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公开(公告)号：US20230183642A1
公开(公告)日：2023-06-15
申请号：US17924699
申请日：2021-05-10
发明人： Fikrettin SAHIN , Bahar SOGUTMAZ OZDEMIR , Batuhan Turhan BOZKURT , Oguz Kaan KIRBAS , Pakize Neslihan TASLI , Umit Cem DERMAN
IPC分类号： C12N5/04
CPC分类号： C12N5/04
摘要： A method of producing plant-derived exosomes from plant tissue culture based cell suspension cultures is provided. The method includes: obtaining the plant tissue culture based cell suspension culture; mixing the the plant tissue culture based cell suspension culture with an isolation solution; centrifuging to obtain a supernatant and an infranatant; and obtaining the plant-derived exosomes from the infranatant. The objective of the present invention is to produce homogenous plant exosomes with high volume and purity by making use of the advantages of the plant suspension culture to be used for purposes such as therapeutics and drug carriers.
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公开(公告)号：US20220017378A1
公开(公告)日：2022-01-20
申请号：US17290292
申请日：2018-11-15
发明人： Fikrettin SAHIN , Pakize Neslihan TASLI , Oguz Kaan KIRBAS , Taha Bartu HAYAL , Batuhan Turhan BOZKURT , Berna BULBUL , Seda BEYAZ
摘要： Use of nano-sized lanthanide borate (erbium borate and dysprosium borate) compounds for wound treatment due to their significant level of wound healing effect on the cells is disclosed. In the scope of the invention, the synthesis of nanometer-sized erbium borate and dysprosium borate compound by buffered-precipitation method at room conditions and the use of these compounds in biological applications are discussed.
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公开(公告)号：US20210101093A1
公开(公告)日：2021-04-08
申请号：US16969997
申请日：2019-02-15
摘要： The present invention is an exosome isolation method for obtaining high purity exosomes inexpensively from samples of large and small amounts and types of samples from which exosomes could not be obtained before such as plant lysates. The exosome isolation method incorporates a two phase fluid extraction system, and includes the steps of isolation using dextran and PEG for removing proteins and undesired substances therein, and the steps of washing and dextran removal to collect exosomes in a pure form.
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公开(公告)号：US20210353747A1
公开(公告)日：2021-11-18
申请号：US17273994
申请日：2019-09-03
摘要： Use of the effects of plant exosomes on the immune system as immune system enhancers, silencers and modulators against diseases is disclosed. The plant derived exosomes are obtained from at least one portion of the plant selected from the group consisting of the entire plant, fruit, leaf, seed, root, or differentiated tissues like the plant's tissue culture medium, stem cell, waste material, shell or phloem. In the scope of the invention, the plant exosomes having immunomodulatory effects are used mainly in autoimmune diseases, and in cell, tissue, organ transplantations and in Graft Versus Host disease as immune system enhancers, suppressors or, if necessary, as modulators performing both of the first two functions.
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公开(公告)号：US20210023038A1
公开(公告)日：2021-01-28
申请号：US16955087
申请日：2018-12-17
IPC分类号： A61K31/216 , A61K9/127
摘要： A production of a drug, wherein the drug is specific for SH-SY5Y neuroblastoma cancer by loading caffeic acid phenethyl ester (CAPE) to a plurality of microvesicles that a specialized skin cell leaves into a nutrient solution. The objective of the present invention is to provide a cell-specific targeted vesicle development by loading the CAPE to the plurality of microvesicles obtained as a result of culturing and subsequent specialization of a plurality of tissue cells; and to use the CAPE at lower concentrations compared to a state of the art applications to minimize a toxicity of the CAPE to both a plurality of cells other than a plurality of targeted cells and a body.
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公开(公告)号：US20220362194A1
公开(公告)日：2022-11-17
申请号：US17840700
申请日：2022-06-15
IPC分类号： A61K31/216 , A61K9/127
摘要： A method of producing a caffeic acid phenethyl ester loaded microvesicular cancer drug targeting SH-SY5Y neuroblastoma cancer. The method includes seeding a plurality of skin stem cells in a medium; enabling the plurality of skin stem cells in the medium to reach a confluency of 70-80% to be seeded in a plurality of culture plates; preparing a caffeic acid phenethyl ester stock solution by dissolving the caffeic acid phenethyl ester in dimethyl sulfoxide DMSO; performing a microvesicle isolation from specialized skin cells; adding the caffeic acid phenethyl ester into a plurality of microvesicles; and separating the caffeic acid phenethyl ester loaded microvesicles from the caffeic acid phenethyl ester which is free in the solution and not loaded to a microvesicle.
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公开(公告)号：US20220331230A1
公开(公告)日：2022-10-20
申请号：US17639614
申请日：2020-09-02
IPC分类号： A61K8/9789 , A61K36/88 , A61K36/8962 , A61K36/185 , A61P17/14 , A61Q7/00
摘要： A use of plant exosomes as a product having the effect of enhancing viability and, by stimulating the hair follicles, enhancing hair growth in skin cells. The plant exosomes are used to revitalize and strengthen unhealthy skin and hair that have lost their vitality, to stop hair loss, to provide faster hair growth by stimulating hair follicles, and to provide a regulating effect in improving the effects such as wrinkles and age spots caused by aging skin cells. The plant exosomes are isolated from single, double, or triple combinations of plants selected from a group consisting of pineapple plant, garlic plant, and pomegranate plant. For example, a triple combination includes 1 ng-1 mg of the plant exosomes isolated from the pineapple plant, 1 ng-10 μg of the plant exosomes isolated from the garlic plant, and 1 ng-1 mg of plant exosomes isolated from the pomegranate plant.
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8.发明申请公开(公告)号：US20220288146A1
公开(公告)日：2022-09-15
申请号：US17631967
申请日：2020-07-30
IPC分类号： A61K36/185 , A61P25/28
摘要： Plant exosomes can be used to reduce the protein aggregates formed in the cells and the damage they cause to the cells. Plant exosomes are of plant origin and not transgenic, and thus, they are reliable as an alternative to the drugs used in the treatment of neurodegenerative diseases, particularly ALS. Moreover, compared to the conventional applications, plant exosomes can provide a product with high efficacy and no side effects which can be produced in high amounts and at affordable prices due to the fact that it is plant-derived.
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公开(公告)号：US20220226393A1
公开(公告)日：2022-07-21
申请号：US17609795
申请日：2020-05-08
发明人： Fikrettin SAHIN , Zeynep ISLEK , Ezgi TASKAN , Pakize Neslihan TASLI , Batuhan Turhan BOZKURT , Oguz Kaan KIRBAS , Mehmet Hikmet UCISIK
IPC分类号： A61K35/68 , A61K39/008 , A61K39/39 , A61P35/00
摘要： Use of parasites and extracellular vesicles obtained from the parasites for a cancer treatment is provided. The use of parasites and extracellular vesicles obtained from parasites is for using in a treatment of a cancer, and loading an active substance on exosomes by using a drug loading capacity of exosomes, and thus, by carrying a specific drug directly to target cancer cells without causing any side effect on healthy cells and to enhance a bioavailability of the specific drug, achieving a desired effect in a tumor specific target region. Particularly Leishmania infantum parasite is used as a source for the extracellular vesicles.
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10.发明公开公开(公告)号：US20240050468A1
公开(公告)日：2024-02-15
申请号：US18268997
申请日：2021-11-09
发明人： Fikrettin SAHIN , Erhan AYSAN , Pakize Neslihan TASLI , Oguz Kaan KIRBAS , Batuhan Turhan BOZKURT , Berna BULBUL
摘要： A formulation in gel form comprising erbium borate nanoparticles, at least one surfactant and at least one gelling agent with carrier gel properties for use in prevention and treatment of wound scars is provided.
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