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1.发明公开公开(公告)号：US20240141397A1
公开(公告)日：2024-05-02
申请号：US18242912
申请日：2023-09-06
申请人： Genomatica, Inc.
发明人： Robin E. Osterhout , Priti Pharkya
IPC分类号： C12P17/10 , C12N9/00 , C12N9/02 , C12N9/04 , C12N9/06 , C12N9/10 , C12N9/16 , C12N15/52 , C12P7/18 , C12P7/40 , C12P7/44 , C12P13/00 , C12P17/08
CPC分类号： C12P17/10 , C12N9/0004 , C12N9/0006 , C12N9/0008 , C12N9/001 , C12N9/0016 , C12N9/1029 , C12N9/1096 , C12N9/13 , C12N9/16 , C12N9/93 , C12N15/52 , C12P7/18 , C12P7/40 , C12P7/44 , C12P13/001 , C12P13/005 , C12P17/08 , C12Y101/01027 , C12Y101/0103 , C12Y101/01035 , C12Y101/01037 , C12Y101/01172 , C12Y103/01031 , C12Y104/01009 , C12Y203/01174 , C12Y206/01019 , C12Y208/03006 , C12Y301/02004 , C12Y603/03004
摘要： Provided herein are non-naturally occurring microbial organisms having biosynthetic pathways for production of target products and one or more genetic modifications that reduce a byproduct of the biosynthetic pathway. Compositions of target products from such cells and methods of using such cells are provided.
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2.发明公开公开(公告)号：US20230371507A1
公开(公告)日：2023-11-23
申请号：US18042728
申请日：2021-08-24
申请人： Noam Sheffer , Limor Poraty-Gavra , Itsik Bar Nahum , Sami Shabtai , Dusan Goranovic , Gregor Kosec , Leon Bedrac , Alen Cusak , Adama Makhteshim Ltd.
发明人： Noam Sheffer , Limor Poraty-Gavra , Itsik Bar Nahum , Sami Shabtai , Dusan Goranovic , Gregor Kosec , Leon Bedrac , Alen Cusak
摘要： The present invention provides a method of treating a locus against pest infestation using a compound of Formula I as described herein or an agriculturally acceptable salt thereof. The present invention also provides combinations and compositions comprising the compound of Formula I or an agriculturally acceptable salt thereof and uses thereof. The present invention also provides methods of extracting the compound of Formula I from a fungus.
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公开(公告)号：US20230175024A1
公开(公告)日：2023-06-08
申请号：US17922695
申请日：2021-05-26
申请人： FF-FUTURE OY
发明人： Simo ELLILÄ , Marja ILMEN , Eemeli HYTÖNEN
摘要： The present invention relates to the fields of industrial biotechnology, renewable raw materials and production of organic acids. Specifically, the invention relates to a method of producing an organic acid or a salt thereof. Still, the present invention relates to a mixture comprising legume molasses and calcium hydroxide or a mixture obtained by combining a carbon substrate composition comprising legume molasses and an aqueous suspension comprising calcium hydroxide, for producing an organic acid or a salt thereof by a microorganism, and use of said mixture for producing an organic acid or a salt thereof. Still further, the present invention relates to a method of producing one or more products selected from the group consisting of polymers, polyesters and polylactic acids.
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公开(公告)号：US11603528B2
公开(公告)日：2023-03-14
申请号：US16718736
申请日：2019-12-18
IPC分类号： C12P19/02 , C12N15/10 , C12P1/04 , C12P7/02 , C12P17/18 , C12P17/06 , C12P29/00 , C12P5/02 , C12P7/40 , C12P7/42 , C12P19/42 , C12P13/22 , C12P19/12 , C12P17/08 , C12P7/46 , C12N1/38 , C12P7/44 , C12P19/44 , C12N15/52 , C12P13/04 , C12P7/58 , C12P13/14 , C12P33/00
摘要： The present invention relates to genetically modified bacteria and methods of optimizing genetically modified bacteria for the production of a metabolite.
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公开(公告)号：US20230022727A1
公开(公告)日：2023-01-26
申请号：US17527902
申请日：2021-11-16
申请人： Genomatica, Inc.
摘要： The invention provides a non-naturally occurring microbial organism having a 6-aminocaproic acid, caprolactam, hexametheylenediamine or levulinic acid pathway. The microbial organism contains at least one exogenous nucleic acid encoding an enzyme in the respective 6-aminocaproic acid, caprolactam, hexametheylenediamine or levulinic acid pathway. The invention additionally provides a method for producing 6-aminocaproic acid, caprolactam, hexametheylenediamine or levulinic acid. The method can include culturing a 6-aminocaproic acid, caprolactam or hexametheylenediamine producing microbial organism, where the microbial organism expresses at least one exogenous nucleic acid encoding a 6-aminocaproic acid, caprolactam, hexametheylenediamine or levulinic acid pathway enzyme in a sufficient amount to produce the respective product, under conditions and for a sufficient period of time to produce 6-aminocaproic acid, caprolactam, hexametheylenediamine or levulinic acid.
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公开(公告)号：US11332751B2
公开(公告)日：2022-05-17
申请号：US16947304
申请日：2020-07-28
发明人： Zengyi Shao , Mingfeng Cao , Miguel Suastegui , Meirong Gao
IPC分类号： C12N15/00 , A01N63/00 , C12N15/81 , C12N15/10 , C12N9/10 , C12N9/02 , C12P5/00 , C12N9/88 , C12P7/44 , C12P7/42
摘要： The present disclosure includes methods and components for production of valuable industrial compounds in yeast. In an embodiment, the present invention provides a nucleic acid construct with increased stability for gene expression or gene editing comprising: a nucleic acid sequence encoding one or more of SEQ ID NO: 1-8 (CENs 1-8); and one or more regulatory elements functional in a yeast cell. In an embodiment of the present invention the nucleic acid constructs are vectors, preferably episomal vectors. High expression promoters, as well as methods for increasing production of compounds such as aromatics are disclosed.
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公开(公告)号：US11248207B2
公开(公告)日：2022-02-15
申请号：US16304803
申请日：2017-05-30
发明人： Kyohei Isobe , Kenji Kawamura , Masateru Ito , Katsushige Yamada
摘要： Provided is a method of producing α-hydromuconic acid, the method including the step of culturing a microorganism belonging to the genus Serratia capable of producing α-hydromuconic acid.
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8.发明申请公开(公告)号：US20220033790A1
公开(公告)日：2022-02-03
申请号：US17299194
申请日：2019-12-04
发明人： Kyoung Heon KIM , Thirumalaisamy BABU , Do Hyoung KIM , Jong Hwa LEE , Jung Moo LEE , Ho Chang LEE , Sung Ho OH , Su Han KIM , Chang Seok HYUN
摘要： The present invention relates to a Candida tropicalis cell line, which comprises a mutant gene, having improved tolerance for cytotoxicity of stromal cells, and a method for producing dicarboxylic acid using the Candida tropicalis cell line. The Candida tropicalis cell line for producing dicarboxylic acid developed according to the present invention has improved tolerance for existing stromal toxicity as well as significantly improved efficiency for producing dicarboxylic acid compared to existing cell lines, thus can be used in biological production of dicarboxylic acid and is expected to have high industrial utility.
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公开(公告)号：US11208673B2
公开(公告)日：2021-12-28
申请号：US16213671
申请日：2018-12-07
申请人： Genomatica, Inc.
摘要： The invention provides a non-naturally occurring microbial organism having a 6-aminocaproic acid, caprolactam, hexametheylenediamine or levulinic acid pathway. The microbial organism contains at least one exogenous nucleic acid encoding an enzyme in the respective 6-aminocaproic acid, caprolactam, hexametheylenediamine or levulinic acid pathway. The invention additionally provides a method for producing 6-aminocaproic acid, caprolactam, hexametheylenediamine or levulinic acid. The method can include culturing a 6-aminocaproic acid, caprolactam or hexametheylenediamine producing microbial organism, where the microbial organism expresses at least one exogenous nucleic acid encoding a 6-aminocaproic acid, caprolactam, hexametheylenediamine or levulinic acid pathway enzyme in a sufficient amount to produce the respective product, under conditions and for a sufficient period of time to produce 6-aminocaproic acid, caprolactam, hexametheylenediamine or levulinic acid.
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公开(公告)号：US11186834B2
公开(公告)日：2021-11-30
申请号：US15523284
申请日：2015-10-29
申请人： Ramon Gonzalez , Alexander Chou , James Clomburg
发明人： Ramon Gonzalez , Alexander Chou , James Clomburg
IPC分类号： C12P7/40 , C12P7/44 , C12P7/18 , C12N9/16 , C12N9/04 , C12N9/88 , C12N15/52 , C12P11/00 , C12P7/24 , C12P13/00 , C12P5/02 , C12P1/04 , C12P7/04 , C12N15/70 , C12P7/20
摘要： An engineered microbe that contains a designed platform for the conversion of one-carbon substrates to chemical products is described. The designed platform embodies a new metabolic architecture that consolidates carbon fixation, central metabolism, and product synthesis into a single pathway. This is made possible by the key finding that 2-hydroxyacyl-CoA lyase, an enzyme in the α-oxidation pathway, is capable of catalyzing the C—C bond formation between formyl-CoA and aldehydes of different chain lengths, allowing for the elongation of the carbon backbone of said aldehyde by one-carbon units. These novel microbes present an opportunity for the production of chemicals from single-carbon feedstocks such as carbon dioxide, carbon monoxide, formate, formaldehyde, methanol or methane.
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