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公开(公告)号：US09724351B2
公开(公告)日：2017-08-08
申请号：US14422920
申请日：2013-08-21
Applicant: Alios BioPharma, Inc.
Inventor： Guangyi Wang , Leonid Beigelman , Anh Truong , Carmela Napolitano , Daniele Andreotti , Haiying He
IPC: C07D409/04 , A61K31/5377 , C07D233/60 , C07D495/14 , C07C251/84 , A61K45/06 , A61K31/381 , A61K31/404 , A61K31/407 , A61K31/4155 , A61K31/4418 , A61K31/4439 , A61K31/444 , A61K31/506 , C07C243/34 , C07C251/80 , C07C255/34 , A61K31/4164 , A61K31/426 , A61K31/4436 , A61K31/496 , A61K31/497 , A61K31/501 , C07D209/20 , C07D233/64 , C07D277/56 , C07D409/06 , C07D409/12 , C07D333/58 , C07D215/12 , C07D215/14 , C07D311/68 , C07D215/42 , C07D217/24 , C07D333/16 , C07D333/20 , C07D233/38 , C07D333/50 , C07D333/54 , C07D233/61 , C07D333/62 , C07D333/66 , C07D333/68 , C07D335/06 , C07D233/88 , C07D401/04 , C07D401/10 , C07D401/12 , C07D405/04 , C07D405/12 , C07D409/14 , C07D413/04 , C07D413/12 , C07D417/04 , C07D417/12 , C07D471/04 , C07D261/20 , C07D495/04 , C07D207/335 , C07D209/08 , C07D209/14 , C07D277/64 , C07D209/86 , C07D213/42 , C07D213/50 , C07D213/65 , C07D213/68 , C07D307/52 , C07D307/81
CPC classification number: C07D495/04 , A61K31/165 , A61K31/277 , A61K31/341 , A61K31/343 , A61K31/352 , A61K31/381 , A61K31/382 , A61K31/40 , A61K31/4025 , A61K31/404 , A61K31/407 , A61K31/4155 , A61K31/4164 , A61K31/4196 , A61K31/423 , A61K31/426 , A61K31/427 , A61K31/428 , A61K31/4365 , A61K31/4375 , A61K31/4418 , A61K31/4427 , A61K31/4436 , A61K31/4439 , A61K31/444 , A61K31/4545 , A61K31/47 , A61K31/4704 , A61K31/4709 , A61K31/4725 , A61K31/496 , A61K31/497 , A61K31/501 , A61K31/506 , A61K31/5377 , A61K31/538 , A61K45/06 , C07C243/18 , C07C243/34 , C07C251/80 , C07C251/84 , C07C255/34 , C07C255/66 , C07C2602/08 , C07D207/335 , C07D209/08 , C07D209/14 , C07D209/20 , C07D209/86 , C07D213/42 , C07D213/50 , C07D213/65 , C07D213/68 , C07D215/12 , C07D215/14 , C07D215/38 , C07D215/42 , C07D217/24 , C07D233/38 , C07D233/60 , C07D233/61 , C07D233/64 , C07D233/88 , C07D261/20 , C07D277/56 , C07D277/64 , C07D307/40 , C07D307/52 , C07D307/81 , C07D307/91 , C07D311/68 , C07D333/16 , C07D333/20 , C07D333/50 , C07D333/54 , C07D333/58 , C07D333/62 , C07D333/66 , C07D333/68 , C07D333/76 , C07D335/06 , C07D401/04 , C07D401/10 , C07D401/12 , C07D405/04 , C07D405/10 , C07D405/12 , C07D409/04 , C07D409/06 , C07D409/12 , C07D409/14 , C07D413/04 , C07D413/12 , C07D413/14 , C07D417/04 , C07D417/12 , C07D471/04 , C07D495/14 , A61K2300/00
Abstract: Disclosed herein are new antiviral compounds, together with pharmaceutical compositions that include one or more antiviral compounds, and methods of synthesizing the same. Also disclosed herein are methods of ameliorating and/or treating a paramyxovirus viral infection with one or more small molecule compounds. Examples of paramyxovirus infection include an infection caused by human respiratory syncytial virus (RSV).
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公开(公告)号：US20170158598A1
公开(公告)日：2017-06-08
申请号：US15439055
申请日：2017-02-22
Applicant: Dow AgroSciences LLC
Inventor： William C. Lo , James E. Hunter , Gerald B. Watson , Akshay Patny , Pravin S. Iyer , Joshodeep Boruwa
IPC: C07C63/70 , C07C255/50 , A01N37/34 , C07C233/65 , A01N37/18 , C07D295/108 , A01N43/84 , C07D213/40 , A01N43/40 , C07D207/26 , A01N43/36 , C07D331/04 , A01N43/20 , C07D277/28 , A01N43/78 , C07D239/26 , A01N43/54 , C07D307/06 , A01N43/08 , C07D307/52 , C07D277/64 , C07D241/12 , A01N43/60 , C07D271/10 , A01N43/82 , C07D405/04 , C07D209/08 , C07D237/32 , C07D209/48 , C07D249/08 , A01N43/653 , A01N37/10
CPC classification number: C07C63/70 , A01N25/08 , A01N33/04 , A01N37/10 , A01N37/18 , A01N37/20 , A01N37/28 , A01N37/30 , A01N37/34 , A01N37/44 , A01N37/46 , A01N41/10 , A01N43/08 , A01N43/16 , A01N43/20 , A01N43/36 , A01N43/38 , A01N43/40 , A01N43/50 , A01N43/54 , A01N43/58 , A01N43/60 , A01N43/653 , A01N43/78 , A01N43/82 , A01N43/84 , A01N47/12 , A01N47/28 , A01N47/32 , A01N53/00 , A01N59/02 , A61K31/38 , A61K31/4015 , A61K31/44 , A61K31/4965 , A61K31/505 , A61K31/5375 , C07C63/74 , C07C211/29 , C07C211/42 , C07C233/12 , C07C233/15 , C07C233/59 , C07C233/64 , C07C233/65 , C07C233/66 , C07C233/78 , C07C237/52 , C07C239/20 , C07C243/36 , C07C243/38 , C07C255/19 , C07C255/50 , C07C255/57 , C07C255/66 , C07C271/14 , C07C275/24 , C07C317/44 , C07C327/42 , C07C327/48 , C07C327/56 , C07C335/02 , C07C335/14 , C07C2601/02 , C07C2602/46 , C07D207/26 , C07D207/27 , C07D209/08 , C07D209/48 , C07D209/50 , C07D211/58 , C07D213/40 , C07D213/56 , C07D213/61 , C07D213/74 , C07D233/64 , C07D237/32 , C07D239/26 , C07D241/12 , C07D249/08 , C07D249/14 , C07D271/10 , C07D277/28 , C07D277/30 , C07D277/64 , C07D295/10 , C07D295/108 , C07D295/192 , C07D307/06 , C07D307/16 , C07D307/52 , C07D309/14 , C07D331/04 , C07D401/10 , C07D405/04
Abstract: This document discloses molecules having the following formula (“Formula One”): and processes associated therewith.
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公开(公告)号：US20160044919A1
公开(公告)日：2016-02-18
申请号：US14880651
申请日：2015-10-12
Applicant: Dow AgroSciences LLC
Inventor： William C. Lo , James E. Hunter , Gerald B. Watson , Akshay Patny , Pravin S. Iyer , Joshodeep Boruwa
IPC: A01N37/18 , A01N37/28 , A01N59/02 , C07C327/56 , C07C255/66 , A01N37/34 , C07C233/78 , C07C63/74 , A01N37/10 , C07C255/57 , C07C233/66 , C07D295/192 , A01N43/84 , C07D213/61 , A01N43/40 , C07D249/08 , A01N43/653 , C07C243/38
CPC classification number: C07C63/70 , A01N25/08 , A01N33/04 , A01N37/10 , A01N37/18 , A01N37/20 , A01N37/28 , A01N37/30 , A01N37/34 , A01N37/44 , A01N37/46 , A01N41/10 , A01N43/08 , A01N43/16 , A01N43/20 , A01N43/36 , A01N43/38 , A01N43/40 , A01N43/50 , A01N43/54 , A01N43/58 , A01N43/60 , A01N43/653 , A01N43/78 , A01N43/82 , A01N43/84 , A01N47/12 , A01N47/28 , A01N47/32 , A01N53/00 , A01N59/02 , A61K31/38 , A61K31/4015 , A61K31/44 , A61K31/4965 , A61K31/505 , A61K31/5375 , C07C63/74 , C07C211/29 , C07C211/42 , C07C233/12 , C07C233/15 , C07C233/59 , C07C233/64 , C07C233/65 , C07C233/66 , C07C233/78 , C07C237/52 , C07C239/20 , C07C243/36 , C07C243/38 , C07C255/19 , C07C255/50 , C07C255/57 , C07C255/66 , C07C271/14 , C07C275/24 , C07C317/44 , C07C327/42 , C07C327/48 , C07C327/56 , C07C335/02 , C07C335/14 , C07C2601/02 , C07C2602/46 , C07D207/26 , C07D207/27 , C07D209/08 , C07D209/48 , C07D209/50 , C07D211/58 , C07D213/40 , C07D213/56 , C07D213/61 , C07D213/74 , C07D233/64 , C07D237/32 , C07D239/26 , C07D241/12 , C07D249/08 , C07D249/14 , C07D271/10 , C07D277/28 , C07D277/30 , C07D277/64 , C07D295/10 , C07D295/108 , C07D295/192 , C07D307/06 , C07D307/16 , C07D307/52 , C07D309/14 , C07D331/04 , C07D401/10 , C07D405/04
Abstract: This document discloses molecules having the following formula (“Formula One”): and processes associated therewith.
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公开(公告)号：US20160037779A1
公开(公告)日：2016-02-11
申请号：US14880696
申请日：2015-10-12
Applicant: Dow AgroSciences LLC
Inventor： William C. Lo , James E. Hunter , Gerald B. Watson , Akshay Patny , Pravin S. Iyer , Joshodeep Boruwa
IPC: A01N47/32 , A01N43/78 , C07D239/26 , A01N43/54 , C07D307/16 , A01N37/10 , A01N43/08 , C07D277/64 , C07D241/12 , A01N43/60 , C07D233/64 , A01N43/50 , C07D309/14 , A01N43/16 , C07D271/10 , C07C255/57 , A01N43/82 , C07D211/58 , C07D209/50 , A01N43/38 , A01N37/34 , C07D249/08 , A01N43/653 , A01N25/08 , A01N37/18 , C07D295/192 , A01N43/84 , C07D213/61 , C07C335/14 , C07C233/59 , C07D237/32 , A01N43/58 , C07C211/29 , A01N33/04 , C07D401/10 , C07C63/70 , A01N43/40 , C07D207/27 , A01N43/36 , C07D331/04 , A01N43/20 , C07D277/30
CPC classification number: C07C63/70 , A01N25/08 , A01N33/04 , A01N37/10 , A01N37/18 , A01N37/20 , A01N37/28 , A01N37/30 , A01N37/34 , A01N37/44 , A01N37/46 , A01N41/10 , A01N43/08 , A01N43/16 , A01N43/20 , A01N43/36 , A01N43/38 , A01N43/40 , A01N43/50 , A01N43/54 , A01N43/58 , A01N43/60 , A01N43/653 , A01N43/78 , A01N43/82 , A01N43/84 , A01N47/12 , A01N47/28 , A01N47/32 , A01N53/00 , A01N59/02 , A61K31/38 , A61K31/4015 , A61K31/44 , A61K31/4965 , A61K31/505 , A61K31/5375 , C07C63/74 , C07C211/29 , C07C211/42 , C07C233/12 , C07C233/15 , C07C233/59 , C07C233/64 , C07C233/65 , C07C233/66 , C07C233/78 , C07C237/52 , C07C239/20 , C07C243/36 , C07C243/38 , C07C255/19 , C07C255/50 , C07C255/57 , C07C255/66 , C07C271/14 , C07C275/24 , C07C317/44 , C07C327/42 , C07C327/48 , C07C327/56 , C07C335/02 , C07C335/14 , C07C2601/02 , C07C2602/46 , C07D207/26 , C07D207/27 , C07D209/08 , C07D209/48 , C07D209/50 , C07D211/58 , C07D213/40 , C07D213/56 , C07D213/61 , C07D213/74 , C07D233/64 , C07D237/32 , C07D239/26 , C07D241/12 , C07D249/08 , C07D249/14 , C07D271/10 , C07D277/28 , C07D277/30 , C07D277/64 , C07D295/10 , C07D295/108 , C07D295/192 , C07D307/06 , C07D307/16 , C07D307/52 , C07D309/14 , C07D331/04 , C07D401/10 , C07D405/04
Abstract: This document discloses molecules having the following formula (“Formula One”): and processes associated therewith.
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5.发明授权2,3-diphenyl-valeronitrile derivatives, method for the production thereof and use thereof as herbicides and plant growth regulators 有权2,3-二苯基 - 戊腈衍生物，其制备方法及其作为除草剂和植物生长调节剂的用途公开(公告)号：US09084425B2
公开(公告)日：2015-07-21
申请号：US14131891
申请日：2012-07-11
Applicant: Marc Mosrin , Harald Jakobi , Alfred Angermann , Elmar Gatzweiler , Isolde Häuser-Hahn , Ines Heinemann , Christopher Hugh Rosinger , Stefan Lehr , Stefan Schnatterer
Inventor： Marc Mosrin , Harald Jakobi , Alfred Angermann , Elmar Gatzweiler , Isolde Häuser-Hahn , Ines Heinemann , Christopher Hugh Rosinger , Stefan Lehr , Stefan Schnatterer
IPC: A01N43/80 , A01N43/56 , A01N43/16 , A01N43/32 , A01N37/42 , A01N37/34 , C07C255/62 , C07C255/66 , C07D319/06 , C07D231/12 , C07D231/16 , C07D231/20 , C07D261/08 , C07C255/40 , C07C255/56 , C07C255/41
CPC classification number: A01N43/80 , A01N37/34 , A01N37/42 , A01N43/16 , A01N43/32 , A01N43/56 , C07C255/40 , C07C255/41 , C07C255/56 , C07C255/62 , C07C255/66 , C07C2601/10 , C07C2601/16 , C07C2602/44 , C07D231/12 , C07D231/16 , C07D231/20 , C07D261/08 , C07D319/06
Abstract: The invention describes compounds of formula (I), processes for preparing the compounds and methods of using the compounds as herbicides for the control of harmful plants or as plant growth regulators.
Abstract translation: 本发明描述了式（I）的化合物，制备化合物的方法和使用该化合物作为除草剂来控制有害植物或作为植物生长调节剂的方法。
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Patent Agency Ranking
6.发明申请Bioavailable Diacylhydrazine Ligands for Modulating the Expression of Exogenous Genes via an Ecdysone Receptor Complex 审中-公开用于通过蜕皮激素受体复合物调节外源基因表达的生物可利用的二酰基肼配体公开(公告)号：US20140045903A1
公开(公告)日：2014-02-13
申请号：US13954376
申请日：2013-07-30
Applicant: Intrexon Corporation
Inventor： Robert Eugene HORMANN , David W. Potter , Orestes Chortyk , Colin M. Tice , Glenn Richard Carlson , Andrew Meyer , Thomas R. Opie
IPC: C07D319/18 , C07D213/87 , C07C243/18
CPC classification number: C07C241/04 , A61K31/166 , A61K31/222 , A61K31/357 , A61K31/404 , A61K31/415 , A61K31/4184 , A61K31/455 , A61K31/4965 , C07C243/18 , C07C243/24 , C07C243/38 , C07C251/08 , C07C251/38 , C07C255/66 , C07C281/10 , C07C309/59 , C07C315/02 , C07C317/44 , C07C317/46 , C07D209/42 , C07D213/81 , C07D213/82 , C07D213/86 , C07D213/87 , C07D231/14 , C07D231/56 , C07D235/06 , C07D235/24 , C07D237/24 , C07D239/52 , C07D241/24 , C07D271/12 , C07D317/68 , C07D319/08 , C07D319/18 , C07D319/20 , C07D405/12 , C12N9/0069 , C12N15/635 , C12P21/00 , Y02A50/471
Abstract: The present invention relates to non-steroidal ligands for use in nuclear receptor-based inducible gene expression system and a method to modulate exogenous gene expression in which an ecdysone receptor complex comprising a DNA binding domain; a ligand binding domain; a transactivation domain; and a ligand is contacted with a DNA construct comprising: the exogenous gene and a response element; wherein the exogenous gene is under the control of the response element and binding of the DNA binding domain to the response element in the presence of the ligand results in activation or suppression of the gene.
Abstract translation: 本发明涉及用于基于核受体的可诱导基因表达系统的非甾体配体和调节外源基因表达的方法，其中包含DNA结合结构域的蜕皮激素受体复合物; 配体结合域; 反式激活域 并且配体与包含以下的DNA构建体接触：外源基因和应答元件; 其中外源基因处于响应元件的控制之下，并且在配体存在下DNA结合结构域与响应元件的结合导致基因的激活或抑制。
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7.发明申请4-(2-(6-SUBSTITUTED-HEXYLIDENE) HYDRAZINYL)BENZONITRILE AND PREPARATION THEREOF 有权4-（2-（6-取代 - 十六烷基）氢化茚）苯并噻唑及其制备方法公开(公告)号：US20140005395A1
公开(公告)日：2014-01-02
申请号：US13932098
申请日：2013-07-01
Applicant: Forest Laboratories Holdings Ltd.
Inventor： Matthew Ronsheim
IPC: C07D405/12 , C07C253/30 , C07C255/66
CPC classification number: C07D405/12 , C07C253/30 , C07C255/66
Abstract: The present teachings provide a compound of Formula (I-B): wherein R1-R10 are as described herein; a pharmaceutically acceptable salt of the compound, a geometric isomer of the compound, or a pharmaceutically acceptable salt of the geometric isomer. Also described are methods of preparing the same, as well as methods for preparing vilazodone using the same.
Abstract translation: 本发明提供式（I-B）的化合物：其中R 1 -R 10如本文所述; 化合物的药学上可接受的盐，化合物的几何异构体或几何异构体的药学上可接受的盐。 还描述了制备该方法的方法，以及使用其制备维拉唑酮的方法。
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8.发明申请Bioavailable Diacylhydrazine Ligands for Modulating the Expression of Exogenous Genes via an Ecdysone Receptor Complex 有权用于通过蜕皮激素受体复合物调节外源基因表达的生物可利用的二酰基肼配体公开(公告)号：US20130040389A1
公开(公告)日：2013-02-14
申请号：US13604001
申请日：2012-09-05
Applicant: Robert Eugene HORMANN , David W. Potter , Orestes Chortyk , Colin M. Tice , Glenn Richard Carlson , Andrew Meyer , Thomas R. Opie
Inventor： Robert Eugene HORMANN , David W. Potter , Orestes Chortyk , Colin M. Tice , Glenn Richard Carlson , Andrew Meyer , Thomas R. Opie
IPC: C07C243/38 , C07D407/12 , C07C317/28 , C07D241/24 , C07D319/14 , C07D235/08 , C07D209/42 , C07D233/90 , C07D231/56 , C07D405/12 , C12N5/00 , C07D213/81
CPC classification number: C07C241/04 , A61K31/166 , A61K31/222 , A61K31/357 , A61K31/404 , A61K31/415 , A61K31/4184 , A61K31/455 , A61K31/4965 , C07C243/18 , C07C243/24 , C07C243/38 , C07C251/08 , C07C251/38 , C07C255/66 , C07C281/10 , C07C309/59 , C07C315/02 , C07C317/44 , C07C317/46 , C07D209/42 , C07D213/81 , C07D213/82 , C07D213/86 , C07D213/87 , C07D231/14 , C07D231/56 , C07D235/06 , C07D235/24 , C07D237/24 , C07D239/52 , C07D241/24 , C07D271/12 , C07D317/68 , C07D319/08 , C07D319/18 , C07D319/20 , C07D405/12 , C12N9/0069 , C12N15/635 , C12P21/00 , Y02A50/471
Abstract: The present invention relates to non-steroidal ligands for use in nuclear receptor-based inducible gene expression system, and a method to modulate exogenous gene expression in which an ecdysone receptor complex comprising: a DNA binding domain; a ligand binding domain; a transactivation domain; and a ligand is contacted with a DNA construct comprising: the exogenous gene and a response element; wherein the exogenous gene is under the control of the response element and binding of the DNA binding domain to the response element in the presence of the ligand results in activation or suppression of the gene.
Abstract translation: 本发明涉及用于基于核受体的诱导型基因表达系统的非甾体配体，以及调节外源基因表达的方法，其中蜕皮激素受体复合物包含：DNA结合结构域; 配体结合域; 反式激活域 并且配体与包含以下的DNA构建体接触：外源基因和应答元件; 其中外源基因处于响应元件的控制之下，并且在配体存在下DNA结合结构域与响应元件的结合导致基因的激活或抑制。
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9.发明申请Compound inhibiting in vivo phosphorous transport and medicine containing the same 失效抑制体内磷运输的化合物和含有其的药物公开(公告)号：US20060217426A1
公开(公告)日：2006-09-28
申请号：US10550857
申请日：2004-03-29
Applicant: Nobuaki Eto , Rika Nagao , Tetsuko Kazama
Inventor： Nobuaki Eto , Rika Nagao , Tetsuko Kazama
IPC: A61K31/4415 , A61K31/165 , C07D211/70 , C07C237/20
CPC classification number: C07C323/60 , C07C251/86 , C07C255/66 , C07C259/10 , C07C317/44 , C07C323/25 , C07C323/66 , C07C2601/14 , C07D209/14 , C07D209/34 , C07D211/46 , C07D213/53 , C07D213/81 , C07D213/82 , C07D249/12 , C07D261/18 , C07D307/38 , C07D307/52 , C07D307/71 , C07D333/22 , C07D333/38 , C07D333/68 , C07D401/12 , C07D405/12 , C07D409/12 , C07D471/04 , C07D491/10 , C07D495/04
Abstract: An objective of the present invention is to provide compounds that can effectively suppress the concentration of phosphorus in serum to effectively prevent or treat diseases induced by an increase in concentration of phosphate in serum. The compounds according to the present invention are compounds represented by formula (I) and pharmaceutically acceptable salts and solvates thereof: wherein A represents an optionally substituted five- to nine-membered unsaturated carbocyclic moiety or a five- to nine-membered unsaturated heterocyclic moiety, and represents a single bond or a double bond, R5 represents optionally substituted aryl or the like, Z represents —N═CHR6R7 or the like, R6 and R7 represent H, optionally substituted alkyl, optionally substituted aryl or the like, R101 and R102 together form ═O, and R103 and R104 represent H, or R101 and R104 together from a bond, and R102 and R103 together form a bond.
Abstract translation: 本发明的目的是提供能有效抑制血清中磷浓度的化合物，以有效预防或治疗血清中磷酸盐浓度增加所引起的疾病。 根据本发明的化合物是由式（I）表示的化合物及其药学上可接受的盐和溶剂合物：其中A表示任选取代的五元至九元不饱和碳环部分或五至九元不饱和杂环部分， “img id =”custom-character-00001“he =”3.13mm“wi =”6.01mm“file =”US20060217426A1-20060928-P00900.TIF“alt =”custom character“img-content =”character“img- 格式=“tif”/>表示单键或双键，R 5表示任选取代的芳基等，Z表示-N-CHR 6 R > 7等，R 6和R 7表示H，任选取代的烷基，任选取代的芳基等，R 101， SUP>和R 102一起形成-O，R 103和R 104代表H或R 101， 和R 104一起来自键，R 102和R 103共同形成键。
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公开(公告)号：US20040242684A1
公开(公告)日：2004-12-02
申请号：US10602617
申请日：2003-06-25
Inventor： Hui Chen , Aviv Gazit , Alexander Levitzki , Klaus Peter Hirth , Elaina Mann , Laura K. Shawver , Jianming Tsai , Peng Cho Tang
IPC: A61K031/277 , C07C255/32
CPC classification number: C07D241/52 , A61K31/245 , A61K31/277 , A61K31/415 , A61K31/4184 , A61K31/4402 , A61K31/498 , A61K31/517 , C07C229/60 , C07C255/36 , C07C255/37 , C07C255/41 , C07C255/42 , C07C255/66 , C07C311/27 , C07C317/46 , C07C327/44
Abstract: The present invention concerns compounds and their use to inhibit the activity of a receptor tyrosine kinase. The invention is preferably used to treat cell proliferative disorders such as cancers charcterized by over-activity or inappropriate activity HER2 or EGFR.
Abstract translation: 本发明涉及化合物及其抑制受体酪氨酸激酶活性的用途。 本发明优选用于治疗细胞增殖性疾病，例如由过度活动或不适当活性HER2或EGFR表征的癌症。
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