公开(公告)号：US11286273B2

公开(公告)日：2022-03-29

申请号：US17257255

申请日：2019-03-08

Applicant: KOREA INSTITUTE OF OCEAN SCIENCE & TECHNOLOGY

Inventor： Hee Jae Shin ,  Byeoung Kyu Choi ,  Hwa Sun Lee ,  Hyi Seung Lee ,  Yeon Ju Lee ,  Jong Seok Lee ,  Ji Hoon Lee ,  Chan Hong Park

IPC: C07H15/04 ,  C07H1/00

Abstract: Disclosed are a novel rhamnolipid compound, an optical isomer thereof, or a pharmaceutically acceptable salt thereof in the present disclosure. The novel rhamnolipid compound, the optical isomer thereof, or the pharmaceutically acceptable salt thereof selectively exhibits cytotoxicity to human cancer cell lines, thereby inhibiting the growth of cancer cells, and thus has particularly excellent preventive or therapeutic effects against the above-mentioned types of cancers.

公开(公告)号：US20210171539A1

公开(公告)日：2021-06-10

申请号：US16768251

申请日：2017-12-27

Applicant: Korea Institute of Ocean Science & Technology

Inventor： Jong Seok Lee ,  Dan Bi Sung ,  Bo Hyun Mun ,  Hyi Seung Lee ,  Yeon Ju Lee ,  Ji Hoon Lee ,  Hee Jae Shin ,  Sol Park

IPC: C07D495/04 ,  C07D519/00 ,  G01N33/533 ,  G01N31/22 ,  C09K11/06

Abstract: The present invention relates to a novel thieno[3,2-b]pyridine-5(4H)-one derivative compound, a preparation method thereof, and a use thereof. The novel thieno[3,2-b]pyridine-5(4H)-one derivative compound according to the present invention is synthesized via an aza-[3+3] cyclization addition reaction using BOP, wherein the compound is obtained by synthesizing a 4-arylthiophen-3-amine in which aryl groups such as 4-piperidyl-C6H4, 4-pyrrolidyl-C6H4, 4-MeOC6H4, 3,4,5-(MeO)3C6H4, C6H5, 4-C6H5C6H4, and 4-F3COC6H4 are introduced via a synthesis process by a bromination reaction, a hydrolysis reaction, a decarboxylation reaction, and a Suzuki coupling reaction of methyl 3-aminothiophene carboxylate, and by synthesizing 4-arylthiophen-3-amine and mono-methyl fumarate via a formal aza-[3+3] cyclization addition reaction using BOP and conjugation. Accordingly, novel thieno[3,2-b]pyridine-5(4H)-one derivative compounds according to the present invention have fluorescence properties with a wide range of emission wavelengths and thus may be utilized in various industrial fields such as physics, chemistry, and biomedical research.

公开(公告)号：US11306103B2

公开(公告)日：2022-04-19

申请号：US16768251

申请日：2017-12-27

Applicant: Korea Institute of Ocean Science & Technology

Inventor： Jong Seok Lee ,  Dan Bi Sung ,  Bo Hyun Mun ,  Hyi Seung Lee ,  Yeon Ju Lee ,  Ji Hoon Lee ,  Hee Jae Shin ,  Sol Park

IPC: C07D495/04 ,  C09K11/00 ,  C07D519/00 ,  C09K11/06 ,  G01N31/22 ,  G01N33/533

Abstract: The present invention relates to a novel thieno[3,2-b]pyridine-5(4H)-one derivative compound, a preparation method thereof, and a use thereof. The novel thieno[3,2-b]pyridine-5(4H)-one derivative compound according to the present invention is synthesized via an aza-[3+3] cyclization addition reaction using BOP, wherein the compound is obtained by synthesizing a 4-arylthiophen-3-amine in which aryl groups such as 4-piperidyl-C6H4, 4-pyrrolidyl-C6H4, 4-MeOC6H4, 3,4,5-(MeO)3C6H4, C6H5, 4-C6H5C6H4, and 4-F3COC6H4 are introduced via a synthesis process by a bromination reaction, a hydrolysis reaction, a decarboxylation reaction, and a Suzuki coupling reaction of methyl 3-aminothiophene carboxylate, and by synthesizing 4-arylthiophen-3-amine and mono-methyl fumarate via a formal aza-[3+3] cyclization addition reaction using BOP and conjugation. Accordingly, novel thieno[3,2-b]pyridine-5(4H)-one derivative compounds according to the present invention have fluorescence properties with a wide range of emission wavelengths and thus may be utilized in various industrial fields such as physics, chemistry, and biomedical research.

公开(公告)号：US20210332063A1

公开(公告)日：2021-10-28

申请号：US17268896

申请日：2018-08-17

Applicant: Korea Institute of Ocean Science & Technology

Inventor： Jong Seok Lee ,  Dan Bi Sung ,  Bo Hyun Mun ,  Sol Park ,  Hyi Seung Lee ,  Yeon Ju Lee ,  Ji Hoon Lee ,  Hee Jae Shin

IPC: C07D495/04 ,  B01J23/52 ,  C09K11/06 ,  G01N31/22 ,  G01N33/58

Abstract: Disclosed are a method for synthesizing a thieno[3,2-b]pyridine-5(4H)-one derivative by using a gold catalyst and a use of the derivative compound, wherein the novel thieno[3,2-b]pyridine-5(4H)-one derivative of the present disclosure, which is a compound synthesized using gold as a catalyst, has fluorescence characteristics with a wide range of emission wavelengths and thus can be helpfully used in various industrial fields, such as physics, chemistry, and biomedicine research.

公开(公告)号：US11878984B2

公开(公告)日：2024-01-23

申请号：US17274988

申请日：2019-06-03

Applicant: KOREA INSTITUTE OF OCEAN SCIENCE & TECHNOLOGY

Inventor： Hee Jae Shin ,  Byeoung Kyu Choi ,  Hwa Sun Lee ,  Hyi Seung Lee ,  Yeon Ju Lee ,  Jong Seok Lee ,  Ji Hoon Lee

IPC: A61K31/35 ,  A61P25/28 ,  C07D493/16

CPC classification number: C07D493/16 ,  A61K31/35 ,  A61P25/28 ,  C07B2200/07

Abstract: The present invention relates to new compounds derived from marine actinomycetes Streptomyces, and the new compound according to the present invention has an inhibitory effect of NO production on BV-2 microglia stimulated with LPS, and thus can be utilized for the prevention and treatment of neuroinflammatory diseases.

公开(公告)号：US20210355151A1

公开(公告)日：2021-11-18

申请号：US17257255

申请日：2019-03-08

Applicant: KOREA INSTITUTE OF OCEAN SCIENCE & TECHNOLOGY

Inventor： Hee Jae Shin ,  Byeoung Kyu Choi ,  Hwa Sun Lee ,  Hyi Seung Lee ,  Yeon Ju Lee ,  Jong Seok Lee ,  Ji Hoon Lee ,  Chan Hong Park

IPC: C07H15/04 ,  C07H1/00

Abstract: Disclosed are a novel rhamnolipid compound, an optical isomer thereof, or a pharmaceutically acceptable salt thereof in the present disclosure. The novel rhamnolipid compound, the optical isomer thereof, or the pharmaceutically acceptable salt thereof selectively exhibits cytotoxicity to human cancer cell lines, thereby inhibiting the growth of cancer cells, and thus has particularly excellent preventive or therapeutic effects against the above-mentioned types of cancers.