPC分类号: A61K9/02 , A61K9/00 , A61K31/573 , A61K47/02 , A61K47/10 , A61K47/14 , A61K47/20 , A61M31/00
CPC分类号: A61K9/025 , A61K9/0031 , A61K9/02 , A61K31/573 , A61K47/02 , A61K47/10 , A61K47/14 , A61K47/20 , A61M31/007 , A61M2210/1064 , A61M2210/1067
摘要: The present invention relates, in various embodiments, to formulations comprising hydrocortisone and silicon dioxide. In additional embodiments, the invention relates to suppositories comprising hydrocortisone and silicon dioxide. The formulations of the present invention are useful for administration to patients who have gastrointestinal diseases and disorders such as, for example, inflammatory bowel disease.
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公开(公告)号:US11298515B2
公开(公告)日:2022-04-12
申请号:US16098623
申请日:2017-05-11
申请人: Cristcot LLC
发明人: Jennifer J. Davagian
摘要: A single-use suppository insertion device includes a barrel, a plunger to be movably coupled to the barrel, and a disabling feature of the barrel or the plunger. The disabling feature may be activated during operational motion of the plunger relative to the barrel, such as during insertion of or withdrawal away from a suppository. The device can include a structural element of the barrel or the plunger to engage with the disabling feature of the barrel or the plunger during insertion of or withdrawal away from the suppository to activate the disabling feature. The disabling feature may be implemented in a number of ways to ensure single-use operation of the single-use suppository insertion device.
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公开(公告)号:US10653623B2
公开(公告)日:2020-05-19
申请号:US15555325
申请日:2016-03-10
申请人: Cristcot LLC
IPC分类号: A61K9/02 , A61K47/02 , A61K31/573 , A61K9/00 , A61K47/10 , A61K47/14 , A61K47/20 , A61M31/00
摘要: The present invention relates, in various embodiments, to formulations comprising hydrocortisone and silicon dioxide. In additional embodiments, the invention relates to suppositories comprising hydrocortisone and silicon dioxide. The formulations of the present invention are useful for administration to patients who have gastrointestinal diseases and disorders such as, for example, inflammatory bowel disease.
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公开(公告)号:US20190151636A1
公开(公告)日:2019-05-23
申请号:US16197005
申请日:2018-11-20
申请人: Cristcot LLC
摘要: Today's suppositories are typically packaged individually for digital administration into the anal canal of a patient. A suppository applicator described herein, which works with individually packaged suppositories, can alternatively be shipped in a prepackaged operational arrangement with a suppository to enable the patient to administer the suppository through use of the applicator in a single operation after opening a hygienic wrapper containing the applicator-suppository combination. A method for manufacturing a suppository includes manufacturing the suppository in the presence of and in contact with an element configured to be used to insert the suppository into a body cavity. The method may include using the element to define a shape of the suppository during the manufacturing. The resulting applicator-suppository combination is more hygienic and easier to handle than the separate applicator and suppository and provides more efficiency from time of opening the packaging to time of commencing administration of the suppository
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公开(公告)号:US12090226B2
公开(公告)日:2024-09-17
申请号:US18588687
申请日:2024-02-27
申请人: Cristcot LLC
IPC分类号: A61K9/02 , A61K9/00 , A61K31/573 , A61K47/02 , A61K47/10 , A61K47/14 , A61K47/20 , A61M31/00
CPC分类号: A61K9/025 , A61K9/0031 , A61K9/02 , A61K31/573 , A61K47/02 , A61K47/10 , A61K47/14 , A61K47/20 , A61M31/007 , A61M2210/1064 , A61M2210/1067
摘要: The present invention relates, in various embodiments, to formulations comprising hydrocortisone and silicon dioxide. In additional embodiments, the invention relates to suppositories comprising hydrocortisone and silicon dioxide. The formulations of the present invention are useful for administration to patients who have gastrointestinal diseases and disorders such as, for example, inflammatory bowel disease.
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公开(公告)号:US20240197630A1
公开(公告)日:2024-06-20
申请号:US18588996
申请日:2024-02-27
申请人: Cristcot LLC
IPC分类号: A61K9/02 , A61K9/00 , A61K31/573 , A61K47/02 , A61K47/10 , A61K47/14 , A61K47/20 , A61M31/00
CPC分类号: A61K9/025 , A61K9/0031 , A61K9/02 , A61K31/573 , A61K47/02 , A61K47/10 , A61K47/14 , A61K47/20 , A61M31/007 , A61M2210/1064 , A61M2210/1067
摘要: The present invention relates, in various embodiments, to formulations comprising hydrocortisone and silicon dioxide. In additional embodiments, the invention relates to suppositories comprising hydrocortisone and silicon dioxide. The formulations of the present invention are useful for administration to patients who have gastrointestinal diseases and disorders such as, for example, inflammatory bowel disease.
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公开(公告)号:US20220287963A1
公开(公告)日:2022-09-15
申请号:US17831946
申请日:2022-06-03
申请人: Cristcot LLC
发明人: Jennifer J. Davagian
IPC分类号: A61K9/02 , A61K47/02 , A61K31/573 , A61K9/00 , A61K47/10 , A61K47/14 , A61K47/20 , A61M31/00
摘要: The present invention relates, in various embodiments, to formulations comprising hydrocortisone and silicon dioxide. In additional embodiments, the invention relates to suppositories comprising hydrocortisone and silicon dioxide. The formulations of the present invention are useful for administration to patients who have gastrointestinal diseases and disorders such as, for example, inflammatory bowel disease.
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