公开(公告)号：US11939285B2

公开(公告)日：2024-03-26

申请号：US17514416

申请日：2021-10-29

申请人： Concert Pharmaceuticals, Inc.

发明人： Roger D. Tung

IPC分类号： A61K31/19 ,  A61K31/18 ,  A61K31/197 ,  A61K31/381 ,  A61K45/06 ,  C07B59/00 ,  C07C59/01 ,  C07C69/675 ,  A61K31/195

CPC分类号： C07C59/01 ,  A61K31/19 ,  A61K31/381 ,  A61K45/06 ,  C07B59/001 ,  C07C69/675 ,  A61K31/195 ,  C07B2200/05

摘要： This invention relates to novel derivatives of 4-hydroxybutyric acid and prodrugs thereof, and pharmaceutically acceptable salts of the foregoing. This invention also provides pharmaceutical compositions comprising a compound of this invention and the use of such compositions in methods of treating narcolepsy, fibromyalgia, other disorders or conditions that are beneficially treated by improving nocturnal sleep or by administering sodium oxybate.

公开(公告)号：US11851389B2

公开(公告)日：2023-12-26

申请号：US16347995

申请日：2017-11-07

申请人： RAMOT AT TEL-AVIV UNIVERSITY LTD.

发明人： Dan Peer ,  Srinivas Ramishetti

IPC分类号： C07C211/22 ,  A61K47/18 ,  C07C215/08 ,  C07C229/12 ,  C07C243/00 ,  C07C243/16 ,  C07C243/28 ,  C07D295/15 ,  C12N15/113 ,  A61K48/00 ,  C07C243/04 ,  C07C59/01 ,  C07C333/10 ,  C07C219/04 ,  C07D233/64 ,  C07C229/02 ,  A61P29/00 ,  C07D295/13 ,  C07C243/26 ,  C07C233/00 ,  C07C243/14 ,  C07C279/04 ,  A61P35/00 ,  C07C229/10 ,  C07C243/10

CPC分类号： C07C211/22 ,  A61K47/18 ,  A61K48/00 ,  A61P29/00 ,  A61P35/00 ,  C07C59/01 ,  C07C215/08 ,  C07C219/04 ,  C07C229/02 ,  C07C229/10 ,  C07C229/12 ,  C07C233/00 ,  C07C243/00 ,  C07C243/10 ,  C07C243/14 ,  C07C243/16 ,  C07C243/26 ,  C07C243/28 ,  C07C279/04 ,  C07C333/10 ,  C07D233/64 ,  C07D295/13 ,  C07D295/15 ,  C12N15/113 ,  C12N2310/14

摘要： The present invention provides cationic lipids and lipid nanoparticle formulations comprising these lipids, alone or in combination with other lipids. These lipid nanoparticles may be formulated with nucleic acids to facilitate their intracellular delivery both in vitro and for therapeutic applications. The present invention also provides methods of chemical synthesis of these lipids, lipid nanoparticle preparation and formulation with nucleic acids.

公开(公告)号：US11834402B2

公开(公告)日：2023-12-05

申请号：US17649392

申请日：2022-01-31

申请人： CARGILL, INCORPORATED

发明人： Timothy Walter Abraham ,  Erik Allen ,  John J. Hahn ,  Paraskevas Tsobanakis ,  Eric Christopher Bohnert ,  Christopher Lawrence Frank

IPC分类号： C07C5/44 ,  B01D3/00 ,  B01D3/10 ,  C07C51/44 ,  C07C51/42 ,  C12P7/42 ,  C07C51/41 ,  B01D3/34 ,  B01D15/36

CPC分类号： C07C51/44 ,  B01D3/002 ,  B01D3/10 ,  B01D3/34 ,  B01D15/363 ,  C07C51/412 ,  C07C51/42 ,  C12P7/42 ,  C07C51/412 ,  C07C59/01 ,  C07C51/44 ,  C07C59/01 ,  C07C51/42 ,  C07C59/01

摘要： A method for recovering a composition enriched in 3-hydroxypropionic acid from a fermentation broth comprising 3-hydroxypropionic acid and/or salts thereof comprises the steps of: (a) providing the fermentation broth having a pH of from about 2 to about 8 comprising: 3-hydroxypropionic acid and/or salts thereof, (b) acidifying the fermentation broth; (c) reducing the total sulfate ion and phosphate ion (d) distilling the resulting reduced ion aqueous solution and (e) recovering the product.

公开(公告)号：US20190031590A1

公开(公告)日：2019-01-31

申请号：US16151268

申请日：2018-10-03

申请人： Apeel Technology, Inc.

发明人： Ronald C. Bakus, II ,  Louis Perez ,  Camille Mol ,  James Rogers ,  Gabriel Rodriguez

IPC分类号： C07C51/09 ,  A23L3/3454 ,  C09D167/00 ,  C09D5/00 ,  C07C67/03 ,  C07C51/367 ,  A23B7/16 ,  C07C51/36 ,  C07C51/00 ,  C08G63/06 ,  C07C67/08 ,  C09D167/04 ,  C08G63/00 ,  C07C59/105 ,  C07C53/126 ,  C07C59/01 ,  C07C69/24 ,  C07C69/675 ,  C07C69/58 ,  C07C69/732 ,  C07C69/533 ,  C07C57/12 ,  C07C57/03 ,  C07C59/42 ,  C07C69/587

CPC分类号： A23B7/16 ,  A23L3/3454 ,  A23V2002/00 ,  B01D11/0284 ,  C07C29/132 ,  C07C29/17 ,  C07C51/00 ,  C07C51/09 ,  C07C51/36 ,  C07C51/367 ,  C07C51/377 ,  C07C63/00 ,  C07C67/03 ,  C07C67/08 ,  C07C67/475 ,  C07D303/38 ,  C08G63/00 ,  C08G63/06 ,  C09D5/00 ,  C09D167/00 ,  C09D167/04 ,  C07C59/105 ,  C07C53/126 ,  C07C59/01 ,  C07C69/24 ,  C07C69/675 ,  C07C69/58 ,  C07C69/732 ,  C07C69/533 ,  C07C57/12 ,  C07C57/03 ,  C07C59/42 ,  C07C69/587

摘要： Described herein are methods of preparing cutin-derived monomers, oligomers, or combinations thereof from cutin-containing plant matter. The methods can include heating the cutin-derived plant matter in a solvent at elevated temperature and pressure. In some preferred embodiments, the methods can be carried out without the use of additional acidic or basic species.

公开(公告)号：US20180057619A1

公开(公告)日：2018-03-01

申请号：US15550111

申请日：2016-02-12

申请人： Novomer, Inc.

发明人： Sadesh H. SOOKRAJ

IPC分类号： C08F20/06 ,  C07C51/14 ,  C07C51/145 ,  C07C51/377 ,  C07C57/04 ,  C07C59/01 ,  C08F2/01 ,  C08F2/18

CPC分类号： C08F20/06 ,  C07C51/12 ,  C07C51/14 ,  C07C51/145 ,  C07C51/377 ,  C07C57/04 ,  C07C59/01 ,  C08F2/01 ,  C08F2/18

摘要： Disclosed are systems and methods for the production of polyacrylic acid and superabsorbent polymers from ethylene oxidation to form ethylene oxide. Reacting the ethylene oxide with carbon monoxide to form to beta propiolactone (BPL) or polypropiolactone (PPL), or a combination thereof. An outlet configured to provide a carbonylation stream comprising the BPL or PPL, or a combination thereof and using one or more reactors to convert BPL to acrylic acid or to convert at least some of the BPL to PPL, and then to convert PPL to acrylic acid. An outlet configured to provide a PPL stream to a second reactor tm to convert at least some of the PPL to AA or a third reactor to convert at least some of the PPL to AA. The outlet configured to provide an AA stream to a fourth reactor to convert the AA to polyacrylic acid.

公开(公告)号：US20180044276A1

公开(公告)日：2018-02-15

申请号：US15680541

申请日：2017-08-18

申请人： aPEEL Technology, Inc.

发明人： Louis Perez ,  Camille Mol ,  Ronald C. Bakus, II ,  James Rogers ,  Gabriel Rodriguez

IPC分类号： C07C51/09 ,  C07C67/08 ,  C08G63/06 ,  A23L3/3454 ,  C09D5/00 ,  C09D167/00 ,  C09D167/04 ,  A23B7/16 ,  C07C51/36 ,  C08G63/00

CPC分类号： C07C51/09 ,  A23B7/16 ,  A23L3/3454 ,  A23V2002/00 ,  C07C51/00 ,  C07C51/36 ,  C07C51/367 ,  C07C67/03 ,  C07C67/08 ,  C08G63/00 ,  C08G63/06 ,  C09D5/00 ,  C09D167/00 ,  C09D167/04 ,  C07C59/105 ,  C07C53/126 ,  C07C59/01 ,  C07C69/24 ,  C07C69/675 ,  C07C69/58 ,  C07C69/732 ,  C07C69/533 ,  C07C57/12 ,  C07C57/03 ,  C07C59/42 ,  C07C69/587

摘要： Described herein are methods of preparing cutin-derived monomers, oligomers, or combinations thereof from cutin-containing plant matter. The methods can include heating the cutin-derived plant matter in a solvent at elevated temperature and pressure. In some preferred embodiments, the methods can be carried out without the use of additional acidic or basic species.

公开(公告)号：US20180002729A1

公开(公告)日：2018-01-04

申请号：US15642269

申请日：2017-07-05

申请人： INVISTA North America S.á r.l.

发明人： Alex Van Eck Conradie ,  Adriana Leonora Botes ,  Ramdane Haddouche

IPC分类号： C12P13/00 ,  C07C47/12 ,  C07C59/01 ,  C07C59/325 ,  C07C223/02 ,  C08G63/06 ,  C12N9/02 ,  C12P7/64 ,  C12P7/62 ,  C12P7/44 ,  C07C47/02 ,  C12P7/40 ,  C12P7/24 ,  C12N9/10 ,  C12P7/42

CPC分类号： C12P13/001 ,  C07C47/02 ,  C07C47/12 ,  C07C59/01 ,  C07C59/325 ,  C07C223/02 ,  C08G63/06 ,  C12N9/0008 ,  C12N9/0077 ,  C12N9/1007 ,  C12N9/1096 ,  C12P7/24 ,  C12P7/40 ,  C12P7/42 ,  C12P7/44 ,  C12P7/62 ,  C12P7/6409 ,  C12P7/6436 ,  C12Y102/99006 ,  C12Y114/15001 ,  C12Y114/15003 ,  C12Y206/01018 ,  C12Y206/01019 ,  C12Y206/01029 ,  C12Y206/01048 ,  C12Y206/01082

摘要： This document describes biochemical pathways for producing 7-hydroxyheptanoate methyl ester and heptanoic acid heptyl ester using one or more of a fatty acid O-methyltransferase, an alcohol O-acetyltransferase, and a monooxygenase, as well as recombinant hosts expressing one or more of such exogenous enzymes. 7-hydroxyheptanoate methyl esters and heptanoic acid heptyl esters can be enzymatically converted to pimelic acid, 7-aminoheptanoate, 7-hydroxyheptanoate, heptamethylenediamine, or 1,7-heptanediol.

公开(公告)号：US20170349516A1

公开(公告)日：2017-12-07

申请号：US15487623

申请日：2017-04-14

申请人： Esperion Therapeutics, Inc.

发明人： Jean-Louis H. Dasseux ,  Carmen D. Oniciu

IPC分类号： C07C31/27 ,  C07F9/24 ,  A61K31/191 ,  A61K31/194 ,  C07F9/12 ,  C07F9/117 ,  C07F9/11 ,  C07F9/09 ,  C07D495/04 ,  C07D405/12 ,  C07D309/30 ,  C07D309/12 ,  C07D309/10 ,  C07D307/33 ,  C07D305/12 ,  C07D261/12 ,  C07D261/08 ,  C07D257/04 ,  C07D213/80 ,  C07C309/25 ,  C07C309/24 ,  C07C309/08 ,  C07C255/00 ,  C07C69/757 ,  C07C69/675 ,  C07C69/017 ,  C07C69/003 ,  C07C65/17 ,  C07C62/06 ,  C07C62/02 ,  C07C61/12 ,  C07C59/54 ,  C07C59/48 ,  C07C59/46 ,  C07C59/29 ,  C07C59/285 ,  C07C59/245 ,  C07C59/11 ,  C07C59/105 ,  C07C59/01 ,  C07C47/34 ,  C07C47/19 ,  C07C33/26 ,  C07C31/24 ,  C07C31/22 ,  C07C31/20 ,  A61K31/23 ,  A61K31/20 ,  C07F9/44 ,  C07C2601/02 ,  C07C2601/04 ,  C07C2601/08

CPC分类号： C07C31/27 ,  A61K31/191 ,  A61K31/194 ,  A61K31/20 ,  A61K31/23 ,  C07C31/20 ,  C07C31/22 ,  C07C31/24 ,  C07C33/26 ,  C07C47/19 ,  C07C47/34 ,  C07C59/01 ,  C07C59/105 ,  C07C59/11 ,  C07C59/245 ,  C07C59/285 ,  C07C59/29 ,  C07C59/46 ,  C07C59/48 ,  C07C59/54 ,  C07C61/12 ,  C07C62/02 ,  C07C62/06 ,  C07C65/17 ,  C07C69/003 ,  C07C69/017 ,  C07C69/675 ,  C07C69/757 ,  C07C255/00 ,  C07C309/08 ,  C07C309/24 ,  C07C309/25 ,  C07C2101/02 ,  C07C2101/04 ,  C07C2101/08 ,  C07C2601/02 ,  C07C2601/04 ,  C07C2601/08 ,  C07D213/80 ,  C07D257/04 ,  C07D261/08 ,  C07D261/12 ,  C07D305/12 ,  C07D307/33 ,  C07D309/10 ,  C07D309/12 ,  C07D309/30 ,  C07D405/12 ,  C07D495/04 ,  C07F9/093 ,  C07F9/094 ,  C07F9/11 ,  C07F9/117 ,  C07F9/12 ,  C07F9/2408 ,  C07F9/2416 ,  C07F9/242 ,  C07F9/2425 ,  C07F9/4423

摘要： The present invention relates to novel hydroxyl compounds, compositions comprising hydroxyl compounds, and methods useful for treating and preventing a variety of diseases and conditions such as, but not limited to aging, Alzheimer's Disease, cancer, cardiovascular disease, diabetic nephropathy, diabetic retinopathy, a disorder of glucose metabolism, dyslipidemia, dyslipoproteinemia, hypertension, impotence, inflammation, insulin resistance, lipid elimination in bile, obesity, oxysterol elimination in bile, pancreatitis, pancreatitius, Parkinson's disease, a peroxisome proliferator activated receptor-associated disorder, phospholipid elimination in bile, renal disease, septicemia, metabolic syndrome disorders (e.g., Syndrome X), thrombotic disorder. Compounds and methods of the invention can also be used to modulate C reactive protein or enhance bile production in a patient. In certain embodiments, the compounds, compositions, and methods of the invention are useful in combination therapy with other therapeutics, such as hypocholesterolemic and hypoglycemic agents.

公开(公告)号：US20170197901A1

公开(公告)日：2017-07-13

申请号：US15380222

申请日：2016-12-15

申请人： SK Innovation Co., Ltd.

发明人： Min Su Koo

IPC分类号： C07C51/377 ,  C07C51/43

CPC分类号： C07C51/377 ,  C07C51/44 ,  C07C59/01 ,  C07C57/04

摘要： The present invention relates to a method including: directly heating a fermentation broth to remove impurities, thereby preparing an organic vapor-phase dehydration feedstock; and continuously subjecting the organic vapor-phase dehydration feedstock to a vapor-phase dehydration reaction. According to the present invention, impurities in a fermentation broth, which have been removed by a multi-step process in the prior art, can be completely removed in a single-step process, and thus the time, cost and energy required for a process for preparing an organic vapor-phase dehydration feedstock from the fermentation broth can be effectively reduced, and the process for preparing the organic vapor-phase dehydration feedstock and a vapor-phase dehydration reaction can be continuously performed in an effective manner.

公开(公告)号：US20160318837A1

公开(公告)日：2016-11-03

申请号：US15210586

申请日：2016-07-14

申请人： PURAC BIOCHEM BV

发明人： Adriaan Dirk KON ,  André Banier DE HAAN ,  Paulus Loduvicus Johannes VAN DER WEIDE ,  Tanja ÐEKIC ZIVKOVIC ,  Lucien Henri Leander Jozef DE KONINCK

IPC分类号： C07C51/02 ,  B01J39/04 ,  B01J49/00 ,  C01F5/30

CPC分类号： C07C51/02 ,  B01J39/05 ,  B01J49/53 ,  C01B7/035 ,  C01F5/02 ,  C01F5/10 ,  C01F5/16 ,  C01F5/30 ,  C07C55/10 ,  C07C59/08 ,  C07C53/122 ,  C07C59/01 ,  C07C59/265 ,  C07C55/14 ,  C07C57/15 ,  C07C57/145 ,  C07C63/26 ,  C07C57/04

摘要： The invention is directed to a method for recovering carboyxlic acid from an magnesium carboxylate containing aqueous mixture, including the steps of: contacting the aqueous mixture with an acidic ion exchanger, thereby forming a carboxylic acid mixture and an ion exchanger loaded with magnesium ions; contacting the ion exchanger loaded with magnesium ions with a hydrochloric acid solution, thereby forming a magnesium chloride solution; and thermally decomposing the magnesium chloride solution at a temperature of at least 300° C., thereby forming magnesium oxide (MgO) and hydrogen chloride (HCl).