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![Synthesis of deuterated catechols and benzo[D][1,3]dioxoles and derivatives thereof](/abs-image/US/2009/06/04/US20090143432A1/abs.jpg.150x150.jpg)
1.发明申请Synthesis of deuterated catechols and benzo[D][1,3]dioxoles and derivatives thereof 有权氘代儿茶酚和苯并[D] [1,3]二氧戊环及其衍生物的合成公开(公告)号：US20090143432A1
公开(公告)日：2009-06-04
申请号：US12283621
申请日：2008-09-12
IPC分类号： A61K31/4525 , C07D405/12 , C07D487/04 , C07D491/02 , C07D307/77 , C07C39/10
CPC分类号： C07D317/46 , C07D317/48 , C07D405/12 , C07D471/14 , C07D491/14
摘要： The present invention provides a convenient and efficient process for the synthesis of d2-benzo[d][1,3]dioxoles.
摘要翻译： 本发明提供了合成d2-苯并[d] [1,3]二氧杂环戊烷的方便且有效的方法。
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![SYNTHESIS OF DEUTERATED CATECHOLS AND BENZO[D][1,3]DIOXOLES AND DERIVATIVES THEREOF](/abs-image/US/2014/11/13/US20140336387A1/abs.jpg.150x150.jpg)
2.发明申请SYNTHESIS OF DEUTERATED CATECHOLS AND BENZO[D][1,3]DIOXOLES AND DERIVATIVES THEREOF 有权去离子化合物和苯并[D] [1,3]二氧化物及其衍生物的合成公开(公告)号：US20140336387A1
公开(公告)日：2014-11-13
申请号：US14340143
申请日：2014-07-24
IPC分类号： C07D317/46 , C07D405/12
CPC分类号： C07D317/46 , C07D317/48 , C07D405/12 , C07D471/14 , C07D491/14
摘要： The present invention provides a convenient and efficient process for the synthesis of d2-benzo[d][1,3]dioxoles.
摘要翻译： 本发明提供了合成d2-苯并[d] [1,3]二氧杂环戊烷的方便且有效的方法。
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![Synthesis of deuterated catechols and benzo[D][1,3]dioxoles and derivatives thereof](/abs-image/US/2014/09/02/US08822498B2/abs.jpg.150x150.jpg)
3.发明授权Synthesis of deuterated catechols and benzo[D][1,3]dioxoles and derivatives thereof 有权氘代儿茶酚和苯并[D] [1,3]二氧戊环及其衍生物的合成公开(公告)号：US08822498B2
公开(公告)日：2014-09-02
申请号：US12283621
申请日：2008-09-12
IPC分类号： A61K31/445 , C07D211/22
CPC分类号： C07D317/46 , C07D317/48 , C07D405/12 , C07D471/14 , C07D491/14
摘要： The present invention provides a convenient and efficient process for the synthesis of d2-benzo[d][1,3]dioxoles.
摘要翻译： 本发明提供了合成d2-苯并[d] [1,3]二氧杂环戊烷的方便且有效的方法。
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公开(公告)号：US20140343119A1
公开(公告)日：2014-11-20
申请号：US14255331
申请日：2014-04-17
IPC分类号： C07C59/125 , A61K45/06 , A61K31/19 , A61K31/225 , C07C69/708 , A61K31/22 , C07C69/675
CPC分类号： C07C59/115 , A61K31/19 , A61K31/22 , A61K31/225 , A61K45/06 , C07B59/001 , C07B2200/05 , C07C59/01 , C07C59/125 , C07C69/67 , C07C69/675 , C07C69/708
摘要： This invention relates to novel derivatives of 4-hydroxybutyric acid and prodrugs thereof, and pharmaceutically acceptable salts of the foregoing. This invention also provides pharmaceutical compositions comprising a compound of this invention and the use of such compositions in methods of treating narcolepsy, fibromyalgia, other disorders or conditions that are beneficially treated by improving nocturnal sleep or by administering sodium oxybate.
摘要翻译： 本发明涉及4-羟基丁酸的新衍生物及其前体药物及其药学上可接受的盐。 本发明还提供了包含本发明化合物的药物组合物以及这些组合物在治疗发作性睡病，纤维肌痛，其它障碍或通过改善夜间睡眠或通过施用羟酸钠有益治疗的病症的方法中的用途。
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公开(公告)号：US08710072B2
公开(公告)日：2014-04-29
申请号：US13119905
申请日：2009-09-18
IPC分类号： A61K31/485 , A61P25/04 , A61P25/08 , A61P17/00 , A61P25/14 , A61P29/00 , A61P25/28 , A61P25/00 , A61P27/06 , A61P35/00 , C07D221/28
CPC分类号： A61K31/485 , A61K31/195 , A61K31/4709 , A61K45/06 , C07D221/28
摘要： This invention relates to novel morphinan compounds and pharmaceutically acceptable salts thereof. This invention also provides compositions comprising a compound of this invention and the use of such compositions in methods of treating diseases and conditions that are beneficially treated by administering a σ1 receptor agonist that also has NMDA antagonist activity.
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![NOVEL TETRAHYDRO-1H-PYRIDO[4,3-B]INDOLES](/abs-image/US/2010/06/03/US20100137215A1/abs.jpg.150x150.jpg)
公开(公告)号：US20100137215A1
公开(公告)日：2010-06-03
申请号：US12625059
申请日：2009-11-24
IPC分类号： A61K38/18 , A61K31/55 , A61K31/437 , C07D471/04 , A61P25/28 , A61P25/00
CPC分类号： C07D471/04 , A61K31/437 , A61K31/475 , A61K31/55 , A61K45/06
摘要： This invention relates to novel tetrahydro-1H-pyrido[4,3-b]indoles, their derivatives and pharmaceutically acceptable salts thereof. This invention also provides compositions comprising a compound of this invention and the use of such compositions in methods of treating diseases and conditions that are beneficially treated by NMDA antagonists, acetylcholinesterase inhibitors, 5-HT6 antagonists, other neuroprotectors, antihistamines and agents that delay age-related pathologies and conditions.
摘要翻译： 本发明涉及新的四氢-1H-吡啶并[4,3-b]吲哚及其衍生物及其药学上可接受的盐。 本发明还提供了包含本发明化合物和这些组合物在治疗由NMDA拮抗剂，乙酰胆碱酯酶抑制剂，5-HT6拮抗剂，其它神经保护剂，抗组胺剂和延缓衰老的药剂有益治疗的疾病和病症的方法中的用途。 相关病理和病情。
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公开(公告)号：US20110257214A1
公开(公告)日：2011-10-20
申请号：US13119905
申请日：2009-09-18
IPC分类号： A61K31/485 , A61P25/04 , A61P25/08 , A61P17/00 , A61P25/14 , A61P29/00 , A61P25/28 , A61P25/00 , A61P27/06 , A61P9/00 , C07D221/28 , A61P35/00
CPC分类号： A61K31/485 , A61K31/195 , A61K31/4709 , A61K45/06 , C07D221/28
摘要： This invention relates to novel morphinan compounds and pharmaceutically acceptable salts thereof. This invention also provides compositions comprising a compound of this invention and the use of such compositions in methods of treating diseases and conditions that are beneficially treated by administering a σ1 receptor agonist that also has NMDA antagonist activity.
摘要翻译： 本发明涉及新的吗啡喃化合物及其药学上可接受的盐。 本发明还提供包含本发明化合物的组合物以及这些组合物在治疗通过施用也具有NMDA拮抗剂活性的1受体激动剂有益治疗的疾病和病症的方法中的用途。
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公开(公告)号：US20130012565A1
公开(公告)日：2013-01-10
申请号：US13372989
申请日：2012-02-14
IPC分类号： A61K31/225 , C07C69/34 , C07C69/353 , C07C69/40 , C07C69/675 , A61K31/19 , A61K31/222 , A61P25/00 , A61P29/00 , A61P21/00 , A61P25/18 , A61P25/32 , A61P25/16 , A61P25/30 , A61K31/197 , C07C59/01
CPC分类号： C07C59/115 , A61K31/19 , A61K31/22 , A61K31/225 , A61K45/06 , C07B59/001 , C07B2200/05 , C07C59/01 , C07C59/125 , C07C69/67 , C07C69/675 , C07C69/708
摘要： This invention relates to novel derivatives of 4-hydroxybutyric acid and prodrugs thereof, and pharmaceutically acceptable salts of the foregoing. This invention also provides pharmaceutical compositions comprising a compound of this invention and the use of such compositions in methods of treating narcolepsy, fibromyalgia, other disorders or conditions that are beneficially treated by improving nocturnal sleep or by administering sodium oxybate.
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公开(公告)号：US20120029007A1
公开(公告)日：2012-02-02
申请号：US13155827
申请日：2011-06-08
IPC分类号： A61K31/485 , A61P25/00 , A61P25/28 , A61P9/00 , A61P27/06 , A61P25/14 , A61P35/00 , A61P29/00 , A61P3/10 , A61P27/02 , A61P25/08 , A61P15/00 , A61P11/14 , A61P17/00 , A61P25/30 , C07D221/28
CPC分类号： A61K31/485 , A61K31/195 , A61K31/4709 , A61K45/06 , A61P25/08 , A61P25/16 , A61P29/00 , C07B59/002 , C07D221/28 , C07D471/08
摘要： This invention relates to novel morphinan compounds and pharmaceutically acceptable salts thereof. This invention also provides compositions comprising a compound of this invention and the use of such compositions in methods of treating diseases and conditions that are beneficially treated by administering a σ1 receptor agonist that also has NMDA antagonist activity.
摘要翻译： 本发明涉及新的吗啡喃化合物及其药学上可接受的盐。 本发明还提供包含本发明化合物的组合物以及这些组合物在治疗通过施用也具有NMDA拮抗剂活性的1受体激动剂有益治疗的疾病和病症的方法中的用途。
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