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    Kind of piperphentonamine hydrochloride lyophilized powder for injection and preparation and use thereof
    2.
    发明授权
    Kind of piperphentonamine hydrochloride lyophilized powder for injection and preparation and use thereof 有权
    盐酸椒苯酮胺冻干粉末的制备方法及用途

    公开(公告)号：US08513301B2

    公开(公告)日：2013-08-20

    申请号：US12598356

    申请日：2007-01-31

    申请人： Huayin Wan ,  Rubing Li ,  Yonghe Li ,  Lijian Zhou ,  Tieqiu Liu ,  Xiaohui Zhong

    发明人： Huayin Wan ,  Rubing Li ,  Yonghe Li ,  Lijian Zhou ,  Tieqiu Liu ,  Xiaohui Zhong

    IPC分类号： A61K31/36 ,  A61K31/445 ,  A61K9/00

    CPC分类号： A61K31/36 ,  A61K9/0014 ,  A61K9/19 ,  A61K47/10 ,  A61K47/183 ,  A61K47/26 ,  C07D317/48

    摘要： A kind of piperphentonamine hydrochloride lyophilized powder for injection and a preparation method thereof. The injection is prepared by one portion of piperphentonamine hydrochloride, 2.5-30 parts of excipient and 400-600 parts of water for injection with pH 1.5-5.5 via freeze-drying. The excipient is mannitol, dextran, lactose, saccharose, polyethylene glycol, poloxamer, glycine, etc.; It is preferred that the injection comprises one part of piperphentonamine hydrochloride, 10 parts of mannitol and 500 parts of water for injection with pH 2.0-3.0. The product is prepared by adding said piperphentonamine hydrochloride and excipient into water for injection, heating at 40° C.-90° C., ultrasonic dissolving, degerming, individually packing, pre-freezing and multistage drying, and packaging. Individually packing into a tubular glass bottle with brown color is preferred. The appearance, color & luster and solubility of the injection are excellent, the stability is good and with long storage period. The invention also provides the uses of the injection in the preparation of a medicament for treatment of heart failure and/or cardioprotection.

    摘要翻译： 一种盐酸椒苯酮胺冻干粉末及其制备方法。 注射液由盐酸椒苯酮胺，2.5-30份赋形剂和400-600份注射用水通过冷冻干燥制备，pH为1.5-5.5。 赋形剂是甘露糖醇，葡聚糖，乳糖，蔗糖，聚乙二醇，泊洛沙姆，甘氨酸等; 注射剂优选包含一部分盐酸椒苯酮胺，10份甘露醇和500份注射用水，pH为2.0-3.0。 通过将所述盐酸椒苯酮胺和赋形剂加入注射用水中，在40℃〜90℃加热，超声溶解，除菌，单独包装，预冷冻和多级干燥以及包装，制备产品。 单独包装成棕色的管状玻璃瓶是首选。 注射剂的外观，颜色，光泽和溶解性优异，稳定性好，储存时间长。 本发明还提供了注射用于制备用于治疗心力衰竭和/或心脏保护的药物的用途。

    CARBOXYLIC ACID COMPOUNDS AND MEDICINAL COMPOSITIONS CONTAINING THE SAME AS THE ACTIVE INGREDIENT
    4.
    发明申请
    CARBOXYLIC ACID COMPOUNDS AND MEDICINAL COMPOSITIONS CONTAINING THE SAME AS THE ACTIVE INGREDIENT 有权
    羧酸化合物和含有相同活性成分的药物组合物

    公开(公告)号：US20100029631A1

    公开(公告)日：2010-02-04

    申请号：US12551860

    申请日：2009-09-01

    申请人： Atsushi Naganawa ,  Maki Iwahashi ,  Atsushi Kinoshita ,  Atsushi Shimabukuro ,  Seiji Ogawa ,  Koji Yano ,  Kaoru Kobayashi ,  Yutaka Okada ,  Yoko Kishida ,  Shouji Kawauchi ,  Kohki Tsukamoto ,  Yoko Matsunaga ,  Fumio Nambu

    发明人： Atsushi Naganawa ,  Maki Iwahashi ,  Atsushi Kinoshita ,  Atsushi Shimabukuro ,  Seiji Ogawa ,  Koji Yano ,  Kaoru Kobayashi ,  Yutaka Okada ,  Yoko Kishida ,  Shouji Kawauchi ,  Kohki Tsukamoto ,  Yoko Matsunaga ,  Fumio Nambu

    IPC分类号： A61K31/538 ,  C07D265/36 ,  A61P37/08 ,  A61P11/06

    CPC分类号： C07D307/80 ,  A61K31/343 ,  A61K31/538 ,  C07D265/36 ,  C07D317/48

    摘要： A compound represented by formula (I) wherein the symbols in the formula are the same meanings as those in specification, salts thereof, solvates thereof, or prodrugs thereof binds to DP receptor and shows antagonistic activity for DP receptor. Thus, it is useful for prevention and/or treatment of diseases such as allergic disease (e.g., allergic rhinitis, allergic conjunctivitis, atopic dermatitis, bronchial asthma and food allergy), systemic mastocytosis, disorders accompanied by systemic mast cell activation, anaphylaxis shock, bronchoconstriction, urticaria, eczema, diseases accompanied by itch (e.g., atopic dermatitis and urticaria), diseases (e.g., cataract, retinal detachment, inflammation, infection and sleeping disorders) which is generated secondarily as a result of behavior accompanied by itch (e.g., scratching and beating), inflammation, chronic obstructive pulmonary diseases, ischemic reperfusion injury, cerebrovascular accident, chronic rheumatoid arthritis, pleurisy, ulcerative colitis, etc. Since it specifically binds to DP receptor and binds weakly to other prostaglandins receptors, they can be pharmaceuticals having little side effect.

    摘要翻译： 由式（I）表示的化合物，其中式中的符号与说明书中的符号相同，其盐，溶剂合物或其前药与DP受体结合并显示DP受体的拮抗活性。 因此，它可用于预防和/或治疗过敏性疾病（例如过敏性鼻炎，过敏性结膜炎，特应性皮炎，支气管哮喘和食物过敏），系统性肥大细胞增多症，伴有全身性肥大细胞活化的病症，过敏性休克， 支气管收缩，荨麻疹，湿疹，伴有瘙痒的疾病（例如特应性皮炎和荨麻疹），伴随瘙痒的行为的结果产生的疾病（例如白内障，视网膜脱离，炎症，感染和睡眠障碍）（例如， 搔抓和殴打），炎症，慢性阻塞性肺疾病，缺血再灌注损伤，脑血管意外，慢性类风湿关节炎，胸膜炎，溃疡性结肠炎等。由于其特异性结合DP受体并且弱结合到其他前列腺素受体，它们可以是具有 小副作用。

    Benzodioxole derivatives useful as pesticides
    8.
    发明授权
    Benzodioxole derivatives useful as pesticides 失效
    苯二酮衍生物作为杀虫剂有用

    公开(公告)号：US3736338A

    公开(公告)日：1973-05-29

    申请号：US3736338D

    申请日：1971-04-01

    申请人： FISONS LTD

    发明人： GATES P ,  GILLON J

    IPC分类号： C07D317/46 ,  C07D317/48 ,  C07D317/64 ,  C07D317/72 ,  C07D13/10

    CPC分类号： C07D317/72 ,  C07D317/46 ,  C07D317/48 ,  C07D317/64 ,  Y10S514/951 ,  Y10S514/953

    摘要： SUBSTITUTED BENZODIOXOLES OF THE FORMULA:

    2-R1,2-R2,4-(R3-N(-R4)-COO-),5-R5,6-R6,7-R7-1,3-BENZO-

    DIOXOLE

    WHEREIN R1 AND R2 ARE HYDROGEN OR ALKYL OF 1 TO 6 CARBON ATOMS OR TOGETHER WITH THE LINKING CARBON ATOM FROM A CYCLOALKANE RING OF 5 TO 7 ATOMS, R3 IS HYDROGEN, ALKYL OF 1 TO 4 CARBON ATOMS OR ACETYL, R4 IS ALKYL OFUP TO 4 CARBON ATOMS, ALKENYL OF UP TO 4 CARBON ATOMS, OR ALKYNYL OF UP TO 4 CARBON ATOMS, AND ONE OF R5, R6 AND R7 IS HYDROGEN, HALOGEN OR ALKYL OF 1 TO 4 CARBON ATOMS, AND THE OTHER OF R5 AND R6 AND R7 EACH REPRESENTS A HYDROGEN ATOM ARE VALUABLE PSTICIDES, PARTICULARLY INSECTICIDES.