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公开(公告)号：US20230183642A1
公开(公告)日：2023-06-15
申请号：US17924699
申请日：2021-05-10
发明人： Fikrettin SAHIN , Bahar SOGUTMAZ OZDEMIR , Batuhan Turhan BOZKURT , Oguz Kaan KIRBAS , Pakize Neslihan TASLI , Umit Cem DERMAN
IPC分类号： C12N5/04
CPC分类号： C12N5/04
摘要： A method of producing plant-derived exosomes from plant tissue culture based cell suspension cultures is provided. The method includes: obtaining the plant tissue culture based cell suspension culture; mixing the the plant tissue culture based cell suspension culture with an isolation solution; centrifuging to obtain a supernatant and an infranatant; and obtaining the plant-derived exosomes from the infranatant. The objective of the present invention is to produce homogenous plant exosomes with high volume and purity by making use of the advantages of the plant suspension culture to be used for purposes such as therapeutics and drug carriers.
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公开(公告)号：US20220017378A1
公开(公告)日：2022-01-20
申请号：US17290292
申请日：2018-11-15
发明人： Fikrettin SAHIN , Pakize Neslihan TASLI , Oguz Kaan KIRBAS , Taha Bartu HAYAL , Batuhan Turhan BOZKURT , Berna BULBUL , Seda BEYAZ
摘要： Use of nano-sized lanthanide borate (erbium borate and dysprosium borate) compounds for wound treatment due to their significant level of wound healing effect on the cells is disclosed. In the scope of the invention, the synthesis of nanometer-sized erbium borate and dysprosium borate compound by buffered-precipitation method at room conditions and the use of these compounds in biological applications are discussed.
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公开(公告)号：US20170135339A1
公开(公告)日：2017-05-18
申请号：US15322125
申请日：2016-02-10
发明人： Fikrettin SAHIN , Zeynep USTAOGLU , Okan DEMIR
摘要： The present invention relates to a coating formulation which is developed for sterilization of annual and perennial plant seeds and agricultural implements. With the present invention; an antifungal, anticandidal, antibacterial and antiviral coating formulation containing zinc pyrithione, triclosan and carboxymethyl cellulose is obtained. Furthermore, thanks to the present invention, contaminations due to the areas of use of annual and perennial plant seeds and the silo, storehouse and warehouse surfaces, where the seeds are stored before seeding, can be prevented. The present invention can be used for sterilization of agricultural implements and equipment.
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公开(公告)号：US20160346325A1
公开(公告)日：2016-12-01
申请号：US15114854
申请日：2015-01-14
发明人： Fikrettin SAHIN , Aysegül DOGAN , Selami DEMIRCI , Nese BASAK , Bulent DEDE
摘要： The present invention relates to a chemotherapeutic drug combination containing heterodinuclear Cu (II)-Mn(II) complex. The objective of the present invention is to provide a drug combination, which will be actively used in chemotherapy, is anticarcinogenic and has no side effects, facilitates penetration into the cell, shows selectivity only for cancer cells and does not harm healthy cells, and is not toxic for the tissues and organs in the body, and which can prepared easily and provides a definitive and fast treatment.
摘要翻译： 本发明涉及含有异二核Cu（II）-Mn（II）配合物的化疗药物组合。 本发明的目的是提供一种药物组合，其主要用于化学疗法，具有抗癌作用，无副作用，有利于细胞渗透，仅对癌细胞具有选择性，不会损害健康细胞，而且 对身体中的组织和器官没有毒性，并且可以容易地制备并提供确定和快速的治疗。
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公开(公告)号：US20240241134A1
公开(公告)日：2024-07-18
申请号：US18562841
申请日：2022-05-20
IPC分类号： G01N33/68 , G01N33/573
CPC分类号： G01N33/689 , G01N33/573 , G01N2333/49 , G01N2333/70596 , G01N2333/91085 , G01N2800/364 , G01N2800/52
摘要： Combinations of the novel biological markers that can be used in the diagnosis of endometriosis are provided. The objective of the invention is to detect biological markers that are expressed differently in eMSCs isolated from endometrial biopsy samples in the diagnosis of endometriosis compared to healthy eMSCs. A tissue transglutaminase is configured as a biomarker for a diagnosis of an endometriosis in isolated endometrial mesenchymal stem cells derived from an endometrial biopsy and/or a menstrual blood from endometriosis patients.
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公开(公告)号：US20240000831A1
公开(公告)日：2024-01-04
申请号：US18038738
申请日：2020-11-25
发明人： Fikrettin SAHIN , Emre CEBECI , Huseyin ABDIK
摘要： sodium borates are provided and alone as an active ingredient to prevent and/or treat fatty liver. In addition, the sodium borates reduce the expression levels of AADIPOR2, PRKAG2, IRS1, PIK3R1, NFKB1, MAP3K11, BID, CYCS, BAX, CASP3 and TGFB1 genes in the non-alcoholic fatty liver pathway and thereby to prevent and/or treat fatty liver by inhibiting the functioning of the non-alcoholic fatty liver pathway.
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公开(公告)号：US20210353747A1
公开(公告)日：2021-11-18
申请号：US17273994
申请日：2019-09-03
摘要： Use of the effects of plant exosomes on the immune system as immune system enhancers, silencers and modulators against diseases is disclosed. The plant derived exosomes are obtained from at least one portion of the plant selected from the group consisting of the entire plant, fruit, leaf, seed, root, or differentiated tissues like the plant's tissue culture medium, stem cell, waste material, shell or phloem. In the scope of the invention, the plant exosomes having immunomodulatory effects are used mainly in autoimmune diseases, and in cell, tissue, organ transplantations and in Graft Versus Host disease as immune system enhancers, suppressors or, if necessary, as modulators performing both of the first two functions.
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公开(公告)号：US20210023038A1
公开(公告)日：2021-01-28
申请号：US16955087
申请日：2018-12-17
IPC分类号： A61K31/216 , A61K9/127
摘要： A production of a drug, wherein the drug is specific for SH-SY5Y neuroblastoma cancer by loading caffeic acid phenethyl ester (CAPE) to a plurality of microvesicles that a specialized skin cell leaves into a nutrient solution. The objective of the present invention is to provide a cell-specific targeted vesicle development by loading the CAPE to the plurality of microvesicles obtained as a result of culturing and subsequent specialization of a plurality of tissue cells; and to use the CAPE at lower concentrations compared to a state of the art applications to minimize a toxicity of the CAPE to both a plurality of cells other than a plurality of targeted cells and a body.
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公开(公告)号：US20200230196A1
公开(公告)日：2020-07-23
申请号：US16482719
申请日：2018-01-31
发明人： Fikrettin SAHIN , Merve YILDIRIM , Polen KOCAK , Burge ULUKAN
IPC分类号： A61K36/899 , A61K36/8962 , A61K36/9068
摘要： A product containing plant derived exosome that may be used in cancer treatment and wound healing. The product enables to provide a low-cost product, which does not cause toxic effects in human body, does not cause damage in the healthy cells during the course of the cancer treatment, does not pose any infection risk since it does not require any procedure such as radiotherapy or surgery, and the side effects occurring in chemotherapy treatment are not experienced. Wheatgrass, garlic and ginger can be used alone or in combination in the product as the plant source.
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公开(公告)号：US20160051724A1
公开(公告)日：2016-02-25
申请号：US14783081
申请日：2014-04-08
发明人： Fikrettin SAHIN , Selami DEMIRCI , Aysegul DOGAN
CPC分类号： A61L26/0019 , A61K8/042 , A61K8/19 , A61K8/84 , A61K8/90 , A61K9/0014 , A61K47/32 , A61K47/34 , A61L15/26 , A61L15/44 , A61L15/46 , A61L26/0004 , A61L26/0066 , A61L26/008 , A61L2300/10 , A61L2300/404 , A61L2300/412 , A61Q17/005 , A61Q19/08 , C08K3/38 , C08K2003/387 , C08L71/02
摘要： The present invention relates to an anti-aging antimicrobial wound healing polymer based hydrogel. In the study of the present invention, a wound healing gel formulation is developed by combining poloxamer polymers and boron component at adequate concentrations in a carbopol based gel. The said gel exhibits fast action on the damaged area and prevents scar formation.
摘要翻译： 本发明涉及抗老化抗微生物伤口愈合聚合物基水凝胶。 在本发明的研究中，通过将泊洛沙姆聚合物和硼组分以足够的浓度结合在基于carbopol的凝胶中来开发伤口愈合凝胶制剂。 所述凝胶在损伤区域上表现出快速作用并防止瘢痕形成。
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