公开(公告)号：US20180363019A1

公开(公告)日：2018-12-20

申请号：US16001786

申请日：2018-06-06

Applicant: ModernaTX, Inc.

Inventor： Stephen Hoge ,  William Issa ,  Edward J. Miracco ,  Jennifer Nelson ,  Amy E. Rabideau ,  Gabor Butora

IPC: C12P19/34

Abstract: The invention relates to improved RNA compositions for use in therapeutic applications. The RNA compositions are particularly suited for use in human therapeutic application (e.g., in RNA therapeutics). The RNA compositions are made by inproved processes, in particular, improved in vitro-transcription (IVT) processes. The invention also relates to methods for producing and purifying RNA (e.g, therapeutic RNAs), as well as methods for using the RNA compositions and therapeutic applications thereof.

公开(公告)号：US12233084B2

公开(公告)日：2025-02-25

申请号：US17523060

申请日：2021-11-10

Applicant: ModernaTX, Inc.

Inventor： Stephen Hoge ,  William Issa ,  Edward J. Miracco ,  Jennifer Nelson ,  Amy E. Rabideau ,  Gabor Butora

IPC: A61K31/7105 ,  A61P31/04 ,  A61P31/12 ,  A61P33/00 ,  A61P35/00 ,  C07K14/505 ,  C12N15/10 ,  C12P19/34 ,  G01N33/68

Abstract: The invention relates to improved RNA compositions for use in therapeutic applications. The RNA compositions are particularly suited for use in human therapeutic application (e.g., in RNA therapeutics). The RNA compositions are made by inproved processes, in particular, improved in vitro-transcription (IVT) processes. The invention also relates to methods for producing and purifying RNA (e.g, therapeutic RNAs), as well as methods for using the RNA compositions and therapeutic applications thereof.

公开(公告)号：US20190247417A1

公开(公告)日：2019-08-15

申请号：US16333330

申请日：2017-09-14

Applicant: ModernaTX, Inc.

Inventor： Stephen Hoge ,  William Issa ,  Edward J. Miracco ,  Jennifer Nelson ,  Amy E. Rabideau ,  Gabor Butora

IPC: A61K31/7105 ,  G01N33/68 ,  C12N15/10 ,  A61P33/00 ,  A61P31/04 ,  A61P35/00 ,  A61P31/12

CPC classification number: A61K31/7105 ,  A61P31/04 ,  A61P31/12 ,  A61P33/00 ,  A61P35/00 ,  C07K14/505 ,  C12N15/10 ,  C12P19/34 ,  G01N33/6851

Abstract: The invention relates to improved RNA compositions for use in therapeutic applications. The RNA compositions are particularly suited for use in human therapeutic application (e.g., in RNA therapeutics). The RNA compositions are made by improved processes, in particular, improved in vitro-transcription (IVT) processes. The invention also relates to methods for producing and purifying RNA (e.g, therapeutic RNAs), as well as methods for using the RNA compositions and therapeutic applications thereof.

公开(公告)号：US11202793B2

公开(公告)日：2021-12-21

申请号：US16333330

申请日：2017-09-14

Applicant: ModernaTX, Inc.

Inventor： Stephen Hoge ,  William Issa ,  Edward J. Miracco ,  Jennifer Nelson ,  Amy E. Rabideau ,  Gabor Butora

IPC: A61K31/7105 ,  C07K14/505 ,  C12P19/34 ,  A61P33/00 ,  A61P31/12 ,  A61P31/04 ,  A61P35/00 ,  C12N15/10 ,  G01N33/68

Abstract: The invention relates to improved RNA compositions for use in therapeutic applications. The RNA compositions are particularly suited for use in human therapeutic application (e.g., in RNA therapeutics). The RNA compositions are made by improved processes, in particular, improved in vitro-transcription (IVT) processes. The invention also relates to methods for producing and purifying RNA (e.g, therapeutic RNAs), as well as methods for using the RNA compositions and therapeutic applications thereof.

公开(公告)号：US10653712B2

公开(公告)日：2020-05-19

申请号：US16001786

申请日：2018-06-06

Applicant: ModernaTX, Inc.

Inventor： Stephen Hoge ,  William Issa ,  Edward J. Miracco ,  Jennifer Nelson ,  Amy E. Rabideau ,  Gabor Butora

IPC: C12P19/34 ,  A61K31/7105 ,  C07K14/505 ,  A61P33/00 ,  A61P31/12 ,  A61P31/04 ,  A61P35/00 ,  C12N15/10 ,  G01N33/68

Abstract: The invention relates to improved RNA compositions for use in therapeutic applications. The RNA compositions are particularly suited for use in human therapeutic application (e.g., in RNA therapeutics). The RNA compositions are made by improved processes, in particular, improved in vitro-transcription (IVT) processes. The invention also relates to methods for producing and purifying RNA (e.g, therapeutic RNAs), as well as methods for using the RNA compositions and therapeutic applications thereof.

公开(公告)号：US11384352B2

公开(公告)日：2022-07-12

申请号：US16468838

申请日：2017-12-13

Applicant: ModernaTX, Inc.

Inventor： Edward J. Miracco

IPC: C12N15/10 ,  C12N9/22 ,  C12N11/14

Abstract: Provided herein, in some embodiments, are methods of purifying a nucleic acid preparation. The methods may comprise contacting a nucleic acid preparation comprising messenger ribonucleic acid with an RNase III enzyme that is immobilized on a solid support and binds to double-stranded RNA contaminants.

公开(公告)号：US20220096522A1

公开(公告)日：2022-03-31

申请号：US17523060

申请日：2021-11-10

Applicant: ModernaTX, Inc.

Inventor： Stephen Hoge ,  William Issa ,  Edward J. Miracco ,  Jennifer Nelson ,  Amy E. Rabideau ,  Gabor Butora

IPC: A61K31/7105 ,  C07K14/505 ,  C12P19/34 ,  A61P33/00 ,  A61P31/12 ,  A61P31/04 ,  A61P35/00 ,  C12N15/10 ,  G01N33/68

Abstract: The invention relates to improved RNA compositions for use in therapeutic applications. The RNA compositions are particularly suited for use in human therapeutic application (e.g., in RNA therapeutics). The RNA compositions are made by inproved processes, in particular, improved in vitro-transcription (IVT) processes. The invention also relates to methods for producing and purifying RNA (e.g, therapeutic RNAs), as well as methods for using the RNA compositions and therapeutic applications thereof.

公开(公告)号：US20220096521A1

公开(公告)日：2022-03-31

申请号：US17523034

申请日：2021-11-10

Applicant: ModernaTX, Inc.

Inventor： Stephen Hoge ,  William Issa ,  Edward J. Miracco ,  Jennifer Nelson ,  Amy E. Rabideau ,  Gabor Butora

IPC: A61K31/7105 ,  C07K14/505 ,  C12P19/34 ,  A61P33/00 ,  A61P31/12 ,  A61P31/04 ,  A61P35/00 ,  C12N15/10 ,  G01N33/68

Abstract: The invention relates to improved RNA compositions for use in therapeutic applications. The RNA compositions are particularly suited for use in human therapeutic application (e.g., in RNA therapeutics). The RNA compositions are made by improved processes, in particular, improved in vitro-transcription (IVT) processes. The invention also relates to methods for producing and purifying RNA (e.g, therapeutic RNAs), as well as methods for using the RNA compositions and therapeutic applications thereof.

公开(公告)号：US20230212645A1

公开(公告)日：2023-07-06

申请号：US17852974

申请日：2022-06-29

Applicant: ModernaTX, Inc.

Inventor： David Marquardt ,  Nicholas J. Amato ,  Edward J. Miracco ,  Tao Jiang ,  Serenus Hua ,  Huijuan Li

IPC: C12Q1/6806 ,  C12Q1/6809 ,  C12Q1/68

CPC classification number: C12Q1/6806 ,  C12Q1/68 ,  C12Q1/6809

Abstract: Novel methods for identification and analysis of mRNA are provided herein. The methods may involve digestion and fingerprinting analysis.

公开(公告)号：US20220290125A1

公开(公告)日：2022-09-15

申请号：US17830742

申请日：2022-06-02

Applicant: ModernaTx, Inc.

Inventor： Edward J. Miracco

IPC: C12N15/10 ,  C12N9/22 ,  C12N11/14

Abstract: Provided herein, in some embodiments, are methods of purifying a nucleic acid preparation. The methods may comprise contacting a nucleic acid preparation comprising messenger ribonucleic acid with an RNase III enzyme that is immobilized on a solid support and binds to double-stranded RNA contaminants.