-
公开(公告)号：US4365077A
公开(公告)日：1982-12-21
申请号：US13899
申请日：1979-02-22
IPC分类号： C07C405/00 , C07D257/04 , C07D307/935 , C07D309/12 , C07F9/40 , C07C177/00
CPC分类号： C07D257/04 , C07C405/00 , C07D307/935 , C07D309/12 , C07F9/4006
摘要： 11-Desoxy-16-aryloxy-.omega.-tetranorprostaglandins are disclosed. The novel prostaglandins of this invention have been found to have activity profiles comparable to the parent prostaglandins but they exhibit a greater tissue specificity of action.
摘要翻译： 公开了11-脱氧-16-芳氧基-ω-抗原前列腺素。 已经发现本发明的新型前列腺素具有与母体前列腺素相当的活性谱，但它们表现出较大的组织作用特异性。
-
公开(公告)号：US4078021A
公开(公告)日：1978-03-07
申请号：US790235
申请日：1977-04-25
IPC分类号： A61K31/275 , A61K31/557 , A61K31/5575 , A61P11/08 , A61P43/00 , C07C67/00 , C07C401/00 , C07C405/00 , C07D307/935 , C07F9/38 , C07F9/40
CPC分类号： C07D307/935 , C07C405/00 , C07F9/4006 , Y02P20/55
摘要： The 19-cyano-20-nor derivatives of prostaglandins E.sub.1 and E.sub.2, and certain esters thereof, are bronchodilatory agents, useful in the treatment of bronchial asthma, bronchitis, pneumonia and emphysema. The 19-cyano-20-nor derivatives of prostaglandins E.sub.1 and E.sub.2, and certain esters thereof, which also have protecting groups on the hydroxy groups at C-11 and C-15 are useful intermediates for the preparation of the bronchodilatory agents of this invention.
摘要翻译： 前列腺素E1和E2的19-氰基-20-衍生物及其某些酯是支气管扩张剂，可用于治疗支气管哮喘，支气管炎，肺炎和肺气肿。 在C-11和C-15的羟基上也具有保护基的前列腺素E1和E2的19-氰基-20-还是衍生物及其某些酯是制备本发明的支气管扩张剂的有用中间体 。
-
公开(公告)号：US4074044A
公开(公告)日：1978-02-14
申请号：US790234
申请日：1977-04-25
IPC分类号： A61K31/275 , A61K31/557 , A61K31/5575 , A61P11/08 , A61P43/00 , C07C67/00 , C07C401/00 , C07C405/00 , C07D307/935 , C07F9/38 , C07F9/40 , C07C177/00 , C07D309/10
CPC分类号： C07D307/935 , C07C405/00 , C07F9/4006 , Y02P20/55
摘要： The 19-cyano-20-nor derivatives of prostaglandins E.sub.1 and E.sub.2, and certain esters thereof, are bronchodilatory agents, useful in the treatment of bronchial asthma, bronchitis, pneumonia and emphysema. The 19-cyano-20-nor derivatives of prostaglandins E.sub.1 and E.sub.2, and certain esters thereof, which also have protecting groups on the hydroxy groups at C-11 and C-15 are useful intermediates for the preparation of the bronchodilatory agents of this invention.
摘要翻译： 前列腺素E1和E2的19-氰基-20-衍生物及其某些酯是支气管扩张剂，可用于治疗支气管哮喘，支气管炎，肺炎和肺气肿。 在C-11和C-15的羟基上也具有保护基的前列腺素E1和E2的19-氰基-20-还是衍生物及其某些酯是制备本发明的支气管扩张剂的有用中间体 。
-
公开(公告)号：US4045465A
公开(公告)日：1977-08-30
申请号：US712361
申请日：1976-08-06
IPC分类号： A61K31/275 , A61K31/557 , A61K31/5575 , A61P11/08 , A61P43/00 , C07C67/00 , C07C401/00 , C07C405/00 , C07D307/935 , C07F9/38 , C07F9/40 , C07C121/48
CPC分类号： C07D307/935 , C07C405/00 , C07F9/4006 , Y02P20/55
摘要： The 19-cyano-20-nor derivatives of prostaglandins E.sub.1 and E.sub.2, and certain esters thereof, are bronchodilatory agents, useful in the treatment of bronchial asthma, bronchitis, pneumonia and emphysema. The 19-cyano-20-nor derivatives of prostaglandins E.sub.1 and E.sub.2, and certain esters thereof, which also have protecting groups on the hydroxy groups at C-11 and C-15 are useful intermediates for the preparations of the bronchodilatory agents of this invention.
摘要翻译： 前列腺素E1和E2的19-氰基-20-衍生物及其某些酯是支气管扩张剂，可用于治疗支气管哮喘，支气管炎，肺炎和肺气肿。 在C-11和C-15的羟基上也具有保护基的前列腺素E1和E2的19-氰基-20-还是衍生物及其某些酯是制备本发明支气管扩张剂的有用中间体 。
-
5.发明授权13,14-Dihydro-15-substituted-.omega.-pentanorprostaglandins of the two series 失效两系列的13,14-二氢-15-取代的-7-天然淀粉
公开(公告)号：US4011262A
公开(公告)日：1977-03-08
申请号：US485431
申请日：1974-07-03
IPC分类号： C07C405/00 , C07F9/6553 , C07C61/06
CPC分类号： C07C405/00 , C07F9/655345 , B63B2211/02 , Y10S514/927 , Y10S514/929
摘要： The 15-substituted-.omega.-pentanorprostaglandins and various intermediates employed in their preparation. The novel prostaglandins of this invention have been found to have activity profiles comparable to the parent prostaglandins, but exhibit a greater tissue specificity of action.
-
">
公开(公告)号：US3992439A
公开(公告)日：1976-11-16
申请号：US549875
申请日：1975-02-14
申请人： Thomas K. Schaaf , Elias J. Corey
发明人： Thomas K. Schaaf , Elias J. Corey
IPC分类号： C07C405/00 , C07C177/00
CPC分类号： C07C405/00
摘要： In the synthesis of prostaglandins of the "one" -series an alteration in the conventional reaction sequence avoids side reactions and provides an improved synthesis via a series of novel intermediates. In this improved synthesis the side chain at the 8 position is attached to the five membered ring before the side chain at the 12 position is attached.
摘要翻译： 在“一”系列的前列腺素的合成中，常规反应顺序的改变避免了副反应，并通过一系列新型中间体提供了改进的合成。 在这种改进的合成中，在8位的侧链连接到五元环，然后在12位的侧链连接。
-
公开(公告)号：US3971826A
公开(公告)日：1976-07-27
申请号：US485599
申请日：1974-07-03
IPC分类号： C07C405/00 , C07D307/54 , C07D307/935 , C07D309/12 , C07D317/60 , C07D333/24 , C07F9/40 , C07F9/6553 , C07C63/592
CPC分类号： C07D307/935 , C07C405/00 , C07D307/54 , C07D309/12 , C07D317/60 , C07D333/24 , C07F9/40 , C07F9/4059 , C07F9/655345 , B63B2211/02 , Y10S514/929
摘要： The 15-substituted-.omega.-pentanorprostaglandins and various intermediates employed in their preparation. The novel prostaglandins of this invention have been found to have activity profiles comparable to the parent prostaglandins, but exhibit a greater tissue specificity of action.
-
公开(公告)号：US3953466A
公开(公告)日：1976-04-27
申请号：US491784
申请日：1974-07-25
IPC分类号： C07C405/00 , C07D257/04 , C07D307/935 , C07D309/12 , C07F9/54 , C07F9/6524 , C08G63/19
CPC分类号： C07D257/04 , C07C405/00 , C07D307/935 , C07D309/12 , C07F9/5407 , C07F9/6524 , C08G63/19
摘要： 4(Tetrazol-5-yl)-butyltriphenylphosphonium compounds are disclosed which are useful for preparing tetrazoyl derivatives of naturally occurring prostaglandins.
摘要翻译： 公开了可用于制备天然存在的前列腺素的四唑衍生物的4（四唑-5-基） - 丁基三苯基鏻化合物。
-
公开(公告)号：US4404372A
公开(公告)日：1983-09-13
申请号：US805879
申请日：1977-06-13
IPC分类号： A61K31/557 , A61K31/19 , A61K31/5575 , A61P43/00 , C07C67/00 , C07C401/00 , C07C405/00 , C07D307/935 , C07C143/76
CPC分类号： C07D307/935 , C07C405/00
摘要： 15-Substituted-.omega.-pentanorprostaglandin C-1 tetrazoles, imides and sulfonimides.Their use as anti-secretory agents or as agents for the control of fertility.
摘要翻译： 15-取代的ω-前药前列腺素C-1四唑，酰亚胺和磺酰亚胺。 它们用作抗分泌剂或作为控制生育力的药剂。
-
公开(公告)号：US4157341A
公开(公告)日：1979-06-05
申请号：US849752
申请日：1977-11-09
IPC分类号： C07F9/38 , A61K31/5575 , C07C67/00 , C07C401/00 , C07C405/00 , C07D257/04 , C07D307/935 , C07D309/12 , C07F9/40 , C07C177/00
CPC分类号： C07D257/04 , C07C405/00 , C07D307/935 , C07D309/12 , C07F9/4006
摘要： 11-Desoxy-16-aryloxy-.omega.-tetranorprostaglandins are disclosed. The novel prostaglandins of this invention have been found to have activity profiles comparable to the parent prostaglandins but they exhibit a greater tissue specificity of action.
摘要翻译： 公开了11-脱氧-16-芳氧基-ω-抗原前列腺素。 已经发现本发明的新型前列腺素具有与母体前列腺素相当的活性谱，但它们表现出较大的组织作用特异性。
-
-
-
-
-
-
-
-
-
搜索结果
35 条记录 (耗时 0.02 秒)
