公开(公告)号：US12109315B2

公开(公告)日：2024-10-08

申请号：US18193692

申请日：2023-03-31

申请人： Imam Abdulrahman Bin Faisal University

发明人： B. Rabindran Jermy ,  Vijaya Ravinayagam ,  Ayman A. Elbadry

IPC分类号： A61K9/51 ,  A61K31/05 ,  A61K31/12 ,  A61P33/00

CPC分类号： A61K9/5115 ,  A61K31/05 ,  A61K31/12 ,  A61P33/00

摘要： A nanomedicinal composition comprising a nanocarrier and an antioxidant. The nanocarrier contains a metal organic framework and a porous silicate and/or aluminosilicate matrix. The antioxidant is disposed in the pores and/or on the surface of the nanocarrier by a solution phase impregnation process. The nanomedicinal composition is used in a method of treating Blastocystis infection.

公开(公告)号：US11896594B2

公开(公告)日：2024-02-13

申请号：US17273111

申请日：2019-09-03

申请人： Zoetis Services LLC

发明人： Sachin Pundlik Kolhe ,  Supriya Gautam Thakur

IPC分类号： A61K31/506 ,  A61P33/00 ,  A61K9/00 ,  A61K9/20 ,  A61K31/365 ,  A61K31/422 ,  A61K31/7048

CPC分类号： A61K31/506 ,  A61K9/0056 ,  A61K9/2018 ,  A61K9/2054 ,  A61K9/2068 ,  A61K31/365 ,  A61K31/422 ,  A61K31/7048 ,  A61P33/00

摘要： The present invention is directed to a palatable, hard chewable composition comprising a therapeutically effective amount of a veterinary acceptable isoxazoline, a stabilized macrocyclic lactone, an acceptable salt form of pyrantel, at least one natural animal based palatant, and at least one veterinary acceptable excipient; and methods for treating or preventing a parasitic infection or infestation in an animal in need thereof with said composition.

公开(公告)号：US11884643B2

公开(公告)日：2024-01-30

申请号：US17256946

申请日：2019-07-03

申请人： Bayer Aktiengesellschaft

发明人： David Bernier ,  Stéphane Brunet ,  Jérémy Dufour ,  Thomas Knobloch ,  Lionel Nicolas ,  Tomoki Tsuchiya

IPC分类号： C07D333/38 ,  A01P1/00 ,  A01N43/10 ,  A01N55/00 ,  C07D409/12 ,  C07F7/08 ,  A61P33/00 ,  A61P31/04 ,  A01P13/00 ,  A01N43/76 ,  C07D413/04

CPC分类号： C07D333/38 ,  A01N43/10 ,  A01N43/76 ,  A01N55/00 ,  A01P1/00 ,  A01P13/00 ,  A61P31/04 ,  A61P33/00 ,  C07D409/12 ,  C07D413/04 ,  C07F7/083 ,  C07F7/0812

摘要： The present disclosure relates to thienyloxazolones and analogues thereof of formula (III) that may be used for protecting plants from bacterial diseases, in particular from bacterial diseases caused by bacteria belonging to the genus Xanthomonas.

公开(公告)号：US20230172978A1

公开(公告)日：2023-06-08

申请号：US17923244

申请日：2021-05-04

申请人： YEDITEPE UNIVERSITESI

发明人： Fikrettin SAHIN ,  Zeynep ISLEK ,  Batuhan Turhan BOZKURT ,  Oguz Kaan KIRBAS ,  Mehmet Hikmet UCISIK

IPC分类号： A61K35/15 ,  A61P33/00

CPC分类号： A61K35/15 ,  A61P33/00 ,  A61K35/74

摘要： A use of extracellular vesicles obtained from macrophages infected with parasites as immunotherapeutic and prophylactic agents in the disease Leishmaniasis is disclosed. The objective of the invention is the use of a drug formulation, which exhibits almost complete activity on Leishmania parasites and infected cells within 72 hours, but does not have any show side effects on healthy cells, in the treatment and prophylaxis of Leishmaniasis.

公开(公告)号：US20230159604A1

公开(公告)日：2023-05-25

申请号：US17778232

申请日：2020-11-19

申请人： CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS (CSIC) ,  THE UNIVERSITY COURT OF THE UNIVERSITY OF ABERDEEN

发明人： Carolina TAFALLA PIÑEIRO ,  Estefanía MUNOZ ATIENZA ,  Christopher J. SECOMBES ,  Jason W. HOLLAND ,  Marc FABER

IPC分类号： C07K14/55 ,  C12N15/85 ,  C12N15/62 ,  C07K14/705 ,  A61P29/00 ,  A61P13/12 ,  A61P33/00

CPC分类号： C07K14/55 ,  C12N15/85 ,  C12N15/625 ,  C07K14/70578 ,  A61P29/00 ,  A61P13/12 ,  A61P33/00 ,  C12N2800/106 ,  C07K2319/02 ,  C07K2319/30 ,  C07K2319/035 ,  A61K38/00

摘要： The present invention relates to a plasmid that encodes a fusion protein comprising a signal peptide and the extracellular domain of the B-cell activating factor receptor (BAFF-R), and optionally, a fragment of the constant region (Fc) of an immunoglobulin. The invention also relates to compositions comprising said plasmid, and to the use of same in the treatment and/or prevention of inflammatory diseases in fish, more preferably in salmonids.

公开(公告)号：US20220372565A1

公开(公告)日：2022-11-24

申请号：US17805657

申请日：2022-06-06

申请人： Touchlight IP Limited

发明人： Vanessa Hill

IPC分类号： C12Q1/6853 ,  C12N15/11 ,  A61K39/00 ,  A61K48/00 ,  C12N9/02 ,  C12Q1/6844 ,  A61P37/08 ,  A61P39/02 ,  A61P37/04 ,  A61P35/00 ,  A61P33/00 ,  A61P37/00

摘要： An in vitro process for the production of closed linear deoxyribonucleic acid (DNA) comprises (a) contacting a DNA template comprising at least one protelomerase target sequence with at least one DNA polymerase in the presence of one or more primers under conditions promoting amplification of the template; and (b) contacting amplified DNA produced in (a) with at least one protelomerase under conditions promoting production of closed linear DNA. A kit provides components necessary in the process.

公开(公告)号：US20220087952A1

公开(公告)日：2022-03-24

申请号：US17424527

申请日：2020-01-19

申请人： THE STATE OF ISRAEL, MINISTRY OF AGRICULTURE & RURAL DEVELOPMENT, AGRICULTURAL RESEARCH ORGANIZATION ,  THE NATIONAL SOCIETY FOR HEALTH RESEARCH & SERVICES (R.A.)

发明人： Hassan AZAIZEH ,  Serge LANDAU ,  Liora GUR

IPC分类号： A61K31/05 ,  A61K31/192 ,  A61K31/7048 ,  A61K36/63 ,  A61P33/00

摘要： The invention is directed to Anti-Apicomplexan compositions, methods for producing the same, and methods for their use.

公开(公告)号：US11202793B2

公开(公告)日：2021-12-21

申请号：US16333330

申请日：2017-09-14

申请人： ModernaTX, Inc.

发明人： Stephen Hoge ,  William Issa ,  Edward J. Miracco ,  Jennifer Nelson ,  Amy E. Rabideau ,  Gabor Butora

IPC分类号： A61K31/7105 ,  C07K14/505 ,  C12P19/34 ,  A61P33/00 ,  A61P31/12 ,  A61P31/04 ,  A61P35/00 ,  C12N15/10 ,  G01N33/68

摘要： The invention relates to improved RNA compositions for use in therapeutic applications. The RNA compositions are particularly suited for use in human therapeutic application (e.g., in RNA therapeutics). The RNA compositions are made by improved processes, in particular, improved in vitro-transcription (IVT) processes. The invention also relates to methods for producing and purifying RNA (e.g, therapeutic RNAs), as well as methods for using the RNA compositions and therapeutic applications thereof.

公开(公告)号：US11179372B2

公开(公告)日：2021-11-23

申请号：US16523780

申请日：2019-07-26

申请人： Intervet Inc.

发明人： Annie Flochlay-Sigognault ,  Anne Lehay

IPC分类号： A61K31/42 ,  A61K31/355 ,  A61K31/422 ,  A61P33/00

摘要： For the prevention of parasite infestation of animals, an isoxazoline can be administered by drinking water route. However the inventors have found that when the drinking water is sanitized, for instance by using hypochlorite, the isoxazoline becomes degraded. Surprisingly, the isoxazoline can be protected from degradation by the use of a vitamin E. A pharmaceutical composition can now be prepared containing a concentrated solution of the isoxazoline in a solvent and co-solvent, with vitamin E. The composition can be diluted in drinking water, even when sanitized, to prepare medicated drinking water for animals. This way an anti-parasitic treatment can be mass-administered, leading to a highly effective reduction of the parasite infestation of an animal, and its surroundings.

公开(公告)号：US11174260B2

公开(公告)日：2021-11-16

申请号：US16495357

申请日：2018-03-20

申请人： THE BROAD INSTITUTE, INC. ,  PRESIDENT AND FELLOWS OF HARVARD COLLEGE

发明人： Eamon Comer ,  Nobutaka Kato ,  Marshall Morningstar ,  Bruno Melillo

IPC分类号： A61K31/397 ,  A61K31/44 ,  A61K31/4406 ,  A61P33/00 ,  A61P33/06 ,  C07D487/04

摘要： Provided herein are compounds useful for the treatment of various parasitic diseases. These compounds, as well as pharmaceutically acceptable salts thereof may be formulated in pharmaceutical compostions, veterinary compositions and may be used in methods of treatment and/or prophylaxis of diseases spread by parasites, including malaria and cryptosporidiosis.