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公开(公告)号：US08293929B2
公开(公告)日：2012-10-23
申请号：US12902811
申请日：2010-10-12
申请人： Gerald J. Tanoury , Minzhang Chen , Andrew D. Jones , Philip L. Nyce , Martin Trudeau , David J. Guerin , John R. Snoonian
发明人： Gerald J. Tanoury , Minzhang Chen , Andrew D. Jones , Philip L. Nyce , Martin Trudeau , David J. Guerin , John R. Snoonian
IPC分类号： C07D307/02 , C07C205/00 , C07C233/00
CPC分类号： C07D207/16 , C07D209/52 , C07D211/60 , C07D405/12 , C07D417/06 , C07D417/12 , C07D417/14 , Y02P20/55
摘要： The invention relates to processes and compounds useful for producing modified aspartic acid derivatives, such as aspartic acid aldehyde moieties. Aspartic acid derivatives are useful for preparing caspase inhibitors and/or prodrugs thereof.
摘要翻译： 本发明涉及可用于生产改性天冬氨酸衍生物如天冬氨酸醛部分的方法和化合物。 天冬氨酸衍生物可用于制备半胱天冬酶抑制剂和/或其前药。
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![PROCESS FOR PREPARING SUBSTITUTED 5-AMINO-PYRAZOLO-[4,3-e]-1,2,4-TRIAZOLO[1,5-c]PYRIMIDINES](/abs-image/US/2009/12/31/US20090326241A1/abs.jpg.150x150.jpg)
2.发明申请公开(公告)号：US20090326241A1
公开(公告)日：2009-12-31
申请号：US12552765
申请日：2009-09-02
IPC分类号： C07D231/38
CPC分类号： C07D487/14
摘要： A process for preparing substituted 5-amino-pyrazolo[4,3-e]-1,2,4-triazolo-[1,5-c]pyrimidine compounds having an aminoalkyl substituent at the 7-position is disclosed, wherein the pyrimidine ring is cyclized using a cyanating agent.
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![SYNTHESIS OF DEUTERATED CATECHOLS AND BENZO[D][1,3]DIOXOLES AND DERIVATIVES THEREOF](/abs-image/US/2014/11/13/US20140336387A1/abs.jpg.150x150.jpg)
3.发明申请SYNTHESIS OF DEUTERATED CATECHOLS AND BENZO[D][1,3]DIOXOLES AND DERIVATIVES THEREOF 有权去离子化合物和苯并[D] [1,3]二氧化物及其衍生物的合成公开(公告)号：US20140336387A1
公开(公告)日：2014-11-13
申请号：US14340143
申请日：2014-07-24
IPC分类号： C07D317/46 , C07D405/12
CPC分类号： C07D317/46 , C07D317/48 , C07D405/12 , C07D471/14 , C07D491/14
摘要： The present invention provides a convenient and efficient process for the synthesis of d2-benzo[d][1,3]dioxoles.
摘要翻译： 本发明提供了合成d2-苯并[d] [1,3]二氧杂环戊烷的方便且有效的方法。
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公开(公告)号：US08029007B2
公开(公告)日：2011-10-04
申请号：US10904996
申请日：2004-12-08
申请人： Andrew D. Jones , Robin Peng , Ralph Sonderegger , Bart Peterson , Kevin Kinkade
发明人： Andrew D. Jones , Robin Peng , Ralph Sonderegger , Bart Peterson , Kevin Kinkade
IPC分类号： B62B9/12
摘要： The present invention is a passenger assembly for a stroller and is adaptable to almost any stroller and is capable of practice in numerous embodiments. The preferred embodiment features a chassis mounted platform with adjustable mounting arms. A mounting mechanism is located at the terminus of each arm and is attachable and removable from the stroller frame with the passenger assembly. A number of potential mounting mechanisms are disclosed. An extension handle is provided to allow users greater control of the stroller from a distance further than normal, as the assembly occupies the position proximate the stroller, where the user ordinarily stands. Modules are capable of addition to the assembly, such as a seat or basket, or a stow strap for securement of the assembly when not in use.
摘要翻译： 本发明是一种用于婴儿车的乘客组件，并且几乎适用于任何婴儿车，并且能够在许多实施例中实践。 优选实施例具有可调安装臂的底盘安装平台。 安装机构位于每个臂的终点处，并且可与乘客组件从婴儿车框架附接和移除。 公开了许多潜在的安装机构。 提供延伸手柄以允许用户从正常的距离更大程度地控制婴儿车，因为组件占据婴儿车附近的位置，其中用户通常站立。 模块能够添加到组件中，例如座椅或篮子或用于在不使用时固定组件的收起带。
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![Process for preparing substituted 5-amino-pyrazolo-[4,3-e]-1,2,4-triazolo[1,5-c]pyrimidines](/abs-image/US/2009/10/13/US07601833B2/abs.jpg.150x150.jpg)
5.发明授权Process for preparing substituted 5-amino-pyrazolo-[4,3-e]-1,2,4-triazolo[1,5-c]pyrimidines 有权取代的5-氨基 - 吡唑并[4,3-e] -1,2,4-三唑并[1,5-c]嘧啶的制备方法公开(公告)号：US07601833B2
公开(公告)日：2009-10-13
申请号：US12208717
申请日：2008-09-11
IPC分类号： C07D491/00
CPC分类号： C07D487/14
摘要： A process for preparing substituted 5-amino-pyrazolo[4,3-e]-1,2,4-triazolo-[1,5-c]pyrimidine compounds having an aminoalkyl substituent at the 7-position is disclosed, wherein the pyrimidine ring is cyclized using a cyanating agent.
摘要翻译： 公开了一种在7-位具有氨基烷基取代基的取代的5-氨基 - 吡唑并[4,3-e] -1,2,4-三唑并 - [1,5-c]嘧啶化合物的制备方法，其中嘧啶 环使用氰化剂环化。
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![PROCESS FOR PREPARING SUBSTITUTED 5-AMINO-PYRAZOLO-[4,3-e]-1,2,4-TRIAZOLO[1,5-c]PYRIMIDINES](/abs-image/US/2009/01/01/US20090005559A1/abs.jpg.150x150.jpg)
6.发明申请PROCESS FOR PREPARING SUBSTITUTED 5-AMINO-PYRAZOLO-[4,3-e]-1,2,4-TRIAZOLO[1,5-c]PYRIMIDINES 有权制备取代的5-氨基 - 吡唑并[4,3-e] -1,2,4-三唑[1,5-c]吡啶的方法公开(公告)号：US20090005559A1
公开(公告)日：2009-01-01
申请号：US12208717
申请日：2008-09-11
IPC分类号： C07D487/14 , C07D231/38
CPC分类号： C07D487/14
摘要： A process for preparing substituted 5-amino-pyrazolo[4,3-e]-1,2,4-triazolo-[1,5-c]pyrimidine compounds having an aminoalkyl substituent at the 7-position is disclosed, wherein the pyrimidine ring is cyclized using a cyanating agent.
摘要翻译： 公开了一种在7-位具有氨基烷基取代基的取代的5-氨基 - 吡唑并[4,3-e] -1,2,4-三唑并 - [1,5-c]嘧啶化合物的制备方法，其中嘧啶 环使用氰化剂环化。
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![Process for preparing substituted 5-amino-pyrazolo-[4,3-e]-1,2,4-triazolo[1,5-c]pyrimidines](/abs-image/US/2008/10/21/US07439361B2/abs.jpg.150x150.jpg)
7.发明授权Process for preparing substituted 5-amino-pyrazolo-[4,3-e]-1,2,4-triazolo[1,5-c]pyrimidines 有权取代的5-氨基 - 吡唑并[4,3-e] -1,2,4-三唑并[1,5-c]嘧啶的制备方法公开(公告)号：US07439361B2
公开(公告)日：2008-10-21
申请号：US11788682
申请日：2007-04-20
IPC分类号： C07D403/00
CPC分类号： C07D487/14
摘要： A process for preparing substituted 5-amino-pyrazolo[4,3-e]-1,2,4-triazolo-[1,5-c]pyrimidine compounds having an aminoalkyl substituent at the 7-position is disclosed, wherein the pyrimidine ring is cyclized using a cyanating agent.
摘要翻译： 公开了一种在7-位具有氨基烷基取代基的取代的5-氨基 - 吡唑并[4,3-e] -1,2,4-三唑并 - [1,5-c]嘧啶化合物的制备方法，其中嘧啶 环使用氰化剂环化。
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公开(公告)号：US5866914A
公开(公告)日：1999-02-02
申请号：US784347
申请日：1997-01-15
申请人： Andrew D. Jones
发明人： Andrew D. Jones
摘要： A system for shaping a radiation beam exiting from a radiation source. The system includes a mount coupleable to the radiation source. The mount has a beam aperture with a tapered inner surface extending through the mount, through which the radiation beam passes. The system further includes a die having a tapered outer surface capable of engaging the tapered inner surface of the beam aperture. The die has a beam window extending through the die which is substantially transparent at at least a selected radiation power such that the radiation emerging from the beam window has the same size and shape as the beam window.
摘要翻译： 一种用于整形从辐射源出射的辐射束的系统。 该系统包括可耦合到辐射源的安装件。 安装座具有光束孔径，锥形内表面延伸穿过安装座，辐射束穿过该孔。 该系统还包括具有能够接合光束孔的锥形内表面的锥形外表面的模具。 模具具有延伸穿过模具的梁窗，其至少在选定的辐射功率下基本上是透明的，使得从光束窗口出射的辐射具有与光束窗口相同的尺寸和形状。
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公开(公告)号：US07381827B2
公开(公告)日：2008-06-03
申请号：US11078147
申请日：2005-03-11
申请人： Gerald J. Tanoury , Minzhang Chen , Andrew D. Jones , Philip L. Nyce , Martin Trudeau , David J. Guerin , John R. Snoonian
发明人： Gerald J. Tanoury , Minzhang Chen , Andrew D. Jones , Philip L. Nyce , Martin Trudeau , David J. Guerin , John R. Snoonian
IPC分类号： C07D207/06 , C07D295/02 , C07D305/00 , C07C239/00
CPC分类号： C07D207/16 , C07D209/52 , C07D211/60 , C07D405/12 , C07D417/06 , C07D417/12 , C07D417/14 , Y02P20/55
摘要： The invention relates to processes and compounds useful for producing modified aspartic acid derivatives, such as aspartic acid aldehyde moieties. Aspartic acid derivatives are useful for preparing caspase inhibitors and/or prodrugs thereof.
摘要翻译： 本发明涉及可用于生产改性天冬氨酸衍生物如天冬氨酸醛部分的方法和化合物。 天冬氨酸衍生物可用于制备半胱天冬酶抑制剂和/或其前药。
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![Process for preparing substituted 5-amino-pyrazolo-[4,3-e]-1,2,4-triazolo-[1,5-c]-pyrimidines](/abs-image/US/2007/05/29/US07223861B2/abs.jpg.150x150.jpg)
10.发明授权Process for preparing substituted 5-amino-pyrazolo-[4,3-e]-1,2,4-triazolo-[1,5-c]-pyrimidines 有权取代的5-氨基 - 吡唑并[4,3-e] -1,2,4-三唑并 - [1,5-c] - 嘧啶的制备方法公开(公告)号：US07223861B2
公开(公告)日：2007-05-29
申请号：US10973631
申请日：2004-10-26
IPC分类号： C07D239/00
CPC分类号： C07D487/14
摘要： A process for preparing substituted 5-amino-pyrazolo[4,3-e]-1,2,4-triazolo-[1,5-c]pyrimidine compounds having an aminoalkyl substituent at the 7-position is disclosed, wherein the pyrimidine ring is cyclized using a cyanating agent.
摘要翻译： 公开了一种在7-位具有氨基烷基取代基的取代的5-氨基 - 吡唑并[4,3-e] -1,2,4-三唑并 - [1,5-c]嘧啶化合物的制备方法，其中嘧啶 环使用氰化剂环化。
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