知搜-全球专利检索

  1. Login
  2. Sign Up

Search Results

2087 records (took 0.028 seconds)

    SESQUITERPENOID DERIVATIVE AND USE THEREOF IN PREPARING BROAD-SPECTRUM ANTIVIRAL DRUG
    1.
    发明公开
    SESQUITERPENOID DERIVATIVE AND USE THEREOF IN PREPARING BROAD-SPECTRUM ANTIVIRAL DRUG 审中-公开

    公开(公告)号：US20240270754A1

    公开(公告)日：2024-08-15

    申请号：US18625188

    申请日：2024-04-02

    Applicant: KUNMING UNIVERSITY OF SCIENCE AND TECHNOLOGY

    Inventor： Min XU ,  Shaoxing DAI

    IPC: C07D493/10 ,  A61K31/35 ,  A61P31/14

    CPC classification number: C07D493/10 ,  A61K31/35 ,  A61P31/14

    Abstract: A sesquiterpenoid derivative and use thereof in preparing a broad-spectrum antiviral drug provided. The sesquiterpenoid derivative can stimulate heterogeneous nuclear ribonucleoprotein A2/B1, activate the cell signal pathway of TANK-binding kinase 1-interferon regulatory factor 3, and increase the expression and secretion of endogenous type I interferon. As a result, it can inhibiting various viruses and can be used as a broad-spectrum antiviral drug for preventing or treating various viral infectious diseases and symptoms, including Covid-19, vesicular stomatitis virus VSV-G, AIDS virus, hepatitis C virus, Japanese encephalitis virus, influenza virus, poliovirus, Coxsackie virus, dengue virus, rotavirus, tobacco mosaic virus, measles virus, mumps virus, Ebola virus, Marburg virus, herpes virus and adenovirus. Sesquiterpenoid derivatives can be made as a raw material into oral dosage form such as tablet, capsule and dripping pill, or clinically acceptable pharmaceutical preparation such as inhalant and injection.

    SYSTEMS AND METHODS FOR TREATING AND INHIBITING WOUND INFECTIONS
    2.
    发明公开
    SYSTEMS AND METHODS FOR TREATING AND INHIBITING WOUND INFECTIONS 审中-公开

    公开(公告)号：US20240050735A1

    公开(公告)日：2024-02-15

    申请号：US18493925

    申请日：2023-10-25

    Applicant: Board of Regents of the University of Nebraska

    Inventor： Siwei Zhao ,  Fan Zhao

    IPC: A61N1/04 ,  A61K31/35 ,  A61K38/12

    CPC classification number: A61N1/0468 ,  A61K31/35 ,  A61K38/12 ,  A61N1/0472

    Abstract: Systems and methods for treating and inhibiting wound infections employ a hydrogel ionic circuit (HIC)-based device for therapeutic iontophoresis and/or biofilm debridement. The HIC-based device includes: a first chamber containing a salt solution; a second chamber containing a therapeutic or buffer solution, the second chamber being configured to interface with a surface overlaying a target region; a hydrogel membrane separating the first chamber from the second chamber; and an electrode configured to apply an electrical current to the first chamber of the working device to induce an ion current in the salt solution, wherein the ion current acts on the second chamber to iontophoretically transport therapeutic molecules across the surface overlaying the target region and/or debride biofilm at the surface overlaying the target region.

Patent Agency Ranking