公开(公告)号：US20240327882A1

公开(公告)日：2024-10-03

申请号：US18592932

申请日：2024-03-01

申请人： Morgan State University

发明人： Viji Sitther ,  Yavuz Yalcin ,  Busra Aydin

IPC分类号： C12P7/6409 ,  C12N1/20 ,  C12R1/01

CPC分类号： C12P7/6409 ,  C12N1/205 ,  C12R2001/01

摘要： Methods and compositions are detailed for increasing bio-products in cyanobacteria where the cyanobacteria is incubated in the presence of non-lethal amounts of antibiotic. Non-lethal doses of antibiotic weaken the cell membrane facilitating migration of fatty acids from the cell, reducing inhibition feedback, leading to an increase in bio-products.

公开(公告)号：US20240287556A1

公开(公告)日：2024-08-29

申请号：US18115585

申请日：2023-02-28

申请人： Halliburton Energy Services, Inc.

发明人： Ronald Bosch ,  Antonio Recio, III ,  Enrique Antonio Reyes

IPC分类号： C12P7/6436 ,  C12N1/20 ,  C12N9/10 ,  C12P7/6409

CPC分类号： C12P7/6436 ,  C12N1/20 ,  C12N9/1029 ,  C12P7/6409 ,  C12Y203/01075

摘要： A method may include: introducing a hydrocarbon containing waste source into a bioreactor, metabolizing at least a portion of hydrocarbons from the hydrocarbon containing waste source using a bacterial organism to form a biologically derived intermediate product; and introducing at least a portion of the biologically derived intermediate product into a chemical reactor and reacting at least a portion of the biologically derived intermediate product to form a chemical product.

公开(公告)号：US12059441B2

公开(公告)日：2024-08-13

申请号：US16860377

申请日：2020-04-28

申请人： International N&H Denmark ApS

发明人： Michael John Janusz ,  Anna Malgorzata Plechaty

IPC分类号： A61K35/741 ,  C12N1/20 ,  C12P7/6409

CPC分类号： A61K35/741 ,  C12N1/20 ,  C12P7/6409

摘要： Disclosed herein are probiotic bacterial strains or species that produce short chain fatty acids (SCFA), such as butyrate, and compositions comprising the same. The bacterial strains or compositions prepared thereby are used in preparing food, supplements, compositions, and other consumables to provide health benefits, including therapeutic applications, for a variety of disorders, including metabolic, immune, intestinal, and inflammatory disorders. Thus, also disclosed herein are methods of treating a subject suffering from a disorder, such as a metabolic disorder, an immune disorder, an intestinal disorder, or an inflammatory disorder with a composition comprising the probiotic bacterial strains or species disclosed herein. Uses of a bacterial strain or species and a composition comprising them provided in a nutritional product or medicament to improve health or prevent or treat a variety of disorders in a subject are also disclosed.

公开(公告)号：US20240175062A1

公开(公告)日：2024-05-30

申请号：US18549900

申请日：2022-03-10

申请人： EWHA UNIVERSITY - INDUSTRY COLLABORATION FOUNDATION ,  KONKUK UNIVERSITY INDUSTRIAL COOPERATION CORP

发明人： Jin Byung Park ,  Jeong Hoo Lee ,  Hee Jeong Cha ,  Jeong Hye Yoon ,  Deok Kun OH

IPC分类号： C12P7/6409 ,  C12N9/02

CPC分类号： C12P7/6409 ,  C12N9/0069

摘要： The present invention relates to: recombinant microorganisms expressing lipoxygenase; and recombinant microorganisms co-expressing lipoxygenase and Chlorella-derived decarboxylase. It was confirmed that when using lipoxygenase-based recombinant microorganisms according to the present invention as whole-cell biocatalysts, hydroxy fatty acids can be produced from unsaturated fatty acids. In addition, it was confirmed that when using the recombinant microorganisms co-expressing lipoxygenase and Chlorella-derived decarboxylase as whole-cell biocatalysts, secondary fatty alcohols can be produced from unsaturated fatty acids. Thus, the recombinant microorganisms constructed in the present invention can be used in various ways in the field of hydroxy fatty acid and secondary fatty alcohol production.

公开(公告)号：US20240067996A1

公开(公告)日：2024-02-29

申请号：US18499560

申请日：2023-11-01

申请人： Jiangnan University ,  Inner Mongolia Mengniu Dairy (Group) Company Limited

发明人： Long LIU ,  Jian Chen ,  Xueqin LV ,  Wenyang Wu ,  Guocheng Du ,  Jianghua Li ,  Guolin Zhou ,  Yanfeng Liu ,  Chenyang Zhang

IPC分类号： C12P7/6409 ,  C12N9/10 ,  C12N9/20 ,  C12N15/81

CPC分类号： C12P7/6409 ,  C12N9/1029 ,  C12N9/20 ,  C12N15/81 ,  C12Y203/01051 ,  C12Y301/01003 ,  C12N2800/102

摘要： The invention provides a Saccharomyces cerevisiae strain for producing a human milk lipid substitute. By integrating a heterologous lysophosphatidic acid acyltransferase into Saccharomyces cerevisiae and knocking out its own natural lysophosphatidic acid acyltransferase, the content of palmitic acid (C16:0) at Sn-2 position of triacylglycerol produced by Saccharomyces cerevisiae is increased, to synthesize a human milk lipid substitute. On this basis, a metabolic pathway related gene is knocked out, to further increase the content of human milk lipid substitute in the product. In the present invention, a human milk lipid substitute is de novo synthesized by Saccharomyces cerevisiae for the first time, in which the total fatty acid is 15% or more, and the relative content of C16:0 at Sn-2 position reaches about 60%.

公开(公告)号：US20240060191A1

公开(公告)日：2024-02-22

申请号：US18210901

申请日：2023-06-16

申请人： Kiverdi, Inc.

发明人： John S. Reed ,  Jil Geller ,  Sonali Hande

IPC分类号： C25B1/04 ,  C12N1/20 ,  C12P1/04 ,  C12P5/00 ,  C12P7/64 ,  C12P13/04 ,  C12P21/02 ,  C12P7/6409 ,  C12P17/16 ,  C12P13/00 ,  C12P25/00

CPC分类号： C25B1/04 ,  C12N1/20 ,  C12P1/04 ,  C12P5/00 ,  C12P7/64 ,  C12P13/04 ,  C12P21/02 ,  C12P7/6409 ,  C12P17/167 ,  C12P13/001 ,  C12P25/00

摘要： Microorganisms and bioprocesses are provided that convert gaseous C1 containing substrates, such as syngas, producer gas, and renewable H2 combined with CO2, into nutritional and other useful bioproducts.

公开(公告)号：US20240060112A1

公开(公告)日：2024-02-22

申请号：US18490398

申请日：2023-10-19

申请人： MARA Renewables Corporation

发明人： Kevin Berryman ,  Zhiyong Sun ,  Michael Milway ,  Mercia Valentine ,  Roberto E. Armenta

IPC分类号： C12Q1/06 ,  C12N1/10 ,  C12N1/04 ,  C12P7/6409 ,  C12P7/6427

CPC分类号： C12Q1/06 ,  C12N1/10 ,  C12N1/04 ,  C12P7/6409 ,  C12P7/6427

摘要： Provided herein are methods of culturing a microorganism. The method includes providing a container comprising one or more microorganisms and medium, wherein the microorganisms and medium form a start volume. The microorganisms and medium are cultured until the culture reaches a threshold indicator, wherein culturing comprises feeding one or more carbon sources to the culture and wherein the culture is at a threshold volume when the threshold indicator is reached. The method also includes harvesting a portion of the threshold volume to leave a residual volume that is 40% or less of the start volume and adding fresh medium to the container in an amount to return the volume of the culture to the start volume.

公开(公告)号：US20240026412A1

公开(公告)日：2024-01-25

申请号：US17917016

申请日：2021-04-09

申请人： Valneva Austria GmbH

发明人： Robert Schlegl ,  Franz Moisi ,  Markus Hanner ,  Urban Lundberg

IPC分类号： C12P21/02 ,  C07K1/107 ,  C07K14/33 ,  C07K14/005 ,  C07K1/14 ,  C12P7/6409

CPC分类号： C12P21/02 ,  C07K1/1077 ,  C07K14/33 ,  C07K14/005 ,  C07K1/145 ,  C12P7/6409 ,  C12N2770/20022

摘要： The present invention relates to method of producing a lipidated protein, a pharmaceutical composition comprising the protein of any of SEQ ID NOs: 1, 2, and/or 3 and/or the lipidated form of a protein comprising the protein of SEQ ID NO: 7 (C-TAB.G5) and/or SEQ ID NO: 8 (C-TAB.G5.1), especially the protein of SEQ ID NO: 12 (Lip-C-TAB.G5.1), and/or a lipidated form of a protein comprising the protein of SEQ ID NO: 15 (Spike protein of SARS-CoV-2) and/or a lipidated form of a protein comprising the any of the proteins of SEQ ID NOs: 16-22 (hMPV F protein), and the pharmaceutical composition for use as a medicament, particularly a vaccine and/or for use in a method for eliciting an immune response in a human against Lyme disease, a disease caused by Clostridium difficile or hMPV and/or of SARS-CoV-2 (COVID-19).

公开(公告)号：US20230407314A1

公开(公告)日：2023-12-21

申请号：US18035068

申请日：2021-11-02

申请人： Ambareesh Govind Phadnavis

发明人： Ambareesh Govind Phadnavis

IPC分类号： C12N15/52 ,  C12P7/6409 ,  C12P7/6445 ,  C12P13/08 ,  C12P7/06 ,  C12N9/88 ,  C12N9/10 ,  C12N9/04 ,  C12N9/12 ,  C12N9/16 ,  C12N9/00

CPC分类号： C12N15/52 ,  C12P7/6409 ,  C12P7/6445 ,  C12P13/08 ,  C12P7/06 ,  C12N9/88 ,  C12Y401/01032 ,  C12Y402/01036 ,  C12N9/1096 ,  C12Y206/01001 ,  C12N9/1025 ,  C12Y203/03001 ,  C12N9/0006 ,  C12Y101/01087 ,  C12Y101/01008 ,  C12Y101/01042 ,  C12Y101/09001 ,  C12Y401/02048 ,  C12N9/1029 ,  C12Y203/01054 ,  C12Y206/01042 ,  C12N9/1205 ,  C12Y207/01086 ,  C12N9/16 ,  C12Y301/02014 ,  C12N9/93 ,  C12Y604/01002

摘要： The invention provides a genetically modified eukaryotic microorganism for anaerobic production of essential amino acids and optionally the co-production of one or more co-products. The microorganism is genetically modified to redirect carbon flow from PEP via oxaloacetate and asparatate semialdehyde, towards the synthesis of increased amounts of essential amino acids. The microorganism may be genetically modified to produce increased amounts of one or more co-product by enhancing carbon flow from PEP via pyruvate, acetyl CoA and malonyl CoA to produce alcohols and lipids, such as triglycerides, fatty esters, fatty alcohols, fatty aldehydes, fatty amides. The invention provides a method for anaerobic production of essential amino acids using the genetically modified eukaryotic microorganism and optionally co-production of said one or more co-products. The genetically modified eukaryotic microorganism may be used for the anaerobic production of essential amino acids and optionally the co-production of said one or more co-products.

公开(公告)号：US20230332189A1

公开(公告)日：2023-10-19

申请号：US18210805

申请日：2023-06-16

申请人： POET Grain (Octane), LLC

发明人： Jason Bootsma

IPC分类号： C12P7/10 ,  C12P7/6409 ,  C12M1/00 ,  C12P19/02 ,  C12P7/14 ,  C12P19/14 ,  B01D17/02 ,  B01D33/00 ,  C11B1/10

CPC分类号： C12P7/10 ,  C12P7/6409 ,  C12M47/10 ,  C12P19/02 ,  C12P7/14 ,  C12P19/14 ,  B01D17/0217 ,  B01D33/00 ,  C11B1/10 ,  C12M45/04 ,  C12P2201/00 ,  C12N9/2437

摘要： Improved processes and systems for recovering products from a corn fermentation mash. In some examples, a process recovers an oil product, a protein meal product, and a fiber product from a slurry. A process includes the following steps: introducing the slurry into a device with a flexible screen and mechanical agitation to produce a filtrate and a fibrous solid stream; and introducing the filtrate into a three-phase centrifuge to produce an oil stream, a high protein solids stream, and a water with solubles stream. The flexible screen includes a washing nozzle. The slurry is whole stillage from an ethanol process. The three-phase centrifuge is a three-phase decanter. The filtrate is heated before introducing into the three-phase centrifuge. The filtrate is optionally evaporated before introducing into the three-phase centrifuge.